Works (458)

Updated: August 23rd, 2023 21:16

2020 journal article

Impact of Frictional Interactions on Conductivity, Diffusion, and Transference Number in Ether- and Perfluoroether-Based Electrolytes

JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 167(12).

Source: Web Of Science
Added: October 5, 2020

2020 journal article

Lithium Salt Distribution and Thermodynamics in Electrolytes Based on Short Perfluoropolyether-block-Poly(ethylene oxide) Copolymers

MACROMOLECULES, 53(4), 1142–1153.

By: M. Chintapalli*, K. Timachova*, K. Olson*, S. Mecham*, J. DeSimone n & N. Balsara*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 30, 2020

2020 journal article

Pulmonary Delivery of Nanoparticle-Bound Toll-like Receptor 9 Agonist for the Treatment of Metastatic Lung Cancer

ACS NANO, 14(6), 7200–7215.

By: J. Perry*, S. Tian*, N. Sengottuvel*, E. Harrison*, B. Gorentla*, C. Kapadia*, N. Cheng*, J. Luft* ...

author keywords: nanoparticles; PRINT; CpG; immunotherapy; pulmonary delivery; lung cancer
MeSH headings : Animals; Carcinoma, Non-Small-Cell Lung; Lung; Lung Neoplasms / drug therapy; Mice; Mice, Inbred C57BL; Nanoparticles; Oligodeoxyribonucleotides; Toll-Like Receptor 9
TL;DR: Results demonstrate that PRINT-CpG is a potent nanoplatform for local treatment of lung cancer that has collateral therapeutic effects on systemic disease, an encouraging toxicity profile, and may have the potential to treat lung metastasis of other cancer types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 20, 2020

2019 journal article

3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body

ACS CENTRAL SCIENCE, 5(3), 419–427.

By: H. Oh*, M. Aboian*, M. Yi*, J. Maslyn*, W. Loo*, . Jiang*, D. Parkinson*, M. Wilson* ...

TL;DR: The introduction of the absorbers into the blood of swine models enables the capture of 64 ± 6% of the administered drug (doxorubicin) without any immediate adverse effects, a significant step forward in minimizing toxic side effects of chemotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 9, 2019

2019 journal article

Difference between approximate and rigorously measured transference numbers in fluorinated electrolytes

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 21(15), 7857–7866.

By: D. Shah*, H. Nguyen*, L. Grundy*, K. Olson*, S. Mecham*, J. DeSimone n, N. Balsara*

TL;DR: This work presents a complete set of ion transport properties for mixtures of a functionalized perfluoroether, dimethyl carbonate terminated perfluorinated tetraethylene ether, and lithium bis(fluorosulfonyl)imide (LiFSI). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 20, 2019

2019 journal article

Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine

ACS OMEGA, 4(3), 5547–5555.

By: C. Kapadia*, S. Tian*, J. Perry*, J. Luft* & J. Desimone n

TL;DR: High antigen density NPs presented the highest p-MHC-I on the surface of BMDCs and induced higher proliferation of T cells, whereas NPs with low peptide density resulted in higher DC cell uptake and elevated frequency of IFN-γ producing CD8+ T cells in mice as compared to the medium- and high-density formulations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2019

2018 journal article

Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins

JOURNAL OF CONTROLLED RELEASE, 278, 9–23.

By: C. Bloomquist*, M. Mecham*, M. Paradzinsky*, R. Janusziewicz*, S. Warner n, J. Luft*, S. Mecham*, A. Wang*, J. DeSimone n

author keywords: Continuous Liquid Interface Production; 3D printing; Additive manufacturing; Drug delivery; Crosslink density; Medical device
MeSH headings : Chemistry, Pharmaceutical / methods; Delayed-Action Preparations; Dexamethasone / administration & dosage; Dexamethasone / analogs & derivatives; Dexamethasone / chemistry; Docetaxel / administration & dosage; Docetaxel / chemistry; Drug Carriers / chemistry; Drug Delivery Systems; Drug Liberation; Polyesters / chemistry; Polyethylene Glycols / chemistry; Precision Medicine / methods; Printing, Three-Dimensional; Rhodamines / administration & dosage; Rhodamines / chemistry; Technology, Pharmaceutical / methods; Time Factors
TL;DR: The potential of the CLIP manufacturing platform to serve as a method to fabricate biocompatible and drug‐loaded devices with controlled release properties, using liquid resins containing active pharmaceutical ingredients (API) is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery

PHARMACEUTICAL RESEARCH, 35(10).

By: E. Wilson*, J. Luft* & J. DeSimone*

author keywords: aerosols; dry powder inhalers; particle engineering; pulmonary protein delivery
MeSH headings : Administration, Inhalation; Aerosols / chemistry; Chemistry, Pharmaceutical; Drug Delivery Systems / methods; Dry Powder Inhalers; Humans; Lung; Particle Size; Powders / chemistry; Serum Albumin, Bovine / chemistry
TL;DR: Pulmonary delivery of biologics is of great interest, as it can be used for the local treatment of respiratory diseases or as a route to systemic drug delivery, and a formulation platform capable of producing high performance aerosols without altering protein native structure is required. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(6), 991–998.

By: J. Byrne*, M. Jajja*, . Adrian T. O'Neill*, A. Schorzman*, A. Keeler*, J. Luft*, W. Zamboni*, J. DeSimone n, J. Yeh*

author keywords: Iontophoresis; FOLFIRINOX; Pancreatic cancer; Device delivery; Chemotherapy
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics; Biological Transport; Drug Combinations; Drug Delivery Systems; Electrolytes / metabolism; Fluorouracil / administration & dosage; Humans; Iontophoresis; Irinotecan; Leucovorin / administration & dosage; Mice; Organometallic Compounds / administration & dosage; Oxaliplatin; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / pathology; Time Factors; Tissue Distribution; Treatment Outcome; Xenograft Model Antitumor Assays
TL;DR: It is found that reducing the duration of iontophoretic treatment from 10 to 5 min per solution resulted in a significant decrease in drug concentrations, and electrolyte concentrations were underlying the difference in drug transport of the formulations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Optimization of Surface Display of DENV2 E Protein on a Nanoparticle to Induce Virus Specific Neutralizing Antibody Responses

BIOCONJUGATE CHEMISTRY, 29(5), 1544–1552.

By: J. Coffman n, S. Metz*, A. Brackbill*, M. Paul*, M. Miley*, J. DeSimone n, J. Luft*, A. Silva*, S. Tian*

MeSH headings : Adsorption; Animals; Antibodies, Neutralizing / immunology; Antibodies, Viral / immunology; Antibody Formation; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue Vaccines / administration & dosage; Dengue Vaccines / chemistry; Dengue Vaccines / immunology; Dengue Virus / chemistry; Dengue Virus / immunology; Female; Immobilized Proteins / administration & dosage; Immobilized Proteins / chemistry; Immobilized Proteins / immunology; Immunization; Mice, Inbred BALB C; Models, Molecular; Nanoparticles / chemistry; Vero Cells; Viral Envelope Proteins / administration & dosage; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / immunology
TL;DR: This work optimized the display of DENV-E conjugated to the surface of a nanoparticle through EDC/NHS chemistry, establishing a platform that can be expanded upon in future work to fully control the display, and improving both protein stability and epitope display. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery

JOURNAL OF CONTROLLED RELEASE, 284, 122–132.

By: C. Caudill*, J. Perry*, S. Tian*, J. Luft* & J. DeSimone n

author keywords: Microneedles; Additive manufacturing; 3D printing; Continuous liquid interface production; Transdermal drug delivery; Coating
MeSH headings : Administration, Cutaneous; Animals; Cattle; Drug Delivery Systems / instrumentation; Female; Mice, Inbred BALB C; Microinjections / instrumentation; Needles; Proteins / administration & dosage; Proteins / pharmacokinetics; Serum Albumin, Bovine / administration & dosage; Serum Albumin, Bovine / pharmacokinetics; Skin / metabolism; Skin Absorption; Swine; Transdermal Patch
TL;DR: The utility of a versatile coating platform for preparation of precisely coated microneedles for transdermal therapeutic delivery is demonstrated and is demonstrated using the novel additive manufacturing technique Continuous Liquid Interface Production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 review

Use of iontophoresis for the treatment of cancer

[Review of ]. JOURNAL OF CONTROLLED RELEASE, 284, 144–151.

By: J. Byrne, J. Yeh* & J. DeSimone n

author keywords: Iontophoresis; Chemotherapies; Devices; Drug delivery; Cancer
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Equipment Design; Humans; Iontophoresis / instrumentation; Iontophoresis / methods; Neoplasms / drug therapy; Translational Research, Biomedical
TL;DR: Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer and have shown promise in pre‐clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2017 journal article

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

NATURE NANOTECHNOLOGY, 12(9), 877-+.

By: Y. Min*, K. Roche*, S. Tian*, M. Eblan*, K. McKinnon*, J. Caster*, S. Chai*, L. Herring* ...

MeSH headings : Animals; Antigens, Neoplasm / immunology; CD4-CD8 Ratio; Cell Line, Tumor; Female; Immunotherapy / methods; Melanoma, Experimental / immunology; Melanoma, Experimental / therapy; Mice, Inbred C57BL; Nanomedicine / methods; Nanoparticles / therapeutic use; Neoplasms / immunology; Neoplasms / therapy; Programmed Cell Death 1 Receptor / antagonists & inhibitors; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes, Cytotoxic / immunology
TL;DR: It is shown that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of αPD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC- NPs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Crosslinked perfluoropolyether solid electrolytes for lithium ion transport

SOLID STATE IONICS, 310, 71–80.

By: D. Devaux*, I. Villaluenga, M. Bhatt, D. Shah, X. Chen, J. Thelen, J. DeSimone*, N. Balsara

author keywords: Perfluoropolyether; Polyhedral oligomeric silsesquioxane; Solid electrolyte; Crosslinked electrolyte; Lithium battery
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer

NANO LETTERS, 17(1), 242–248.

By: C. Bowerman*, J. Byrne*, K. Chu*, A. Schorzman*, A. Keeler*, C. Sherwood*, J. Perry*, J. Luft* ...

author keywords: Nanoparticles; docetaxel; triple-negative breast cancer; genetically engineered mouse model; chemoresistance
MeSH headings : A549 Cells; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Bridged-Ring Compounds / metabolism; Cell Survival; Docetaxel; Drug Carriers / chemistry; Drug Liberation; Drug Resistance, Neoplasm; Female; Humans; Lactic Acid / chemistry; Mice, Nude; Nanoparticles / chemistry; Particle Size; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Surface Properties; Taxoids / administration & dosage; Taxoids / chemistry; Taxoids / metabolism; Taxoids / pharmacokinetics; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / genetics
TL;DR: The potential of nanotechnology to improve the therapeutic index of chemotherapies and rescue therapeutic efficacy to treat nonresponsive cancers is demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Effect of Anion Size on Conductivity and Transference Number of Perfluoroether Electrolytes with Lithium Salts

JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 164(14), A3511–A3517.

By: D. Shah*, K. Olson*, A. Karny*, S. Mecham*, J. DeSimone n & N. Balsara*

Source: Web Of Science
Added: August 6, 2018

2017 journal article

Incipient microphase separation in short chain perfluoropolyether-block-poly(ethylene oxide) copolymers

SOFT MATTER, 13(22), 4047–4056.

By: M. Chintapalli*, K. Timachova*, K. Olson*, M. Banaszak*, J. Thelen*, S. Mecham*, J. DeSimone n, N. Balsara*

TL;DR: The ability to detect concentration fluctuations was enabled by both a relatively large value of χ and significant scattering contrast, enabling the detection of high degree of immiscibility between the PFPE and PEO blocks. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Mechanism of ion transport in perfluoropolyether electrolytes with a lithium salt

SOFT MATTER, 13(32), 5389–5396.

By: K. Timachova*, M. Chintapalli*, K. Olson*, S. Mecham*, J. DeSimone n & N. Balsara*

TL;DR: The analysis suggests that transport in electrolytes with low dielectric constants (low β) is dictated by ion hopping between clusters, and a non-dimensional parameter, β, that depends on the salt diffusion coefficients and ionic conductivity is calculated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Mediating Passive Tumor Accumulation through Particle Size, Tumor Type, and Location

NANO LETTERS, 17(5), 2879–2886.

