Works (95)

Updated: February 1st, 2024 04:44

2023 article

Dissection of MKK6 and p38 Signaling Using Light-Activated Protein Kinases

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2023, November 7). CHEMBIOCHEM, Vol. 11.

By: S. Rahman n, W. Zhou *, A. Deiters* & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: apoptosis; autophagy; cell death; growth factors; mitogen-activated protein kinases; optogenetics; signal transduction
Sources: Web Of Science, ORCID
Added: December 4, 2023

2023 journal article

G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions

BIOPHYSICAL JOURNAL, 122(18), 3816–3829.

By: R. Appalabhotla n, M. Butler *, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Web Of Science, ORCID
Added: October 30, 2023

2023 article

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

Zhou, W., Ryan, A., Janosko, C. P., Shoger, K. E., Haugh, J. M., Gottschalk, R. A., & Deiters, A. (2023, August 25). RSC CHEMICAL BIOLOGY, Vol. 8.

By: W. Zhou, A. Ryan, C. Janosko, K. Shoger, J. Haugh , R. Gottschalk, A. Deiters

Sources: Web Of Science, ORCID
Added: October 2, 2023

2023 journal article

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

RSC CHEMICAL BIOLOGY, 4(10), 765–773.

By: W. Zhou *, A. Ryan*, C. Janosko*, K. Shoger*, J. Haugh n , R. Gottschalk *, A. Deiters *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Web Of Science, ORCID
Added: October 16, 2023

2023 journal article

On the inference of ERK signaling dynamics from protein biosensor measurements

MOLECULAR BIOLOGY OF THE CELL, 34(6).

By: S. Rahman n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Biosensing Techniques; Extracellular Signal-Regulated MAP Kinases / metabolism; MAP Kinase Signaling System; Phosphorylation; Signal Transduction
Sources: Web Of Science, ORCID
Added: June 12, 2023

2023 journal article

Semi-autonomous wound invasion via matrix-deposited, haptotactic cues

JOURNAL OF THEORETICAL BIOLOGY, 568.

By: S. Baldwin n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Cell migration; Wound healing; Gradient sensing; Tissue dynamics; Traveling wave
MeSH headings : Cues; Cell Movement / physiology; Chemotaxis / physiology; Wound Healing / physiology; Fibroblasts; Cytokines
Sources: Web Of Science, ORCID
Added: June 12, 2023

2022 journal article

A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

JOURNAL OF BIOLOGICAL CHEMISTRY, 298(5).

By: J. Nosbisch n, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Carrier Proteins / metabolism; Isoenzymes / metabolism; Kinetics; Mammals / metabolism; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation; Protein-Tyrosine Kinases / metabolism; Type C Phospholipases / metabolism; src Homology Domains / genetics
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling

BIOPHYSICAL JOURNAL, 121(1), 102–118.

By: A. Chandra n, M. Butler *, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin Cytoskeleton / metabolism; Actins / metabolism; Cell Surface Extensions; Myosin Type II / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: January 18, 2022

2021 journal article

Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration

BIOMICROFLUIDICS, 15(4).

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Web Of Science, ORCID
Added: July 26, 2021

2020 journal article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

PLOS COMPUTATIONAL BIOLOGY, 16(4).

By: J. Nosbisch n, A. Rahman n, K. Mohan n, T. Elston*, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
Sources: Web Of Science, ORCID
Added: May 26, 2020

2020 journal article

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(25), 8494–8504.

By: S. Rahman n, W. Zhou *, A. Deiters* & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: optogenetics; signal transduction; cell signaling; mitogen-activated protein kinases; apoptosis; cell death; cell stress; mitogen-activated protein kinase (MAPK)
MeSH headings : Animals; Apoptosis / radiation effects; Cell Line; Cell Proliferation / radiation effects; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; Mice; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mutagenesis; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins B-raf / metabolism; Signal Transduction / radiation effects; Ultraviolet Rays; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
Sources: Web Of Science, ORCID
Added: July 27, 2020

2019 journal article

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

SCIENCE SIGNALING, 12(584).

By: K. Tiruthani n, A. Mischler n, S. Ahmed*, J. Mahinthakumar n, J. Haugh n  & B. Rao n

co-author countries: Bangladesh πŸ‡§πŸ‡© United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Biosensing Techniques; Cell Line; Endocytosis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Mice; Microscopy, Fluorescence; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation / genetics; src Homology Domains
Sources: Web Of Science, ORCID
Added: June 24, 2019

2019 journal article

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients

INTEGRATIVE BIOLOGY, 11(6), 280–292.

