Works (64)

2019 journal article

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

SCIENCE SIGNALING, 12(584).

By: K. Tiruthani, A. Mischler, S. Ahmed, J. Mahinthakumar, J. Haugh & B. Rao

Source: Web Of Science
Added: June 24, 2019

2019 journal article

Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients

INTEGRATIVE BIOLOGY, 11(6), 280–292.

By: C. Miller, P. LaFosse, S. Asokan, J. Haugh, J. Bear & T. Elston

Source: Web Of Science
Added: October 28, 2019

2017 journal article

A A reaction-diffusion model explains amplification of the PLC/PKC pathway in fibroblast chemotaxis

Biophysical Journal, 113(1), 185–194.

By: K. Mohan, J. Nosbisch, T. Elston, J. Bear & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Kinetic modeling and analysis of the akt/mechanistic target of rapamycin complex 1 (mtorc1) signaling axis reveals cooperative, feedforward regulation

Journal of Biological Chemistry, 292(7), 2866–2872.

By: A. Rahman & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Are filopodia privileged signaling structures in migrating cells?

Biophysical Journal, 111(9), 1827–1830.

By: H. Johnson & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Lamellipodia are crucial for haptotactic sensing and response

Journal of Cell Science, 129(12), 2329–2342.

By: S. King, S. Asokan, E. Haynes, S. Zimmerman, J. Rotty, J. Alb, A. Tagliatela, D. Blake ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Quantitative analysis of B-lymphocyte migration directed by CXCL13

Integrative Biology, 8(8), 894–903.

By: X. Liu, S. Asokan, J. Bear & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 988, 166–174.

By: L. Herring, K. Grant, K. Blackburn, J. Haugh & M. Goshe

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

Journal of Cell Biology, 208(4), 443–455.

By: H. Johnson, S. King, S. Asokan, J. Rotty, J. Bear & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

GMF beta controls branched actin content and lamellipodial retraction in fibroblasts

Journal of Cell Biology, 209(6), 803–812.

By: E. Haynes, S. Asokan, S. King, H. Johnson, J. Haugh & J. Bear

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Linking morphodynamics and directional persistence of T lymphocyte migration

Journal of the Royal Society Interface, 12(106).

By: X. Liu, E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways

Developmental Cell, 32(1), 54–67.

By: J. Rotty, C. Wu, E. Haynes, C. Suarez, J. Winkelman, H. Johnson, J. Haugh, D. Kovar, J. Bear

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration

Colloids and Surfaces. B, Biointerfaces, 123, 225–235.

By: V. Vernekar, C. Wallace, M. Wu, J. Chao, S. O'Connor, A. Raleigh, X. Liu, J. Haugh, W. Reichert

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Molecular Systems Biology, 10(1).

By: S. Ahmed, K. Grant, L. Edwards, A. Rahman, M. Cirit, M. Goshe, J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Deactivation of a negative regulator: A distinct signal transduction mechanism, pronounced in Akt signaling

Biophysical Journal, 107(10), L29–32.

By: A. Rahman & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

Current Opinion in Cell Biology, 30, 74–82.

By: J. Bear & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Mesenchymal chemotaxis requires selective inactivation of Myosin II at the leading edge via a noncanonical PLC gamma/PKC alpha pathway

Developmental Cell, 31(6), 747–760.

By: S. Asokan, H. Johnson, A. Rahman, S. King, J. Rotty, I. Lebedeva, J. Haugh, J. Bear

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

Molecular Biology of the Cell, 24(24), 3945–3955.

By: E. Welf, H. Johnson & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Fibroblast migration is regulated by myristoylated alanine-rich C-kinase substrate (MARCKS) protein

PLoS One, 8(6).

By: L. Ott, E. Sung, A. Melvin, M. Sheats, J. Haugh, K. Adler, S. Jones

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Cell regulation: A time to signal, a time to respond (Comment on DOI 10.1002/bies.201100172)

BioEssays, 34(7), 528–529.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation

Biochemical Journal (London, England : 1984), 441, 77–85.

By: M. Cirit & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Live-cell fluorescence microscopy with molecular biosensors: What are we really measuring?

Biophysical Journal, 102(9), 2003–2011.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

Journal of Cell Biology, 197(1), 105–114.

By: E. Welf, S. Ahmed, H. Johnson, A. Melvin & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 article

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells (vol 3, pg 30, 2010)

Cellular and Molecular Bioengineering.

By: E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 conference paper

Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics

In Methods in cell biology, vol 110: computational methods in cell biology (Vol. 110, pp. 223–241).

By: E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132

PLoS One, 7(11).

By: M. Cirit, K. Grant & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase

Journal of Biological Chemistry, 286(5), 3323–3331.