By: J. Perry, K. Reuter, J. Luft, C. Pecot, W. Zamboni & J. DeSimone n

author keywords: Nanoparticles; PRINT; tumor accumulation; tumor model; tumor histology
MeSH headings : Animals; Cell Line, Tumor; Cellular Microenvironment / physiology; Fluorescent Dyes / chemistry; Heterografts; Humans; Mice; Nanoparticles / chemistry; Neoplasm Metastasis; Neoplasms / blood supply; Neoplasms / immunology; Neoplasms / metabolism; Neoplasms / pathology; Particle Size; Permeability
TL;DR: The EPR effect was examined as a function of nanoparticle size, tumor model, and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumors-associated immune cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Co-opting Moore's law: Therapeutics, vaccines and interfacially active particles manufactured via PRINT®

Journal of Controlled Release, 240, 541–543.

By: J. DeSimone n

author keywords: Nanoparticle; PRINT; cGMP delivery vehicle; Liquidia technologies; Team-based science; Clinical trials; Particle engineering; Drug delivery vehicle; Particulate vaccine; Calibration quality particles
MeSH headings : Drug Carriers / chemistry; Nanomedicine / instrumentation; Nanomedicine / methods; Nanoparticles / chemistry; Particle Size; Pharmaceutical Preparations / administration & dosage; Surface Properties; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Vaccines / administration & dosage
TL;DR: Particle replication in non-wetting templates (PRINT®) is one molding technique that allows for fabrication of "calibration quality" micro and nanoparticles with independent control over their physical parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: June 30, 2019

2016 journal article

Compliant glass-polymer hybrid single ion-conducting electrolytes for lithium batteries

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(1), 52–57.

By: I. Villaluenga*, K. Wujcik*, W. Tong*, D. Devaux*, D. Wong*, J. DeSimone n, N. Balsara*

author keywords: hybrid electrolytes; inorganic sulfide glasses; fluorinated polymers; lithium batteries; lithium-sulfur batteries
TL;DR: X-ray absorption spectroscopy indicates that the hybrid electrolyte limits lithium polysulfide dissolution and is, thus, ideally suited for Li-S cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Conductivity of carbonate- and perfluoropolyether-based electrolytes in porous separators

JOURNAL OF POWER SOURCES, 323, 158–165.

By: D. Devaux*, Y. Chang, I. Villaluenga, X. Chen, M. Chintapalli, J. DeSimone*, N. Balsara

author keywords: Perfluoropolyether; Conductivity; Separators; Battery; Polyolefin; Polytetrafluoroethylene
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT® nanoparticle formulation against non-small-cell lung cancer brain metastases

Nanomedicine, 11(15), 1947–1955.

By: M. Sambade, A. Deal, A. Schorzman*, J. Luft, C. Bowerman*, K. Chu*, O. Karginova*, A. Swearingen ...

author keywords: acid-labile docetaxel prodrug; blood-brain barrier; Particle Replication in Non-wetting Templates (PRINT)(R) PLGA nanoparticle
MeSH headings : Animals; Blood-Brain Barrier / metabolism; Brain / drug effects; Brain / pathology; Brain Neoplasms / drug therapy; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinoma, Non-Small-Cell Lung / drug therapy; Carcinoma, Non-Small-Cell Lung / pathology; Carcinoma, Non-Small-Cell Lung / secondary; Cell Line, Tumor; Docetaxel; Heterografts; Humans; Lactic Acid / chemistry; Lung Neoplasms / drug therapy; Lung Neoplasms / pathology; Mice; Mice, Nude; Nanoparticles / chemistry; Neoplasm Transplantation; Particle Size; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Taxoids / administration & dosage; Taxoids / chemistry; Taxoids / pharmacokinetics
TL;DR: The decreased toxicity of the PRINT-C2-docetaxel improved treatment efficacy against non-small-cell lung cancer brain metastasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 30, 2019

2016 journal article

Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8), 2200–2205.

By: J. Byrne*, M. Jajja*, A. Schorzman*, A. Keeler*, J. Luft*, W. Zamboni*, J. DeSimone n, J. Yeh*

author keywords: iontophoresis; FOLFIRINOX; pancreatic cancer; device delivery; chemotherapy
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics; Camptothecin / administration & dosage; Camptothecin / analogs & derivatives; Camptothecin / pharmacokinetics; Carcinoma, Pancreatic Ductal / drug therapy; Carcinoma, Pancreatic Ductal / metabolism; Carcinoma, Pancreatic Ductal / pathology; Cell Proliferation / drug effects; Fluorouracil / administration & dosage; Fluorouracil / pharmacokinetics; Humans; Infusion Pumps, Implantable; Iontophoresis / instrumentation; Leucovorin / administration & dosage; Leucovorin / pharmacokinetics; Mice; Mice, Nude; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / pharmacokinetics; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / metabolism; Pancreatic Neoplasms / pathology; Xenograft Model Antitumor Assays
TL;DR: Local iontophoretic delivery of cytotoxic agents should be considered for the treatment of patients with unresectable nonmetastatic disease and for patients with the need for palliation of local symptoms, and may be considered as a neoadjuvant approach to improve resection rates and outcome in patients with localized and locally advanced pancreatic cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Layerless fabrication with continuous liquid interface production

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42), 11703–11708.

By: R. Janusziewicz*, J. Tumbleston*, A. Quintanilla n, S. Mecham* & J. DeSimone n

author keywords: stereolithogaphy; continuous liquid interface production; 3D printing; additive manufacturing; isotropic properties
TL;DR: The advantages of continuous production enable the fabrication of large overhangs without the use of supports, reduction of the staircasing effect without compromising fabrication time, and isotropic mechanical properties. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Liquid perfluoropolyether electrolytes with enhanced ionic conductivity for lithium battery applications

POLYMER, 100, 126–133.

By: K. Olson*, D. Wong*, M. Chintapalli*, K. Timachova*, R. Janusziewicz*, W. Daniel*, S. Mecham*, S. Sheiko*, N. Balsara*, J. DeSimone n

author keywords: Perfluoropolyether; Electrolyte; Battery
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 12(3), 677–687.

By: C. Fromen n, T. Rahhal*, G. Robbins*, M. Kai n, T. Shen*, J. Luft*, J. DeSimone n

author keywords: Nanoparticle; Lung; Dendritic cell; Pulmonary drug delivery; Vaccine
TL;DR: The interaction of nanoparticles with various types of lung antigen presenting cells is investigated in an attempt to understand the cellular mechanisms that explain the increased efficacy of cationic formulations as a pulmonary vaccine carrier. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Novel materials

Proceedings of the National Academy of Sciences, 113(42), 11667–11669.

By: J. Rogers & J. DeSimone*

TL;DR: This Special Feature on Novel Materials presents a collection of perspectives articles, short reviews, and original research papers designed to capture some of the breadth and excitement in recent materials research. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2016 journal article

Organic Polymer Chemistry in the Context of Novel Processes

ACS CENTRAL SCIENCE, 2(9), 588–597.

By: J. DeSimone n, S. Mecham* & C. Farrell*

TL;DR: This article was written to shed light on a series of what some have stated are not so obvious connections that link polymer synthesis in supercritical CO2 to cancer treatment and vaccines, nonflammable polymer electrolytes for lithium ion batteries, and 3D printing. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses

PLOS NEGLECTED TROPICAL DISEASES, 10(10).

By: S. Metz*, S. Tian*, G. Hoekstra*, X. Yi*, M. Stone*, K. Horvath*, M. Miley*, J. DeSimone n, C. Luft*, A. Silva*

MeSH headings : Animals; Antibodies, Neutralizing / biosynthesis; Antibodies, Neutralizing / immunology; Antibodies, Viral / blood; Antibodies, Viral / immunology; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue Vaccines / administration & dosage; Dengue Vaccines / immunology; Dengue Virus / immunology; Humans; Immunoglobulin G / blood; Lactic Acid / chemistry; Lymph Nodes / immunology; Nanoparticles; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Recombinant Proteins / administration & dosage; Recombinant Proteins / isolation & purification; Serogroup; Surface Properties; Vaccines, Subunit / administration & dosage; Vaccines, Subunit / chemistry; Vaccines, Subunit / immunology; Vero Cells; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology
TL;DR: The results demonstrate that PRINT nanoparticles are a promising platform for delivering subunit vaccines against flaviviruses such as dengue and Zika. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung

MOLECULAR PHARMACEUTICS, 13(5), 1626–1635.

By: T. Rahhal*, C. Fromen n, E. Wilson*, M. Kai n, T. Shen*, J. Luft*, J. DeSimone n

author keywords: butyrylcholinesterase; pulmonary delivery; biologics; micro/nanoparticle
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Animals; Bronchoalveolar Lavage Fluid / chemistry; Butyrylcholinesterase / administration & dosage; Chemistry, Pharmaceutical / methods; Chemokine CXCL2 / metabolism; Dry Powder Inhalers / methods; Interleukin-6 / metabolism; Lung / drug effects; Lung / metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Particle Size; Powders / administration & dosage; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Findings provide evidence for the feasibility of optimizing the use of butyrylcholinesterase (BuChE) in the clinic; PRINT BuChE particles can be readily formulated for use in DPIs, providing a convenient and effective treatment option. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Reduction Sensitive PEG Hydrogels for Codelivery of Antigen and Adjuvant To Induce Potent CTLs

Molecular Pharmaceutics, 13(10), 3381–3394.

By: C. Kapadia, S. Tian, J. Perry, J. Luft & J. DeSimone n

author keywords: nanoparticles; cancer vaccine; peptide vaccine; disulfide linkers; cytotoxic T cells (CTL)
MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antigens / administration & dosage; Antigens / immunology; Bone Marrow Cells / cytology; CD8-Positive T-Lymphocytes / metabolism; Cancer Vaccines / administration & dosage; Cancer Vaccines / metabolism; Cell Proliferation / physiology; Chromatography, High Pressure Liquid; Dendritic Cells / metabolism; Dynamic Light Scattering; Female; Hydrogels / chemistry; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Nanoparticles / chemistry; Oligodeoxyribonucleotides / chemistry; Oligodeoxyribonucleotides / immunology; Peptide Fragments / chemistry; Peptide Fragments / immunology; Polyethylene Glycols / chemistry; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / metabolism; Thermogravimetry
TL;DR: It is demonstrated that the reduction sensitive NP subunit vaccine elicits a potent CTL response and provides compelling evidence that this approach could be utilized to engineer particulate vaccines to deliver tumor or pathogen associated antigenic peptides to harness the immune system to fight against cancer and infectious diseases. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2016 journal article

Relationship between Conductivity, Ion Diffusion, and Transference Number in Perfluoropolyether Electrolytes

MACROMOLECULES, 49(9), 3508–3515.

By: M. Chintapalli*, K. Timachova*, K. Olson*, S. Mecham*, D. Devaux*, J. DeSimone n, N. Balsara*

Source: Web Of Science
Added: August 6, 2018

2016 journal article

Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production

PLOS ONE, 11(9).

By: A. Johnson n, C. Caudill*, J. Tumbleston*, C. Bloomquist*, K. Moga*, A. Ermoshkin*, D. Shirvanyants*, S. Mecham*, J. Luft*, J. DeSimone n

MeSH headings : Acrylates / pharmacology; Animals; Drug Delivery Systems / methods; Fluorescent Dyes / pharmacology; Mice, Nude; Microinjections; Permeability / drug effects; Skin Absorption / drug effects
TL;DR: A novel additive manufacturing technique called Continuous Liquid Interface Production (CLIP) is utilized to rapidly prototype sharp microneedles with tuneable geometries (size, shape, aspect ratio, spacing) that effectively pierced murine skin ex vivo and released the fluorescent drug surrogate rhodamine. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties

Nanomedicine: Nanotechnology, Biology and Medicine, 12(4), 1053–1062.

By: L. Roode*, H. Brighton*, T. Bo*, J. Perry*, M. Parrott*, F. Kersey*, J. Luft*, J. Bear*, J. DeSimone*, I. Davis*

author keywords: PRINT; Nanomedicine; Nanoparticle; Flow cytometry; Cancer
MeSH headings : Animals; Cell Line, Tumor; Disease Models, Animal; Flow Cytometry; Humans; Macrophages / drug effects; Macrophages / pathology; Melanoma / diagnostic imaging; Melanoma / pathology; Nanomedicine; Nanoparticles / administration & dosage; Nanoparticles / adverse effects; Particle Size; Tissue Distribution; Xenograft Model Antitumor Assays
TL;DR: The authors utilized PRINT-produced nanoparticles to investigate specific tumor uptake by multi-color flow cytometry and in vivo confocal tumor imaging, which allowed further in-depth correlation between nanoparticle properties and tumor cells and should improve future design. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2016 journal article

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance

ACS NANO, 10(1), 861–870.

