Works (23)
Updated: April 8th, 2024 06:13
2024 journal article
Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics
ACS BIOMATERIALS SCIENCE & ENGINEERING, 10(2), 905–920.
author keywords: hydrogel; chitosan; immunotherapy; intratumoral
TL;DR:
The goal of the present work was to construct a novel, injectable hydrogel that could be tuned for localized immunotherapy delivery and displayed several clinically important features, including injectability, biocompatibility, and imageability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: March 4, 2024
2024 article
Chitosan-nanoclay embolic material for catheter-directed arterial embolization
Varghese, P. J. G., Zhao, K., Chen, P., & Hu, J. (2024, January 16). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 1.
author keywords: embolic agent; hydrogel; minimally invasive procedure; rheology; transcatheter injectability
TL;DR:
A gel embolic agent comprising chitosan nanofibers and nanoclay with excellent catheter injectability and tunable mechanical properties for embolization is introduced with the potential for transcatheter embolization of vascular malformation and malignant/benign tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Web Of Science
Added: January 26, 2024
2024 journal article
Developing a transcatheter injectable nanoclay- alginate gel for minimally invasive procedures
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 152.
author keywords: Minimally invasive procedure; Gel embolic agent; Shear -thinning; Transcatheter injectability
TL;DR:
Overall, NC/alginate gel exhibited excellent stability and tunable injectability by optimizing the composition of each component, highlighting the gel's potential as a robust embolic agent for a wide range of minimally invasive procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Web Of Science
Added: February 4, 2024
2022 journal article
Triptorelin-functionalized PEG-coated biosynthesized gold nanoparticles: Effects of receptor-ligand interactions on adhesion to triple negative breast cancer cells
Biomaterials Advances, 4, 212801.
author keywords: Adhesion; PEG-coated gold nanoparticles; Molecular dynamic simulation; Triptorelin; AFM; Triple negative breast cancer
MeSH headings : Cell Line, Tumor; Gold / pharmacology; Humans; Ligands; Metal Nanoparticles; Triple Negative Breast Neoplasms / drug therapy; Triptorelin Pamoate / pharmacology
TL;DR:
The molecular dynamics model reveals insights into the effects of receptor density, molecular configuration, and receptor-ligand docking characteristics on the interactions of triptorelin-functionalized PEG-coated gold nanoparticles with TNBC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2021 journal article
Actin cytoskeletal structure and the statistical variations of the mechanical properties of non-tumorigenic breast and triple-negative breast cancer cells
Journal of the Mechanical Behavior of Biomedical Materials, 119, 104505.
author keywords: Shear assay technique; Actin cytoskeleton; Viscoelastic properties; Statistical variations
MeSH headings : Actins; Cytoskeleton; Elastic Modulus; Humans; Triple Negative Breast Neoplasms; Viscosity
TL;DR:
The variation in the actin content of the cell cytoskeletal structures is shown to be consistent with the viscoelastic properties of theCell as it progresses from non-tumorigenic to more metastatic states and for the development of shear assay techniques and mechanical biomarkers for the detection of triple-negative breast cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2021 article
Investigation of creep properties and the cytoskeletal structures of non-tumorigenic breast cells and triple-negative breast cancer cells
Onwudiwe, K., Obayemi, J., Hu, J., Oparah, J., Onyekanne, C., Nwazojie, C., … Soboyejo, W. (2021, December 29). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 110.
author keywords: cancer detection; cell viscoelastic; creep properties; confocal microscopy; cytoskeletal proteins; immunofluorescence staining; relative volume density; shear assay
MeSH headings : Actins; Cytoskeleton; Elastic Modulus; Elasticity; Humans; Triple Negative Breast Neoplasms; Viscosity
TL;DR:
The study reveals significant differences between the creep and viscoelastic properties of non-tumorigenic breast cells versus tumorigenic cells and the variations in the creep strain rates are shown to be well characterized by lognormal distributions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: January 10, 2022
2021 journal article
Percutaneous liquid ablation agent for tumor treatment and drug delivery
Science Translational Medicine, 13(580).
