Joseph Ronald Burclaff

Works (17)

Updated: January 3rd, 2025 01:31

2024 journal article

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal epithelial cells

SCIENTIFIC REPORTS, 14(1).

By: M. Cotton n, P. Ariel *, K. Chen  n, V. Walcott*, M. Dixit n, K. Breau *, C. Hinesley *, K. Kedziora * ...

author keywords: Cell cycle phase; Intestinal stem cell; Fluorescent reporter; Live imaging analysis; Collagen press
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Sources: Web Of Science, NC State University Libraries
Added: July 22, 2024

2024 article

Gastric intestinal metaplasia: progress and remaining challenges

Tong, Q.-Y., Pang, M.-J., Hu, X.-H., Huang, X.-Z., Sun, J.-X., Wang, X.-Y., … Miao, Z.-F. (2024, January 19). JOURNAL OF GASTROENTEROLOGY, Vol. 1.

By: Q. Tong*, M. Pang*, X. Hu*, X. Huang *, J. Sun *, X. Wang *, J. Burclaff n , J. Mills *, Z. Wang *, Z. Miao *

author keywords: Gastric cancer; Precancerous disease; Paneth cell; Microenvironment; Paligenosis
TL;DR: This exhaustive review of the progression from gastric disease to GIM aims to establish the groundwork for future research endeavors dedicated to elucidating the etiology of GIM and developing strategies for its prevention and treatment, considering its potential precancerous nature. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 journal article

Metabolic regulator ERRy governs gastric stem cell differentiation into acid-secreting parietal cells

CELL STEM CELL, 31(6).

By: M. Adkins-Threats *, S. Arimura*, Y. Huang *, M. Divenko*, S. To *, H. Mao*, Y. Zeng *, J. Hwang* ...

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Sources: Web Of Science, NC State University Libraries
Added: July 17, 2024

2024 article

The keratin cytoskeleton emerges as a regulator of mitochondria in the colonic epithelium

Dixit, M., & Burclaff, J. (2024, November 30). AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol. 327, pp. G699–G700.

By: M. Dixit n & J. Burclaff n 

Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024

2023 journal article

Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.

By: K. Rivera n, R. Bilton, J. Burclaff n , M. Czerwinski *, J. Liu *, J. Trueblood*, C. Hinesley *, K. Breau * ...

author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR: A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

2022 journal article

A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics.

Cellular and Molecular Gastroenterology and Hepatology.

Contributors: J. Burclaff* 

TL;DR: This comprehensive cell atlas of the healthy adult human intestinal epithelium resolves likely functional differences across anatomical regions along the gastrointestinal tract and advances the understanding of human intestinal physiology. (via Semantic Scholar)
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Source: ORCID
Added: August 31, 2023

2020 journal article

A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.

Cell Stem Cell.

Joseph Burclaff

TL;DR: It is shown that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation, and activated KLF4 in progenitors to reduce self-renewal and promote PC fate, whereas AMPK-PGC1α activation within the PC lineage promotes maturation, providing a potential suggestion for why metformin increases acid secretion and reduces gastric cancer risk in humans. (via Semantic Scholar)
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Source: ORCID
Added: August 31, 2023

2019 journal article

Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia.

Gastroenterology.

Joseph Burclaff

TL;DR: The findings indicated that mucous neck cells do not contribute substantially to generation of ZCs during homeostasis and that ZCs maintain their own census, likely through infrequent self-replication. (via Semantic Scholar)
Source: ORCID
Added: August 31, 2023

2018 journal article

Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas.

Disease Models & Mechanisms.

Joseph Burclaff

TL;DR: Epithelial cells in diverse tissues have an innate plasticity program such that differentiated cells can become regenerative upon large-scale insults to an organ, which invites us to refine theories about the cell of origin of cancer such as the multi-hit model of tumorigenesis. (via Semantic Scholar)
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Source: ORCID
Added: August 31, 2023

2018 journal article

Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine.

Disease Models & Mechanisms.

Joseph Burclaff

TL;DR: This final installment of a two-part Review discusses how cycles of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumors. (via Semantic Scholar)
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Source: ORCID
Added: August 31, 2023

2018 journal article

Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.

The EMBO Journal.

Joseph Burclaff

TL;DR: It is shown here that differentiated cells in diverse organs become proliferative via a shared program, which is proposed to be a fundamental process, like apoptosis, available to differentiated cells to fuel regeneration following injury. (via Semantic Scholar)
Source: ORCID
Added: August 31, 2023

2017 journal article

Cell biology: Healthy skin rejects cancer

Nature, 548(7667), 289–290.

By: J. Burclaff*  & J. Mills *

Contributors: J. Burclaff*  & J. Mills *

Source: ORCID
Added: August 31, 2023

2017 journal article

Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.

Gastroenterology.

Joseph Burclaff

TL;DR: The findings indicate that SPEM can arise by direct reprogramming of existing cells-mainly of chief cells in gland bases, rather than the proliferative stem cell zone. (via Semantic Scholar)
Source: ORCID
Added: August 31, 2023

2017 journal article

Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice

Bone Research, 5.

By: J. Lim *, J. Burclaff* , G. He *, J. Mills * & F. Long *

Contributors: J. Lim *, J. Burclaff* , G. He *, J. Mills * & F. Long *

TL;DR: Cre/loxP technology has been widely used to study cell type-specific functions of genes, but caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types. (via Semantic Scholar)
Source: ORCID
Added: August 31, 2023

2016 chapter

Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss

In I. A. Ivanov (Ed.), Gastrointestinal Physiology and Diseases: Methods and Protocols (pp. 329–339).

By: J. Saenz *, J. Burclaff*  & J. Mills *

Ed(s): I. Ivanov

Event: at New York, NY

TL;DR: Methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events are detailed. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 31, 2023

2016 journal article

Mutations in Mtr4 structural domains reveal their important role in regulating tRNA<inf>i</inf><sup>Met</sup> turnover in saccharomyces cerevisiae and Mtr4p enzymatic activities in vitro

PLoS ONE, 11(1), 0148090,

By: Y. Li *, J. Burclaff*  & J. Anderson *

Contributors: Y. Li *, J. Burclaff*  & J. Anderson *

TL;DR: Overall, it is concluded that arch domain plays a role in RNA binding but is largely dispensable for Mtr4p enzymatic activities, however the structural domains in the helicase core significantly contribute to Mtr 4p ATPase and unwinding activities. (via Semantic Scholar)
Source: ORCID
Added: August 31, 2023

2016 journal article

Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach

Gastroenterology, 152(4), 762–766.

By: J. Burclaff* , L. Osaki *, D. Liu *, J. Goldenring * & J. Mills *

Contributors: J. Burclaff* , L. Osaki *, D. Liu *, J. Goldenring * & J. Mills *

TL;DR: Mice developed that express the diphtheria toxin receptor specifically in parietal cells to induce their death found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 31, 2023

Employment

Updated: November 9th, 2022 10:28

2022 - present

University of North Carolina at Chapel Hill Chapel Hill, North Carolina, US
Assistant Professor Biomedical Engineering

2019 - 2022

University of North Carolina Chapel Hill, NC, US
Postdoctoral Fellow Center for Gastrointestinal Biology and Disease

Education

Updated: April 2nd, 2019 10:12

2013 - 2019

Washington University in St Louis St Louis, MO, US
PhD in Developmental, Regenerative, and Stem Cell Biology Biology

2009 - 2013

Marquette University Milwaukee, WI, US
Bachelors Degree of Biochemistry and Molecular Biology Life Sciences

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