Jun Ninomiya-Tsuji

Works (57)

Updated: August 16th, 2023 21:16
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2023 journal article

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer?s disease mouse models

JOURNAL OF CELL SCIENCE, 136(6).

By: K. Sai n, A. Nakanishi n, K. Scofield n, D. Tokarz n, K. Linder n, T. Cohen *, J. Ninomiya-Tsuji n

author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: May 30, 2023

2021 journal article

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).

By: W. Lopez-Perez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji n

author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
Source: Web Of Science
Added: July 12, 2021

2019 journal article

Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation

STEM CELLS, 37(6), 766–778.

By: H. Hsieh *, S. Agarwal*, D. Cholok *, S. Loder *, K. Kaneko *, A. Huber *, M. Chung *, K. Ranganathan * ...

author keywords: Cellular proliferation; Differentiation; Progenitor cells; Proliferation; Stem; progenitor cell; Tissue regeneration
MeSH headings : Animals; Bone Regeneration / drug effects; Bone Regeneration / genetics; Cell Differentiation / drug effects; Cell Proliferation / drug effects; DNA Nucleotidyltransferases / genetics; DNA Nucleotidyltransferases / metabolism; Female; Founder Effect; Fractures, Bone / drug therapy; Fractures, Bone / enzymology; Fractures, Bone / genetics; Fractures, Bone / pathology; Gene Expression Regulation; Integrases / genetics; Integrases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / enzymology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / enzymology; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Signal Transduction; Skull / drug effects; Skull / injuries; Skull / metabolism; Wound Healing / drug effects; Wound Healing / genetics
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

By: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji n

Contriutors: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji n

MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
Sources: Web Of Science, ORCID
Added: June 24, 2019

2018 journal article

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

GENESIS, 56(3).

By: X. Liu *, S. Hayano *, H. Pan*, M. Inagaki n, J. Ninomiya-Tsuji n, H. Sun *, Y. Mishina *

author keywords: apoptosis; facial prominence; MAP kinase; nasal septum; Smad signaling
MeSH headings : Animals; Apoptosis / genetics; Biomarkers; Bone Morphogenetic Protein Receptors, Type I / genetics; Bone Morphogenetic Protein Receptors, Type I / metabolism; Cell Death / genetics; Craniofacial Abnormalities / diagnosis; Craniofacial Abnormalities / genetics; Genetic Association Studies; Genotype; Gestational Age; Immunohistochemistry; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Mutation; Phenotype; Signal Transduction; Smad Proteins / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

Scientific Reports, 7(1).

By: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n & S. Morioka  n

Source: Crossref
Added: August 28, 2020

2017 journal article

Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGF beta-activated kinase 1

SCIENTIFIC REPORTS, 7.

By: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n & S. Morioka n

Source: Web Of Science
Added: August 6, 2018

2017 journal article

TAK1 regulates resident macrophages by protecting lysosomal integrity

CELL DEATH & DISEASE, 8.

By: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu  n, J. Foley *, M. Fessler *, J. Ninomiya-Tsuji n

MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.

By: K. Hashimoto n, A. Simmons n, R. Kajino-Sakamoto n, Y. Tsuji n & J. Ninomiya-Tsuji n

author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai  n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei  n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n

author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

TAK1 regulates Paneth cell integrity partly through blocking necroptosis

CELL DEATH & DISEASE, 7.

By: A. Simmons n, R. Kajino-Sakamoto  n & J. Ninomiya-Tsuji n

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Apoptosis / drug effects; Bacteria / drug effects; Bacteria / genetics; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Intestinal Mucosa / metabolism; Intestines / microbiology; Intestines / pathology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / deficiency; Myeloid Differentiation Factor 88 / genetics; Myeloid Differentiation Factor 88 / metabolism; Necrosis; Paneth Cells / drug effects; Paneth Cells / metabolism; Paneth Cells / pathology; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Signal Transduction; Toll-Like Receptors / metabolism; Up-Regulation
Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 regulates hepatic lipid homeostasis through SREBP

ONCOGENE, 35(29), 3829–3838.

By: S. Morioka n, K. Sai n, E. Omori n, Y. Ikeda  n, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line; Fatty Liver / genetics; Fatty Liver / metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatocytes / metabolism; Homeostasis; Humans; Immunoblotting; Lipid Metabolism; Liver / metabolism; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Binding; RNA Interference; Risk Factors; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Tak1, Smad4 and Trim33 redundantly mediate TGF-beta 3 signaling during palate development

DEVELOPMENTAL BIOLOGY, 398(2), 231–241.

By: J. Lane*, K. Yumoto*, M. Azhar *, J. Ninomiya-Tsuji n, M. Inagaki n, Y. Hu*, C. Deng, J. Kim *, Y. Mishina *, V. Kaartinen *

author keywords: TGF-beta 3 signaling; Palatogenesis; Tak1; Smad4; Trim33
MeSH headings : Animals; Apoptosis / genetics; Cell Fusion; Cell Proliferation; Crosses, Genetic; Embryo, Mammalian / metabolism; Enzyme Activation; Epithelial Cells / metabolism; Epithelium / metabolism; Female; Gene Deletion; Gene Expression Regulation, Developmental; MAP Kinase Kinase Kinases / metabolism; Male; Matrix Metalloproteinase 13 / metabolism; Mice, Knockout; Models, Biological; Mutation / genetics; Organ Specificity; Palate / abnormalities; Palate / embryology; Palate / enzymology; Palate / metabolism; Signal Transduction; Smad4 Protein / metabolism; Transcription Factors / metabolism; Transforming Growth Factor beta3 / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

PLOS ONE, 9(4).