MeSH headings : Animals; Carcinoma, Hepatocellular / drug therapy; Humans; Liver Neoplasms / drug therapy; Liver Transplantation; Pharmaceutical Preparations; Rabbits; Treatment Outcome
TL;DR:
Results support the use of LATTE for percutaneous ablation of solid tumors and propose that this new LRT may bridge more patients to liver transplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2021 journal article
Silk Embolic Material for Catheter‐Directed Endovascular Drug Delivery
Advanced Materials, 11, 2106865.
author keywords: embolization; immunotherapy; nanoclay; silk; vascular interventions
MeSH headings : Animals; Arteries; Catheters; Cattle; Drug Delivery Systems; Embolization, Therapeutic / methods; Silk; Swine
TL;DR:
A novel silk‐based embolic material (SEM) that is developed and optimized to provide tandem integration of both embolization and the delivery of therapeutics is reported, showing potential in next‐generation multifunctional embolic agent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2020 journal article
Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing
Advanced Materials.
author keywords: decellularized extracellular matrix; embolization; hybrid nanocomposite hydrogels; transcatheter delivery; vascular remodeling
MeSH headings : Animals; Arteries / drug effects; Arteries / pathology; Arteries / physiopathology; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Embolization, Therapeutic / methods; Extracellular Matrix / chemistry; Hydrogels / chemistry; Nanocomposites / chemistry; Shear Strength; Swine; Vascular Remodeling / drug effects
TL;DR:
A decellularized cardiac extracellular matrix (ECM)‐based nanocomposite hydrogel is developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2020 journal article
Blood‐Derived Biomaterial for Catheter‐Directed Arterial Embolization
Advanced Materials.
author keywords: angiography; biomaterials; embolization; platelet rich fibrin; point‐ of‐ care
MeSH headings : Animals; Arteries; Biocompatible Materials / pharmacology; Blood; Catheters; Cell Proliferation / drug effects; Embolization, Therapeutic / instrumentation; Neovascularization, Physiologic / drug effects; Swine
TL;DR:
A novel blood‐derived embolic material (BEM) with regenerative properties, that can achieve instant and durable intra‐arterial hemostasis regardless of coagulopathy, is developed and shown to have significant advantages over embolic materials used today.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2020 journal article
Emerging embolic agents in endovascular embolization: an overview
Progress in Biomedical Engineering, 2(1), 012003.
author keywords: minimally invasive procedures; embolic agents; transcatheter delivery; translational applications
TL;DR:
The clinically available embolic agents, their formulations and applications, and materials in development for embolization are discussed, and the challenges during the process of transitioning from basic science to translational applications in this field are emphasized.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2020 book review
Foundations of Biomaterials Engineering by Maria Cristina Tanzi, Silvia Farè, and Gabriele Candiani
[Review of]. MRS Bulletin.
Source: ORCID
Added: August 10, 2022
2020 journal article
Luteinizing Hormone-Releasing Hormone (LHRH) Conjugated Magnetite Nanoparticles as MRI Contrast Agents for Breast Cancer Imaging
Applied Sciences, 10(15), 5175.
author keywords: triple negative breast cancer (TNBC); luteinizing hormone-releasing hormone (LHRH); magnetite nanoparticles; magnetic resonance imaging (MRI); cancer detection
TL;DR:
The potential of LHRH-MNPs as negative contrast agents for the specific detection of TNBC is shown, with consistent darkening effect in T2-weighted maps.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2020 journal article
Nanocomposite Hydrogel with Tantalum Microparticles for Rapid Endovascular Hemostasis
Advanced Science, n/a(n/a), 2003327.
