Jenna Nicole Meanor
Graduate School
Works (1)
Updated: June 17th, 2023 21:49
2022 journal article
Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3).
author keywords: yeast surface display; histone post-translational modifications; affinity reagents; protein engineering; chromodomain; binder; reader; antibody; epigenome engineering; synthetic biology
MeSH headings : HEK293 Cells; Histone Code; Histones / metabolism; Humans; Jurkat Cells; K562 Cells; Protein Array Analysis; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Saccharomyces cerevisiae
TL;DR:
Specific experimental conditions that affect binding specificities of post-translationally modified histones in classic protein engineering platforms are described and likely explain the relative difficulty with histone targets in these platforms.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
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Added: February 21, 2022
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