Jason M Haugh

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

Zhou, W., Ryan, A., Janosko, C. P., Shoger, K. E., Haugh, J. M., Gottschalk, R. A., & Deiters, A. (2023, August 25). RSC CHEMICAL BIOLOGY, Vol. 8.

On the inference of ERK signaling dynamics from protein biosensor measurements

MOLECULAR BIOLOGY OF THE CELL, 34(6).

Semi-autonomous wound invasion via matrix-deposited, haptotactic cues

JOURNAL OF THEORETICAL BIOLOGY, 568.

A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

JOURNAL OF BIOLOGICAL CHEMISTRY, 298(5).

Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling

BIOPHYSICAL JOURNAL, 121(1), 102–118.

Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration

BIOMICROFLUIDICS, 15(4).

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

PLOS COMPUTATIONAL BIOLOGY, 16(4).

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(25), 8494–8504.

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

SCIENCE SIGNALING, 12(584).

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients

INTEGRATIVE BIOLOGY, 11(6), 280–292.

Simulating Emergent Spatiotemporal Actomyosin Dynamics to Understand Spatial Regulation of Non-Muscle Myosin II

Biophysical Journal, 116(3), 251a.

A Computational Investigation of Asymmetric Emergent Structures in Actomyosin Dynamics During Chemotaxis

Biophysical Journal, 114(3), 381a.

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis

BIOPHYSICAL JOURNAL, 113(1), 185–194.

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(7), 2866–2872.

Are Filopodia Privileged Signaling Structures in Migrating Cells?

BIOPHYSICAL JOURNAL, 111(9), 1827–1830.

Lamellipodia are crucial for haptotactic sensing and response

JOURNAL OF CELL SCIENCE, 129(12), 2329–2342.

Quantitative analysis of B-lymphocyte migration directed by CXCL13

INTEGRATIVE BIOLOGY, 8(8), 894–903.

Systems Cell Biology: An Overview

Encyclopedia of Cell Biology, pp. 1–3.

Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 988, 166–174.

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

JOURNAL OF CELL BIOLOGY, 208(4), 443–455.

GMF beta controls branched actin content and lamellipodial retraction in fibroblasts

JOURNAL OF CELL BIOLOGY, 209(6), 803–812.

Linking morphodynamics and directional persistence of T lymphocyte migration

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(106).

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

DEVELOPMENTAL CELL, 32(1), 54–67.

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration

COLLOIDS AND SURFACES B-BIOINTERFACES, 123, 225–235.

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

MOLECULAR SYSTEMS BIOLOGY, 10(1).

Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling

BIOPHYSICAL JOURNAL, 107(10), L29–L32.

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

CURRENT OPINION IN CELL BIOLOGY, 30, 74–82.

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLC gamma/PKC alpha Pathway

DEVELOPMENTAL CELL, 31(6), 747–760.

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

MOLECULAR BIOLOGY OF THE CELL, 24(24), 3945–3955.

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

PLOS ONE, 8(6).

Quantitative Analysis of Phosphoinositide 3-Kinase (PI3K) Signaling Using Live-Cell Total Internal Reflection Fluorescence (TIRF) Microscopy

Current Protocols in Cell Biology.

Cell regulation: A time to signal, a time to respond (Comment on DOI 10.1002/bies.201100172)

Haugh, J. M. (2012, July). BIOESSAYS, Vol. 34, pp. 528–529.

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation

BIOCHEMICAL JOURNAL, 441(1), 77–85.

Erratum to: Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

Cellular and Molecular Bioengineering, 5(4), 514–516.

Live-Cell Fluorescence Microscopy with Molecular Biosensors: What Are We Really Measuring?

BIOPHYSICAL JOURNAL, 102(9), 2003–2011.

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

JOURNAL OF CELL BIOLOGY, 197(1), 105–114.

Stochastic Models of Cell Protrusion Arising From Spatiotemporal Signaling and Adhesion Dynamics

Computational Methods in Cell Biology, pp. 223–241.

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells (vol 3, pg 30, 2010)

Cellular and Molecular Bioengineering, Vol. 5, pp. 514–516.

Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics

Methods in cell biology, vol 110: computational methods in cell biology, 110, 223–241.

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132

PLOS ONE, 7(11).

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331.

Cells see the light to bring signaling under control

Nature Methods, 8(10), 808–809.

Guidelines for visualizing and annotating rule-based models

MOLECULAR BIOSYSTEMS, 7(10), 2779–2795.

In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling

BIOPHYSICAL JOURNAL, 100(8), 1893–1901.

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009)

Wang, C.-C., Cirit, M., & Haugh, J. M. (2011, August). MOLECULAR SYSTEMS BIOLOGY, Vol. 7.

Poly(vinylmethylsiloxane) Elastomer Networks as Functional Materials for Cell Adhesion and Migration Studies

BIOMACROMOLECULES, 12(4), 1265–1271.

