James P. McCord

Works (8)

Updated: July 6th, 2023 21:14

2022 journal article

Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina

FRONTIERS IN TOXICOLOGY, 4.

By: T. Guillette n, T. Jackson n, M. Guillette n, J. McCord* & S. Belcher n 

author keywords: autoantibodies; autoimmune; crocodilian; immune toxicity; lupus; one health; PFAS
TL;DR: The association of increased PFAS exposure with disrupted immune functions is interpreted to suggest that PFAS broadly alters immune activities resulting in autoimmune-like pathology in American alligators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: January 6, 2023

2020 journal article

Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function

ENVIRONMENT INTERNATIONAL, 136.

By: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n , D. Knappe n  ...

Contributors: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n , D. Knappe  n ...

MeSH headings : Animals; Bass; Biomarkers; Fluorocarbons / toxicity; Liver; Rivers; Water Pollutants, Chemical / toxicity
TL;DR: The elevated PFAS concentrations found in the Cape Fear River Striped Bass were associated with biomarkers of alterations in the liver and immune system, and correlations betweenPFAS concentrations and health-related serum biomarkers were evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 2, 2020

2020 journal article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

ENVIRONMENTAL HEALTH PERSPECTIVES, 128(7).

By: N. Kotlarz n , J. McCord*, D. Collier*, C. Lea *, M. Strynar *, A. Lindstrom *, A. Wilkie  n, J. Islam  n ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 24, 2020

2017 journal article

Perfluorinated alcohol induced coacervates as extraction media for proteomic analysis

JOURNAL OF CHROMATOGRAPHY A, 1523, 293–299.

By: J. McCord n, D. Muddiman n  & M. Khaledi*

author keywords: Coacervation; Surfactants; Perfluorinated alcohol; Proteomics; Membrane proteins
MeSH headings : Membrane Proteins / isolation & purification; Propanols / chemistry; Proteome / analysis; Proteomics / methods; Saccharomyces cerevisiae / metabolism; Surface-Active Agents / chemistry
TL;DR: A novel method for using hexafluoroisopropanol induced coacervates with a variety of surfactants to extract proteins from a yeast whole cell lysate and conduct a global proteomic investigation on the extracted proteins is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

The PeptideAtlas of the Domestic Laying Hen

JOURNAL OF PROTEOME RESEARCH, 16(3), 1352–1363.

By: J. McCord n, Z. Sun *, E. Deutsch*, R. Moritz * & D. Muddiman n 

author keywords: biomarkers; chicken; ovarian cancer; PeptideAtlas
MeSH headings : Acute-Phase Proteins / analysis; Animals; Biomarkers, Tumor / analysis; Chickens; Data Mining; Female; Proteome / analysis; Proteomics / methods
TL;DR: A PeptideAtlas for the domestic chicken is presented, containing an extensive and robust collection of chicken tissue and plasma samples with substantial value for the chicken proteomics community for protein validation and design of downstream targeted proteome quantitation workflows. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

A quantitative glycomics and proteomics combined purification strategy

Jove-Journal of Visualized Experiments, (109).

By: E. Hecht, J. McCord & D. Muddiman 

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Wall modified photonic crystal fibre capillaries as porous layer open tubular columns for in-capillary micro-extraction and capillary chromatography

ANALYTICA CHIMICA ACTA, 905, 1–7.

By: A. Kazarian n, E. Rodriguez *, J. Deverell*, J. McCord n, D. Muddiman n  & B. Paull *

author keywords: Polymer monolith; Porous layer open tubular column; Fused silica photonic crystal fibres; In-capillary extraction; Bioseparations
MeSH headings : Chromatography, Liquid / instrumentation; Chromatography, Liquid / methods; Equipment Design; Photons; Porosity; Reproducibility of Results; Spectrometry, Fluorescence
TL;DR: The modified multi-channel capillaries were applied to the in-capillary micro-extraction of water samples, proving chromatographic potential of the new column format, with run-to-run retention time reproducibility of below 1%. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Definitive Screening Design Optimization of Mass Spectrometry Parameters for Sensitive Comparison of Filter and Solid Phase Extraction Purified, INLIGHT Plasma N-Glycans

ANALYTICAL CHEMISTRY, 87(14), 7305–7312.

By: E. Hecht n, J. McCord n & D. Muddiman n 

MeSH headings : Animals; Chickens; Equipment Design; Mass Spectrometry / instrumentation; Polysaccharides / blood; Polysaccharides / isolation & purification; Solid Phase Extraction / instrumentation
TL;DR: High-throughput, quantitative processing of N-linked glycans would facilitate large-scale studies correlating the glycome with disease and open the field to basic and applied researchers by coupling filter-aided-N-glycan separation to the individuality normalization when labeling with glycan hydrazide tags (INLIGHT) for analysis of plasma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

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