Jason Haugh

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2023, November 7). Dissection of MKK6 and p38 Signaling Using Light-Activated Protein Kinases. CHEMBIOCHEM, Vol. 11. https://doi.org/10.1002/cbic.202300551

Appalabhotla, R., Butler, M. T., Bear, J. E., & Haugh, J. M. (2023). G-actin diffusion is insufficient to achieve F-actin assembly in fast-treadmilling protrusions. BIOPHYSICAL JOURNAL, 122(18), 3816–3829. https://doi.org/10.1016/j.bpj.2023.08.022

Zhou, W., Ryan, A., Janosko, C. P., Shoger, K. E., Haugh, J. M., Gottschalk, R. A., & Deiters, A. (2023, August 25). Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk. RSC CHEMICAL BIOLOGY, Vol. 8. https://doi.org/10.1039/d2cb00157

Zhou, W., Ryan, A., Janosko, C. P., Shoger, K. E., Haugh, J. M., Gottschalk, R. A., & Deiters, A. (2023). Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk. RSC CHEMICAL BIOLOGY, 4(10), 765–773. https://doi.org/10.1039/d2cb00157h

Rahman, S. M. T., & Haugh, J. M. (2023). On the inference of ERK signaling dynamics from protein biosensor measurements. MOLECULAR BIOLOGY OF THE CELL, 34(6). https://doi.org/10.1091/mbc.E22-10-0476

Baldwin, S. A., & Haugh, J. M. (2023). Semi-autonomous wound invasion via matrix-deposited, haptotactic cues. JOURNAL OF THEORETICAL BIOLOGY, 568. https://doi.org/10.1016/j.jtbi.2023.111506

Nosbisch, J. L., Bear, J. E., & Haugh, J. M. (2022). A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation. JOURNAL OF BIOLOGICAL CHEMISTRY, 298(5). https://doi.org/10.1016/j.jbc.2022.101886

Chandra, A., Butler, M. T., Bear, J. E., & Haugh, J. M. (2022). Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling. BIOPHYSICAL JOURNAL, 121(1), 102–118. https://doi.org/10.1016/j.bpj.2021.11.2889

Baldwin, S. A., Van Bruggen, S. M., Koelbl, J. M., Appalabhotla, R., Bear, J. E., & Haugh, J. M. (2021). Microfluidic devices fitted with "flowver" paper pumps generate steady, tunable gradients for extended observation of chemotactic cell migration. BIOMICROFLUIDICS, 15(4). https://doi.org/10.1063/5.0054764

Nosbisch, J. L., Rahman, A., Mohan, K., Elston, T. C., Bear, J. E., & Haugh, J. M. (2020). Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing. PLOS COMPUTATIONAL BIOLOGY, 16(4). https://doi.org/10.1371/journal.pcbi.1007708

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2020). Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(25), 8494–8504. https://doi.org/10.1074/jbc.RA119.012079

Tiruthani, K., Mischler, A., Ahmed, S., Mahinthakumar, J., Haugh, J. M., & Rao, B. M. (2019). Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation. SCIENCE SIGNALING, 12(584). https://doi.org/10.1126/scisignal.aap7584

Miller, C. J., LaFosse, P. K., Asokan, S. B., Haugh, J. M., Bear, J. E., & Elston, T. C. (2019). Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients. INTEGRATIVE BIOLOGY, 11(6), 280–292. https://doi.org/10.1093/intbio/zyz023

Miller, C. J., LaFosse, P., Asokan, S., Haugh, J., Bear, J. E., & Elston, T. C. (2019). Simulating Emergent Spatiotemporal Actomyosin Dynamics to Understand Spatial Regulation of Non-Muscle Myosin II. Biophysical Journal, 116(3), 251a. https://doi.org/10.1016/J.BPJ.2018.11.1372

Miller, C. J., Asokan, S., Haugh, J., Bear, J. E., & Elston, T. C. (2018). A Computational Investigation of Asymmetric Emergent Structures in Actomyosin Dynamics During Chemotaxis. Biophysical Journal, 114(3), 381a. https://doi.org/10.1016/J.BPJ.2017.11.2111

Mohan, K., Nosbisch, J. L., Elston, T. C., Bear, J. E., & Haugh, J. M. (2017). A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis. BIOPHYSICAL JOURNAL, 113(1), 185–194. https://doi.org/10.1016/j.bpj.2017.05.035

Rahman, A., & Haugh, J. M. (2017). Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation. JOURNAL OF BIOLOGICAL CHEMISTRY, 292(7), 2866–2872. https://doi.org/10.1074/jbc.m116.761205

