Works (4)
Updated: July 5th, 2023 15:50
2014 article
Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure
Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.
MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Rats; Rats, Long-Evans; Sex Factors; Sexual Behavior, Animal / drug effects; Social Behavior
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Estrogen and related hormone effects
TL;DR:
Testing the hypothesis that neonatal bisphenol A exposure can alter sex-specific postnatal Esr2 (Erβ) expression in brain regions fundamental to sociosexual behavior in rat demonstrates that region- and sex- specific EsR2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to socIosexual behavior.
(via Semantic Scholar)
open access via rep.bioscientifica.com (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.
author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
topics (OpenAlex): Hypothalamic control of reproductive hormones; Ovarian function and disorders; Neuroendocrine regulation and behavior
TL;DR:
Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
NEUROTOXICOLOGY, 32(1), 38–49.
author keywords: Xenoestrogen; Endocrine disruption; Brain; Sexual differentiation; Development; Estrogen receptor; Neuroendocrine
MeSH headings : Age Factors; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / growth & development; Benzhydryl Compounds; Body Weight / drug effects; Body Weight / physiology; Female; Phenols / toxicity; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / growth & development
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Neuroendocrine regulation and behavior; Hypothalamic control of reproductive hormones
TL;DR:
The results of this and a prior study indicate that the impact of neonatal BPA Exposure within the female rat hypothalamus is region specific and support the hypothesis that developmental BPA exposure may adversely affect reproductive development in females.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
NeuroToxicology, 30(3), 350–357.
author keywords: Bisphenol; Phytoestrogens; Soy; Genistein; Equal; Gonadotropins; Development; Disruption; Estrogen; Estrogen receptor; GnRH; KISS
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Female; Hypothalamus / anatomy & histology; Kisspeptins; Male; Nerve Fibers / drug effects; Nerve Fibers / metabolism; Ovariectomy; Phenols / pharmacology; Phytoestrogens / pharmacology; Progesterone / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sex Characteristics
topics (OpenAlex): Hypothalamic control of reproductive hormones; Plant Reproductive Biology; Ovarian function and disorders
TL;DR:
The results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018