By: M. Kai n, H. Brighton, C. Fromen n, T. Shen, J. Luft, Y. Luft, A. Keeler, G. Robbins ...

author keywords: nanoparticle; orthotopie; pharmacokinetic; immunology; intravital
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Cisplatin / chemistry; Cisplatin / pharmacokinetics; Cisplatin / pharmacology; Drug Compounding; Ear / anatomy & histology; Ear / blood supply; Humans; Hydrogels / chemistry; Immunity, Innate; Liver / drug effects; Liver / immunology; Liver / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Lung Neoplasms / immunology; Lung Neoplasms / pathology; Lung Neoplasms / therapy; Macrophages / drug effects; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles / chemistry; Nanoparticles / metabolism; Neoplasm Transplantation; Primary Cell Culture; Spleen / drug effects; Spleen / metabolism; Time-Lapse Imaging
TL;DR: It is found that tumor presence significantly increased clearance of PRINT hydrogel nanoparticles from the circulation, resulting in increased accumulation in the liver and spleen, due to an increase in M2-like macrophages. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model

Nanomedicine: Nanotechnology, Biology and Medicine, 11(3), 589–599.

By: G. Robbins*, R. Roberts*, H. Guo*, K. Reuter*, T. Shen*, G. Sempowski*, K. McKinnon*, L. Su*, J. DeSimone n, J. Ting*

author keywords: PRINT; Nanoparticles; PEGylation; Humanized mice; Monocytes; Complement; Toxicity
MeSH headings : Animals; Cell Line, Tumor; Cytokines / immunology; Drug Delivery Systems; Drug Evaluation, Preclinical; Humans; Immunity, Innate; Immunization / methods; Lipopolysaccharide Receptors / immunology; Mice; Mice, Inbred NOD; Mice, Knockout; Monocytes / cytology; Monocytes / immunology; Nanoparticles / chemistry; Vaccines / chemistry; Vaccines / pharmacology
TL;DR: Hydrogel nanorods fabricated using the PRINT (Particle Replication In Nonwetting Templates) fabrication process tested the interaction of human immune cells with these particles and found no immunoreactivity, suggesting that monodisperse PRINT particles of identical shape and size could serve a variety of clinical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: June 30, 2019

2015 journal article

Biodistribution and Toxicity Studies of PRINT Hydrogel Nanoparticles in Mosquito Larvae and Cells

PLOS NEGLECTED TROPICAL DISEASES, 9(5).

By: Y. Phanse*, B. Dunphy*, J. Perry*, P. Airs*, C. Paquette*, J. Carlson*, J. Xu*, J. Luft* ...

MeSH headings : Animals; Anopheles / drug effects; Anopheles / genetics; Biological Transport; Drug Carriers / pharmacokinetics; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacokinetics; Hydrogel, Polyethylene Glycol Dimethacrylate / toxicity; Insecticides / pharmacology; Larva / drug effects; Mosquito Control / methods; Nanoparticles / chemistry; Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Polyethylene Glycols / toxicity; RNA Interference; RNA, Small Interfering / pharmacology
TL;DR: A novel method for mosquito control is proposed that employs nanoparticles (NPs) as a platform for delivery of mosquitocidal dsRNA molecules to silence mosquito genes and cause vector lethality. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Biodistribution and Trafficking of Hydrogel Nanoparticles in Adult Mosquitoes

PLOS NEGLECTED TROPICAL DISEASES, 9(5).

By: C. Paquette*, Y. Phanse*, J. Perry*, I. Sanchez-Vargas*, P. Airs*, B. Dunphy*, J. Xu*, J. Carlson* ...

MeSH headings : Animals; Anopheles / metabolism; Arthropod Vectors; Drug Carriers / pharmacokinetics; Fluorescent Dyes; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacokinetics; Insecticides / pharmacology; Kinetics; Microscopy, Fluorescence; Nanoconjugates; Nanoparticles / metabolism; Staining and Labeling
TL;DR: A tool box of NPs with the biodistribution and tissue tropism characteristics for gene structure/function studies and for delivery of vector lethal cargoes for mosquito control is developed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 chapter

Calibration-Quality Cancer Nanotherapeutics

In Cancer Treatment and Research (pp. 275–291).

By: J. Perry*, M. Kai n, K. Reuter*, C. Bowerman*, J. Christopher Luft* & J. DeSimone n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Calibration; Drug Delivery Systems; Humans; Nanoconjugates / chemistry; Nanoconjugates / therapeutic use; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: This work has shown that translational efficacy improves as clinical tumor properties increase, and the field of nanomedicine will continue to have significant clinical impacts as the capabilities of nanoparticulate drug delivery are further enhanced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 30, 2019

2015 journal article

Continuous liquid interface production of 3D objects

SCIENCE, 347(6228), 1349–1352.

By: J. Tumbleston, D. Shirvanyants, N. Ermoshkin, R. Janusziewicz*, A. Johnson n, D. Kelly, K. Chen, R. Pinschmidt ...

TL;DR: The continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers is demonstrated and critical control parameters are delineated and shown that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(2), 488–493.

By: C. Fromen n, G. Robbins*, T. Shen*, M. Kai n, J. Ting* & J. DeSimone n

author keywords: vaccine; cationic; nanoparticle; pulmonary; mucosal
MeSH headings : Animals; Antibody Formation; Antigens / administration & dosage; CD4-Positive T-Lymphocytes / immunology; Chemokines / biosynthesis; Cytokines / biosynthesis; Dendritic Cells / immunology; Hydrogels / administration & dosage; Hydrogels / chemistry; Immunity, Mucosal; Immunization / methods; Ligands; Lung / immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ovalbumin / administration & dosage; Ovalbumin / immunology; Static Electricity; Surface Properties; Toll-Like Receptors / metabolism; Vaccines, Subunit / administration & dosage
TL;DR: It is found that positively charged nanoparticles induce robust mucosal and systemic antibody responses following pulmonary administration, whereas negatively charge nanoparticles fail to do so, and these studies highlight the importance of NP surface charge when designing pulmonary vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery

Pharmaceutical Research, 32(10), 3248–3260.

By: T. Shen*, C. Fromen n, M. Kai n, J. Luft*, T. Rahhal*, G. Robbins*, J. DeSimone n

author keywords: Microparticle; Nanoparticle; PEGylation; Pulmonary drug delivery
MeSH headings : Animals; Cell Line; Chemokine CXCL2 / metabolism; Dendritic Cells / metabolism; Drug Delivery Systems / methods; Female; Granulocytes / metabolism; Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism; Inflammation / metabolism; Interleukin-6 / metabolism; Lung / metabolism; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / metabolism; Particle Size; Polyethylene Glycols / metabolism; Polymers / metabolism
TL;DR: Surface modification with PEGylation was found to significantly increase lung residence times and homogeneous lung distribution, delaying macrophage clearance of all sizes, with the largest increase in residence time observed for 80 × 320 nm particles. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle

JOURNAL OF CONTROLLED RELEASE, 204, 70–77.

By: M. Kai n, A. Keeler*, J. Perry*, K. Reuter*, J. Luft*, . Sara K. O'Neal, W. Zamboni*, J. DeSimone n

author keywords: Cisplatin; PRINT; PEGylation; Pharmacokinetics; Cytotoxicity
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Antineoplastic Agents / toxicity; Cell Line, Tumor; Cell Survival / drug effects; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Cisplatin / pharmacology; Cisplatin / toxicity; Drug Carriers / chemistry; Drug Compounding; Hydrogels / chemistry; Maximum Tolerated Dose; Mice, Inbred C57BL; Nanoparticles / chemistry; Neoplasms, Experimental / drug therapy
TL;DR: The pharmacokinetic profiles of drug in plasma, tumor, and kidney indicate improved exposure in the blood and tumor accumulation, with concurrent renal protection, when cisplatin was formulated in a nanoparticle, suggesting the potential for PRINT-Platin to improve efficacy and reduce toxicity compared to current cis platin therapies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Local iontophoretic administration of cytotoxic therapies to solid tumors

SCIENCE TRANSLATIONAL MEDICINE, 7(273).

By: J. Byrne*, M. Jajja*, . Adrian T. O'Neill*, L. Bickford*, A. Keeler*, N. Hyder*, K. Wagner*, A. Deal* ...

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Death / drug effects; Cell Proliferation / drug effects; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Cisplatin / pharmacology; Cisplatin / therapeutic use; Combined Modality Therapy; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / pharmacokinetics; Deoxycytidine / pharmacology; Deoxycytidine / therapeutic use; Disease Models, Animal; Dogs; Drug Delivery Systems; Equipment Design; Female; Humans; Injections, Intravenous; Iontophoresis; Mice, Inbred BALB C; Neoplasms / drug therapy; Neoplasms / pathology; Neoplasms / radiotherapy; Skin / drug effects; Survival Analysis; Tissue Distribution / drug effects; Tumor Burden / drug effects; Xenograft Model Antitumor Assays; Gemcitabine
TL;DR: A new implantable device that relies on iontophoresis—or, the flow of charged molecules in an electric field—to drive drugs into tumors, which could improve long-term patient outcomes compared with intravenous injection of cytotoxic therapies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Nanoparticulate immunotherapy for cancer

JOURNAL OF CONTROLLED RELEASE, 219, 167–180.

By: C. Kapadia*, J. Perry*, S. Tian*, J. Luft* & J. DeSimone n

author keywords: Nanoparticles; Cancer immunotherapy; Tumor microenvironment; Vaccine; Immunosuppression
MeSH headings : Animals; Drug Carriers / therapeutic use; Humans; Immunotherapy; Nanoparticles / therapeutic use; Neoplasms / immunology; Neoplasms / therapy
TL;DR: The current status of immunotherapy and the potential advantages of utilizing nanocarriers within the field are focused on. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Phase Behavior and Electrochemical Characterization of Blends of Perfluoropolyether, Poly(ethylene glycol), and a Lithium Salt

CHEMISTRY OF MATERIALS, 27(2), 597–603.

By: D. Wong*, A. Vitale*, D. Devaux*, A. Taylor*, A. Pandya*, D. Hallinan*, J. Thelen*, S. Mecham* ...

Source: Web Of Science
Added: August 6, 2018

2015 journal article

Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: Insight into functional group effects and biological activity

BIOORGANIC & MEDICINAL CHEMISTRY, 23(8), 1849–1857.

By: R. Sharpe*, J. Malinowski*, F. Sorana*, J. Luft*, C. Bowerman*, J. DeSimone n, J. Johnson*

author keywords: Pactamycin; Nanoparticles; Structure activity relationships; Structural derivatization
MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Neoplasms / drug therapy; Pactamycin / administration & dosage; Pactamycin / analogs & derivatives; Pactamycin / pharmacology
TL;DR: The synthesis and biological analysis of a number of novel congeners of the aminocyclopentitol pactamycin and select derivatives into the PRINT© nanoparticle technology was investigated as a proof of concept, and evidence of bioactivity modulation through nanoparticle delivery is demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Rapid and Persistent Delivery of Antigen by Lymph Node Targeting PRINT Nanoparticle Vaccine Carrier To Promote Humoral Immunity

MOLECULAR PHARMACEUTICS, 12(5), 1356–1365.

By: S. Mueller, S. Tian* & J. DeSimone n

author keywords: particulate vaccine; PRINT; lymphatic trafficking; PEGylation
MeSH headings : Animals; Antigens / metabolism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunity, Humoral / physiology; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles / chemistry; Polyethylene Glycols / chemistry
TL;DR: It is demonstrated that an antigen-specific humoral response is correlated with antigen delivery to the draining lymph nodes, in particular, B cell rich regions of the lymph nodes and produces a significant humoral immune response, superior to that produced by free antigen alone. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo

MOLECULAR PHARMACEUTICS, 12(10), 3518–3526.

By: D. Ma, S. Tian, J. Baryza*, J. Luft & J. DeSimone n

author keywords: drug delivery; gene therapy; nanoparticles; hydrogel; siRNA
MeSH headings : Animals; Drug Delivery Systems / methods; Electrophoresis, Agar Gel; HeLa Cells; Humans; Hydrogels / therapeutic use; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Particle Size; RNA, Small Interfering / administration & dosage; RNA, Small Interfering / therapeutic use
TL;DR: Red reductively responsive hydrogel nanoparticles with highly uniform size and shape for systemic siRNA delivery in vivo were reported and were highly tunable to achieve high transfection efficiency in vitro. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation

NANO LETTERS, 15(10), 6371–6378.