Johnson, H. E., & Haugh, J. M. (2016). Are Filopodia Privileged Signaling Structures in Migrating Cells? BIOPHYSICAL JOURNAL, 111(9), 1827–1830. https://doi.org/10.1016/j.bpj.2016.09.022

King, S. J., Asokan, S. B., Haynes, E. M., Zimmerman, S. P., Rotty, J. D., Alb, J. G., Jr., … Bear, J. E. (2016). Lamellipodia are crucial for haptotactic sensing and response. JOURNAL OF CELL SCIENCE, 129(12), 2329–2342. https://doi.org/10.1242/jcs.184507

Liu, X., Asokan, S. B., Bear, J. E., & Haugh, J. M. (2016). Quantitative analysis of B-lymphocyte migration directed by CXCL13. INTEGRATIVE BIOLOGY, 8(8), 894–903. https://doi.org/10.1039/c6ib00128a

Lauffenburger, D. A., Haugh, J. M., Byrne, H. M., & Linding, R. (2016). Systems Cell Biology: An Overview. Encyclopedia of Cell Biology, pp. 1–3. https://doi.org/10.1016/b978-0-12-394447-4.40044-1

Herring, L. E., Grant, K. G., Blackburn, K., Haugh, J. M., & Goshe, M. B. (2015). Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 988, 166–174. https://doi.org/10.1016/j.jchromb.2015.02.017

Johnson, H. E., King, S. J., Asokan, S. B., Rotty, J. D., Bear, J. E., & Haugh, J. M. (2015). F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling. JOURNAL OF CELL BIOLOGY, 208(4), 443–455. https://doi.org/10.1083/jcb.201406102

Haynes, E. M., Asokan, S. B., King, S. J., Johnson, H. E., Haugh, J. M., & Bear, J. E. (2015). GMF beta controls branched actin content and lamellipodial retraction in fibroblasts. JOURNAL OF CELL BIOLOGY, 209(6), 803–812. https://doi.org/10.1083/jcb.201501094

Liu, X., Welf, E. S., & Haugh, J. M. (2015). Linking morphodynamics and directional persistence of T lymphocyte migration. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(106). https://doi.org/10.1098/rsif.2014.1412

Rotty, J. D., Wu, C., Haynes, E. M., Suarez, C., Winkelman, J. D., Johnson, H. E., … Bear, J. E. (2015). Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways. DEVELOPMENTAL CELL, 32(1), 54–67. https://doi.org/10.1016/j.devcel.2014.10.026

Vernekar, V. N., Wallace, C. S., Wu, M., Chao, J. T., Shannon K. O'Connor, Raleigh, A., … Reichert, W. M. (2014). Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration. COLLOIDS AND SURFACES B-BIOINTERFACES, 123, 225–235. https://doi.org/10.1016/j.colsurfb.2014.09.020

Ahmed, S., Grant, K. G., Edwards, L. E., Rahman, A., Cirit, M., Goshe, M. B., & Haugh, J. M. (2014). Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states. MOLECULAR SYSTEMS BIOLOGY, 10(1). https://doi.org/10.1002/msb.134708

Rahman, A., & Haugh, J. M. (2014). Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling. BIOPHYSICAL JOURNAL, 107(10), L29–L32. https://doi.org/10.1016/j.bpj.2014.10.003

Bear, J. E., & Haugh, J. M. (2014). Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. CURRENT OPINION IN CELL BIOLOGY, 30, 74–82. https://doi.org/10.1016/j.ceb.2014.06.005

Asokan, S. B., Johnson, H. E., Rahman, A., King, S. J., Rotty, J. D., Lebedeva, I. P., … Bear, J. E. (2014). Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLC gamma/PKC alpha Pathway. DEVELOPMENTAL CELL, 31(6), 747–760. https://doi.org/10.1016/j.devcel.2014.10.024

Welf, E. S., Johnson, H. E., & Haugh, J. M. (2013). Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility. MOLECULAR BIOLOGY OF THE CELL, 24(24), 3945–3955. https://doi.org/10.1091/mbc.e13-06-0311

Ott, L. E., Sung, E. J., Melvin, A. T., Sheats, M. K., Haugh, J. M., Adler, K. B., & Jones, S. L. (2013). Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein. PLOS ONE, 8(6). https://doi.org/10.1371/journal.pone.0066512

Johnson, H. E., & Haugh, J. M. (2013). Quantitative Analysis of Phosphoinositide 3-Kinase (PI3K) Signaling Using Live-Cell Total Internal Reflection Fluorescence (TIRF) Microscopy. Current Protocols in Cell Biology. https://doi.org/10.1002/0471143030.cb1414s61