By: C. Miller *, P. LaFosse *, S. Asokan, J. Haugh n , J. Bear & T. Elston *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin Cytoskeleton / metabolism; Actomyosin / physiology; Animals; Cell Movement; Chemotaxis; Computer Simulation; Fibroblasts / cytology; Humans; Models, Biological; Myosin Type II / metabolism; Pattern Recognition, Automated; Platelet-Derived Growth Factor / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: October 28, 2019

2019 journal article

Simulating Emergent Spatiotemporal Actomyosin Dynamics to Understand Spatial Regulation of Non-Muscle Myosin II

Biophysical Journal, 116(3), 251a.

By: C. Miller *, P. LaFosse *, S. Asokan*, J. Haugh n , J. Bear * & T. Elston *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Crossref, ORCID
Added: February 24, 2020

2018 journal article

A Computational Investigation of Asymmetric Emergent Structures in Actomyosin Dynamics During Chemotaxis

Biophysical Journal, 114(3), 381a.

By: C. Miller *, S. Asokan*, J. Haugh n , J. Bear * & T. Elston *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Crossref, ORCID
Added: February 24, 2020

2017 journal article

A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis

BIOPHYSICAL JOURNAL, 113(1), 185–194.

By: K. Mohan n, J. Nosbisch n, T. Elston *, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Membrane / metabolism; Chemotaxis / physiology; Diffusion; Feedback, Physiological / physiology; Fibroblasts / enzymology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Signal Transduction / physiology; Type C Phospholipases / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(7), 2866–2872.

By: A. Rahman n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Kinetics; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes / metabolism; NIH 3T3 Cells; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Are Filopodia Privileged Signaling Structures in Migrating Cells?

BIOPHYSICAL JOURNAL, 111(9), 1827–1830.

By: H. Johnson n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Movement; Mice; NIH 3T3 Cells; Optical Imaging; Pseudopodia / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Lamellipodia are crucial for haptotactic sensing and response

JOURNAL OF CELL SCIENCE, 129(12), 2329–2342.

By: S. King*, S. Asokan*, E. Haynes *, S. Zimmerman*, J. Rotty*, J. Alb*, A. Tagliatela*, D. Blake * ...

co-author countries: United Kingdom of Great Britain and Northern Ireland πŸ‡¬πŸ‡§ United States of America πŸ‡ΊπŸ‡Έ
author keywords: Haptotaxis; Arp2/3; Lamellipodia; Directed migration
MeSH headings : Actin-Related Protein 2-3 Complex / metabolism; Actins / metabolism; Animals; Chemotaxis / drug effects; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibronectins / pharmacology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Focal Adhesions / metabolism; Guanine Nucleotide Exchange Factors / metabolism; Integrin beta1 / metabolism; Mice; Models, Biological; Pseudopodia / metabolism; Signal Transduction / drug effects; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Wiskott-Aldrich Syndrome Protein / metabolism; Wiskott-Aldrich Syndrome Protein Family / metabolism; rac GTP-Binding Proteins / metabolism; src-Family Kinases / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Quantitative analysis of B-lymphocyte migration directed by CXCL13

INTEGRATIVE BIOLOGY, 8(8), 894–903.

By: X. Liu n, S. Asokan*, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Adsorption; Animals; B-Lymphocytes / cytology; Cell Movement; Chemokine CXCL13 / metabolism; Computational Biology; Computer Simulation; Intercellular Adhesion Molecule-1 / metabolism; Mice; Mice, Inbred C57BL; Microfluidics; Microscopy, Fluorescence; Phenotype
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 article

Systems Cell Biology: An Overview

Encyclopedia of Cell Biology, pp. 1–3.

By: D. Lauffenburger*, J. Haugh n , H. Byrne * & R. Linding *

co-author countries: Denmark πŸ‡©πŸ‡° United Kingdom of Great Britain and Northern Ireland πŸ‡¬πŸ‡§ United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

2015 journal article

Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 988, 166–174.

By: L. Herring n, K. Grant*, K. Blackburn n, J. Haugh n  & M. Goshe n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Phosphopeptide enrichment; Liquid chromatography; Mass spectrometry; Motif analysis; Pathway analysis
MeSH headings : Amino Acid Sequence; Chromatography, Liquid / methods; Molecular Sequence Data; Phosphopeptides / analysis; Phosphopeptides / chemistry; Proteomics / methods; Signal Transduction / physiology; Tandem Mass Spectrometry / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

JOURNAL OF CELL BIOLOGY, 208(4), 443–455.

By: H. Johnson n, S. King*, S. Asokan*, J. Rotty*, J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : 3T3 Cells; Actin Cytoskeleton; Actin-Related Protein 2-3 Complex / genetics; Actin-Related Protein 2-3 Complex / metabolism; Actins / physiology; Animals; Cell Adhesion / physiology; Cell Line; Cell Shape; Chemotaxis / genetics; Chemotaxis / physiology; Fibroblasts / cytology; Fibronectins / metabolism; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Microfilament Proteins / biosynthesis; Microfilament Proteins / genetics; Microscopy, Fluorescence; Molecular Sequence Data; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / physiology; RNA Interference; RNA, Small Interfering; Receptors, Odorant / biosynthesis; Receptors, Odorant / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

GMF beta controls branched actin content and lamellipodial retraction in fibroblasts

JOURNAL OF CELL BIOLOGY, 209(6), 803–812.

