Juan David Rojas

Works (16)

Updated: July 13th, 2023 21:14

2022 journal article

Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors

SCIENTIFIC REPORTS, 12(1).

By: J. Rojas*, J. Joiner *, B. Velasco  n, K. Bautista  n, A. Aji*, C. Moore*, N. Beaumont *, Y. Pylayeva-Gupta * ...

MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
TL;DR: It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2021 journal article

Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis

CANCER RESEARCH, 82(1), 105–113.

By: H. Sendi *, M. Yazdimamaghani *, M. Hu *, N. Sultanpuram *, J. Wang *, A. Moody  n, E. McCabe*, J. Zhang * ...

MeSH headings : Animals; Colorectal Neoplasms / complications; Colorectal Neoplasms / genetics; Humans; Liver Neoplasms / secondary; Mice; MicroRNAs / metabolism; Nanoparticles / metabolism; Neoplasm Metastasis; Tumor Microenvironment
TL;DR: Mechanistic studies revealed that delivery of miR-122 was associated with downregulation of key genes involved in metastatic and cancer inflammation pathways, including several proinflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes, which makes the liver more conducive to antitumor immune response. (via Semantic Scholar)
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Source: Web Of Science
Added: January 24, 2022

2020 journal article

Transient acoustic vaporization signatures unique to low boiling point phase change contrast agents enable super-resolution ultrasound imaging without spatiotemporal filtering

AIP ADVANCES, 10(10).

By: R. DeRuiter n, E. Markley n, J. Rojas n, G. Pinton n & P. Dayton n

TL;DR: The proposed PCCA SR technique does not require the use of user-dependent and flow-dependent spatio-temporal filtering via singular-value decomposition, rather, matched filters selected by Fourier-domain analysis are able to identify and localize PCCAs activations. (via Semantic Scholar)
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Source: Web Of Science
Added: November 24, 2020

2019 article

A preclinical ultrasound platform for widefield 3D imaging of rodent tumors

Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: T. Czernuszewicz*, V. Papadopoulou  n, J. Rojas*, R. Rajamahendiran*, J. Perdomo *, J. Butler *, M. Harlacher*, G. O'Connell * ...

TL;DR: A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging. (via Semantic Scholar)
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Source: Web Of Science
Added: October 21, 2019

2019 journal article

EFFECT OF HYDROSTATIC PRESSURE, BOUNDARY CONSTRAINTS AND VISCOSITY ON THE VAPORIZATION THRESHOLD OF LOW-BOILING-POINT PHASE-CHANGE CONTRAST AGENTS

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(4), 968–979.

By: J. Rojas n, M. Borden * & P. Dayton n

author keywords: Phase change; Contrast agents; Acoustic droplet vaporization; Vaporization threshold; Decafluoro-butane; Nanoemulsion
MeSH headings : Animals; Contrast Media / administration & dosage; Female; Hydrostatic Pressure; Image Enhancement / methods; Kidney / anatomy & histology; Models, Animal; Rats; Rats, Inbred F344; Ultrasonography / methods; Viscosity; Volatilization
TL;DR: Constraints caused by the surrounding tissue and capillary walls, as well as increased viscosity in vivo, contribute to the increased vaporization threshold compared with in vitro experiments, although more work is required to confirm all relevant factors. (via Semantic Scholar)
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Source: Web Of Science
Added: March 18, 2019

2019 article

Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform

Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: J. Rojas*, R. Rajamahendiran*, T. Czernuszewicz*, B. Velasco  n, J. Perdomo *, M. Harlacher*, G. O'Connell *, J. Butler * ...

TL;DR: It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies. (via Semantic Scholar)
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Source: Web Of Science
Added: October 21, 2019

2018 journal article

IN VIVO MOLECULAR IMAGING USING LOW-BOILING-POINT PHASE-CHANGE CONTRAST AGENTS: A PROOF OF CONCEPT STUDY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 177–191.

By: J. Rojas n & P. Dayton n

author keywords: Ultrasound molecular imaging; Molecular targeting; Phase-change contrast agents; Acoustic droplet vaporization
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Feasibility Studies; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Molecular Imaging / methods; Proof of Concept Study; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Data indicate that PCCA-specific imaging is more sensitive to small numbers of bound agents than conventional contrast imaging, however, data also revealed that contrast from targeted microbubbles was greater than that provided by PCCAs. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

2018 journal article

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(3), 873–880.

By: J. Rojas n, V. Papadopoulou  n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch * ...

author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
TL;DR: Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements. (via Semantic Scholar)
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Source: Web Of Science
Added: March 11, 2019

2018 journal article

VAPORIZATION DETECTIONIMAGING: A TECHNIQUE FOR IMAGING LOW-BOILING-POINTPHASE-CHANGE ONTRAST AGENTS WITH A HIGH DEPTH OF PENETRATION AND CONTRAST-TO-TISSUERATIO

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 192–207.

By: J. Rojas n & P. Dayton n

author keywords: Phasechange; Contrast agents; Acoustic droplet vaporization; Vaporization detection; Perfluorobutane; Perfluoropropane; Nanodroplet
MeSH headings : Animals; Contrast Media; Kidney / diagnostic imaging; Models, Animal; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Ultrasonography; Volatilization
TL;DR: This work explores the effect of pulse length and concentration on the vaporization signal of PCCAs and a new technique to capture and use the signals to make high contrast-to-tissue ratio images in vivo and indicates that using a short pulse may be ideal for imaging. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

2017 journal article

OPTIMIZING SENSITIVITY OF ULTRASOUND CONTRAST-ENHANCED SUPER-RESOLUTION IMAGING BY TAILORING SIZE DISTRIBUTION OF MICROBUBBLE CONTRAST AGENT

ULTRASOUND IN MEDICINE AND BIOLOGY, 43(10), 2488–2493.

