@misc{wheeler_williams_yu_mishra_2024, title={Brain Natriuretic Peptide Exerts Inflammation and Peripheral Itch in a Mouse Model of Atopic Dermatitis}, volume={144}, ISSN={["1523-1747"]}, DOI={10.1016/j.jid.2023.09.273}, abstractNote={Atopic dermatitis (AD) is a globally prevalent disease that affects both children and adults, and the incidence of AD is increasing worldwide (Bylund et al, 2020). AD is characterized by dry, inflamed, and itchy skin, but the etiology behind neuroinflammation and itch related to AD skin is only beginning to be understood. The brain natriuretic peptide (BNP), a byproduct of the NPPB gene, is expressed in primary afferent neurons, which are known to be responsible for central itch (Meng et al, 2018; Mishra and Hoon, 2013; Mishra et al, 2020; Pitake et al, 2018; Usoskin et al, 2015).}, number={3}, journal={JOURNAL OF INVESTIGATIVE DERMATOLOGY}, author={Wheeler, Joshua J. and Williams, Nidha and Yu, Junho and Mishra, Santosh K.}, year={2024}, month={Mar}, pages={705–707} }
 @article{mishra_wheeler_pitake_ding_jiang_fukuyama_paps_ralph_coyne_parkington_et al._2020, title={Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch}, volume={31}, ISSN={["2211-1247"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85082772179&partnerID=MN8TOARS}, DOI={10.1016/j.celrep.2020.03.036}, abstractNote={Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the integrin αVβ3 expressed on a subset of sensory neurons as the periostin receptor. Using pharmacological and genetic approaches, we inhibited the function of neuronal integrin αVβ3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch.}, number={1}, journal={CELL REPORTS}, author={Mishra, Santosh K. and Wheeler, Joshua J. and Pitake, Saumitra and Ding, Huiping and Jiang, Changyu and Fukuyama, Tomoki and Paps, Judy S. and Ralph, Patrick and Coyne, Jacob and Parkington, Michelle and et al.}, year={2020}, month={Apr} }