By: E. Haynes *, S. Asokan*, S. King*, H. Johnson n, J. Haugh n  & J. Bear *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin-Related Protein 2-3 Complex / antagonists & inhibitors; Actin-Related Protein 2-3 Complex / metabolism; Actins / biosynthesis; Animals; Cell Line; Cell Movement / physiology; Enzyme Activation; Fibroblasts / physiology; Fibronectins / pharmacology; Glia Maturation Factor / physiology; Indoles / pharmacology; Mice; Protein Isoforms / biosynthesis; Pseudopodia / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Linking morphodynamics and directional persistence of T lymphocyte migration

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(106).

By: X. Liu n, E. Welf n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: cell migration; chemokine; TIRF microscopy; image analysis
MeSH headings : Actins / physiology; Animals; Cell Movement / physiology; Cell Polarity / physiology; Cell Size; Cells, Cultured; Computer Simulation; Humans; Membrane Fluidity / physiology; Mice; Models, Biological; Models, Statistical; Molecular Motor Proteins / physiology; Stochastic Processes; T-Lymphocytes / cytology; T-Lymphocytes / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

DEVELOPMENTAL CELL, 32(1), 54–67.

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin Cytoskeleton / metabolism; Actin-Related Protein 2-3 Complex / metabolism; Actins / metabolism; Animals; Female; Fetal Proteins; Fibroblasts / cytology; Formins; Image Processing, Computer-Assisted; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microscopy, Fluorescence; Nuclear Proteins; Profilins / metabolism; Signal Transduction; Stress Fibers
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration

COLLOIDS AND SURFACES B-BIOINTERFACES, 123, 225–235.

By: V. Vernekar*, C. Wallace*, M. Wu*, J. Chao*, . Shannon K. O'Connor, A. Raleigh*, X. Liu n, J. Haugh n , W. Reichert*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Chemotaxis; Chemokine; Cell adhesion molecule; Surface immobilization; Surface gradients; B lymphocyte
MeSH headings : Animals; B-Lymphocytes / cytology; Cell Movement / physiology; Cells, Cultured; Chemokine CXCL12 / chemistry; Intercellular Adhesion Molecule-1 / chemistry; Mice; Mice, Transgenic; Ultraviolet Rays
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

MOLECULAR SYSTEMS BIOLOGY, 10(1).

By: S. Ahmed n, K. Grant n, L. Edwards n, A. Rahman n, M. Cirit n, M. Goshe n, J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling

BIOPHYSICAL JOURNAL, 107(10), L29–L32.

By: A. Rahman n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Kinetics; Models, Biological; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

CURRENT OPINION IN CELL BIOLOGY, 30, 74–82.

By: J. Bear * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin Cytoskeleton / metabolism; Cell Movement / physiology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Neutrophils / cytology; Neutrophils / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLC gamma/PKC alpha Pathway

DEVELOPMENTAL CELL, 31(6), 747–760.

By: S. Asokan*, H. Johnson n, A. Rahman n, S. King*, J. Rotty*, I. Lebedeva*, J. Haugh n , J. Bear *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Line; Cell Movement; Chemotaxis / physiology; Diglycerides / chemistry; Green Fluorescent Proteins / metabolism; Humans; Ligands; Mesoderm / physiology; Mice; Mice, Transgenic; Myosin Type II / metabolism; Phorbol Esters; Phospholipase C gamma / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C-alpha / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

MOLECULAR BIOLOGY OF THE CELL, 24(24), 3945–3955.

By: E. Welf n, H. Johnson n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Actin Cytoskeleton; Actins / metabolism; Actomyosin / physiology; Animals; Cell Adhesion / physiology; Cell Adhesion Molecules / genetics; Cell Movement / physiology; Computer Simulation; Extracellular Matrix / metabolism; Focal Adhesions / physiology; Integrins / genetics; Integrins / metabolism; Integrins / physiology; Mechanotransduction, Cellular; Myosin Type II / metabolism; Pseudopodia / metabolism; Signal Transduction / genetics; rhoA GTP-Binding Protein / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

PLOS ONE, 8(6).

By: L. Ott n, E. Sung  n, A. Melvin n, M. Sheats n , J. Haugh n , K. Adler n, S. Jones n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ

Ed(s): P. Aspenstrom

MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 article

Quantitative Analysis of Phosphoinositide 3-Kinase (PI3K) Signaling Using Live-Cell Total Internal Reflection Fluorescence (TIRF) Microscopy

Current Protocols in Cell Biology.

