@article{kennedy_thomas_durrant_jiang_motsinger-reif_breen_2019, title={Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex}, volume={27}, ISSN={["1573-6849"]}, DOI={10.1007/s10577-019-09606-0}, abstractNote={Canine histiocytic malignancies (HM) are rare across the general dog population, but overrepresented in certain breeds, such as Bernese mountain dog and flat-coated retriever. Accurate diagnosis relies on immunohistochemical staining to rule out histologically similar cancers with different prognoses and treatment strategies (e.g., lymphoma and hemangiosarcoma). HM are generally treatment refractory with overall survival of less than 6 months. A lack of understanding regarding the mechanisms of disease development and progression hinders development of novel therapeutics. While the study of human tumors can benefit veterinary medicine, the rarity of the suggested orthologous disease (dendritic cell sarcoma) precludes this. This study aims to improve the understanding of underlying disease mechanisms using genome-wide DNA copy number and gene expression analysis of spontaneous HM across several dog breeds. Extensive DNA copy number disruption was evident, with losses of segments of chromosomes 16 and 31 detected in 93% and 72% of tumors, respectively. Droplet digital PCR (ddPCR) evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. Transcriptional analysis demonstrated disruption of the spindle assembly complex, which is linked to genomic instability and reduced therapeutic impact in humans. A key signature detected was up-regulation of Matrix Metalloproteinase 9 (MMP9), supported by an immunohistochemistry-based assessment of MMP9 protein levels. Since MMP9 has been linked with rapid metastasis and tumor aggression in humans, the data in this study offer a possible mechanism of aggression in HM.}, number={3}, journal={CHROMOSOME RESEARCH}, author={Kennedy, Katherine and Thomas, Rachael and Durrant, Jessica and Jiang, Tao and Motsinger-Reif, Alison and Breen, Matthew}, year={2019}, month={Sep}, pages={179–202} }
 @article{williams_long_durrant_mckeon_shive_griffith_messenger_fish_2017, title={Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)}, volume={56}, number={4}, journal={Journal of the American Association for Laboratory Animal Science}, author={Williams, M. D. and Long, C. T. and Durrant, J. R. and McKeon, G. P. and Shive, H. R. and Griffith, E. H. and Messenger, K. M. and Fish, R. E.}, year={2017}, pages={436–442} }
 @article{curto_clode_durrant_montgomery_gilger_2015, title={Retrobulbar pigmented peripheral nerve sheath tumor in a dog}, volume={19}, ISSN={1463-5216}, url={http://dx.doi.org/10.1111/vop.12327}, DOI={10.1111/vop.12327}, abstractNote={Abstract}, number={6}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Curto, Elizabeth and Clode, Alison B and Durrant, Jessica and Montgomery, Keith W and Gilger, Brian C}, year={2015}, month={Nov}, pages={518–524} }
 @article{slocum_durrant_bailey_yoon_jordan_barton_brown_clifton_milliken_harrington_et al._2013, title={Responses of brown adipose tissue to diet-induced obesity, exercise, dietary restriction and ephedrine treatment}, volume={65}, number={5}, journal={Experimental and Toxicologic Pathology}, author={Slocum, N. and Durrant, J. R. and Bailey, D. and Yoon, L. and Jordan, H. and Barton, J. and Brown, R. H. and Clifton, L. and Milliken, T. and Harrington, W. and et al.}, year={2013}, pages={549–557} }