Works (5)
Updated: April 4th, 2024 14:40
2022 journal article
Evaluation of a method to measure fluorescent cell burden in complex culture systems
Biomedical Physics & Engineering Express, 8(3), 037003.
MeSH headings : Brain Neoplasms; Computer Simulation; Humans; Software
TL;DR:
The FCB method accurately measured an integrated fluorescent light intensity to within 5% of ground truth for a wide range of simulated image data spanning the range of observed variability in experimental data.
(via Semantic Scholar)
doi.org (publisher)
Source: ORCID
Added: March 6, 2023
2020 journal article
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
Cell Reports, 32(12), 108166.
Contributors: D. Edwards*, R. Maganti*, J. Tanksley*, J. Luo *, J. Park *, E. Balkanska-Sinclair*, J. Ling*, S. Floyd *
MeSH headings : Animals; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; DNA Damage; DNA Replication / genetics; HEK293 Cells; HeLa Cells; Humans; Loss of Function Mutation / genetics; Mice; Protein Domains; Proteolysis; R-Loop Structures; RNA Polymerase II / metabolism; S Phase; Structure-Activity Relationship; Transcription Elongation, Genetic; Transcription Factors / chemistry; Transcription Factors / metabolism
TL;DR:
It is demonstrated that BET bromodomain inhibitors can damage DNA via induction of R-loops in highly replicative cells.
(via Semantic Scholar)
Source: ORCID
Added: March 6, 2023
2020 journal article
HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair
SLAS DISCOVERY: Advancing the Science of Drug Discovery, 5(8), 247255522091836.
Contributors: I. Tay*, J. Park *, A. Price*, B. Engelward* & S. Floyd *
MeSH headings : Apoptosis / drug effects; DNA Breaks, Double-Stranded / drug effects; DNA End-Joining Repair / drug effects; DNA End-Joining Repair / genetics; Gene Library; Genetic Testing / trends; High-Throughput Screening Assays; Humans; Neoplasm Proteins / genetics; Neoplasms / drug therapy; Neoplasms / genetics; Protein Serine-Threonine Kinases / genetics; RNA, Small Interfering / genetics; Robotics; Tumor Suppressor Proteins / genetics
TL;DR:
A novel discovery platform based on the comet assay that leverages previous technical advances in assay precision by incorporating high-throughput robotics and identifies LATS2 as a novel DNA repair factor as well as a modulator of apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 6, 2023
2019 journal article
B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.
EBioMedicine, 47, 33–43.
Contributors: D. Nehama*, N. Di Ianni *, S. Musio *, H. Du *, M. Patané *, B. Pollo *, G. Finocchiaro *, J. Park *
MeSH headings : Animals; Antigens, Neoplasm / immunology; B7 Antigens / genetics; B7 Antigens / metabolism; Biomarkers; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / mortality; Brain Neoplasms / therapy; Cell Line, Tumor; Disease Models, Animal; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / mortality; Glioblastoma / therapy; Humans; Immunophenotyping; Immunotherapy, Adoptive; Mice; Neoplastic Stem Cells / immunology; Neoplastic Stem Cells / metabolism; Receptors, Antigen, T-Cell / metabolism; Receptors, Chimeric Antigen / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; Xenograft Model Antitumor Assays
TL;DR:
It is demonstrated that B7-H3 is highly expressed in GBM specimens and neurospheres that contain putative cancer stem cells, and that B 7- H3-redirected CAR-T cells can effectively control tumor growth.
(via Semantic Scholar)
Source: ORCID
Added: March 6, 2023
2019 article
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
Edwards, D., Maganti, R., Tanksley, J. P., Luo, J., Park, J. J. H., Balkanska-Sinclair, E., … Floyd, S. R. (2019, November 26). (Vol. 11). Vol. 11.
Source: ORCID
Added: March 6, 2023
Employment
Updated: September 7th, 2022 18:51
2019 - 2022
Duke University Durham, NC, US
Research Analyst I
Radiation Oncology
2016 - 2019
Duke University Durham, NC, US
Research Technician II
Radiation Oncology
Education
Updated: September 7th, 2022 18:52
2022 - present
North Carolina State University Raleigh, North Carolina, US
PhD Student
Bioinformatics
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