Haugh, J. M. (2012, July). Cell regulation: A time to signal, a time to respond (Comment on DOI 10.1002/bies.201100172). BIOESSAYS, Vol. 34, pp. 528–529. https://doi.org/10.1002/bies.201200077

Cirit, M., & Haugh, J. M. (2012). Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation. BIOCHEMICAL JOURNAL, 441(1), 77–85. https://doi.org/10.1042/bj20110833

Welf, E. S., & Haugh, J. M. (2012). Erratum to: Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells. Cellular and Molecular Bioengineering, 5(4), 514–516. https://doi.org/10.1007/S12195-012-0252-9

Haugh, J. M. (2012). Live-Cell Fluorescence Microscopy with Molecular Biosensors: What Are We Really Measuring? BIOPHYSICAL JOURNAL, 102(9), 2003–2011. https://doi.org/10.1016/j.bpj.2012.03.055

Welf, E. S., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. (2012). Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. JOURNAL OF CELL BIOLOGY, 197(1), 105–114. https://doi.org/10.1083/jcb.201108152

Welf, E. S., & Haugh, J. M. (2012). Stochastic Models of Cell Protrusion Arising From Spatiotemporal Signaling and Adhesion Dynamics. Computational Methods in Cell Biology, pp. 223–241. https://doi.org/10.1016/b978-0-12-388403-9.00009-6

Welf, E. S., & Haugh, J. M. (2012). Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells (vol 3, pg 30, 2010). Cellular and Molecular Bioengineering, Vol. 5, pp. 514–516.

Welf, E. S., & Haugh, J. M. (2012). Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics. Methods in cell biology, vol 110: computational methods in cell biology, 110, 223–241.

Cirit, M., Grant, K. G., & Haugh, J. M. (2012). Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132. PLOS ONE, 7(11). https://doi.org/10.1371/journal.pone.0050975

Buhrman, G., Kumar, V. S. S., Cirit, M., Haugh, J. M., & Mattos, C. (2011). Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331. https://doi.org/10.1074/jbc.m110.193854

Haugh, J. M. (2011). Cells see the light to bring signaling under control. Nature Methods, 8(10), 808–809. https://doi.org/10.1038/nmeth.1708

Chylek, L. A., Hu, B., Blinov, M. L., Emonet, T., Faeder, J. R., Goldstein, B., … Hlavacek, W. S. (2011). Guidelines for visualizing and annotating rule-based models. MOLECULAR BIOSYSTEMS, 7(10), 2779–2795. https://doi.org/10.1039/c1mb05077j

Melvin, A. T., Welf, E. S., Wang, Y., Irvine, D. J., & Haugh, J. M. (2011). In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling. BIOPHYSICAL JOURNAL, 100(8), 1893–1901. https://doi.org/10.1016/j.bpj.2011.02.047

Wang, C.-C., Cirit, M., & Haugh, J. M. (2011, August). PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009). MOLECULAR SYSTEMS BIOLOGY, Vol. 7. https://doi.org/10.1038/msb.2011.61

Ahmed, S., Yang, H.-kwan, Ozcam, A. E., Efimenko, K., Weiger, M. C., Genzer, J., & Haugh, J. M. (2011). Poly(vinylmethylsiloxane) Elastomer Networks as Functional Materials for Cell Adhesion and Migration Studies. BIOMACROMOLECULES, 12(4), 1265–1271. https://doi.org/10.1021/bm101549y

Cirit, M., & Haugh, J. M. (2011). Quantitative models of signal transduction networks. Communicative & Integrative Biology, 4(3), 353–356. https://doi.org/10.4161/cib.4.3.15149

Welf, E. S., & Haugh, J. M. (2011). Signaling pathways that control cell migration: models and analysis. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 3(2), 231–240. https://doi.org/10.1002/wsbm.110

Weiger, M. C., Ahmed, S., Welf, E. S., & Haugh, J. M. (2010). Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling. BIOPHYSICAL JOURNAL, 98(1), 67–75. https://doi.org/10.1016/j.bpj.2009.09.051

Welf, E. S., & Haugh, J. M. (2010). Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells. CELLULAR AND MOLECULAR BIOENGINEERING, 3(1), 30–39. https://doi.org/10.1007/s12195-010-0100-8

Cirit, M., Krajcovic, M., Choi, C. K., Welf, E. S., Horwitz, A. F., & Haugh, J. M. (2010). Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells. PLOS COMPUTATIONAL BIOLOGY, 6(2). https://doi.org/10.1371/journal.pcbi.1000688