By: H. Johnson  n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Image Processing, Computer-Assisted; Mice; Microscopy, Fluorescence / methods; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoprotein Phosphatases / genetics; Phosphoprotein Phosphatases / metabolism; Protein Binding; Protein Transport; Receptor Cross-Talk; Recombinant Fusion Proteins / genetics; Signal Transduction
Source: ORCID
Added: July 13, 2021

2012 article

Cell regulation: A time to signal, a time to respond (Comment on DOI 10.1002/bies.201100172)

Haugh, J. M. (2012, July). BIOESSAYS, Vol. 34, pp. 528–529.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Communication; Extracellular Signal-Regulated MAP Kinases / metabolism; Gene Regulatory Networks; Humans; Models, Theoretical; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation

BIOCHEMICAL JOURNAL, 441(1), 77–85.

By: M. Cirit n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: computational biology; cross-talk; growth factor; kinetic analysis; mitogen-activated protein kinase (MAPK); receptor tyrosine kinase
MeSH headings : Animals; Becaplermin; Computer Simulation; Extracellular Signal-Regulated MAP Kinases / genetics; Extracellular Signal-Regulated MAP Kinases / metabolism; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / metabolism; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-sis / genetics; Proto-Oncogene Proteins c-sis / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Receptors, Fibroblast Growth Factor / genetics; Receptors, Fibroblast Growth Factor / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Erratum to: Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

Cellular and Molecular Bioengineering, 5(4), 514–516.

By: E. Welf  n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Crossref, ORCID
Added: February 24, 2020

2012 journal article

Live-Cell Fluorescence Microscopy with Molecular Biosensors: What Are We Really Measuring?

BIOPHYSICAL JOURNAL, 102(9), 2003–2011.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Humans; Microscopy, Fluorescence / methods; Molecular Imaging / methods; Molecular Probe Techniques; Molecular Probes / metabolism; Protein Interaction Mapping / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

JOURNAL OF CELL BIOLOGY, 197(1), 105–114.

By: E. Welf n, S. Ahmed n, H. Johnson n, A. Melvin n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 article

Stochastic Models of Cell Protrusion Arising From Spatiotemporal Signaling and Adhesion Dynamics

Computational Methods in Cell Biology, pp. 223–241.

By: E. Welf  n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Algorithms; Animals; CHO Cells; Cell Adhesion; Cell Movement; Cell Shape; Computer Simulation; Cricetinae; Kinetics; Models, Biological; Signal Transduction / physiology; Stochastic Processes
Source: ORCID
Added: July 13, 2021

2012 article

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells (vol 3, pg 30, 2010)

Cellular and Molecular Bioengineering, Vol. 5, pp. 514–516.

By: E. Welf & J. Haugh 

Source: NC State University Libraries
Added: August 6, 2018

2012 conference paper

Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics

Methods in cell biology, vol 110: computational methods in cell biology, 110, 223–241.

By: E. Welf & J. Haugh 

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132

PLOS ONE, 7(11).

By: M. Cirit n, K. Grant n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ

Ed(s): L. Buday

MeSH headings : Animals; Computer Simulation; Dual-Specificity Phosphatases / metabolism; Embryo, Mammalian / cytology; Enzyme Activation / drug effects; Fibroblast Growth Factors / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Humans; Leupeptins / pharmacology; MAP Kinase Signaling System / drug effects; Mesoderm / cytology; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; NIH 3T3 Cells; Phosphorylation / drug effects; Platelet-Derived Growth Factor / pharmacology; Proteasome Inhibitors / pharmacology; Up-Regulation / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331.

By: G. Buhrman*, V. Kumar, M. Cirit n, J. Haugh n  & C. Mattos*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Allosteric Regulation; Allosteric Site; Animals; Guanosine Triphosphate / metabolism; Kinetics; Mice; Mutation, Missense; NIH 3T3 Cells; Protein Conformation; Protein Stability; Signal Transduction; raf Kinases / metabolism; ras Proteins / genetics; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Cells see the light to bring signaling under control

Nature Methods, 8(10), 808–809.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Feedback, Physiological / radiation effects; Humans; Light; Signal Transduction / radiation effects
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Guidelines for visualizing and annotating rule-based models

MOLECULAR BIOSYSTEMS, 7(10), 2779–2795.

co-author countries: China πŸ‡¨πŸ‡³ Poland πŸ‡΅πŸ‡± United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Allosteric Regulation; Models, Theoretical; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling

BIOPHYSICAL JOURNAL, 100(8), 1893–1901.

