2008 journal article

Effects of differences in nasal anatomy on airflow distribution: A comparison of four individuals at rest

ANNALS OF BIOMEDICAL ENGINEERING, 36(11), 1870–1882.

By: R. Segal*, G. Kepler n & J. Kimbell*

author keywords: Computational fluid dynamics; Nasal airflow simulation; Flow experiments; Flow visualization; Human; Inspiratory airflow
MeSH headings : Adult; Computer Simulation; Female; Humans; Male; Models, Anatomic; Nasal Cavity / anatomy & histology; Nasal Cavity / physiology; Nasopharynx / physiology; Pulmonary Ventilation / physiology
TL;DR: It is suggested that significant inter-individual differences exist in bulk airflow patterns in the nose as well as streamlines and velocity magnitudes predicted by the computational model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Nasal uptake of inhaled acrolein in rats

INHALATION TOXICOLOGY, 20(3), 217–225.

By: M. Struve, V. Wong*, M. Marshall*, J. Kimbell*, J. Schroeter* & D. Dorman n

MeSH headings : Acrolein / pharmacokinetics; Air Pollutants / pharmacokinetics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione / metabolism; Inhalation Exposure; Lung / metabolism; Male; Nasal Cavity / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / metabolism
TL;DR: Acrolein UE in naive animals was dependent on the concentration of inspired acrolein, airflow rate, and duration of exposure, with increased UE occurring with lower ac rolein exposure concentrations, and a statistically significant decline in UE occurred during the exposures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey

TOXICOLOGY AND APPLIED PHARMACOLOGY, 150(1), 1–11.

By: G. Kepler*, R. Richardson*, K. Morgan* & J. Kimbell*

MeSH headings : Air Movements; Air Pressure; Animals; Computer Simulation; Gases / pharmacokinetics; Macaca mulatta; Male; Microcomputers; Nasal Cavity / physiology; Respiratory Mechanics / physiology
TL;DR: This rhesus computer model will provide a means for confirming the extrapolation of toxicity data between species by extrapolating rat simulation results to monkeys and comparing these predictions with primate lesion data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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