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Works (6)
Updated: April 26th, 2024 10:27
2024 journal article
Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma
SCIENCE TRANSLATIONAL MEDICINE, 16(742).
Source: Web Of Science
Added: April 22, 2024
2023 article
Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles
Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
TL;DR:
Thrombin-sensitive PLPs are created that exhibit a wound-triggered shape change, induce significant clot retraction following exposure to thrombin and promote hemostasis and healing in vivo after trauma.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2021 article
Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo
Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.
author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
TL;DR:
The therapeutic efficacy of targeted fibrin‐specific nanogel (FSN) design for targeted delivery of tPA to treat thrombotic complications is demonstrated and key translational parameters for tPA‐FSN therapeutics are evaluated, including optimal tPA •FSN dosage in a DIC rodent model and safety of intravenous tPA•FSN therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: December 20, 2021
2020 journal article
Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.
Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n
author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
TL;DR:
It is found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes, and Ag-PLPs have great promise for treating hemorrhage and improving healing following trauma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020
2019 journal article
Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting
Molecular Pharmaceutics, 17(2), 392–403.
author keywords: drug delivery; click chemistry; pancreatic cancer; brain delivery; extracellular matrix; computer modeling
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Brain / metabolism; Cell Line, Tumor; Click Chemistry / methods; Computational Biology / methods; Computer Simulation; Disease Models, Animal; Drug Delivery Systems / methods; Esters / administration & dosage; Esters / chemistry; Esters / pharmacokinetics; Extracellular Matrix / drug effects; Female; Hydrogels / administration & dosage; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / pathology; Succinimides; Tissue Distribution
TL;DR:
ECM-anchored click groups do not elicit any noticeable local or systemic toxicity or immune response and specifically capture systemically-circulating molecules at intradermal, intratumoral, and intracranial sites for multiple months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 20, 2020
2018 journal article
Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas
CELL TRANSPLANTATION, 27(3), 542–550.
author keywords: islet isolation; selective osmotic shock; GLUT2; canine; cadaveric
MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Dogs; Female; Glucose / pharmacology; Glucose Transporter Type 2 / metabolism; Islets of Langerhans / metabolism; Male; Osmotic Pressure / drug effects; Osmotic Pressure / physiology
TL;DR:
A novel islet isolation protocol utilizing high concentrations of glucose to cause selective osmotic shock (SOS) provides a widely available means for researchers to isolate canine islets for use in islet transplantation or in studies of canine islet physiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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