By: A. Melvin n, E. Welf n, Y. Wang *, D. Irvine * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Alginates / chemistry; Animals; Cell Surface Extensions / drug effects; Cell Surface Extensions / metabolism; Chemotaxis / drug effects; Dose-Response Relationship, Drug; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Mice; Microspheres; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / chemistry; Platelet-Derived Growth Factor / pharmacology; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / drug effects; Stochastic Processes
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 article

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009)

Wang, C.-C., Cirit, M., & Haugh, J. M. (2011, August). MOLECULAR SYSTEMS BIOLOGY, Vol. 7.

By: C. Wang n, M. Cirit n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

Poly(vinylmethylsiloxane) Elastomer Networks as Functional Materials for Cell Adhesion and Migration Studies

BIOMACROMOLECULES, 12(4), 1265–1271.

By: S. Ahmed n, H. Yang n, A. Ozcam n, K. Efimenko n , M. Weiger n, J. Genzer n , J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Mice; Microscopy, Fluorescence; Molecular Sequence Data; NIH 3T3 Cells; Oligopeptides / chemistry; Polyvinyls / chemistry; Siloxanes / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Quantitative models of signal transduction networks

Communicative & Integrative Biology, 4(3), 353–356.

By: M. Cirit n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

2011 journal article

Signaling pathways that control cell migration: models and analysis

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 3(2), 231–240.

By: E. Welf n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cell Movement / physiology; Humans; Models, Biological; Signal Transduction / physiology; Systems Biology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

BIOPHYSICAL JOURNAL, 98(1), 67–75.

By: M. Weiger n, S. Ahmed n, E. Welf n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Movement / physiology; Computer Simulation; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

CELLULAR AND MOLECULAR BIOENGINEERING, 3(1), 30–39.

By: E. Welf n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Integrins; Focal adhesions; Signal transduction; Paxillin; Src-family kinases; Myosin
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

PLOS COMPUTATIONAL BIOLOGY, 6(2).

By: M. Cirit n, M. Krajcovic n, C. Choi*, E. Welf n, A. Horwitz* & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ

Ed(s): A. Asthagiri

MeSH headings : Animals; CHO Cells; Cell Adhesion / physiology; Cell Movement / physiology; Cell Surface Extensions / metabolism; Computational Biology / methods; Computer Simulation; Cricetinae; Cricetulus; Extracellular Matrix / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Integrins / metabolism; Models, Biological; Myosins / metabolism; Paxillin / genetics; Paxillin / metabolism; Signal Transduction / physiology; Stochastic Processes; rac GTP-Binding Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(47), 36736–36744.

By: M. Cirit n, C. Wang n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Humans; Immunoblotting; Kinetics; Mice; Mitogen-Activated Protein Kinases / metabolism; NIH 3T3 Cells; Phosphorylation; Signal Transduction; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

PLOS COMPUTATIONAL BIOLOGY, 5(4).

By: D. Barua n, J. Faeder * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ

Ed(s): N. Kannan

MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / metabolism; Binding Sites; Computer Simulation; Enzyme Activation; Janus Kinases / chemistry; Janus Kinases / metabolism; Models, Biological; Models, Chemical; Phosphorylation; Protein Binding; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Analysis of Reaction-Diffusion Systems with Anomalous Subdiffusion

BIOPHYSICAL JOURNAL, 97(2), 435–442.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cell Membrane / metabolism; Diffusion; Fluorescence Recovery After Photobleaching; Models, Biological; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

PI3K‐dependent cross‐talk interactions converge with Ras as quantifiable inputs integrated by Erk

Molecular Systems Biology, 5(1), 246.

By: C. Wang  n, M. Cirit n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: kinetic model; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; receptor tyrosine kinase; signal transduction
MeSH headings : Computational Biology; Extracellular Signal-Regulated MAP Kinases / metabolism; Humans; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Receptor Cross-Talk; Signal Transduction; ras Proteins / metabolism
Sources: Crossref, ORCID
Added: August 28, 2020

2009 journal article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

JOURNAL OF CELL SCIENCE, 122(3), 313–323.

By: M. Weiger n, C. Wang n, M. Krajcovic n, A. Melvin n, J. Rhoden n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

Biophysics - Cells get in shape for a crawl

Haugh, J. M. (2008, May 22). NATURE, Vol. 453, pp. 461–462.

By: J. Haugh* 

MeSH headings : Actin Cytoskeleton / chemistry; Actin Cytoskeleton / metabolism; Animals; Cell Movement / physiology; Cell Shape / physiology; Epithelial Cells / cytology; Fishes; Models, Biological
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties

Cell Adhesion & Migration, 2(2), 137–145.

By: M. Monine* & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: wound healing; chemotaxis; gradient sensing; mathematical model; stochastic; signal transduction; phosphoinositide 3-kinase; PDGF
MeSH headings : Cell Survival; Chemotaxis; Fibroblasts; Models, Biological; Phosphatidylinositol 3-Kinases / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; Skin / injuries; Skin / metabolism; Skin / pathology; Substrate Specificity
Source: ORCID
Added: July 13, 2021

2008 journal article

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and-4 Receptors in a Helper T-H2 Cell Line

CELLULAR AND MOLECULAR BIOENGINEERING, 1(2-3), 163–172.

