Jacob Paull LeBarre
College of Engineering
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Works (4)
Updated: April 30th, 2024 05:02
2024 journal article
Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments
Journal of Chromatography A, 1718, 464717.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 25, 2024
2024 journal article
Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode
Journal of Chromatography A, 1720, 464772.
author keywords: Antibody fragments; Product polishing; Mixed -mode ligands; Silica resin; Flow -through chromatography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 29, 2024
2023 article
Peptonics: A new family of cell-protecting surfactants for the recombinant expression of therapeutic proteins in mammalian cell cultures
Zhang, K., Barbieri, E., Lebarre, J., Rameez, S., Mostafa, S., & Menegatti, S. (2023, October 18). BIOTECHNOLOGY JOURNAL, Vol. 10.
author keywords: antibodies; mammalian cells; Peptonics; peptoids; Pluronics; surfactants
TL;DR:
Peptonics, a novel family of peptide and peptoid surfactants whose monomer composition and sequence are designed to achieve high cell viability and productivity at a fraction of chain length and cost of Pluronics, can improve significantly purification of mAbs, thus increasing their availability at lower cost to patients.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2023 journal article
The downstream bioprocess toolbox for therapeutic viral vectors
JOURNAL OF CHROMATOGRAPHY A, 1709.
author keywords: Viral vectors; Gene therapy; Affinity ligands; Chromatography; Adsorbents; AAV
TL;DR:
This study presents a comprehensive overview of the downstream bioprocess toolbox for viral vectors established in the last decade, and discusses present efforts and future directions contributing to the success of this promising class of biological medicines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023
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