Cirit, M., Wang, C.-C., & Haugh, J. M. (2010). Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(47), 36736–36744. https://doi.org/10.1074/jbc.m110.148759

Barua, D., Faeder, J. R., & Haugh, J. M. (2009). A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases. PLOS COMPUTATIONAL BIOLOGY, 5(4). https://doi.org/10.1371/journal.pcbi.1000364

Haugh, J. M. (2009). Analysis of Reaction-Diffusion Systems with Anomalous Subdiffusion. BIOPHYSICAL JOURNAL, 97(2), 435–442. https://doi.org/10.1016/j.bpj.2009.05.014

Wang, C. C., Cirit, M., & Haugh, J. M. (2009). PI3K‐dependent cross‐talk interactions converge with Ras as quantifiable inputs integrated by Erk. Molecular Systems Biology, 5(1), 246. https://doi.org/10.1038/msb.2009.4

Weiger, M. C., Wang, C.-C., Krajcovic, M., Melvin, A. T., Rhoden, J. J., & Haugh, J. M. (2009). Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. JOURNAL OF CELL SCIENCE, 122(3), 313–323. https://doi.org/10.1242/jcs.037564

Haugh, J. M. (2008, May 22). Biophysics - Cells get in shape for a crawl. NATURE, Vol. 453, pp. 461–462. https://doi.org/10.1038/453461a

Monine, M. I., & Haugh, J. M. (2008). Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties. Cell Adhesion & Migration, 2(2), 137–145. https://doi.org/10.4161/cam.2.2.6511

Comfort, K. K., & Haugh, J. M. (2008). Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and-4 Receptors in a Helper T-H2 Cell Line. CELLULAR AND MOLECULAR BIOENGINEERING, 1(2-3), 163–172. https://doi.org/10.1007/s12195-008-0015-9

Barua, D., Faeder, J. R., & Haugh, J. M. (2008). Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(12), 7338–7345. https://doi.org/10.1074/jbc.M708359200

DeLisa, M., & Haugh, J. (2008). First International Conference on Biomolecular Engineering (ICBE). Biotechnology Progress, 24(1), 1–1.

Haugh, J. M. (2008, May). Mathematical Modelling of Biological Signaling Networks. Wiley Encyclopedia of Chemical Biology. https://doi.org/10.1002/9780470048672.wecb646

Monine, M. I., & Haugh, J. M. (2008). Signal transduction at point-blank range: Analysis of a spatial coupling mechanism for pathway crosstalk. BIOPHYSICAL JOURNAL, 95(5), 2172–2182. https://doi.org/10.1529/biophysj.108.128892

Haugh, J. M. (2007, June 1). Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology. https://doi.org/10.1529/biophysj.107.105213

Barua, D., Faeder, J. R., & Haugh, J. M. (2007). Structure-based kinetic models of modular signaling protein function: Focus on Shp2. BIOPHYSICAL JOURNAL, 92(7), 2290–2300. https://doi.org/10.1529/biophysj.106.093484

Haugh, J. M. (2006). Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing. BIOPHYSICAL JOURNAL, 90(7), 2297–2308. https://doi.org/10.1529/biophysj.105.077610

Haugh, J. M., & Schneider, I. C. (2006). Effectiveness factor for spatial gradient sensing in living cells. CHEMICAL ENGINEERING SCIENCE, 61(17), 5603–5611. https://doi.org/10.1016/j.ces.2006.04.041

Bryan, K., Haugh, J., & McCune, D. (2006). Fast imaging of partially conductive linear cracks using impedance data. INVERSE PROBLEMS, 22(4), 1337–1358. https://doi.org/10.1088/0266-5611/22/4/013

Schneider, I. C., & Haugh, J. M. (2006). Mechanisms of gradient sensing and chemotaxis - Conserved pathways, diverse regulation. CELL CYCLE, 5(11), 1130–1134. https://doi.org/10.4161/cc.5.11.2770

Kaur, H., Park, C. S., Lewis, J. M., & Haugh, J. M. (2006). Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. BIOCHEMICAL JOURNAL, 393(1), 235–243. https://doi.org/10.1042/bj20051022

Schneider, I. C., & Haugh, J. M. (2005). Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. JOURNAL OF CELL BIOLOGY, 171(5), 883–892. https://doi.org/10.1083/jcb.200509028

Monine, M. I., & Haugh, J. M. (2005). Reactions on cell membranes: Comparison of continuum theory and Brownian dynamics simulations. JOURNAL OF CHEMICAL PHYSICS, 123(7). https://doi.org/10.1063/1.2000236