By: K. Comfort n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Cytokine receptor; Lymphocyte; Clonal expansion; Kinetic analysis; STAT; Phosphatidylinositol 3-kinase
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(12), 7338–7345.

By: D. Barua n, J. Faeder * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Humans; Kinetics; Models, Biological; Phosphatidylinositol 3-Kinases / chemistry; Phosphatidylinositol 3-Kinases / metabolism; Receptor, Platelet-Derived Growth Factor beta / chemistry; Receptor, Platelet-Derived Growth Factor beta / metabolism; Surface Plasmon Resonance / methods; src Homology Domains / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

First International Conference on Biomolecular Engineering (ICBE)

Biotechnology Progress, 24(1), 1–1.

By: M. DeLisa & J. Haugh 

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Mathematical Modelling of Biological Signaling Networks

Haugh, J. M. (2008, May). Wiley Encyclopedia of Chemical Biology.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

2008 journal article

Signal transduction at point-blank range: Analysis of a spatial coupling mechanism for pathway crosstalk

BIOPHYSICAL JOURNAL, 95(5), 2172–2182.

By: M. Monine n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Algorithms; Cell Membrane / metabolism; Computer Simulation; Models, Biological; Phosphatidylinositol 3-Kinases / metabolism; Receptor Cross-Talk; Signal Transduction; ras Guanine Nucleotide Exchange Factors / metabolism; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 personal communication

Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology

Haugh, J. M. (2007, June 1).

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cell Membrane / physiology; Eukaryotic Cells / cytology; Eukaryotic Cells / physiology; Intercellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Structure-based kinetic models of modular signaling protein function: Focus on Shp2

BIOPHYSICAL JOURNAL, 92(7), 2290–2300.

By: D. Barua n, J. Faeder * & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Computer Simulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins / chemistry; Intracellular Signaling Peptides and Proteins / metabolism; Kinetics; Models, Biological; Models, Chemical; Models, Molecular; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases / chemistry; Protein Tyrosine Phosphatases / metabolism; Protein Tyrosine Phosphatases / ultrastructure; SH2 Domain-Containing Protein Tyrosine Phosphatases; Structure-Activity Relationship
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing

BIOPHYSICAL JOURNAL, 90(7), 2297–2308.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Biophysics / methods; Cell Membrane / metabolism; Cell Movement; Cell Physiological Phenomena; Cell Proliferation; Chemotaxis; Diffusion; Endocytosis; Fibroblasts / metabolism; Kinetics; Mice; Models, Biological; Models, Statistical; Models, Theoretical; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Platelet-Derived Growth Factor / physiology; Receptors, Platelet-Derived Growth Factor / metabolism; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction; Wound Healing
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Effectiveness factor for spatial gradient sensing in living cells

CHEMICAL ENGINEERING SCIENCE, 61(17), 5603–5611.

By: J. Haugh n  & I. Schneider n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: cellular biology and engineering; kinetics; diffusion; mathematical modeling; chemotaxis; cell migration
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Fast imaging of partially conductive linear cracks using impedance data

INVERSE PROBLEMS, 22(4), 1337–1358.

By: K. Bryan*, J. Haugh  n & D. McCune*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Mechanisms of gradient sensing and chemotaxis - Conserved pathways, diverse regulation

CELL CYCLE, 5(11), 1130–1134.

By: I. Schneider* & J. Haugh* 

author keywords: signal transduction; cell migration; phosphoinositide 3-kinase; Rho-family GTPases; mathematical modeling; diffusion; wound healing
MeSH headings : Animals; Chemotactic Factors / physiology; Chemotaxis / physiology; Fibroblasts / cytology; Humans; Wound Healing
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

BIOCHEMICAL JOURNAL, 393(1), 235–243.

By: H. Kaur n, C. Park n, J. Lewis n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: mathematical modelling; phosphoinositide 3-kinase (PI3K); platelet-derived growth factor (PDGF); Ras; receptor tyrosine kinase; signal transduction
MeSH headings : Animals; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; ras GTPase-Activating Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

JOURNAL OF CELL BIOLOGY, 171(5), 883–892.

By: I. Schneider n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : 3T3 Cells; Algorithms; Animals; Chemotaxis / physiology; Dictyostelium / cytology; Dictyostelium / physiology; Fibroblasts / physiology; Mice; Models, Biological; Neutrophils / physiology; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Reactions on cell membranes: Comparison of continuum theory and Brownian dynamics simulations

JOURNAL OF CHEMICAL PHYSICS, 123(7).