Source: ORCID
Added: August 10, 2022
2019 journal article
A shear assay study of single normal/breast cancer cell deformation and detachment from poly-di-methyl-siloxane (PDMS) surfaces
Journal of the Mechanical Behavior of Biomedical Materials, 91, 76–90.
author keywords: Cell deformation and detachment; Shear assay technique; Viscoelastic cell deformation; Vinculin pull-out; Interfacial fracture
MeSH headings : Biomechanical Phenomena; Breast / cytology; Breast / pathology; Breast Neoplasms / pathology; Cell Adhesion; Cell Line, Tumor; Cytoskeleton / metabolism; Dimethylpolysiloxanes; Elasticity; Humans; Hydrodynamics; Nylons; Shear Strength; Surface Properties; Viscosity
TL;DR:
The results of a combined experimental and analytical/computational study of viscoelastic cell deformation and detachment from poly-di-methyl-siloxane (PDMS) surfaces are presented and the implications are discussed for the design of interfaces that are relevant to implantable biomedical devices and normal/cancer tissue.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2019 journal article
Advances in Biomaterials and Technologies for Vascular Embolization
Advanced Materials.
author keywords: catheter-based delivery; embolic agents; interventional radiology; minimally invasive surgery; vascular embolization
MeSH headings : Animals; Biocompatible Materials / chemistry; Embolization, Therapeutic / instrumentation; Embolization, Therapeutic / methods; Endovascular Procedures; Humans; Metals / chemistry; Microspheres; Polymers / chemistry
TL;DR:
The aim here is to provide a comprehensive overview of current and emerging technologies in endovascular embolization with respect to devices, materials, mechanisms, and design guidelines.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2019 journal article
Compressive Deformation and Failure of Trabecular Structures in A Turtle Shell
Acta Biomaterialia.
author keywords: Turtle shell; Trabecular bone; Compressive deformation; Failure; Foam structure
MeSH headings : Animal Shells / chemistry; Animal Shells / diagnostic imaging; Animals; Porosity; Stress, Mechanical; Turtles / anatomy & histology; X-Ray Microtomography
TL;DR:
The proposed work shows that the turtle shell structures can be analyzed as sandwich structures that have the capacity to concentrate deformation and stresses within the trabecular bones, which enables significant energy absorption during compressive deformation.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2018 journal article
An investigation of the viscoelastic properties and the actin cytoskeletal structure of triple negative breast cancer cells
Journal of the Mechanical Behavior of Biomedical Materials, 86, 1–13.
author keywords: Shear assay method; Digital image correlation; Cell viscoelasticity; Actin cytoskeletal structure; Cancer diagnosis
MeSH headings : Actin Cytoskeleton / metabolism; Biomechanical Phenomena; Cell Line, Tumor; Elasticity; Humans; Neoplasm Metastasis; Triple Negative Breast Neoplasms / pathology; Viscosity
TL;DR:
The results suggest that the shear assay measurements of cell viscoelastic properties may be used as effective biomarkers for TNBC diagnosis and screening.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2018 journal article
Enhanced cellular uptake of LHRH-conjugated PEG-coated magnetite nanoparticles for specific targeting of triple negative breast cancer cells
Materials Science and Engineering C, 88, 32–45.
Contributors: * , J. Obayemi *, K. Malatesta*, A. Košmrlj * & W. Soboyejo *
author keywords: Luteinizing hormone releasing hormone (LHRH); LHRH-conjugated PEG-coated magnetite anoparticles (LHRH-MNPs); Triple negative breast cancer (TNBC); Specific targeting
MeSH headings : Cell Line, Tumor; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacokinetics; Coated Materials, Biocompatible / pharmacology; Drug Delivery Systems / methods; Female; Gonadotropin-Releasing Hormone / chemistry; Gonadotropin-Releasing Hormone / pharmacokinetics; Gonadotropin-Releasing Hormone / pharmacology; Humans; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / therapeutic use; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Polyethylene Glycols / pharmacology; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / metabolism
TL;DR:
The results show that the presence of LHRH enhances the uptake of L HRH-MNPs into TNBC cells, and the trends in the predicted nanoparticle entry times and the size ranges of the engulfed nanoparticles are shown to be consistent with experimental observations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2018 journal article
Investigation of adhesive interactions in the specific targeting of Triptorelin-conjugated PEG-coated magnetite nanoparticles to breast cancer cells
Acta Biomaterialia, 71, 363–378.