By: K. Reuter, J. Perry, D. Kim, J. Luft, R. Liu & J. DeSimone n

author keywords: PRINT; nanoparticle; active targeting; ligand density; pharmacokinetics; tumor accumulation
MeSH headings : Endocytosis; Hydrogels; Ligands; Microscopy, Electron, Scanning; Nanoparticles; Tissue Distribution
TL;DR: Overall, nanoparticle size and passive accumulation were the dominant factors eliciting tumor sequestration and ligand density only significantly altered in vitro internalization rates for the 80 nm × 320 nm particle. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Towards programming immune tolerance through geometric manipulation of phosphatidylserine

BIOMATERIALS, 72, 1–10.

By: R. Roberts*, T. Eitas*, J. Byrne*, B. Johnson*, P. Short*, K. McKinnon*, S. Reisdorf*, J. Luft*, J. DeSimone n, J. Ting*

author keywords: Autoimmunity; Immunoengineering; Immunomodulation; Nanoparticles; PRINT; PLGA; Phosphatidylserine; Tolerance; Transplantation
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Cytokines / metabolism; Dendritic Cells / pathology; Down-Regulation; Humans; Immune Tolerance; Inflammation / pathology; Lymphocyte Activation / immunology; Mice, Inbred C57BL; Myelin Sheath / metabolism; Nanotubes; Particulate Matter / chemistry; Phosphatidylserines / chemistry; Phosphatidylserines / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A versatile acid-labile linker for antibody-drug conjugates

MEDCHEMCOMM, 5(9), 1355–1358.

By: M. Finniss*, K. Chu*, C. Bowerman*, J. Luft*, Z. Haroon* & J. DeSimone n

TL;DR: Silyl ether chemistry was used to couple the mAb trastuzumab with the chemotherapeutic, gemcitabine, to demonstrate the use of silyl Ethers as a potential linker for ADCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on in Vivo Circulation of Polyelectrolyte Microgels

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(28), 9947–9952.

By: K. Chen, J. Xu, J. Luft, S. Tian, J. Raval & J. DeSimone n

MeSH headings : Amines / chemistry; Blood Substitutes; Cell Survival / drug effects; Cross-Linking Reagents; Electrolytes / chemistry; Female; Human Umbilical Vein Endothelial Cells / drug effects; Humans; Hydrogels / chemistry; Nanoparticles / chemistry; Particle Size; Polyethylene Glycols / chemistry; Pregnancy; Surface Properties
TL;DR: A method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups is developed and demonstrated extended circulation in vivo compared to their counterparts with a charged surface. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Driving Convergence with Human Diversity

DeSimone, J. M., & Farrell, C. L. (2014, May 28). SCIENCE TRANSLATIONAL MEDICINE, Vol. 6.

By: J. DeSimone n & C. Farrell n

MeSH headings : Cooperative Behavior; Humans; Research
TL;DR: Convergent science will require human diversity—individuals with different backgrounds and life experiences—to drive it forward. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Metronomic docetaxel in PRINT® nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer

Molecular Cancer Therapeutics, 13(7), 1750–1757.

By: K. Gharpure, K. Chu, C. Bowerman*, T. Miyake, S. Pradeep, S. Mangala*, H. Han*, R. Rupaimoole ...

MeSH headings : Administration, Metronomic; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Docetaxel; Enhancer of Zeste Homolog 2 Protein; Female; Gene Silencing / drug effects; Humans; Mice; Mice, Nude; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / genetics; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Polycomb Repressive Complex 2 / antagonists & inhibitors; Polycomb Repressive Complex 2 / genetics; Polycomb Repressive Complex 2 / metabolism; RNA, Small Interfering / administration & dosage; RNA, Small Interfering / genetics; Randomized Controlled Trials as Topic; Taxoids / administration & dosage; Taxoids / chemistry
TL;DR: Investigation of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and antiangiogenic mEZH2 siRNA incorporated into chitosan nanoparticles showed significant antitumor activity in preclinical models of ovarian cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: January 3, 2021

2014 journal article

Nonflammable perfluoropolyether-based electrolytes for lithium batteries

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(9), 3327–3331.

By: D. Wong*, J. Thelen*, Y. Fu*, D. Devaux*, A. Pandya*, V. Battaglia*, N. Balsara*, J. DeSimone n

author keywords: fluorinated polymers; nonflammable electrolytes
MeSH headings : Electric Power Supplies; Electrolytes / chemistry; Ethers / chemistry; Fluorocarbons / chemistry; Lithium / chemistry; Temperature; Transportation
TL;DR: A unique class of nonflammable electrolytes for lithium-ion batteries that are based on functionalized perfluoropolyethers (PFPEs) are described, demonstrating that PFPEs may be used as a major component in operating batteries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity

Nano Letters, 14(3), 1472–1476.

By: K. Chu, M. Finniss, A. Schorzman, J. Kuijer, J. Luft, C. Bowerman, M. Napier, Z. Haroon, W. Zamboni, J. DeSimone n

author keywords: Soft-lithography; docetaxel; polylactic acid; silyl ether
MeSH headings : Animals; Docetaxel; Drug Carriers / chemistry; Drug Carriers / pharmacology; Humans; Mice; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / drug therapy; Neoplasms / pathology; Prodrugs / chemistry; Prodrugs / pharmacology; Taxoids / chemistry; Taxoids / pharmacology; Wettability; Xenograft Model Antitumor Assays
TL;DR: Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery and reduce systemic free docetaxel concentrations. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Analysis of the Murine Immune Response to Pulmonary Delivery of Precisely Fabricated Nano- and Microscale Particles

PLOS ONE, 8(4).

By: R. Roberts*, T. Shen*, I. Allen*, W. Hasan*, J. DeSimone n & J. Ting*

MeSH headings : Animals; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Drug Delivery Systems; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Immunity / drug effects; Lactic Acid / pharmacology; Lung / drug effects; Lung / immunology; Macrophages / drug effects; Macrophages / metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nanoparticles / administration & dosage; Nanoparticles / ultrastructure; Nanotechnology; Particle Size; Pneumonia / pathology; Polyethylene Glycols / pharmacology; Polyglycolic Acid / pharmacology; Polylactic Acid-Polyglycolic Acid Copolymer
TL;DR: Rational design of nanoparticle physical parameters can be used for sustained and localized delivery of therapeutics to the lungs by using the recently developed PRINT fabrication process to address the role of particle design parameters on the murine innate immune response. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Development of a nanoparticle-based influenza vaccine using the PRINT® technology

Nanomedicine: Nanotechnology, Biology and Medicine, 9(4), 523–531.

By: A. Galloway*, A. Murphy*, J. DeSimone n, J. Di*, J. Herrmann*, M. Hunter*, J. Kindig*, F. Malinoski* ...

author keywords: Nanotechnology; Influenza vaccine; PRINT; Soft lithography; Hemagglutinin
MeSH headings : Animals; Female; Influenza Vaccines / administration & dosage; Influenza Vaccines / immunology; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Rabbits
TL;DR: A novel particle-based approach, which independently controls size, shape, and composition to control the delivery and presentation of vaccine antigen to the immune system is described and this technology is tested here in murine models to effectively deliver influenza vaccine. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2013 review

Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

[Review of ]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(26), 6580–6589.

By: J. Xu*, D. Wong*, J. Byrne*, K. Chen*, C. Bowerman* & J. DeSimone n

author keywords: colloids; drug delivery; nanomedicine; nanoparticles; soft lithography
MeSH headings : Biopharmaceutics / methods; Drug Design; Electromagnetic Fields; Electronics; Humans; Materials Testing; Nanomedicine / methods; Nanoparticles / chemistry; Nanotechnology / methods; Particle Size; Prodrugs / chemical synthesis; RNA, Small Interfering / metabolism; Surface Properties
TL;DR: Some of the most recent work involving the PRINT technology for application in the biomedical and material sciences is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Generating Better Medicines for Cancer

ACS MACRO LETTERS, 2(5), 393–397.

By: S. Dunn*, J. Byrne, J. Perry, K. Chen & J. DeSimone n

TL;DR: The engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

JOURNAL OF CLINICAL INVESTIGATION, 123(7), 3061–3073.

By: S. Jones*, R. Roberts, G. Robbins*, J. Perry*, M. Kai n, K. Chen, T. Bo*, M. Napier* ...

MeSH headings : Animals; Area Under Curve; Drug Carriers / pharmacokinetics; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Fluorescence; Nanoparticles; Species Specificity; Th1 Cells / immunology; Th1 Cells / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR: It is demonstrated that mouse strains that are prone to Th1 immune responses clear nanoparticles at a slower rate than Th2-prone mice, and this effect was confirmed in human monocyte-derived macrophages, suggesting that global immune regulation has a significant impact on nanoparticle clearance in humans. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy

BIOMATERIALS, 34(33), 8424–8429.

By: K. Chu*, A. Schorzman*, M. Finniss*, C. Bowerman*, L. Peng*, J. Luft*, A. Madden*, A. Wang*, W. Zamboni*, J. DeSimone n

author keywords: Soft-lithography; Docetaxel; Polylactic acid; Drug loading; Pharmacokinetics
MeSH headings : Animals; Cell Line, Tumor; Chromatography, Liquid; Docetaxel; Female; Humans; Lactic Acid / chemistry; Mice; Mice, Nude; Nanoparticles / chemistry; Polyesters; Polymers / chemistry; Tandem Mass Spectrometry; Taxoids / chemistry; Taxoids / pharmacokinetics
TL;DR: The lower weight loading (9%-NP) of docetaxel was found to have a superior pharmacokinetic profile and enhanced efficacy in a murine cancer model when compared to that of a higher docetAXel loading (20%-NP). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanotechnology: An Enduring Bridge Between Engineering and Medicine

The Bridge: Linking Engineering and Society, 7–15.

By: S. Petrosko, C. Fromen, E. Auyeung, J. DeSimone & C. Mirkin

Source: NC State University Libraries
Added: June 30, 2019

2013 chapter

PRINT Technology: A Versatile Platform for Novel Applications in Nanomedicine

In S. Yin & A. Wei (Eds.), Nanomaterials for Pharmaceutical Scientists. New York: Wiley.

By: J. Byrne, W. Hasan, S. Blake, C. Farrell & J. DeSimone

Ed(s): S. Yin & A. Wei

Source: NC State University Libraries
Added: June 30, 2019

2013 journal article

Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft

Nanomedicine: Nanotechnology, Biology and Medicine, 9(5), 686–693.

By: K. Chu*, W. Hasan*, S. Rawal*, M. Walsh*, E. Enlow*, J. Luft*, A. Bridges*, J. Kuijer* ...

author keywords: Soft-lithography; PLGA; Nanoparticle; Shape; Pharmacokinetics
MeSH headings : Animals; Carcinoma / blood; Carcinoma / drug therapy; Carcinoma / pathology; Cell Line, Tumor; Docetaxel; Female; Humans; Mice; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ovarian Neoplasms / blood; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / pathology; Particle Size; Taxoids / administration & dosage; Taxoids / blood; Taxoids / pharmacokinetics; Tissue Distribution; Xenograft Model Antitumor Assays
TL;DR: It is concluded that the use of particles with smaller feature size may be preferred to decrease clearance by organs of the mononuclear phagocyte system. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

RNA Replicon Delivery via Lipid-Complexed PRINT Protein Particles

MOLECULAR PHARMACEUTICS, 10(9), 3366–3374.

By: J. Xu, J. Luft, X. Yi, S. Tian, G. Owens*, J. Wang, A. Johnson n, P. Berglund* ...

author keywords: RNA replicon; gene delivery; PRINT; protein particle; lipid
TL;DR: The data suggest that (1) this lipid-complexed protein particle is a promising system for delivery of RNA replicon-based vaccines and (2) it is necessary to use a degradable cross-linker for successful delivery ofRNA replicon via protein-based particles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Rapidly-Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

ADVANCED MATERIALS, 25(36), 5060–5066.

By: K. Moga*, L. Bickford*, R. Geil*, S. Dunn*, A. Pandya*, Y. Wang*, J. Fain*, C. Archuleta*, . Adrian T. O'Neill*, J. DeSimone n

author keywords: microneedles; microprojections; PRINT; soft lithography; drug delivery
TL;DR: Biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles

ADVANCED MATERIALS, 25(34), 4707–4713.

