Jonathan Russell Hall

Works (11)

Updated: March 9th, 2026 08:16

2025 article

C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses

Tobin, E. E., Sharma, A., Kros, S. T., Jima, D. D., Gray, S. C., & Hall, J. R. (2025, September 3). Frontiers in Cell Death, Vol. 9.

By: E. Tobin n, A. Sharma  n, S. Kros n, D. Jima n, S. Gray n & J. Hall n 

topics (OpenAlex): Skin Protection and Aging; Immune Response and Inflammation
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function

Mills, K. J., Doyle, M., House, J. S., Witherspoon, J. G., Krakko, D., Stutts, W. L., … Smart, R. C. (2025, June 25). (S. H. A. Raza, Ed.). PLoS ONE, Vol. 20.

By: K. Mills n, M. Doyle n, J. House n , J. Witherspoon n, D. Krakko n , W. Stutts n , J. Chappel n, J. Hall n , E. Baker n , R. Smart n 

Ed(s): S. Raza

MeSH headings : Animals; Epidermis / metabolism; Mice; Mice, Knockout; Lipid Metabolism / genetics; Lipids / biosynthesis; CCAAT-Enhancer-Binding Proteins / genetics; CCAAT-Enhancer-Binding Proteins / metabolism; Keratinocytes / metabolism; Lipogenesis / genetics; Lipidomics
topics (OpenAlex): melanin and skin pigmentation; Retinoids in leukemia and cellular processes; Plant Molecular Biology Research
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 25, 2025

2024 article

Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors

Witherspoon, J. G., Hall, J. R., Jima, D., Atkins, H. M., Wamsley, N. T., Major, M. B., … Smart, R. C. (2024, June 28). Redox Biology, Vol. 75.

By: J. Witherspoon n, J. Hall n , D. Jima n, H. Atkins  n, N. Wamsley *, M. Major *, B. Weissman *, R. Smart n 

author keywords: Nrf2; KEAP1; Mouse skin multistage carcinogenesis model; Ras; Papilloma; Squamous cell carcinoma; Proteomics; RNAseq; Cancer; Progression; Conversion; Promotion
MeSH headings : NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Animals; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Skin Neoplasms / metabolism; Skin Neoplasms / chemically induced; Mice; Keratinocytes / metabolism; Mutation; Disease Progression; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism; 9,10-Dimethyl-1,2-benzanthracene / toxicity; Humans; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / metabolism; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Tetradecanoylphorbol Acetate / toxicity
topics (OpenAlex): Genomics, phytochemicals, and oxidative stress; Glutathione Transferases and Polymorphisms
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 22, 2024

2023 article

C/EBPβ deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors

House, J. S., Gray, S., Owen, J. R., Jima, D. D., Smart, R. C., & Hall, J. R. (2023, January 1). Innate Immunity, Vol. 29, pp. 14–24.

By: J. House n , S. Gray n, J. Owen  n, D. Jima n, R. Smart n  & J. Hall n 

author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
topics (OpenAlex): interferon and immune responses; Immune Response and Inflammation; RNA regulation and disease
TL;DR: The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 30, 2023

2021 article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

Kaur, P., Barnes, R., Pan, H., Detwiler, A. C., Liu, M., Mahn, C., … Wang, H. (2021, December 8). Nucleic Acids Research, Vol. 49, pp. 13000–13018.

By: P. Kaur n, R. Barnes *, H. Pan n, A. Detwiler *, M. Liu n, C. Mahn n, J. Hall n , Z. Messenger n ...

MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Advanced biosensing and bioanalysis techniques; DNA Repair Mechanisms
TL;DR: A molecular model in which TIN2 functions as an architectural protein to promote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres is proposed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 18, 2022

2019 article

C/EBPβ suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer

Tam, H. W., Hall, J. R., Messenger, Z. J., Jima, D. D., House, J. S., Linder, K., & Smart, R. C. (2019, January 23). Carcinogenesis, Vol. 40, pp. 1099–1109.

By: H. Tam n, J. Hall n , Z. Messenger n, D. Jima n, J. House n , K. Linder n, R. Smart n 

Contributors: H. Tam n, J. Hall n , Z. Messenger n, D. Jima n, J. House n , K. Linder n, R. Smart n 

topics (OpenAlex): interferon and immune responses; Skin Protection and Aging
TL;DR: A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 18, 2019

2018 journal article

C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event

Cell Death & Disease, 9(11).

By: Z. Messenger*, J. Hall* , D. Jima n, J. House n , H. Tam, D. Tokarz n, R. Smart* 

Contributors: Z. Messenger*, J. Hall* , D. Jima n, J. House n , H. Tam, D. Tokarz n, R. Smart* 

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
topics (OpenAlex): FOXO transcription factor regulation; Melanoma and MAPK Pathways
TL;DR: The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: October 29, 2018

2018 article

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

Duke, K. S., Thompson, E. A., Ihrie, M. D., Taylor-Just, A. J., Ash, E. A., Shipkowski, K. A., … Bonner, J. C. (2018, October 14). Nanotoxicology, Vol. 12, pp. 975–991.

By: K. Duke n, E. Thompson n, M. Ihrie n, A. Taylor-Just n, E. Ash n, K. Shipkowski n, J. Hall n , D. Tokarz n ...

author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
topics (OpenAlex): Nanoparticles: synthesis and applications; Graphene and Nanomaterials Applications; Carbon Nanotubes in Composites
TL;DR: Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 4, 2019

2015 article

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes

Hall, J. R., Messenger, Z. J., Tam, H. W., Phillips, S. L., Recio, L., & Smart, R. C. (2015, March 19). Cell Death and Disease, Vol. 6.

By: J. Hall n , Z. Messenger n, H. Tam n, S. Phillips*, L. Recio * & R. Smart n 

MeSH headings : Animals; Apoptosis / genetics; Apoptosis / radiation effects; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cell Line; Cell Proliferation / genetics; Cell Proliferation / radiation effects; DNA Damage / genetics; DNA Damage / radiation effects; Gene Expression Regulation / radiation effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Mice; RNA, Long Noncoding / biosynthesis; RNA, Long Noncoding / genetics; Skin / metabolism; Skin / pathology; Skin / radiation effects; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Tumor Suppressor Protein p53 / genetics; Ultraviolet Rays
topics (OpenAlex): Cancer-related molecular mechanisms research
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint

Cell Cycle, 13(22), 3602–3610.

By: J. Hall n , M. Bereman n, A. Nepomuceno n, E. Thompson n, D. Muddiman n  & R. Smart n 

author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Ubiquitin and proteasome pathways; DNA Repair Mechanisms
TL;DR: Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 article

C/EBPα Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBPα Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

Thompson, E. A., Zhu, S., Hall, J. R., House, J. S., Ranjan, R., Burr, J. A., … Smart, R. C. (2011, February 24). Journal of Investigative Dermatology, Vol. 131, pp. 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n , J. House n , R. Ranjan n, J. Burr n, Y. He *, D. Owens *, R. Smart n 

Contributors: E. Thompson n, S. Zhu n, J. Hall n , J. House n , R. Ranjan n, J. Burr n, Y. He *, D. Owens *, R. Smart n 

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
topics (OpenAlex): DNA Repair Mechanisms; Retinoids in leukemia and cellular processes; Cancer-related Molecular Pathways
TL;DR: It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

Employment

Updated: January 28th, 2026 12:20

North Carolina State University Raleigh, North Carolina, US
Assistant Professor Biological Sciences

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