James Park

Also known as: James J.H. Park
College of Sciences

Works (5)

Updated: April 4th, 2024 14:40

2022 journal article

Evaluation of a method to measure fluorescent cell burden in complex culture systems

Biomedical Physics & Engineering Express, 8(3), 037003.

By: R. Holden *, J. Park* , A. Price *, S. Floyd * & M. Oldham *

MeSH headings : Brain Neoplasms; Computer Simulation; Humans; Software
TL;DR: The FCB method accurately measured an integrated fluorescent light intensity to within 5% of ground truth for a wide range of simulated image data spanning the range of observed variability in experimental data. (via Semantic Scholar)
Source: ORCID
Added: March 6, 2023

2020 journal article

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

Cell Reports, 32(12), 108166.

By: D. Edwards *, R. Maganti *, J. Tanksley*, J. Luo *, J. Park* , E. Balkanska-Sinclair *, J. Ling*, S. Floyd *

Contributors: D. Edwards *, R. Maganti *, J. Tanksley*, J. Luo *, J. Park *, E. Balkanska-Sinclair *, J. Ling*, S. Floyd *

MeSH headings : Animals; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; DNA Damage; DNA Replication / genetics; HEK293 Cells; HeLa Cells; Humans; Loss of Function Mutation / genetics; Mice; Protein Domains; Proteolysis; R-Loop Structures; RNA Polymerase II / metabolism; S Phase; Structure-Activity Relationship; Transcription Elongation, Genetic; Transcription Factors / chemistry; Transcription Factors / metabolism
TL;DR: It is demonstrated that BET bromodomain inhibitors can damage DNA via induction of R-loops in highly replicative cells. (via Semantic Scholar)
Source: ORCID
Added: March 6, 2023

2020 journal article

HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair

SLAS DISCOVERY: Advancing the Science of Drug Discovery, 5(8), 247255522091836.

By: I. Tay *, J. Park* , A. Price*, B. Engelward * & S. Floyd *

Contributors: I. Tay *, J. Park *, A. Price*, B. Engelward * & S. Floyd *

MeSH headings : Apoptosis / drug effects; DNA Breaks, Double-Stranded / drug effects; DNA End-Joining Repair / drug effects; DNA End-Joining Repair / genetics; Gene Library; Genetic Testing / trends; High-Throughput Screening Assays; Humans; Neoplasm Proteins / genetics; Neoplasms / drug therapy; Neoplasms / genetics; Protein Serine-Threonine Kinases / genetics; RNA, Small Interfering / genetics; Robotics; Tumor Suppressor Proteins / genetics
TL;DR: A novel discovery platform based on the comet assay that leverages previous technical advances in assay precision by incorporating high-throughput robotics and identifies LATS2 as a novel DNA repair factor as well as a modulator of apoptosis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 6, 2023

2019 journal article

B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.

EBioMedicine, 47, 33–43.

By: D. Nehama*, N. Di Ianni *, S. Musio *, H. Du *, M. Patané *, B. Pollo *, G. Finocchiaro *, J. Park * ...

Contributors: D. Nehama*, N. Di Ianni *, S. Musio *, H. Du *, M. Patané *, B. Pollo *, G. Finocchiaro *, J. Park * ...

MeSH headings : Animals; Antigens, Neoplasm / immunology; B7 Antigens / genetics; B7 Antigens / metabolism; Biomarkers; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / mortality; Brain Neoplasms / therapy; Cell Line, Tumor; Disease Models, Animal; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / mortality; Glioblastoma / therapy; Humans; Immunophenotyping; Immunotherapy, Adoptive; Mice; Neoplastic Stem Cells / immunology; Neoplastic Stem Cells / metabolism; Receptors, Antigen, T-Cell / metabolism; Receptors, Chimeric Antigen / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; Xenograft Model Antitumor Assays
TL;DR: It is demonstrated that B7-H3 is highly expressed in GBM specimens and neurospheres that contain putative cancer stem cells, and that B 7- H3-redirected CAR-T cells can effectively control tumor growth. (via Semantic Scholar)
Source: ORCID
Added: March 6, 2023

2019 article

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

Edwards, D., Maganti, R., Tanksley, J. P., Luo, J., Park, J. J. H., Balkanska-Sinclair, E., … Floyd, S. R. (2019, November 26). (Vol. 11). Vol. 11.

By: D. Edwards *, R. Maganti *, J. Tanksley*, J. Luo *, J. Park* , E. Balkanska-Sinclair *, J. Ling*, S. Floyd *

Source: ORCID
Added: March 6, 2023

Employment

Updated: September 7th, 2022 18:51

2019 - 2022

Duke University Durham, NC, US
Research Analyst I Radiation Oncology

2016 - 2019

Duke University Durham, NC, US
Research Technician II Radiation Oncology

Education

Updated: September 7th, 2022 18:52

2022 - present

North Carolina State University Raleigh, North Carolina, US
PhD Student Bioinformatics

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