By: S. Morton*, K. Herlihy*, K. Shopsowitz*, Z. Deng*, K. Chu*, C. Bowerman*, J. DeSimone n, P. Hammond*

author keywords: core; shell nanoparticles; thin films; nanoimprinting; nanomedicine
MeSH headings : Carbocyanines / chemistry; Cell Line, Tumor; Drug Carriers / chemistry; Humans; Lactic Acid / chemistry; Microscopy, Atomic Force; Microscopy, Confocal; Nanomedicine; Nanoparticles / chemistry; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Polylysine / chemistry; Polyvinyl Alcohol / chemistry
TL;DR: A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Synthesis and characterization of monodisperse uniformly shaped respirable aerosols

AICHE JOURNAL, 59(9), 3184–3194.

By: C. Fromen n, T. Shen*, A. Larus*, P. Mack*, B. Maynor*, J. Luft*, J. DeSimone n

author keywords: aerosols; biomedical engineering; nanotechnology; particle technology; particle; count; measurements
TL;DR: Dynamic shape factors for this novel set of uniformly shaped particles were determined by correcting the drag of nonspherical particles in the ultra-Stokesian flow conditions of the aerodynamic particle sizer (APS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Chevreul Medal for Uwe T. Bornscheuer

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 51, pp. 6563–6563.

By: J. DeSimone, J. Goodenough, J. Groves & U. Bornscheuer

Source: Web Of Science
Added: August 6, 2018

2012 journal article

Delivery of Multiple siRNAs Using Lipid-Coated PLGA Nanoparticles for Treatment of Prostate Cancer

NANO LETTERS, 12(1), 287–292.

By: W. Hasan, K. Chu, A. Gullapalli, S. Dunn, E. Enlow, J. Luft, S. Tian*, M. Napier ...

author keywords: Soft lithography; siRNA delivery; PLGA; lipids; PRINT; prostate cancer
MeSH headings : Animals; Coated Materials, Biocompatible / chemical synthesis; Genetic Therapy / methods; Humans; Lactic Acid / chemistry; Lipids / chemistry; Male; Nanocapsules / therapeutic use; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Prostatic Neoplasms / genetics; Prostatic Neoplasms / therapy; RNA, Small Interfering / genetics; RNA, Small Interfering / therapeutic use
TL;DR: Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Effect of Aspect Ratio and Deformability on Nanoparticle Extravasation through Nanopores

LANGMUIR, 28(23), 8773–8781.

By: F. Kersey, T. Merkel, J. Perry, M. Napier & J. DeSimone n

MeSH headings : Hydrogels; Light; Microscopy, Atomic Force; Microscopy, Electron; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nanopores; Nanotechnology / methods; Particle Size; Polyethylene Glycols / chemistry; Scattering, Radiation; Spectrometry, Fluorescence
TL;DR: The results show that particle recovery is mostly independent of aspect ratio at all cross-linker concentrations utilized, with the exception of 96 wt % PEG diacrylate 80 × 5000 nm particles, which showed the lowest percent recovery. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 review

Engineering nanomedicines using stimuli-responsive biomaterials

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 64(11), 1021–1030.

By: Y. Wang*, J. Byrne*, M. Napier* & J. DeSimone n

author keywords: Top-down; Trigger-release; Microfluidic; Photolithography; PRINT
MeSH headings : Biocompatible Materials / administration & dosage; Drug Delivery Systems; Nanomedicine / methods; Nanoparticles / administration & dosage; Nanotechnology / methods
TL;DR: This article examines several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery and special attention is given to Particle Replication In Nonwetting Templates (PRINT®) technology and the application of novel triggered-release synthetic and natural polymers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain

Journal of Controlled Release, 158(1), 63–71.

By: S. Benhabbour, J. Luft*, D. Kim*, A. Jain, S. Wadhwa, M. Parrott*, R. Liu*, J. DeSimone*, R. Mumper*

author keywords: Lipid-based nanoparticles; Nickel; Histidine-tagged proteins; EGFR targeting; Heptameric Z(EGFR) domain
MeSH headings : Animals; Cell Line, Tumor; Drug Carriers / administration & dosage; Drug Carriers / chemistry; ErbB Receptors / chemistry; ErbB Receptors / metabolism; Humans; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Nude; Neoplasms / metabolism; Nickel / administration & dosage; Nickel / chemistry; Nitrilotriacetic Acid / administration & dosage; Nitrilotriacetic Acid / chemistry; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / chemistry; Protein Structure, Tertiary; Succinimides / administration & dosage; Succinimides / chemistry; Surface-Active Agents / administration & dosage; Surface-Active Agents / chemistry; Tissue Distribution; Triglycerides / administration & dosage; Triglycerides / chemistry
TL;DR: The novel high affinity histidine×6-tagged EGFR-binding Z domain (heptameric Z(EGFR) domain) could be a very useful tool for targeting and drug delivery to a wide range of EGFR positive cancers. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2012 journal article

Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(18), 7978–7982.

By: M. Parrott, M. Finniss, J. Luft, A. Pandya, A. Gullapalli, M. Napier, J. Desimone n

MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Camptothecin / administration & dosage; Camptothecin / pharmacology; Cell Line, Tumor; Dasatinib; Delayed-Action Preparations / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / pharmacology; Ethers / administration & dosage; Ethers / pharmacology; Humans; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / drug therapy; Prodrugs / administration & dosage; Prodrugs / pharmacology; Pyrimidines / administration & dosage; Pyrimidines / pharmacology; Silanes / administration & dosage; Silanes / pharmacology; Thiazoles / administration & dosage; Thiazoles / pharmacology; Gemcitabine
TL;DR: A family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months were found. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Interview: From traditional polymer science to nanomedicine: the interplay between disciplines to drive innovation

Nanomedicine, 7(8), 1125–1128.

By: J. DeSimone n

MeSH headings : Halogenation; Humans; Microfluidics / methods; Nanomedicine / methods; Polymers / chemistry; Polytetrafluoroethylene / chemistry
TL;DR: Professor Joseph DeSimone speaks to Hannah Stanwix, Assistant Commissioning Editor about Liquidia Technologies, which received the first ever equity investment by the Bill and Mel... (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Source: Crossref
Added: June 30, 2019

2012 journal article

Low Modulus Biomimetic Microgel Particles with High Loading of Hemoglobin

BIOMACROMOLECULES, 13(9), 2748–2759.

By: K. Chen, T. Merkel, A. Pandya, M. Napier, J. Luft, W. Daniel, S. Sheiko, J. DeSimone n

MeSH headings : Acrylates / chemistry; Animals; Biological Transport; Biomimetic Materials / analysis; Biomimetic Materials / chemical synthesis; Blood Substitutes / analysis; Blood Substitutes / chemical synthesis; Cattle; Circular Dichroism; Cross-Linking Reagents / chemistry; Diffusion; Elastic Modulus; Erythrocytes / cytology; Erythrocytes / metabolism; Fluorescent Dyes; Gels; Hemoglobins / chemistry; Hemoglobins / metabolism; Mice; Microfluidic Analytical Techniques; Oxygen / chemistry; Oxygen / metabolism; Particle Size; Polymers / chemistry; Rheology; Viscosity
TL;DR: Hb-loaded particles with moderate loading ratios demonstrated excellent deformability in microfluidic devices, easily deforming to pass through restricted pores half as wide as the diameter of the particles. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

NANO LETTERS, 12(10), 5304–5310.

By: J. Perry, K. Reuter, M. Kai n, K. Herlihy, S. Jones, J. Luft, M. Napier, J. Bear*, J. DeSimone n

author keywords: PRINT; nanoparticle; PEGylation; protein adsorption; macrophage association; pharmacokinetics
MeSH headings : Adsorption; Animals; Female; Hydrogels; Macrophages / physiology; Mice; Mice, Inbred BALB C; Molecular Conformation; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanotechnology; Phagocytosis; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Protein Binding; Surface Properties; Tissue Distribution
TL;DR: Overall, the methodology provides a rapid screening technique to predict particle behavior in vivo and the results deliver further insight to what PEG density is necessary to facilitate long-circulation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(17), 7423–7430.

By: S. Dunn, S. Tian*, S. Blake*, J. Wang*, A. Galloway*, A. Murphy*, P. Pohlhaus*, J. Rolland*, M. Napier, J. DeSimone n

MeSH headings : Cell Survival; Delayed-Action Preparations / chemistry; Gene Silencing; HeLa Cells; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Luciferases / genetics; Nanoparticles / chemistry; Oxidation-Reduction; Polyethylene Glycols / chemistry; RNA, Small Interfering / administration & dosage; RNA, Small Interfering / genetics; Transfection
TL;DR: Hydrogel nanoparticles of defined dimensions and compositions, prepared via a particle molding process that is a unique off-shoot of soft lithography known as particle replication in nonwetting templates (PRINT), were explored in these studies as delivery vectors to enable efficacious targeted in vivo RNAi therapies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Rendering Protein-Based Particles Transiently Insoluble for Therapeutic Applications

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(21), 8774–8777.

By: J. Xu*, J. Wang*, J. Luft, S. Tian*, G. Owens*, A. Pandya, P. Bergund, P. Pohlhaus* ...

MeSH headings : Animals; Cattle; Chlorocebus aethiops; Cytoplasm / metabolism; Disulfides / chemistry; Drug Carriers / chemistry; Drug Carriers / metabolism; Microtechnology / methods; Nanotechnology / methods; Particle Size; RNA / metabolism; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Solubility; Time Factors; Vero Cells
TL;DR: The fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker demonstrates that cleavage of the cross- linker leaves no chemical residue on the reactive amino group. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

The effect of particle size on the biodistribution of low-modulus hydrogel PRINT particles

Journal of Controlled Release, 162(1), 37–44.

By: T. Merkel, K. Chen, S. Jones*, A. Pandya, S. Tian, M. Napier, W. Zamboni*, J. DeSimone n

author keywords: Hydrogel; Deformability; Biodistribution; Long circulating; Biomimetic
MeSH headings : Acrylates / chemistry; Acrylates / pharmacokinetics; Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Elastic Modulus; Erythrocytes / cytology; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacokinetics; Mice; Mice, Inbred BALB C; Particle Size; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 30, 2019

2012 journal article

Tuning Multiphase Amphiphilic Rods to Direct Self-Assembly

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(13), 5801–5806.

By: J. Wang*, Y. Wang*, S. Sheiko*, D. Betts* & J. DeSimone n

MeSH headings : Animals; Anisotropy; Hydrophobic and Hydrophilic Interactions; Oils / chemistry; Organic Chemicals / chemistry; Printing / methods; Water / chemistry; Wettability
TL;DR: A lithographic technique for fabrication of chemically anisotropic rod-like particles in which one can specify both the size and shape of particles and implement multiple diverse materials to control interfacial interactions is developed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Amphiphilic Co-networks with Moisture-Induced Surface Segregation for High-Performance Nonfouling Coatings

LANGMUIR, 27(17), 10365–10369.

By: Y. Wang*, J. Finlay*, D. Betts*, T. Merkel*, J. Luft*, M. Callow*, J. Callow*, J. DeSimone n

MeSH headings : Ethers / chemistry; Fluorocarbons / chemistry; Humidity; Molecular Structure; Particle Size; Polyethylene Glycols / chemistry; Surface Properties; Ulva / chemistry
TL;DR: The design of a photocurable amphiphilic co-network consisting of perfluoropolyether and poly(ethylene glycol) segments that display outstanding nonfouling characteristics with respect to spores of green fouling alga Ulva when cured under high humidity conditions is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Biomimetic microlens array with antireflective “moth-eye” surface

Soft Matter, 7(14), 6404.

By: D. Ko*, J. Tumbleston*, K. Henderson*, L. Euliss*, J. DeSimone*, R. Lopez*, E. Samulski*

Source: Crossref
Added: June 30, 2019

2011 journal article

Dodging Drug-Resistant Cancer with Diamonds

SCIENCE TRANSLATIONAL MEDICINE, 3(73).

By: T. Merkel* & J. DeSimone*

MeSH headings : ATP-Binding Cassette Transporters / metabolism; Animals; Antineoplastic Agents / administration & dosage; Diamond; Drug Carriers; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Mice; Nanomedicine; Nanostructures; Nanotechnology; Neoplasms / drug therapy; Neoplasms / metabolism
TL;DR: Nanodiamond-mediated delivery of the chemotherapeutic doxorubicin (Dox) allowed for prolonged activity and increased apoptosis with decreased toxicity when compared with free Dox in liver cancer cells in culture as well as in vivo in mouse liver tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Generation of a Library of Particles Having Controlled Sizes and Shapes via the Mechanical Elongation of Master Templates

LANGMUIR, 27(2), 524–528.