Quantitative models of signal transduction networks

Communicative & Integrative Biology, 4(3), 353–356.

Signaling pathways that control cell migration: models and analysis

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 3(2), 231–240.

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

BIOPHYSICAL JOURNAL, 98(1), 67–75.

Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

CELLULAR AND MOLECULAR BIOENGINEERING, 3(1), 30–39.

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

PLOS COMPUTATIONAL BIOLOGY, 6(2).

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(47), 36736–36744.

A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

PLOS COMPUTATIONAL BIOLOGY, 5(4).

Analysis of Reaction-Diffusion Systems with Anomalous Subdiffusion

BIOPHYSICAL JOURNAL, 97(2), 435–442.

PI3K‐dependent cross‐talk interactions converge with Ras as quantifiable inputs integrated by Erk

Molecular Systems Biology, 5(1), 246.

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

JOURNAL OF CELL SCIENCE, 122(3), 313–323.

Biophysics - Cells get in shape for a crawl

Haugh, J. M. (2008, May 22). NATURE, Vol. 453, pp. 461–462.

Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties

Cell Adhesion & Migration, 2(2), 137–145.

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and-4 Receptors in a Helper T-H2 Cell Line

CELLULAR AND MOLECULAR BIOENGINEERING, 1(2-3), 163–172.

Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(12), 7338–7345.

First International Conference on Biomolecular Engineering (ICBE)

Biotechnology Progress, 24(1), 1–1.

Mathematical Modelling of Biological Signaling Networks

Haugh, J. M. (2008, May). Wiley Encyclopedia of Chemical Biology.

Signal transduction at point-blank range: Analysis of a spatial coupling mechanism for pathway crosstalk

BIOPHYSICAL JOURNAL, 95(5), 2172–2182.

Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology

Haugh, J. M. (2007, June 1).

Structure-based kinetic models of modular signaling protein function: Focus on Shp2

BIOPHYSICAL JOURNAL, 92(7), 2290–2300.

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing

BIOPHYSICAL JOURNAL, 90(7), 2297–2308.

Effectiveness factor for spatial gradient sensing in living cells

CHEMICAL ENGINEERING SCIENCE, 61(17), 5603–5611.

Fast imaging of partially conductive linear cracks using impedance data

INVERSE PROBLEMS, 22(4), 1337–1358.

Mechanisms of gradient sensing and chemotaxis - Conserved pathways, diverse regulation

CELL CYCLE, 5(11), 1130–1134.

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

BIOCHEMICAL JOURNAL, 393(1), 235–243.

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

JOURNAL OF CELL BIOLOGY, 171(5), 883–892.

Reactions on cell membranes: Comparison of continuum theory and Brownian dynamics simulations

JOURNAL OF CHEMICAL PHYSICS, 123(7).

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts, III: Influence of cell morphology and morphological polarity

BIOPHYSICAL JOURNAL, 89(2), 1420–1430.

Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists

BIOTECHNOLOGY PROGRESS, 20(5), 1337–1344.

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling

JOURNAL OF THEORETICAL BIOLOGY, 230(1), 119–132.

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups

BIOPHYSICAL JOURNAL, 86(1), 589–598.

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments

BIOPHYSICAL JOURNAL, 86(1), 599–608.

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(39), 37064–37072.

A unified model for signal transduction reactions in cellular membranes

BIOPHYSICAL JOURNAL, 82(2), 591–604.

Active EGF receptors have limited access to PtdIns(4,5)P2 in endosomes: implications for phospholipase C and PI 3-kinase signaling

Journal of Cell Science.

Active EGF receptors have limited access to Ptdlns(4,5)P-2 in endosomes: implications for phospholipase C and PI 3-kinase signaling

Journal of Cell Science, 115(2), 303–310.

Localization of Receptor-Mediated Signal Transduction Pathways: The Inside Story

Molecular Interventions, 2(5), 292–307.

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

BIOTECHNOLOGY AND BIOENGINEERING, 70(2), 225–238.

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

Biotechnology and Bioengineering, 70(2), 225–238.

Spatial sensing in fibroblasts mediated by 3 ' phosphoinositides

JOURNAL OF CELL BIOLOGY, 151(6), 1269–1279.

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C- 1 Signaling Pathway

Journal of Biological Chemistry, 274(13), 8958–8965.

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21ras in Fibroblasts

Journal of Biological Chemistry, 274(48), 34350–34360.

Analysis of Receptor Internalization as a Mechanism for Modulating Signal Transduction

Journal of Theoretical Biology, 195(2), 187–218.

Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics

Chemistry & Biology, 5(10), R257–R263.

Physical modulation of intracellular signaling processes by locational regulation

Biophysical Journal, 72(5), 2014–2031.

Modeling Intracellular Signal Transduction Processes

Haugh, J. M., & Weiger, M. C. Chemical Biology, pp. 1061–1081.

PI3K's Pivotal Role in Cell Migration

Welf, E., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. SciVee.