Jacob Paull LeBarre

College of Engineering

Works (4)

Updated: April 30th, 2024 05:02

2024 journal article

Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments


By: S. Altern*, A. Kocot*, J. Lebarre n, C. Boi, M. Phillips, D. Roush*, S. Menegatti n, S. Cramer*

UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2024 journal article

Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode


By: J. Lebarre n, W. Chu n, S. Altern*, A. Kocot*, D. Bhandari, E. Barbieri, J. Sly, M. Crapanzano ...

author keywords: Antibody fragments; Product polishing; Mixed -mode ligands; Silica resin; Flow -through chromatography
Sources: Web Of Science, NC State University Libraries
Added: April 29, 2024

2023 article

Peptonics: A new family of cell-protecting surfactants for the recombinant expression of therapeutic proteins in mammalian cell cultures

Zhang, K., Barbieri, E., Lebarre, J., Rameez, S., Mostafa, S., & Menegatti, S. (2023, October 18). BIOTECHNOLOGY JOURNAL, Vol. 10.

By: K. Zhang n, E. Barbieri n, J. Lebarre n, S. Rameez*, S. Mostafa* & S. Menegatti n

author keywords: antibodies; mammalian cells; Peptonics; peptoids; Pluronics; surfactants
TL;DR: Peptonics, a novel family of peptide and peptoid surfactants whose monomer composition and sequence are designed to achieve high cell viability and productivity at a fraction of chain length and cost of Pluronics, can improve significantly purification of mAbs, thus increasing their availability at lower cost to patients. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

2023 journal article

The downstream bioprocess toolbox for therapeutic viral vectors


By: R. Kilgore n, A. Minzoni n, S. Shastry n, W. Smith n, E. Barbieri n, Y. Wu n, J. Lebarre n, W. Chu n, J. O'Brien n, S. Menegatti n

author keywords: Viral vectors; Gene therapy; Affinity ligands; Chromatography; Adsorbents; AAV
TL;DR: This study presents a comprehensive overview of the downstream bioprocess toolbox for viral vectors established in the last decade, and discusses present efforts and future directions contributing to the success of this promising class of biological medicines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023

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