Schneider, I. C., Parrish, E. M., & Haugh, J. M. (2005). Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts, III: Influence of cell morphology and morphological polarity. BIOPHYSICAL JOURNAL, 89(2), 1420–1430. https://doi.org/10.1529/biophysj.105.061218

Haugh, J. M. (2004). Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists. BIOTECHNOLOGY PROGRESS, 20(5), 1337–1344. https://doi.org/10.1021/bp0499101

Haugh, J. M., Schneider, I. C., & Lewis, J. M. (2004). On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling. JOURNAL OF THEORETICAL BIOLOGY, 230(1), 119–132. https://doi.org/10.1016/j.jtbi.2004.04.023

Haugh, J. M., & Schneider, I. C. (2004). Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups. BIOPHYSICAL JOURNAL, 86(1), 589–598. https://doi.org/10.1016/S0006-3495(04)74137-5

Schneider, I. C., & Haugh, J. M. (2004). Spatial analysis of 3 ' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. BIOPHYSICAL JOURNAL, 86(1), 599–608. https://doi.org/10.1016/S0006-3495(04)74138-7

Park, C. S., Schneider, I. C., & Haugh, J. M. (2003). Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(39), 37064–37072. https://doi.org/10.1074/jbc.M304968200

Haugh, J. M. (2002). A unified model for signal transduction reactions in cellular membranes. BIOPHYSICAL JOURNAL, 82(2), 591–604. https://doi.org/10.1016/S0006-3495(02)75424-6

Active EGF receptors have limited access to PtdIns(4,5)P2 in endosomes: implications for phospholipase C and PI 3-kinase signaling. (2002). Journal of Cell Science.

Haugh, J. M., & Meyer, T. (2002). Active EGF receptors have limited access to Ptdlns(4,5)P-2 in endosomes: implications for phospholipase C and PI 3-kinase signaling. Journal of Cell Science, 115(2), 303–310.

Haugh, J. M. (2002). Localization of Receptor-Mediated Signal Transduction Pathways: The Inside Story. Molecular Interventions, 2(5), 292–307. https://doi.org/10.1124/mi.2.5.292

Haugh, J. M., Wells, A., & Lauffenburger, D. A. (2000). Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions. BIOTECHNOLOGY AND BIOENGINEERING, 70(2), 225–238. https://doi.org/10.1002/1097-0290(20001020)70:2<225::AID-BIT12>3.0.CO;2-S

Haugh, J. M., Wells, A., & Lauffenburger, D. A. (2000). Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions. Biotechnology and Bioengineering, 70(2), 225–238. https://doi.org/10.1002/1097-0290(20001020)70:2<225::aid-bit12>3.3.co;2-j

Haugh, J. M., Codazzi, F., Teruel, M., & Meyer, T. (2000). Spatial sensing in fibroblasts mediated by 3 ' phosphoinositides. JOURNAL OF CELL BIOLOGY, 151(6), 1269–1279. https://doi.org/10.1083/jcb.151.6.1269

Haugh, J. M., Schooler, K., Wells, A., Wiley, H. S., & Lauffenburger, D. A. (1999). Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C- 1 Signaling Pathway. Journal of Biological Chemistry, 274(13), 8958–8965. https://doi.org/10.1074/jbc.274.13.8958

Haugh, J. M., Huang, A. C., Wiley, H. S., Wells, A., & Lauffenburger, D. A. (1999). Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21ras in Fibroblasts. Journal of Biological Chemistry, 274(48), 34350–34360. https://doi.org/10.1074/jbc.274.48.34350

Haugh, J. M., & Lauffenburger, D. A. (1998). Analysis of Receptor Internalization as a Mechanism for Modulating Signal Transduction. Journal of Theoretical Biology, 195(2), 187–218. https://doi.org/10.1006/jtbi.1998.0791

Lauffenburger, D. A., Fallon, E. M., & Haugh, J. M. (1998). Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. Chemistry & Biology, 5(10), R257–R263. https://doi.org/10.1016/s1074-5521(98)90110-7

Haugh, J. M., & Lauffenburger, D. A. (1997). Physical modulation of intracellular signaling processes by locational regulation. Biophysical Journal, 72(5), 2014–2031. https://doi.org/10.1016/s0006-3495(97)78846-5

Haugh, J. M., & Weiger, M. C. Modeling Intracellular Signal Transduction Processes. Chemical Biology, pp. 1061–1081. https://doi.org/10.1002/9783527619375.ch17b

Welf, E., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. PI3K's Pivotal Role in Cell Migration. SciVee. https://doi.org/10.4016/47795.01