By: F. Lin n, J. Tsuruta  n, J. Rojas n & P. Dayton n

author keywords: Super resolution; Microbubble contrast agent; Sensitivity; Size distribution
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Female; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Microbubbles; Microvessels / diagnostic imaging; Particle Size; Phantoms, Imaging; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Experiments in phantom vessels and in vivo experiments imaging rat tumors revealed that the sensitivity of contrast-enhanced super-resolution imaging can be improved by using microbubbles with a larger diameter. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 journal article

Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma

PLOS ONE, 12(3).

By: J. Tsuruta  n, N. Schaub*, J. Rojas n, J. Streeter n, N. Klauber-DeMore* & P. Dayton n

MeSH headings : Animals; Avidin / metabolism; Biomarkers, Tumor / metabolism; Cell Line, Tumor; Contrast Media / metabolism; Hemangiosarcoma / metabolism; Humans; Membrane Proteins / metabolism; Membrane Proteins / ultrastructure; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Ultrasonography / methods
TL;DR: Basing the targeted contrast on NeutrAvidin™-functionalized microbubbles, using IgY antibodies for the authors' control contrast, and optimizing the imaging protocol significantly increased the SFRP2-specific signal returned from angiosarcoma vasculature, and may provide new opportunities for targeted molecular imaging. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography

ANNALS OF BIOMEDICAL ENGINEERING, 45(4), 939–948.

By: B. Lindsey  n, S. Shelton n , K. Martin n, K. Ozgun  n, J. Rojas n, F. Foster *, P. Dayton*

author keywords: Ultrasound; Perfusion; Microbubble; High frequency; Low flow imaging; Quantitative imaging; Angiogenesis; Superharmonic
MeSH headings : Angiography / methods; Animals; Chick Embryo; Chorioallantoic Membrane / blood supply; Chorioallantoic Membrane / diagnostic imaging; Contrast Media / pharmacology; Microbubbles / therapeutic use; Perfusion Imaging / methods; Ultrasonography / methods
TL;DR: The feasibility of dynamic contrast-enhanced superharmonic perfusion imaging at low flow rates is demonstrated and the feasibility of quantitatively mapping perfusion rate in 2D in a mouse model with spatial resolution of ~100 μm is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Optimizing Acoustic Activation of Phase Change Contrast Agents With the Activation Pressure Matching Method: A Review

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 64(1), 264–272.

By: J. Rojas n & P. Dayton n

author keywords: Acoustic droplet vaporization (ADV); activation pressure matching (APM); nanodroplet; optimized droplet activation; perfluorocarbon (PFC); phase change contrast agents (PCCAs)
MeSH headings : Animals; Contrast Media / chemistry; Fluorocarbons / chemistry; Image Processing, Computer-Assisted; Kidney / diagnostic imaging; Microbubbles; Pressure; Rats; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: This paper discusses the application of this method with a Verasonics V1 Research Ultrasound System to modulate the output pressure from an ATL L11-5 transducer and demonstrates the feasibility of this approach both in vivo and in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

ON THE RELATIONSHIP BETWEEN MICROBUBBLE FRAGMENTATION, DEFLATION AND BROADBAND SUPERHARMONIC SIGNAL PRODUCTION

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(6), 1711–1725.

By: B. Lindsey  n, J. Rojas n & P. Dayton n

author keywords: Contrast agent; Microbubble; Harmonic; Superharmonic; Cavitation; Acoustic angiography; Dual frequency
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media / chemistry; Kidney / blood supply; Kidney / diagnostic imaging; Microbubbles; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Ultrasonography
TL;DR: Although the existence of superharmonic signals when bubbles shrink has the potential to prolong the imaging efficacy of microbubbles, parameters such as frame rate and peak pressure must be balanced with expected re-perfusion rate to maintain adequate contrast during in vivo imaging. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

In Vivo Quantification of Image Enhancement and Circulation Kinetics for Phase Change Perfluorocarbon Agents Using Custom Pulse Sequences

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 417–420.

By: P. Sheeran n, J. Rojas n, C. Puett  n, J. Hjelmquist n, C. Arena  n & P. Dayton n

TL;DR: This study develops a custom pulse sequence to vaporize and image droplets using the Verasonics research platform, and demonstrates a novel concept in contrast-enhanced ultrasound: capture of droplet-generated contrast wash-out in the target organ. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

Optimization of Contrast-to-tissue Ratio and Role of Bubble Destruction in Dual-Frequency Contrast-Specific "Acoustic Angiography" Imaging

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1774–1777.

By: B. Lindsey *, J. Rojas*, K. Martin*, S. Shelton*  & P. Dayton*

author keywords: superharmonic; microbubble; high frequency ultrasound; cavitation; dual-frequency; contrast-to-tissue ratio
TL;DR: This work examines the imaging parameters for optimizing contrast-to-tissue ratio (CTR) for dual-frequency imaging and the relationship between bubble destruction and broadband harmonic signal production and indicates that superharmonic signals having the broadest bandwidth and highest energy are associated with shell fragmentation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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