By: Y. Wang*, T. Merkel*, K. Chen*, C. Fromen n, D. Betts* & J. DeSimone n

MeSH headings : Colloids / chemistry; Dimethylpolysiloxanes / chemistry; Ethers / chemistry; Fluorocarbons / chemistry; Particle Size; Polyethylene Glycols / chemistry; Silicon / chemistry; Surface Properties
TL;DR: A versatile and readily scalable approach for the fabrication of particles with a variety of shapes and sizes from a single master template by augmenting the particle replication in nonwetting templates (PRINT) method with mechanical elongation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Influence of the Fluid-to-Film Transition on Photophysical Properties of MLCT Excited States in a Polymerizable Dimethacrylate Fluid

The Journal of Physical Chemistry B, 115(1), 64–70.

By: T. Knight*, A. Goldstein*, M. Brennaman*, T. Cardolaccia*, A. Pandya*, J. DeSimone*, T. Meyer*

TL;DR: The extent of loss of medium dipole reorientation in the rigid environment, and the increased emission energies in the film, resulted in enhanced emission quantum yields and excited state lifetimes in accordance with the energy gap law. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: June 30, 2019

2011 journal article

Institutional Profile: The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives

Nanomedicine, 6(1), 19–24.

By: R. Juliano, S. Sunnarborg*, J. DeSimone* & Z. Haroon*

MeSH headings : Academic Medical Centers / history; Academic Medical Centers / trends; Drug Delivery Systems / methods; History, 21st Century; Humans; Nanomedicine / methods; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Neoplasms / therapy; North Carolina
TL;DR: Two key focus areas of the C-CCNE are, first, the selective delivery of drugs and imaging agents utilizing advanced nanoparticle technology, and second, novel approaches to imaging and radiotherapy utilizing carbon nanotube-based x-ray sources. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2011 journal article

Investigation of the role of hydrophilic chain length in amphiphilic perfluoropolyether/poly(ethylene glycol) networks: towards high-performance antifouling coatings

Biofouling, 27(10), 1139–1150.

By: Y. Wang*, L. Pitet*, J. Finlay*, L. Brewer*, G. Cone*, D. Betts*, M. Callow*, J. Callow* ...

author keywords: amphiphilic coating; adhesion; antifouling; fouling-release; perfluoropolyether
MeSH headings : Animals; Biofilms / drug effects; Biofilms / growth & development; Biofouling / prevention & control; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacology; Diatoms / drug effects; Diatoms / physiology; Equipment and Supplies / microbiology; Ethers / chemistry; Ethers / pharmacology; Fluorocarbons / chemistry; Fluorocarbons / pharmacology; Hydrophobic and Hydrophilic Interactions; Microbiological Phenomena / drug effects; Pliability; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacology; Ships / instrumentation; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacology; Thoracica / drug effects; Thoracica / physiology; Ulva / drug effects; Ulva / physiology
TL;DR: The preferential interfacial aggregation of the larger PEG segments enables the coating surface to have a substantially enhanced resistance to settlement of spores of the green seaweed Ulva, cells of the diatom Navicula and cypris larvae of the barnacle Balanus amphitrite as well as low adhesion of sporelings (young plants) of UlvA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: June 30, 2019

2011 review

More Effective Nanomedicines through Particle Design

[Review of ]. SMALL, 7(14), 1919–1931.

By: J. Wang*, J. Byrne*, M. Napier* & J. DeSimone n

MeSH headings : Cells / metabolism; Drug Design; Endocytosis; Nanomedicine / methods; Nanoparticles / chemistry; Tissue Distribution
TL;DR: This review covers recent major advancement in the nanomedicine field and also highlights studies using the PRINT technology, which focuses on both nanoparticles and microparticles. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 review

Novel Platforms for Vascular Carriers with Controlled Geometry

[Review of ]. IUBMB LIFE, 63(8), 596–606.

By: J. Pillai*, S. Dunn*, M. Napier* & J. DeSimone n

author keywords: vascular targeting; particle platforms; controlled geometry; drug delivery; shape design
MeSH headings : Drug Carriers; Humans; Vascular Diseases / drug therapy
TL;DR: Recent developments in novel vascular platforms with controlled geometry that enhance or modulate delivery functions are focused on, with a focus on shape modulation as a key design element. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

Accounts of Chemical Research, 44(10), 990–998.

By: J. Perry*, K. Herlihy*, M. Napier* & J. DeSimone*

MeSH headings : Animals; Contrast Media / chemistry; Contrast Media / metabolism; Contrast Media / therapeutic use; Humans; Nanomedicine / methods; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Particle Size
TL;DR: The use of particle replication in nonwetting templates (PRINT) to fabricate shape- and size-specific microparticles and nanoparticles and the loading of PRINT particles with chemotherapeutics, magnetic resonance contrast agents, and fluorophores is demonstrated. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2011 journal article

Photocurable Amphiphilic Perfluoropolyether/Poly(ethylene glycol) Networks for Fouling-Release Coatings

MACROMOLECULES, 44(4), 878–885.

By: Y. Wang*, D. Betts*, J. Finlay*, L. Brewer*, M. Callow*, J. Callow*, D. Wendt*, J. DeSimone n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings

NANO LETTERS, 11(2), 808–813.

By: E. Enlow, J. Luft, M. Napier & J. DeSimone*

author keywords: PLGA; nanoparticle; docetaxel; PRINT
MeSH headings : Absorption; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Crystallization / methods; Diffusion; Docetaxel; Drug Compounding / methods; Lactic Acid / chemistry; Nanocapsules / chemistry; Nanocapsules / ultrastructure; Particle Size; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Taxoids / administration & dosage; Taxoids / chemistry
TL;DR: The fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Relieving PEGylation

Nature Chemistry, 4(1), 13–14.

By: M. Parrott* & J. DeSimone*

MeSH headings : Polyethylene Glycols / chemistry; Proteins / chemistry
TL;DR: A new type of protein–polymer conjugate provides improved stability without detrimentally affecting bioactivity, and thus offers great potential for the development of new peptide-based drugs. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2011 journal article

Shear thickening and jamming in densely packed suspensions of different particle shapes

Physical Review E, 84(3).

By: E. Brown*, H. Zhang*, N. Forman*, B. Maynor*, D. Betts*, J. DeSimone*, H. Jaeger*

TL;DR: It is shown that the jamming transition can be identified by simply looking at the surface of suspensions, and the relationship between shear and normal stresses is found to be linear in both theShear thickening and jammed regimes, indicating that the shear stresses come from friction. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2011 journal article

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(2), 586–591.

By: T. Merkel, S. Jones, K. Herlihy, F. Kersey*, A. Shields, M. Napier*, J. Luft*, H. Wu ...

author keywords: biomimetic; deformability; drug carriers; long circulating; red blood cell mimic
MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics; Drug Carriers / chemistry; Equipment Design; Erythrocytes / cytology; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Kinetics; Materials Testing; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence / methods; Particle Size; Polymers / chemistry; Time Factors; Tissue Distribution
TL;DR: Lowering the modulus of hydrogel microparticles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventionalmicroparticles. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 review

Challenging nature's monopoly on the creation of well-defined nanoparticles

[Review of ]. NANOMEDICINE, 5(4), 633–639.

By: W. Jeong*, M. Napier* & J. DeSimone n

author keywords: bottom-up; crosslinking; nanoparticle; perfluoropolyether; poly(dimethylsiloxane); PRINT (R); roll-to-roll process; self-assembly; soft lithography; top-down
MeSH headings : Nanomedicine; Nanoparticles; Polymers
TL;DR: The PRINT technology, which combines modern soft lithography with the unique properties of perfluoropolyether molds, enables the production of nanoparticles with unprecedented control of size, shape, chemical composition, deformability and surface functionality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Continuous precipitation polymerization of vinylidene fluoride in supercritical carbon dioxide: A model for understanding the molecular-weight distribution

CHEMICAL ENGINEERING SCIENCE, 65(2), 651–659.

By: T. Ahmed n, J. DeSimone n & G. Roberts n

author keywords: Carbon dioxide; Supercritical fluid; Polymerization; Mathematical modeling; Bimodal molecular weight distribution; Model; Poly(vinylidene fluoride)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Direct Patterning of CdSe Quantum Dots into Sub-100 nm Structures

LANGMUIR, 26(5), 3012–3015.

By: M. Hampton*, J. Templeton* & J. DeSimone n

TL;DR: Ordered, two-dimensional cadmium selenide arrays have been fabricated on indium-doped tin oxide (ITO) electrodes using the pattern replication in nonwetting templates (PRINT) process, and Nanometer-scale diffraction gratings have been successfully replicated with CdSe QDs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Generality of shear thickening in dense suspensions

Nature Materials, 9(3), 220–224.

By: E. Brown*, N. Forman*, C. Orellana*, H. Zhang*, B. Maynor*, D. Betts*, J. DeSimone*, H. Jaeger*

TL;DR: It is demonstrated that shear thickening can be masked by a yield stress and can be recovered when the yield stress is decreased below a threshold, which opens up possibilities for the design of smart suspensions that combine shear Thickening with electro- or magnetorheological response. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2010 journal article

Hierarchical Control of Polymer Composite Nano- and Micro-Structure with Lithography

CHEMISTRY OF MATERIALS, 22(13), 4069–4075.

By: J. Nunes*, M. Ertas*, L. Du* & J. DeSimone n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

High Modulus, Low Surface Energy, Photochemically Cured Materials from Liquid Precursors

MACROMOLECULES, 43(24), 10397–10405.

By: Z. Hu*, L. Pitet*, M. Hillmyer* & J. DeSimone n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

High-Resolution PFPE-based Molding Techniques for Nanofabrication of High-Pattern Density, Sub-20 nm Features: A Fundamental Materials Approach

NANO LETTERS, 10(4), 1421–1428.

By: S. Williams, S. Retterer*, R. Lopez, R. Ruiz*, E. Samulski & J. DeSimone n

author keywords: Soft lithography; molding; replica molding; nanofabrication; PRINT; perfluoropolyether
MeSH headings : Ethers / chemistry; Fluorocarbons / chemistry; Molecular Structure; Nanostructures / chemistry; Nanotechnology / instrumentation; Nanotechnology / methods; Particle Size; Surface Properties
TL;DR: It was observed that as the feature spacing decreased, high modulus PFPE tetramethacrylate (TMA) composite molds were able to effectively replicate the nanograting structures without cracking or tear-out defects that typically occur with high moduli elastomers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 chapter

Micromolding for the Fabrication of Biological Microarrays

In Methods in Molecular Biology (pp. 249–260).

By: A. Galloway*, A. Murphy*, J. Rolland*, K. Herlihy*, R. Petros*, M. Napier*, J. DeSimone n

author keywords: PRINT (R) process; Molding; Biological microarray; Nanoarray fabrication; Proteins; Oligonucleotides; Gene delivery; Nanoparticles
MeSH headings : Animals; Avidin / chemistry; Avidin / metabolism; Ethers / chemistry; Fluorocarbons / chemistry; Humans; Microarray Analysis / instrumentation; Microtechnology / methods; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nanotechnology / methods; Oligonucleotides / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry; Proteins / chemistry; Proteins / metabolism; Surface Properties
TL;DR: The PRINT(®) (pattern replication in non-wetting templates) process has been developed as a simple, gentle way to pattern films or generate discrete particles in arrays out of either pure biological materials or biomolecules encapsulated within polymeric materials. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2010 journal article

Multifunctional Shape and Size Specific Magneto-Polymer Composite Particles

NANO LETTERS, 10(4), 1113–1119.

By: J. Nunes, K. Herlihy, L. Mair, R. Superfine & J. DeSimone n

author keywords: Magnetic nanoparticle; hydrogel particle; template; rocket; hydrogen peroxide
MeSH headings : Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Hydrogen Peroxide / chemistry; Magnetics; Nanostructures / chemistry; Nanotechnology / instrumentation; Organoplatinum Compounds / chemistry; Particle Size; Platinum / chemistry; Polymers / chemistry; Surface Properties; Water / chemistry
TL;DR: This work fabrication of highly tailored nanoscale and microscale magneto-polymer composite particles using a template based approach for uniform multifunctional magnetic particles is demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 patent

Nano-and micro-cellular foamed thin-walled material, and processes and apparatuses for making the same

By: J. DeSimone, S. Siripurapu, S. Khan, R. Spontak & J. Royer

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Scalable, Shape-Specific, Top-Down Fabrication Methods for the Synthesis of Engineered Colloidal Particles

LANGMUIR, 26(16), 13086–13096.