By: G. Buhrman, V. Kumar, M. Cirit, J. Haugh & C. Mattos

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Cells see the light to bring signaling under control

Nature Methods, 8(10), 808–809.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Guidelines for visualizing and annotating rule-based models

Molecular BioSystems, 7(10), 2779–2795.

By: L. Chylek, B. Hu, M. Blinov, T. Emonet, J. Faeder, B. Goldstein, R. Gutenkunst, J. Haugh ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling

Biophysical Journal, 100(8), 1893–1901.

By: A. Melvin, E. Welf, Y. Wang, D. Irvine & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2011 article

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009)

Molecular Systems Biology.

By: C. Wang, M. Cirit & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies

Biomacromolecules, 12(4), 1265–1271.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Signaling pathways that control cell migration: Models and analysis

Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 3(2), 231–240.

By: E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling

Biophysical Journal, 98(1), 67–75.

By: M. Weiger, S. Ahmed, E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells

Cellular and Molecular Bioengineering, 3(1), 30–39.

By: E. Welf & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells

PLoS Computational Biology, 6(2).

By: M. Cirit, M. Krajcovic, C. Choi, E. Welf, A. Horwitz & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network

Journal of Biological Chemistry, 285(47), 36736–36744.

By: M. Cirit, C. Wang & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

A A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases

PLoS Computational Biology, 5(4).

By: D. Barua, J. Faeder & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Analysis of reaction-diffusion systems with anomalous subdiffusion

Biophysical Journal, 97(2), 435–442.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

Journal of Cell Science, 122(3), 313–323.

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Biophysics - Cells get in shape for a crawl

Nature, 453(7194), 461–462.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Combinatorial signal transduction responses mediated by interleukin-2 and-4 receptors in a helper T-H2 cell line

Cellular and Molecular Bioengineering, 1(2-3), 163–172.

By: K. Comfort & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase

Journal of Biological Chemistry, 283(12), 7338–7345.

By: D. Barua, J. Faeder & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

First International Conference on Biomolecular Engineering (ICBE)

Biotechnology Progress, 24(1), 1–1.

By: M. DeLisa & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Signal transduction at point-blank range: Analysis of a spatial coupling mechanism for pathway crosstalk

Biophysical Journal, 95(5), 2172–2182.

By: M. Monine & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology

Biophysical Journal, 92(11), L93–95.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Structure-based kinetic models of modular signaling protein function: Focus on Shp2

Biophysical Journal, 92(7), 2290–2300.

By: D. Barua, J. Faeder & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing

Biophysical Journal, 90(7), 2297–2308.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Effectiveness factor for spatial gradient sensing in living cells

Chemical Engineering Science, 61(17), 5603–5611.

By: J. Haugh & I. Schneider

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Fast imaging of partially conductive linear cracks using impedance data

Inverse Problems, 22(4), 1337–1358.

By: K. Bryan, J. Haugh & D. McCune

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Mechanisms of gradient sensing and chemotaxis - Conserved pathways, diverse regulation

Cell Cycle, 5(11), 1130–1134.

By: I. Schneider & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

Biochemical Journal (London, England : 1984), 393, 235–243.

By: H. Kaur, C. Park, J. Lewis & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

Journal of Cell Biology, 171(5), 883–892.

By: I. Schneider & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Reactions on cell membranes: Comparison of continuum theory and Brownian dynamics simulations

Journal of Chemical Physics, 123(7).

By: M. Monine & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts, III: Influence of cell morphology and morphological polarity

Biophysical Journal, 89(2), 1420–1430.

By: I. Schneider, E. Parrish & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists

Biotechnology Progress, 20(5), 1337–1344.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling

Journal of Theoretical Biology, 230(1), 119–132.

By: J. Haugh, I. Schneider & J. Lewis

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups

Biophysical Journal, 86(1), 589–598.

By: J. Haugh & I. Schneider

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments

Biophysical Journal, 86(1), 599–608.

By: I. Schneider & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

Journal of Biological Chemistry, 278(39), 37064–37072.

By: C. Park, I. Schneider & J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

A A unified model for signal transduction reactions in cellular membranes

Biophysical Journal, 82(2), 591–604.

By: J. Haugh

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Active EGF receptors have limited access to Ptdlns(4,5)P-2 in endosomes: implications for phospholipase C and PI 3-kinase signaling

Journal of Cell Science, 115(2), 303–310.

By: J. Haugh & T. Meyer

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions

Biotechnology and Bioengineering, 70(2), 225–238.

By: J. Haugh, A. Wells & D. Lauffenburger

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Spatial sensing in fibroblasts mediated by 3' phosphoinositides

Journal of Cell Biology, 151(6), 1269–1279.

By: J. Haugh, F. Codazzi, M. Teruel & T. Meyer

Source: NC State University Libraries
Added: August 6, 2018