Works (16)
Updated: November 18th, 2024 11:06
2024 journal article
An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal epithelial cells
SCIENTIFIC REPORTS, 14(1).
author keywords: Cell cycle phase; Intestinal stem cell; Fluorescent reporter; Live imaging analysis; Collagen press
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 22, 2024
2024 article
Gastric intestinal metaplasia: progress and remaining challenges
Tong, Q.-Y., Pang, M.-J., Hu, X.-H., Huang, X.-Z., Sun, J.-X., Wang, X.-Y., … Miao, Z.-F. (2024, January 19). JOURNAL OF GASTROENTEROLOGY, Vol. 1.
author keywords: Gastric cancer; Precancerous disease; Paneth cell; Microenvironment; Paligenosis
TL;DR:
This exhaustive review of the progression from gastric disease to GIM aims to establish the groundwork for future research endeavors dedicated to elucidating the etiology of GIM and developing strategies for its prevention and treatment, considering its potential precancerous nature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024
2024 journal article
Metabolic regulator ERRy governs gastric stem cell differentiation into acid-secreting parietal cells
CELL STEM CELL, 31(6).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2024
2023 journal article
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.
author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR:
A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2022 journal article
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics.
Cellular and Molecular Gastroenterology and Hepatology.
TL;DR:
This comprehensive cell atlas of the healthy adult human intestinal epithelium resolves likely functional differences across anatomical regions along the gastrointestinal tract and advances the understanding of human intestinal physiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2020 journal article
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell Stem Cell.
TL;DR:
It is shown that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation, and activated KLF4 in progenitors to reduce self-renewal and promote PC fate, whereas AMPK-PGC1α activation within the PC lineage promotes maturation, providing a potential suggestion for why metformin increases acid secretion and reduces gastric cancer risk in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2020 journal article
Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia.
Gastroenterology.
TL;DR:
The findings indicated that mucous neck cells do not contribute substantially to generation of ZCs during homeostasis and that ZCs maintain their own census, likely through infrequent self-replication.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2018 journal article
Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas.
Disease Models & Mechanisms.
TL;DR:
Epithelial cells in diverse tissues have an innate plasticity program such that differentiated cells can become regenerative upon large-scale insults to an organ, which invites us to refine theories about the cell of origin of cancer such as the multi-hit model of tumorigenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2018 journal article
Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine.
Disease Models & Mechanisms.
TL;DR:
This final installment of a two-part Review discusses how cycles of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2018 journal article
Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.
The EMBO Journal.
TL;DR:
It is shown here that differentiated cells in diverse organs become proliferative via a shared program, which is proposed to be a fundamental process, like apoptosis, available to differentiated cells to fuel regeneration following injury.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2017 journal article
Source: ORCID
Added: August 31, 2023
2017 journal article
Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.
Gastroenterology.
TL;DR:
The findings indicate that SPEM can arise by direct reprogramming of existing cells-mainly of chief cells in gland bases, rather than the proliferative stem cell zone.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2017 journal article
Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice
Bone Research, 5.
Contributors: J. Lim *, * , G. He *, J. Mills * & F. Long *
TL;DR:
Cre/loxP technology has been widely used to study cell type-specific functions of genes, but caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2016 chapter
Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss
In I. A. Ivanov (Ed.), Gastrointestinal Physiology and Diseases: Methods and Protocols (pp. 329–339).
Ed(s): I. Ivanov
Event: at New York, NY
TL;DR:
Methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
2016 journal article
Mutations in Mtr4 structural domains reveal their important role in regulating tRNA<inf>i</inf><sup>Met</sup> turnover in saccharomyces cerevisiae and Mtr4p enzymatic activities in vitro
PLoS ONE, 11(1), 0148090,
Contributors: Y. Li *, * & J. Anderson *
TL;DR:
Overall, it is concluded that arch domain plays a role in RNA binding but is largely dispensable for Mtr4p enzymatic activities, however the structural domains in the helicase core significantly contribute to Mtr 4p ATPase and unwinding activities.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2023
2016 journal article
Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach
Gastroenterology, 152(4), 762–766.
Contributors: * , L. Osaki *, D. Liu *, J. Goldenring * & J. Mills *
TL;DR:
Mice developed that express the diphtheria toxin receptor specifically in parietal cells to induce their death found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 31, 2023
Employment
Updated: November 9th, 2022 10:28
2022 - present
University of North Carolina at Chapel Hill Chapel Hill, North Carolina, US
Assistant Professor
Biomedical Engineering
2019 - 2022
University of North Carolina Chapel Hill, NC, US
Postdoctoral Fellow
Center for Gastrointestinal Biology and Disease
Education
Updated: April 2nd, 2019 10:12
2013 - 2019
Washington University in St Louis St Louis, MO, US
PhD in Developmental, Regenerative, and Stem Cell Biology
Biology
2009 - 2013
Marquette University Milwaukee, WI, US
Bachelors Degree of Biochemistry and Molecular Biology
Life Sciences
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