author keywords: Triptorelin-conjugated PEG-coated; magnetite nanoparticles; Adhesive interaction; Atomic force microscopy; Molecular dynamics simulations; Breast cancer targeting
MeSH headings : Breast Neoplasms / drug therapy; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacokinetics; Coated Materials, Biocompatible / pharmacology; Drug Delivery Systems; Female; Humans; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / therapeutic use; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Polyethylene Glycols / pharmacology; Triptorelin Pamoate / chemistry; Triptorelin Pamoate / pharmacokinetics; Triptorelin Pamoate / pharmacology
TL;DR:
This study characterizes and quantifies the work of adhesion, as well as adhesion forces, at the nanocarrier/cell interfaces, unravels the molecular origins of adhesive interactions and highlights the effectiveness of PEG coatings and Triptorelin ligands in the specific targeting of breast cancer cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2017 journal article
Adhesion of ligand-conjugated biosynthesized magnetite nanoparticles to triple negative breast cancer cells
Journal of the Mechanical Behavior of Biomedical Materials, 68, 276–286.
Contributors: J. Obayemi *, * , V. Uzonwanne*, O. Odusanya*, K. Malatesta*, N. Anuku*, W. Soboyejo *
author keywords: Chemically synthesized magnetite nanoparticles (CMNPs); Biosynthesized magnetite nanoparticles (BMNPs); Luteinizing hormone-releasing hormone (LHRH); Breast specific antibody (BSA); Ephrin type-A receptor 2 (EphA2)
MeSH headings : Adhesiveness; Cell Line, Tumor; Drug Delivery Systems; Gonadotropin-Releasing Hormone / chemistry; Humans; Magnetite Nanoparticles / chemistry; Nanoconjugates / chemistry; Receptor, EphA2 / chemistry; Triple Negative Breast Neoplasms / metabolism
TL;DR:
The results of an experimental study of the adhesion forces between components of model conjugated magnetite nanoparticle systems for improved selectivity in the specific targeting of triple negative breast cancer are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 10, 2022
2017 journal article
Biosynthesis of Gold Nanoparticles and Gold/Prodigiosin Nanoparticles with Serratia marcescens Bacteria
Waste and Biomass Valorization, 8(6), 2045–2059.
Contributors: S. Dozie-Nwachukwu*, J. Obayemi *, Y. Danyuo *, G. Etuk-Udo, Y. Chi*, * , N. Anuku*, O. Odusanya, K. Malatesta*, W. Soboyejo *
author keywords: Serratia marcescens; Gold nanoparticles; Cell-free extract; Biomass; Dynamic light scattering; Prodigiosin
TL;DR:
The results show clearly that the production of gold nanoparticles from cell-free extracts require shorter times than the production from the biomass, and the implications of the results are also discussed for the processing ofgold nanoparticles and gold prodigiosin nanoparticles for localized cancer treatment.
(via Semantic Scholar)
Source: ORCID
Added: August 10, 2022
2017 conference paper
Precision control of nanoparticle monolayer assembly: Optimizing rate and crystal quality
2017 IEEE 17th International Conference on Nanotechnology, NANO 2017, 286–289.
Contributors: M. Bedewy *, * & A. Hart *
Source: ORCID
Added: August 10, 2022
Employment
Updated: August 30th, 2021 16:15
2021 - present
North Carolina State University Raleigh, North Carolina, US
Assistant Professor
Mechanical and Aerospace Engineering
2018 - present
Mayo Clinic Arizona Scottsdale, AZ, US
Postdoctoral Research Fellow
Department of Radiology
Education
Updated: June 21st, 2018 11:34
2013 - 2018
Princeton University Princeton, NJ, US
Ph.D.
Mechanical and Aerospace Engineering
2009 - 2013
University of Michigan Ann Arbor, MI, US
B.S.E
Mechanical Engineering
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