By: M. Monine n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Algorithms; Biophysics / methods; Catalysis; Cell Membrane / metabolism; Chemistry, Physical / methods; Computer Simulation; Diffusion; Enzymes / chemistry; Models, Statistical; Models, Theoretical; Molecular Conformation; Signal Transduction; Static Electricity; Substrate Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts, III: Influence of cell morphology and morphological polarity

BIOPHYSICAL JOURNAL, 89(2), 1420–1430.

By: I. Schneider n, E. Parrish n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Polarity / physiology; Cell Size; Kinetics; Metabolic Clearance Rate; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphatidylinositols / metabolism; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists

BIOTECHNOLOGY PROGRESS, 20(5), 1337–1344.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cell Proliferation / drug effects; Computer Simulation; Dimerization; Dose-Response Relationship, Drug; Human Growth Hormone / genetics; Human Growth Hormone / pharmacology; Kinetics; Membrane Proteins / metabolism; Models, Biological; Protein Binding; Protein Transport / drug effects; Protein Transport / physiology; Signal Transduction / drug effects; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling

JOURNAL OF THEORETICAL BIOLOGY, 230(1), 119–132.

By: J. Haugh n , I. Schneider n & J. Lewis n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: signal transduction; receptor; phosphatase; kinase; phosphorylation
MeSH headings : Animals; Cell Membrane / metabolism; Models, Biological; Phosphorylation; Protein Tyrosine Phosphatases / metabolism; Signal Transduction / physiology; src-Family Kinases / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups

BIOPHYSICAL JOURNAL, 86(1), 589–598.

By: J. Haugh n  & I. Schneider n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cells, Cultured; Computer Simulation; Diffusion; Fibroblasts / drug effects; Fibroblasts / metabolism; Humans; Microscopy, Fluorescence / methods; Models, Biological; Phosphatidylinositols / metabolism; Platelet-Derived Growth Factor / pharmacology; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction / physiology; Tissue Distribution
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments

BIOPHYSICAL JOURNAL, 86(1), 599–608.

By: I. Schneider n & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cells, Cultured; Computer Simulation; Diffusion; Fibroblasts / drug effects; Fibroblasts / metabolism; Humans; Microscopy, Fluorescence / methods; Models, Biological; Phosphatidylinositols / metabolism; Platelet-Derived Growth Factor / pharmacology; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction / physiology; Tissue Distribution
Sources: Web Of Science, ORCID
Added: August 6, 2018

2003 journal article

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(39), 37064–37072.

By: C. Park n, I. Schneider* & J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : 3T3 Cells; Animals; Fibroblasts / physiology; Kinetics; Mathematics; Mice; Models, Biological; Phosphatidylinositol 3-Kinases / physiology; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / physiology; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor / physiology; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

A unified model for signal transduction reactions in cellular membranes

BIOPHYSICAL JOURNAL, 82(2), 591–604.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Biophysical Phenomena; Biophysics; Cell Membrane / metabolism; Guanosine Triphosphate / metabolism; Kinetics; Lipid Metabolism; Models, Biological; Models, Chemical; Models, Theoretical; Monomeric GTP-Binding Proteins / metabolism; Monte Carlo Method; Protein Binding; Signal Transduction; Substrate Specificity; Type C Phospholipases / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Active EGF receptors have limited access to PtdIns(4,5)P2 in endosomes: implications for phospholipase C and PI 3-kinase signaling

Journal of Cell Science.

Jason Haugh

Source: ORCID
Added: July 13, 2021

2002 journal article

Active EGF receptors have limited access to Ptdlns(4,5)P-2 in endosomes: implications for phospholipase C and PI 3-kinase signaling

Journal of Cell Science, 115(2), 303–310.

By: J. Haugh  & T. Meyer

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Localization of Receptor-Mediated Signal Transduction Pathways: The Inside Story

Molecular Interventions, 2(5), 292–307.

By: J. Haugh n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Membrane / metabolism; Enzyme Activation; ErbB Receptors / metabolism; Humans; Isoenzymes / metabolism; Membrane Microdomains; Phosphatidylinositol 3-Kinases / metabolism; Phosphatidylinositol 4,5-Diphosphate / metabolism; Phospholipase C gamma / metabolism; Receptor Protein-Tyrosine Kinases / metabolism; Signal Transduction / physiology; ras Proteins / metabolism
Source: ORCID
Added: July 13, 2021

2000 journal article

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

BIOTECHNOLOGY AND BIOENGINEERING, 70(2), 225–238.

By: J. Haugh* , A. Wells * & D. Lauffenburger*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: signaling networks; mathematical model; intracellular processes; complexity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

Biotechnology and Bioengineering, 70(2), 225–238.