By: T. Merkel*, K. Herlihy, J. Nunes, R. Orgel, J. Rolland & J. DeSimone*

MeSH headings : Colloids / chemistry; Microscopy, Electron, Scanning; Nanoparticles / chemistry; Nanotechnology / methods
TL;DR: Several of the most readily scalable top-down methods for the fabrication of shape-specific particles and compare their capabilities with respect to particle composition, size, shape, and complexity as well as the scalability of the method are examined. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Shear thickening in densely packed suspensions of spheres and rods confined to few layers

Journal of Rheology, 54(5), 1023–1046.

By: E. Brown*, H. Zhang*, N. Forman*, B. Maynor*, D. Betts*, J. DeSimone*, H. Jaeger*

Source: Crossref
Added: June 30, 2019

2010 review

Strategies in the design of nanoparticles for therapeutic applications

[Review of ]. NATURE REVIEWS DRUG DISCOVERY, 9(8), 615–627.

By: R. Petros* & J. DeSimone n

MeSH headings : Drug Delivery Systems; Drug Design; Humans; Nanoparticles; Particle Size; Pharmaceutical Preparations / administration & dosage; Surface Properties
TL;DR: This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(32), 11306–11313.

By: J. Wang n, S. Tian n, R. Petros n, M. Napier n & J. DeSimone n

TL;DR: The data clearly reveal that one must be careful in making claims of "lack of toxicity" when a targeting molecule is used on nanoparticles and also raise concerns for unanticipated off-target effects when one is designing targeted chemotherapy nanodelivery agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Tunable Bifunctional Silyl Ether Cross-Linkers for the Design of Acid-Sensitive Biomaterials

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(50), 17928–17932.

By: M. Parrott n, J. Luft n, J. Byrne n, J. Fain n, M. Napier n & J. DeSimone n

MeSH headings : Acids / chemistry; Biocompatible Materials / chemical synthesis; Biocompatible Materials / chemistry; Cross-Linking Reagents; Drug Delivery Systems; Drug Design; Ethers / chemistry; Hydrogen-Ion Concentration; Molecular Structure; Trimethylsilyl Compounds / chemistry
TL;DR: This work designed nontoxic acid-sensitive biomaterials based on silyl ether chemistry, which could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Ultrathin Cross-Linked Perfluoropolyether Film Coatings from Liquid CO2 and Subsequent UV Curing

CHEMISTRY OF MATERIALS, 22(8), 2411–2413.

By: J. Kim n, J. Rolland*, R. Carbonell n & J. DeSimone n

Source: Web Of Science
Added: August 6, 2018

2009 journal article

Deposition of Copper Particles and Films by the Displacement of Two Immiscible Supercritical Phases and Subsequent Reaction

Chemistry of Materials, 21(5), 913–924.

By: J. Kim n, D. Taylor n, J. DeYoung n, J. McClain n, J. DeSimone n & R. Carbonell n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2009 journal article

Fabrication of multiphasic and regio-specifically functionalized PRINT (R) particles of controlled size and shape

NEW JOURNAL OF PHYSICS, 11.

By: H. Zhang*, J. Nunes*, S. Gratton*, K. Herlihy*, P. Pohlhaus* & J. DeSimone n

Source: Web Of Science
Added: August 6, 2018

2009 review

Fluoropolymer synthesis in supercritical carbon dioxide

[Review of ]. JOURNAL OF SUPERCRITICAL FLUIDS, 47(3), 447–457.

By: L. Du*, J. Kelly*, G. Roberts n & J. DeSimone n

author keywords: Supercritical carbon dioxide; Fluoropolymer
Source: Web Of Science
Added: August 6, 2018

2009 conference paper

Green Chemistry and Engineering with Gas Expanded Liquids and Near-Critical Media

In K. W. Hutchenson, A. M. Scurto, & B. Subramaniam (Eds.), ACS Symposium Series (Vol. 90, pp. 259–273).

By: L. Du, J. DeSimone & G. Roberts

Ed(s): K. Hutchenson, A. Scurto & B. Subramaniam

Source: NC State University Libraries
Added: June 30, 2019

2009 journal article

Kinetics of the Homopolymerization of Vinylidene Fluoride and Its Copolymerization with Hexafluoropropylene in Supercritical Carbon Dioxide: The Locus of Polymerization

Macromolecules, 42(1), 148–155.

By: T. Ahmed n, J. DeSimone n & G. Roberts n

Sources: Crossref, Web Of Science
Added: August 6, 2018

2009 journal article

Photochemically Cross-Linked Perfluoropolyether-Based Elastomers: Synthesis, Physical Characterization, and Biofouling Evaluation

MACROMOLECULES, 42(18), 6999–7007.

By: Z. Hu*, J. Finlay*, L. Chen*, D. Betts*, M. Hillmyer*, M. Callow*, J. Callow*, J. DeSimone n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Photonic Crystal Geometry for Organic Solar Cells

Nano Letters, 9(7), 2742–2746.

By: D. Ko*, J. Tumbleston*, L. Zhang*, S. Williams*, J. DeSimone*, R. Lopez*, E. Samulski*

MeSH headings : Aluminum / chemistry; Crystallization; Microscopy, Electron, Scanning; Nanostructures / chemistry; Photons; Solar Energy; Zinc Oxide / chemistry
TL;DR: Organic solar cells with a photonic crystal nanostructure embossed in the photoactive bulk heterojunction layer are reported, a topography that exhibits a 3-fold enhancement of the absorption in specific regions of the solar spectrum in part through multiple excitation resonances. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2009 review

Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 1(4), 391–404.

By: D. Canelas*, K. Herlihy* & J. DeSimone n

MeSH headings : Animals; Contrast Media / chemistry; Diagnostic Imaging / methods; Drug Carriers / chemistry; Drug Delivery Systems / methods; Drug Design; Humans; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nanotechnology / methods; Particle Size
TL;DR: This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers and insights gained into therapeutic cargo and imaging agent delivery from related types of polymer-based carriers are considered. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Alternative fluoropolymers to avoid the challenges associated with perfluorooctanoic acid

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 47(3), 502–508.

By: J. Guo n, P. Resnick n, K. Efimenko n, J. Genzer n & J. DeSimone n

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Continuous copolymerization of vinylidene fluoride with hexafluoropropylene in Supercritical carbon dioxide: High-hexafluoropropylene-content amorphous copolymers

MACROMOLECULES, 41(9), 3086–3097.

By: T. Ahmed n, J. DeSimone n & G. Roberts n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Electrically driven alignment and crystallization of unique anisotropic polymer particles

LANGMUIR, 24(16), 8421–8426.

By: K. Herlihy n, J. Nunes n & J. DeSimone n

MeSH headings : Anisotropy; Crystallization; Electrons; Particle Size; Polymers / chemistry
TL;DR: Micrometer-sized monodisperse anisotropic polymer particles, with disk, rod, fenestrated hexagon (hexnut), and boomerang shapes, were synthesized using the particle replication in nonwetting templates (PRINT) process, and investigations were conducted on aqueous suspensions of these particles when subjected to alternating electric fields. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles

PHARMACEUTICAL RESEARCH, 25(12), 2845–2852.

By: S. Gratton*, M. Napier*, P. Ropp*, S. Tian* & J. DeSimone n

author keywords: cellular uptake; endocytosis; particles; PRINT; surface charge
MeSH headings : Animals; Clathrin / physiology; Drug Carriers / metabolism; Endocytosis; HeLa Cells; Humans; Mice; NIH 3T3 Cells; Particle Size
TL;DR: It was found that PRINT particles with a positive zeta potential were endocytosed into HeLa cells using predominantely clathrin-mediated and macropinocytotic pathways. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Molding Block Copolymer Micelles: A Framework for Molding of Discrete Objects on Surfaces

Langmuir, 24(21), 12671–12679.

By: S. Yu-Su*, D. Thomas*, J. Alford*, I. LaRue*, M. Pitsikalis*, N. Hadjichristidis*, J. DeSimone*, A. Dobrynin*, S. Sheiko*

TL;DR: The successful molding of extended objects is attainable only when the particle is adsorbed on higher energy substrates where deformation can still be kept at a minimum by using stronger materials such as carbon nanotubes for the master. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2008 journal article

Nanostructured Titania−Polymer Photovoltaic Devices Made Using PFPE-Based Nanomolding Techniques

Chemistry of Materials, 20(16), 5229–5234.

By: S. Williams*, M. Hampton*, V. Gowrishankar*, I. Ding*, J. Templeton*, E. Samulski*, J. DeSimone*, M. McGehee*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: June 30, 2019

2008 journal article

Optically Transparent, Amphiphilic Networks Based on Blends of Perfluoropolyethers and Poly(ethylene glycol)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(43), 14244–14252.

By: Z. Hu n, L. Chen n, D. Betts n, A. Pandya n, M. Hillmyer n & J. DeSimone n

TL;DR: By incorporating a threshold amount of PFPEs into PEG-based hydrogel networks, water swelling could be significantly reduced, which may offer a new strategy for a number of medical device applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Reductively Labile PRINT Particles for the Delivery of Doxorubicin to HeLa Cells

Journal of the American Chemical Society, 130(15), 5008–5009.

By: R. Petros*, P. Ropp* & J. DeSimone*

MeSH headings : Cell Survival / drug effects; Doxorubicin / pharmacology; HeLa Cells; Humans; Microscopy, Electron, Scanning; Molecular Structure; Polymers / chemistry
TL;DR: A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro and was found to be highly proficient at killing HeLa cells in vitro. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2008 journal article

Shape-specific, monodisperse nano-molding of protein particles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(16), 5438-+.

By: J. Kelly n & J. DeSimone n

MeSH headings : Adhesiveness; Albumins / chemistry; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Breast Neoplasms / drug therapy; Electronics; Female; Gold / chemistry; Humans; Industry; Microscopy, Electron, Scanning / methods; Microscopy, Fluorescence / methods; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nanotechnology / methods; Particle Size; RNA, Small Interfering / chemistry
TL;DR: N nano-molding proteins for the fabrication of protein PRINT particles of monodisperse size and shape are reported, enabling a gentle, facile route to monod isperse particles of 100% protein as small as 200 nm cylinders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 review

The Pursuit of a Scalable Nanofabrication Platform for Use in Material and Life Science Applications

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 41(12), 1685–1695.

By: S. Gratton, S. Williams, M. Napier, P. Pohlhaus*, Z. Zhou*, K. Wiles, B. Maynor*, C. Shen* ...

MeSH headings : Biological Science Disciplines; Cell Line; Ethers / chemistry; Fluorocarbons / chemistry; Humans; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanomedicine / methods; Nanotechnology / methods
TL;DR: The use of perfluoropolyether (PFPE)-based materials that are able to accurately mold and replicate micro- and nanosized features using traditional techniques such as embossing as well as new techniques that are developed to exploit the exceptional surface characteristics of fluorinated substrates are described. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

The effect of particle design on cellular internalization pathways

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(33), 11613–11618.

By: S. Gratton*, P. Ropp*, P. Pohlhaus*, J. Luft*, V. Madden, M. Napier*, J. DeSimone n

author keywords: PRINT; shape; size; surface charge
MeSH headings : Cell Membrane / metabolism; Endocytosis; HeLa Cells; Humans; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles / ultrastructure; Particle Size
TL;DR: These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

The patterning of sub-500 nm inorganic oxide structures

Advanced Materials, 20(14), 2667-.

By: M. Hampton*, S. Williams*, Z. Zhou*, J. Nunes*, D. Ko*, J. Templeton*, E. Samulski*, J. DeSimone n

TL;DR: This versatile soft-lithography technique can be used to pattern a wide range of materials; in this work inorganic oxides including TiO2, SnO2 , ZnO, ITO, and BaTiO3 are patterned on a variety of substrates with different aspect ratios. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Continuous copolymerization of vinylidene fluoride with hexafluoropropylene in Supercritical carbon dioxide: Low hexafluoropropylene content semicrystalline copolymers

MACROMOLECULES, 40(26), 9322–9331.

By: T. Ahmed n, J. DeSimone n & G. Roberts n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Dynamics of CO2-Plasticized Electron Transport in Au Nanoparticle Films:  Opposing Effects of Tunneling Distance and Local Site Mobility

The Journal of Physical Chemistry C, 111(9), 3778–3785.

By: J. Choi*, M. Coble*, M. Branham*, J. DeSimone* & R. Murray*

Source: Crossref
Added: June 30, 2019

2007 journal article

Etching SiO[sub 2] with HF/pyridine-supercritical carbon dioxide solutions and resultant interfacial electronic properties

Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, 25(4), 1139.

