James P. McCord

Works (10)

Updated: August 23rd, 2025 05:03

2025 article

Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells

Rickard, B. P., Sapienza-Lundie, L. A., Overchuk, M., Tulino, J., Mori, M. P., McCord, J. P., … Rizvi, I. (2025, June 21). Environmental Research, Vol. 284.

By: B. Rickard n , L. Sapienza-Lundie*, M. Overchuk  n, J. Tulino n, M. Mori *, J. McCord*, V. Chappell *, C. Bortner * ...

author keywords: Perfluoroalkyl substances; PFAS; Ovarian cancer; Chemoresistance; Platinum resistance; Mitochondria
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2025

2024 article

Measurement of Hydro-EVE and 6:2 FTS in Blood from Wilmington, North Carolina, Residents, 2017–2018

Kotlarz, N., McCord, J., Wiecha, N., Weed, R. A., Cuffney, M., Enders, J. R., … Hoppin, J. A. (2024, February 1). Environmental Health Perspectives, Vol. 132.

By: N. Kotlarz n , J. McCord*, N. Wiecha n , R. Weed*, M. Cuffney n , J. Enders n , M. Strynar*, D. Knappe n , B. Reich n , J. Hoppin n 

Contributors: N. Kotlarz n , J. McCord*, N. Wiecha n , R. Weed*, M. Cuffney n , J. Enders n , M. Strynar*, D. Knappe n , B. Reich n , J. Hoppin n 

MeSH headings : North Carolina; Fluorocarbons
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Lanthanide and Transition Metal Complexes; Quantum Electrodynamics and Casimir Effect
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 21, 2024

2022 article

Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina

Guillette, T. C., Jackson, T. W., Guillette, M., McCord, J., & Belcher, S. M. (2022, October 20). Frontiers in Toxicology, Vol. 4.

By: T. Guillette n, T. Jackson n, M. Guillette n, J. McCord* & S. Belcher n 

author keywords: autoantibodies; autoimmune; crocodilian; immune toxicity; lupus; one health; PFAS
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Chemical Analysis and Environmental Impact; Toxic Organic Pollutants Impact
TL;DR: The association of increased PFAS exposure with disrupted immune functions is interpreted to suggest that PFAS broadly alters immune activities resulting in autoimmune-like pathology in American alligators. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 6, 2023

2020 article

Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function

Guillette, T. C., McCord, J., Guillette, M., Polera, M. E., Rachels, K. T., Morgeson, C., … Belcher, S. M. (2020, February 6). Environment International, Vol. 136.

By: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n , D. Knappe n  ...

Contributors: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n , D. Knappe n  ...

MeSH headings : Animals; Bass; Biomarkers; Fluorocarbons / toxicity; Liver; Rivers; Water Pollutants, Chemical / toxicity
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
TL;DR: The elevated PFAS concentrations found in the Cape Fear River Striped Bass were associated with biomarkers of alterations in the liver and immune system, and correlations betweenPFAS concentrations and health-related serum biomarkers were evaluated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 2, 2020

2020 article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

Kotlarz, N., McCord, J., Collier, D., Lea, C. S., Strynar, M., Lindstrom, A. B., … Hoppin, J. A. (2020, July 1). Environmental Health Perspectives, Vol. 128.

By: N. Kotlarz n , J. McCord*, D. Collier *, C. Lea *, M. Strynar*, A. Lindstrom *, A. Wilkie  n, J. Islam  n ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Quantum Electrodynamics and Casimir Effect
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2017 article

Perfluorinated alcohol induced coacervates as extraction media for proteomic analysis

McCord, J. P., Muddiman, D. C., & Khaledi, M. G. (2017, June 12). Journal of Chromatography A, Vol. 1523, pp. 293–299.

By: J. McCord n, D. Muddiman n  & M. Khaledi*

author keywords: Coacervation; Surfactants; Perfluorinated alcohol; Proteomics; Membrane proteins
MeSH headings : Membrane Proteins / isolation & purification; Propanols / chemistry; Proteome / analysis; Proteomics / methods; Saccharomyces cerevisiae / metabolism; Surface-Active Agents / chemistry
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Mass Spectrometry Techniques and Applications; Protein purification and stability
TL;DR: A novel method for using hexafluoroisopropanol induced coacervates with a variety of surfactants to extract proteins from a yeast whole cell lysate and conduct a global proteomic investigation on the extracted proteins is described. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

The PeptideAtlas of the Domestic Laying Hen

McCord, J., Sun, Z., Deutsch, E. W., Moritz, R. L., & Muddiman, D. C. (2017, February 7). Journal of Proteome Research, Vol. 16, pp. 1352–1363.

By: J. McCord n, Z. Sun *, E. Deutsch *, R. Moritz * & D. Muddiman n 

author keywords: biomarkers; chicken; ovarian cancer; PeptideAtlas
MeSH headings : Acute-Phase Proteins / analysis; Animals; Biomarkers, Tumor / analysis; Chickens; Data Mining; Female; Proteome / analysis; Proteomics / methods
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Identification and Quantification in Food; Meat and Animal Product Quality
TL;DR: A PeptideAtlas for the domestic chicken is presented, containing an extensive and robust collection of chicken tissue and plasma samples with substantial value for the chicken proteomics community for protein validation and design of downstream targeted proteome quantitation workflows. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

A quantitative glycomics and proteomics combined purification strategy

Jove-Journal of Visualized Experiments, (109).

By: E. Hecht, J. McCord & D. Muddiman 

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT PlasmaN-Glycans

Hecht, E. S., McCord, J. P., & Muddiman, D. C. (2015, June 18). Analytical Chemistry, Vol. 87, pp. 7305–7312.

By: E. Hecht n, J. McCord n & D. Muddiman n 

MeSH headings : Animals; Chickens; Equipment Design; Mass Spectrometry / instrumentation; Polysaccharides / blood; Polysaccharides / isolation & purification; Solid Phase Extraction / instrumentation
topics (OpenAlex): Glycosylation and Glycoproteins Research; Mass Spectrometry Techniques and Applications; Carbohydrate Chemistry and Synthesis
TL;DR: High-throughput, quantitative processing of N-linked glycans would facilitate large-scale studies correlating the glycome with disease and open the field to basic and applied researchers by coupling filter-aided-N-glycan separation to the individuality normalization when labeling with glycan hydrazide tags (INLIGHT) for analysis of plasma. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Wall modified photonic crystal fibre capillaries as porous layer open tubular columns for in-capillary micro-extraction and capillary chromatography

Kazarian, A. A., Rodriguez, E. S., Deverell, J. A., McCord, J., Muddiman, D. C., & Paull, B. (2015, October 24). Analytica Chimica Acta, Vol. 905, pp. 1–7.

By: A. Kazarian n, E. Rodriguez *, J. Deverell*, J. McCord n, D. Muddiman n  & B. Paull *

author keywords: Polymer monolith; Porous layer open tubular column; Fused silica photonic crystal fibres; In-capillary extraction; Bioseparations
MeSH headings : Chromatography, Liquid / instrumentation; Chromatography, Liquid / methods; Equipment Design; Photons; Porosity; Reproducibility of Results; Spectrometry, Fluorescence
topics (OpenAlex): Microfluidic and Capillary Electrophoresis Applications; Mass Spectrometry Techniques and Applications; Innovative Microfluidic and Catalytic Techniques Innovation
TL;DR: The modified multi-channel capillaries were applied to the in-capillary micro-extraction of water samples, proving chromatographic potential of the new column format, with run-to-run retention time reproducibility of below 1%. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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