By: J. Haugh* , A. Wells * & D. Lauffenburger*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

2000 journal article

Spatial sensing in fibroblasts mediated by 3 ' phosphoinositides

JOURNAL OF CELL BIOLOGY, 151(6), 1269–1279.

By: J. Haugh* , F. Codazzi*, M. Teruel * & T. Meyer *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: chemotaxis; signal transduction; phosphatidylinositol 3-kinase; receptor protein-tyrosine kinases; platelet-derived growth factor
MeSH headings : 3T3 Cells; Animals; Cell Adhesion; Chemotaxis / physiology; Fibroblasts / physiology; Green Fluorescent Proteins; Luminescent Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Theoretical; Phosphatidylinositol 3-Kinases / metabolism; Phosphatidylinositols / metabolism; Platelet-Derived Growth Factor / metabolism; Protein Transport; Receptor Protein-Tyrosine Kinases / metabolism; Recombinant Fusion Proteins; Second Messenger Systems; Wound Healing / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-Β 1 Signaling Pathway

Journal of Biological Chemistry, 274(13), 8958–8965.

By: J. Haugh* , K. Schooler*, A. Wells *, H. Wiley * & D. Lauffenburger*

co-author countries: Russian Federation πŸ‡·πŸ‡Ί United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Cell Line; Endocytosis; Epidermal Growth Factor / pharmacology; ErbB Receptors / metabolism; Gene Expression Regulation, Enzymologic / genetics; Isoenzymes / metabolism; Lysosomes / metabolism; Mice; Phosphatidylinositol 4,5-Diphosphate / metabolism; Phospholipase C gamma; Phosphorylation; Phosphotyrosine / metabolism; Signal Transduction / genetics; Transforming Growth Factor alpha / pharmacology; Type C Phospholipases / metabolism
Source: ORCID
Added: July 13, 2021

1999 journal article

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21ras in Fibroblasts

Journal of Biological Chemistry, 274(48), 34350–34360.

By: J. Haugh* , A. Huang, H. Wiley, A. Wells & D. Lauffenburger

MeSH headings : Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Compartmentation; Cells, Cultured; Endocytosis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Flavonoids / pharmacology; Guanosine Diphosphate / metabolism; Guanosine Triphosphate / metabolism; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases / antagonists & inhibitors; Models, Biological; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proteins / metabolism; Proto-Oncogene Proteins p21(ras) / drug effects; Proto-Oncogene Proteins p21(ras) / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine / metabolism; ras Guanine Nucleotide Exchange Factors / drug effects; ras Guanine Nucleotide Exchange Factors / metabolism
Source: ORCID
Added: July 13, 2021

1998 journal article

Analysis of Receptor Internalization as a Mechanism for Modulating Signal Transduction

Journal of Theoretical Biology, 195(2), 187–218.

By: J. Haugh*  & D. Lauffenburger*

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

1998 journal article

Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics

Chemistry & Biology, 5(10), R257–R263.

By: D. Lauffenburger*, E. Fallon* & J. Haugh* 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Cytokines / genetics; Cytokines / metabolism; Epidermal Growth Factor / metabolism; Humans; Interleukin-2 / metabolism; Ligands; Protein Binding; Protein Engineering; Receptors, Cell Surface / metabolism
Source: ORCID
Added: July 13, 2021

1997 journal article

Physical modulation of intracellular signaling processes by locational regulation

Biophysical Journal, 72(5), 2014–2031.

By: J. Haugh*  & D. Lauffenburger *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Biophysical Phenomena; Biophysics; Cell Membrane / chemistry; Cell Membrane / metabolism; Cytosol / chemistry; Cytosol / metabolism; Models, Biological; Receptor Protein-Tyrosine Kinases / chemistry; Receptor Protein-Tyrosine Kinases / metabolism; Receptors, Cell Surface / chemistry; Receptors, Cell Surface / metabolism; Signal Transduction; Up-Regulation
Source: ORCID
Added: July 13, 2021

article

Modeling Intracellular Signal Transduction Processes

Haugh, J. M., & Weiger, M. C. Chemical Biology, pp. 1061–1081.

By: J. Haugh n  & M. Weiger*

co-author countries: Spain πŸ‡ͺπŸ‡Έ United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: July 13, 2021

dataset

PI3K's Pivotal Role in Cell Migration

Welf, E., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. SciVee.

By: E. Welf, S. Ahmed, H. Johnson, A. Melvin & J. Haugh* 

Source: ORCID
Added: July 13, 2021

Employment

Updated: February 14th, 2017 17:13

2000 - present

North Carolina State University Raleigh, NC, US
Professor Chemical & Biomolecular Engineering

Education

Updated: February 14th, 2017 17:11

1995 - 1999

Massachusetts Institute of Technology Cambridge, MA, US
PhD Chemical Engineering

1990 - 1994

North Carolina State University Raleigh, NC, US
BS Chemical Engineering

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