By: Y. Li*, D. Yang*, C. Jones*, J. DeSimone* & E. Irene*

Source: Crossref
Added: June 30, 2019

2007 article

Nanofabricated particles for engineered drug therapies: A preliminary Biodistribution study of PRINT (TM) nanoparticles

Gratton, S. E. A., PohhauS, P. D., Lee, J., Guo, Ii, Cho, M. J., & DeSimone, J. M. (2007, August 16). JOURNAL OF CONTROLLED RELEASE, Vol. 121, pp. 10–18.

By: S. Gratton*, P. PohhauS, J. Lee, . Guo*, M. Cho* & J. DeSimone n

author keywords: PRINT; biodistribution; nanoparticles; pharmacokinetics; nanomedicine
MeSH headings : Acrylates / chemistry; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacokinetics; Drug Therapy; Ethers / chemistry; Fluorocarbons / chemistry; Iodine Radioisotopes; Light; Liposomes / chemistry; Mice; Nanomedicine; Nanoparticles / ultrastructure; Nanotechnology / instrumentation; Nanotechnology / methods; Particle Size; Pharmacokinetics; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Propylene Glycols / chemistry; Scattering, Radiation; Styrenes / chemistry; Tissue Distribution
TL;DR: In vitro and in vivo studies were conducted, demonstrating the future utility of PRINT particles as delivery vectors in nanomedicine, and incubation with HeLa cells showed very little cytotoxicity, even at high concentrations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Nanoparticle Drug Delivery Platform

Polymer Reviews, 47(3), 321–327.

By: M. Napier* & J. DeSimone n

author keywords: drug delivery; nanoparticles; nanotechnology; polymeric nanoparticles; polymers
TL;DR: The PRINT technology used to fabricate monodisperse particles from a wide range of particle matrix materials including biocompatible poly(ethylene glycol) and bioabsorbable poly(d‐lactic acid) is described along with an abbreviated overview of other polymeric drug delivery platforms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 30, 2019

2007 journal article

Supramolecular nanomimetics: Replication of micelles, viruses, and other naturally occurring nanoscale objects

SMALL, 3(5), 845–849.

By: B. Maynor*, I. LaRue*, Z. Hu*, J. Rolland*, A. Pandya*, Q. Fu*, J. Liu*, R. Spontak n ...

author keywords: carbon nanotubes; molding; replication; supramolecular chemistry
MeSH headings : Biomimetic Materials / chemistry; Biomimetics / methods; Crystallization / methods; Ethers / chemistry; Fluorocarbons / chemistry; Macromolecular Substances / chemistry; Materials Testing; Micelles; Molecular Conformation; Nanostructures / chemistry; Nanostructures / ultrastructure; Nanotechnology / methods; Particle Size; Surface Properties; Viruses / chemistry; Viruses / ultrastructure
TL;DR: A nanofabrication method that is able to reproduce shapes normally associated with self-assembly using robust nanoscale replication methods, thereby combining the morphological sophistication of the natural world with the scalable processing technologies associated with lithography is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Weak surface anchoring energy of 4-cyano-4′-pentyl-1,1′-biphenyl on perfluoropolyether Langmuir-Blodgett films

The Journal of Chemical Physics, 126(24), 244706.

By: J. Russell-Tanner*, S. Takayama*, A. Sugimura*, J. DeSimone* & E. Samulski*

TL;DR: A novel polymer material for LC alignment, namely, perfluoropolyether (PFPE), which exhibits a weak surface anchoring energy for bend deformation and is amenable to simple fabrication of grooved surfaces by soft lithography, a surface topography desired for multistable LCDs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: June 30, 2019

2006 journal article

Alicyclic photoresists for CO2-based next-generation microlithography: A tribute to James E. McGrath

POLYMER, 47(11), 4012–4017.

By: M. Boggiano*, D. Vellenga n, R. Carbonell n, V. Ashby* & J. DeSimone n

author keywords: condensed CO2; addition polymerization; photoresist synthesis
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Amorphous Linear Aliphatic Polyesters for the Facile Preparation of Tunable Rapidly Degrading Elastomeric Devices and Delivery Vectors

Journal of the American Chemical Society, 128(41), 13625–13633.

By: D. Olson*, S. Gratton*, J. DeSimone* & V. Sheares*

MeSH headings : Biocompatible Materials / chemical synthesis; Cross-Linking Reagents / chemistry; Elastomers / chemical synthesis; Materials Testing; Microscopy, Electron, Scanning; Models, Chemical; Molecular Weight; Polyesters / chemistry; Temperature; Time Factors
TL;DR: Using traditional and modified imprint lithography techniques, devices are fabricated that demonstrate a wide variety of biologically applicable topologies, which could easily be extended to fabricate devices with more complex geometries. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2006 journal article

Contact angle analysis, surface dynamics, and biofouling characteristics of cross-linkable, random perfluoropolyether-based graft terpolymers

MACROMOLECULES, 39(7), 2521–2528.

By: J. Yarbrough n, J. Rolland n, J. DeSimone n, M. Callow n, J. Finlay n & J. Callow n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Copolymerization of vinylidene fluoride with hexafluoropropylene in supercritical carbon dioxide

MACROMOLECULES, 39(1), 15–18.

By: T. Ahmed n, J. DeSimone n & G. Roberts n

Source: Web Of Science
Added: August 6, 2018

2006 journal article

Cross-linking polymerization of acrylic acid in supercritical carbon dioxide

POLYMER, 47(12), 4276–4281.

By: T. Liu n, J. DeSimone n & G. Roberts n

author keywords: acrylic acid; cross-linking polymerization; supercritical carbon dioxide
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Flexible Biradicals in Liquid and Supercritical Carbon Dioxide:  The Exchange Interaction, the Chain Dynamics, and a Comparison with Conventional Solvents

The Journal of Physical Chemistry A, 110(5), 1767–1774.

By: M. Forbes*, K. Dukes*, N. Avdievich*, E. Harbron* & J. DeSimone*

TL;DR: X-band time-resolved electron paramagnetic resonance (TREPR) spectra of three flexible biradicals of varying chain length and structure were obtained in liquid and supercritical carbon dioxide (CO2) solutions and compared to conventional solvents, finding faster chain dynamics is concluded to be the most likely cause of the observed effects. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2006 journal article

Imparting size, shape, and composition control of materials for nanomedicine

Chemical Society Reviews, 35(11), 1095.

By: L. Euliss, J. DuPont, S. Gratton & J. DeSimone*

MeSH headings : Animals; Biomedical Engineering; Nanomedicine / instrumentation; Nanostructures / chemistry; Nanostructures / ultrastructure; Organic Chemicals / chemistry; Particle Size
TL;DR: An overview of strategies for the synthesis and fabrication of organic nanomaterials, specifically those with potential for use in medical applications, and a novel method used to produce nanoparticles that are shape-specific, can contain any cargo, and can be easily modified are examined. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2006 journal article

Kinetics of the precipitation polymerization of acrylic acid in supercritical carbon dioxide: The locus of polymerization

CHEMICAL ENGINEERING SCIENCE, 61(10), 3129–3139.

By: T. Liu n, J. DeSimone n & G. Roberts n

author keywords: acrylic acid; kinetics; modeling; multiphase reactions; polymerization; supercritical fluid
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Molded, high surface area polymer electrolyte membranes from cured liquid precursors

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(39), 12963–12972.

By: Z. Zhou n, R. Dominey n, J. Rolland n, B. Maynor n, A. Pandya n & J. DeSimone n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Particle formation in precipitation polymerization: Continuous precipitation polymerization of acrylic acid in supercritical carbon dioxide

MACROMOLECULES, 39(19), 6489–6494.

By: T. Liu n, P. Garner n, J. DeSimone n, G. Roberts n & G. Bothun n

Source: Web Of Science
Added: August 6, 2018

2006 journal article

Polymeric nanoparticles from supercritical CO2 microemulsion polymerization

CHINESE JOURNAL OF POLYMER SCIENCE, 24(1), 95–101.

By: W. Ye*, J. Keiper & J. DeSimone

author keywords: supercritical carbon dioxide; nanoparticles; microemulsion polymerization
Source: Web Of Science
Added: August 6, 2018

2006 chapter

Production of Fluoropolymers in Supercritical Carbon Dioxide

In Supercritical Carbon Dioxide (pp. 189–204).

By: C. Wood*, J. Yarbrough*, G. Roberts n & J. DeSimone n

Source: Crossref
Added: August 30, 2019

2006 journal article

Solution properties of a fluorinated alkyl methacrylate polymer in carbon dioxide

MACROMOLECULES, 39(9), 3427–3434.

By: J. Guo n, P. Andre n, M. Adam n, S. Panyukov n, M. Rubinstein n & J. DeSimone n

Source: Web Of Science
Added: August 6, 2018

2006 journal article

Studies on CO2-based slurries and fluorinated silica and alumina particles for chemical mechanical polishing of copper films

JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 153(12), G1064–G1071.

By: P. Visintin*, S. Eichenlaub n, L. Portnow*, R. Carbonell*, S. Beaudoin n, C. Schauer*, J. DeSimone n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Superhydrophobic Behavior of a Perfluoropolyether Lotus-Leaf-like Topography

Langmuir, 22(20), 8576–8580.

By: L. Zhang*, Z. Zhou*, B. Cheng*, J. DeSimone* & E. Samulski*

MeSH headings : Aluminum Oxide / chemistry; Ethers / chemistry; Fluorocarbons / chemistry; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Microscopy, Electron, Scanning; Nanostructures / chemistry; Nanostructures / ultrastructure
TL;DR: Both nanopillars on a flat surface and on a lotus-leaf-like topology exhibit superhydrophobicity, low contact angle hysteresis, and self-cleaning. (via Semantic Scholar)
Source: Crossref
Added: June 30, 2019

2006 journal article

Ultrathin film deposition by liquid CO2 free meniscus coating-uniformity and morphology

LANGMUIR, 22(2), 642–657.

By: J. Kim n, B. Novick n, J. DeSimone n & R. Carbonell n

MeSH headings : Carbon Dioxide / chemistry; Coated Materials, Biocompatible / chemistry; Freezing; Materials Testing; Microscopy, Atomic Force; Silicon / chemistry; Solvents / chemistry; Sucrose / analogs & derivatives; Sucrose / chemistry; Surface Properties
TL;DR: The film thickness and morphology of SOA films deposited from 1-CO2 hFMC were compared to those deposited from toluene and acetone under normal dip coating and were much thinner, more uniform, and exhibited much fewer drying defects and lower RMS roughness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Use of substituted bis(acetylacetone) ethylenediimine and dialkyldithiocarbamate ligands for copper chelation in supercritical carbon dioxide

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 45(26), 8779–8787.

By: A. Dunbar n, D. Omiatek n, S. Thai n, C. Kendrex n, L. Grotzinger n, W. Boyko n, R. Weinstein n, D. Skaf n ...

Source: Web Of Science
Added: August 6, 2018

2005 journal article

Advantages of supercritical carbon dioxide for composite particle synthesis using water-soluble or water-reactive monomers

MACROMOLECULES, 38(10), 4542–4544.

By: J. Young n & J. DeSimone n

Source: Web Of Science
Added: August 6, 2018

2005 journal article

Chemical functionalization of silica and alumina particles for dispersion in carbon dioxide

LANGMUIR, 21(11), 4816–4823.

By: P. Visintin n, R. Carbonell n, C. Schauer n & J. DeSimone n

TL;DR: The steric stabilization and flocculation of modified silica and alumina particle suspensions in condensed CO(2) were studied and the C(8)F(17)COOH-alumina particles gave a significantly higher graft density but are not as stable inCO(2). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Continuous precipitation polymerization of acrylic acid in swercritical carbon dioxide: The polymerization rate and the polymer molecular weight

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 43(12), 2546–2555.

By: T. Liu n, J. Desimone n & G. Roberts n

author keywords: acrylic acid; continuous polymerization; kinetics (polym.); radical polymerization; supercritical carbon dioxide; water-soluble polymers
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Controlled foaming of polymer films through restricted surface diffusion and the addition of nanosilica particles or CO2-philic surfactants

MACROMOLECULES, 38(6), 2271–2280.

By: S. Siripurapu n, J. DeSimone n, S. Khan n & R. Spontak n

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(28), 10096–10100.

By: J. Rolland n, B. Maynor n, L. Euliss n, A. Exner n, G. Denison n & J. DeSimone n