Jacob Paull LeBarre

College of Engineering

Works (6)

Updated: January 23rd, 2026 15:48

2025 article

High-capacity nonwoven increases productivity of mAb purification in an all-membrane process

Fan, J., Lavoie, J., LeBarre, J., Menegatti, S., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2025, March 19). Separation and Purification Technology, Vol. 364.

By: J. Fan n, J. Lavoie n, J. LeBarre n, S. Menegatti n , B. Pourdeyhimi n , C. Boi n , R. Carbonell n

author keywords: Multimodal anion exchange; Membrane adsorber; Membrane chromatography; Nonwoven membrane; monoclonal antibodies (mAbs)
topics (OpenAlex): Recycling and Waste Management Techniques; Extraction and Separation Processes; Protein purification and stability
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2025

2025 article

Modernizing the platform process of antibody purification for enhanced impurity clearance

LeBarre, J., Bhandari, D., Barbieri, E., Shu, Q., Li, X., Chandra, D., … Menegatti, S. (2025, November 20). Separation and Purification Technology, Vol. 11.

By: J. LeBarre n, D. Bhandari *, E. Barbieri*, Q. Shu n , X. Li *, D. Chandra *, X. Xu *, M. Phillips * ...

topics (OpenAlex): Protein purification and stability; Monoclonal and Polyclonal Antibodies Research; Viral Infectious Diseases and Gene Expression in Insects
Sources: NC State University Libraries, NC State University Libraries
Added: January 22, 2026

2024 journal article

Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments

Journal of Chromatography A, 1718, 464717.

By: S. Altern *, A. Kocot*, J. LeBarre n, C. Boi n , M. Phillips, D. Roush *, S. Menegatti n , S. Cramer*

MeSH headings : Antibodies, Monoclonal; Immunoglobulin Fragments; Chromatography, Gel; Diffusion; Cation Exchange Resins / chemistry
topics (OpenAlex): Protein purification and stability; Monoclonal and Polyclonal Antibodies Research; Microfluidic and Capillary Electrophoresis Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 25, 2024

2024 journal article

Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode

Journal of Chromatography A, 1720, 464772.

By: J. LeBarre n, W. Chu n, S. Altern *, A. Kocot*, D. Bhandari, E. Barbieri, J. Sly, M. Crapanzano ...

author keywords: Antibody fragments; Product polishing; Mixed -mode ligands; Silica resin; Flow -through chromatography
MeSH headings : Humans; Antibodies, Monoclonal / chemistry; Chromatography, Ion Exchange / methods; Immunoglobulin G / metabolism; Immunoglobulin Fragments; Ligands
topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Protein purification and stability; Microfluidic and Capillary Electrophoresis Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 29, 2024

2023 article

Peptonics: A new family of cell‐protecting surfactants for the recombinant expression of therapeutic proteins in mammalian cell cultures

Zhang, K., Barbieri, E., LeBarre, J., Rameez, S., Mostafa, S., & Menegatti, S. (2023, October 16). Biotechnology Journal, Vol. 10.

By: K. Zhang n, E. Barbieri n, J. LeBarre n, S. Rameez*, S. Mostafa* & S. Menegatti n 

author keywords: antibodies; mammalian cells; Peptonics; peptoids; Pluronics; surfactants
MeSH headings : Cricetinae; Animals; Humans; Cricetulus; Poloxamer; Surface-Active Agents / pharmacology; CHO Cells; Antibodies, Monoclonal / chemistry; Cell Culture Techniques; Recombinant Proteins / genetics; Recombinant Proteins / pharmacology
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Protein purification and stability; Monoclonal and Polyclonal Antibodies Research
TL;DR: Peptonics, a novel family of peptide and peptoid surfactants whose monomer composition and sequence are designed to achieve high cell viability and productivity at a fraction of chain length and cost of Pluronics, can improve significantly purification of mAbs, thus increasing their availability at lower cost to patients. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

2023 article

The downstream bioprocess toolbox for therapeutic viral vectors

Kilgore, R., Minzoni, A., Shastry, S., Smith, W., Barbieri, E., Wu, Y., … Menegatti, S. (2023, September 9). Journal of Chromatography A, Vol. 1709.

By: R. Kilgore n, A. Minzoni n, S. Shastry n, W. Smith n, E. Barbieri n, Y. Wu n, J. LeBarre n, W. Chu n, J. O'Brien n, S. Menegatti n 

author keywords: Viral vectors; Gene therapy; Affinity ligands; Chromatography; Adsorbents; AAV
topics (OpenAlex): Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects; Bacteriophages and microbial interactions
TL;DR: This study presents a comprehensive overview of the downstream bioprocess toolbox for viral vectors established in the last decade, and discusses present efforts and future directions contributing to the success of this promising class of biological medicines. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.