By: S. Mihaly n, S. Morioka n, J. Ninomiya-Tsuji n & G. Takaesu  n

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Death / drug effects; Cell Death / immunology; Cell Survival / genetics; GTPase-Activating Proteins / antagonists & inhibitors; GTPase-Activating Proteins / genetics; GTPase-Activating Proteins / metabolism; Gene Deletion; Lipopolysaccharides / immunology; MAP Kinase Kinase Kinases / genetics; Macrophage Activation / genetics; Macrophage Activation / immunology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout
Source: Web Of Science
Added: August 6, 2018

2014 journal article

TAK1 Binding Protein 2 Is Essential for Liver Protection from Stressors

PLOS ONE, 9(2).

By: Y. Ikeda  n, S. Morioka n, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Alkylating Agents / toxicity; Animals; Apoptosis / drug effects; Blotting, Western; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / prevention & control; Diethylnitrosamine / toxicity; Electrophoretic Mobility Shift Assay; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Male; Mice; Mice, Knockout; Mice, Transgenic; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
Source: Web Of Science
Added: August 6, 2018

2014 review

TAK1 control of cell death

[Review of ]. CELL DEATH AND DIFFERENTIATION, 21(11), 1667–1676.

By: S. Mihaly n, J. Ninomiya-Tsuji n & S. Morioka n

MeSH headings : Animals; Apoptosis / physiology; Cell Death; Cell Survival; Homeostasis; Humans; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / metabolism; Necrosis / metabolism; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

2014 journal article

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

The Journal of Cell Biology, 204(4), 607–623.

By: S. Morioka  n, P. Broglie n, E. Omori n, Y. Ikeda  n, G. Takaesu  n, K. Matsumoto *, J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Animals; Apoptosis / drug effects; Blotting, Western; Cell Cycle; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Flow Cytometry; Humans; Immunoprecipitation; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Necrosis; Phosphorylation; RNA, Small Interfering / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases / physiology; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
Source: Crossref
Added: February 24, 2020

2013 journal article

Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-kappa B Activation

MOLECULAR AND CELLULAR BIOLOGY, 33(6), 1149–1163.

By: M. Moreno-Garcia *, K. Sommer, H. Rincon-Arano*, M. Brault, J. Ninomiya-Tsuji n, L. Matesic*, D. Rawlings *

MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; B-Lymphocytes / metabolism; CARD Signaling Adaptor Proteins / metabolism; Cell Line; Chickens; Endosomal Sorting Complexes Required for Transport / metabolism; HEK293 Cells; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Protein Kinase C / metabolism; Protein Kinase C beta; Proteolysis; Receptors, Antigen / metabolism; Signal Transduction; T-Lymphocytes / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
Source: Web Of Science
Added: August 6, 2018

2013 journal article

TGF-beta-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(19), 13467–13480.

By: K. Yumoto*, P. Thomas *, J. Lane*, K. Matsuzaki*, M. Inagaki n, J. Ninomiya-Tsuji n, G. Scott *, M. Ray* ...

MeSH headings : Amino Acid Motifs; Animals; Cells, Cultured; Cleft Palate / enzymology; Cleft Palate / genetics; Ectoderm / cytology; Female; Gene Expression Regulation, Developmental; Head / embryology; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Male; Mandible / abnormalities; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases / metabolism; Neural Crest / cytology; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction; Smad Proteins / metabolism; Smad Proteins, Receptor-Regulated / metabolism; TGF-beta Superfamily Proteins / physiology; Wnt1 Protein / genetics; Wnt1 Protein / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Epithelial transforming growth factor  -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

Proceedings of the National Academy of Sciences, 109(9), 3365–3370.

By: E. Omori n, M. Inagaki n, Y. Mishina *, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / deficiency; Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Enzyme Activation; Epidermis / enzymology; Epithelial Cells / enzymology; Intestinal Mucosa / enzymology; Keratinocytes / enzymology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Phenotype; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species / metabolism; Signal Transduction
Source: Crossref
Added: August 28, 2020

2012 journal article

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

PLoS ONE, 7(11), e51073.

By: G. Takaesu *, M. Inagaki n, K. Takubo *, Y. Mishina *, P. Hess n , G. Dean  n, A. Yoshimura *, K. Matsumoto * ...

Ed(s): M. Tjwa

MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; Antigens, Surface / metabolism; Bone Marrow Cells / enzymology; Cell Death; Cell Proliferation; Chimerism; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / enzymology; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Receptors, Tumor Necrosis Factor, Type I / deficiency; Receptors, Tumor Necrosis Factor, Type I / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2011 journal article

Inhibition of autophagy by TAB2 and TAB3

EMBO JOURNAL, 30(24), 4908–4920.

By: A. Criollo *, M. Niso-Santano*, S. Malik *, M. Michaud*, E. Morselli *, G. Marino *, S. Lachkar*, A. Arkhipenko* ...

author keywords: Beclin 1 interactome; mTOR; p53; pifithrin alpha; rapamycin; stress response
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Non-canonical beta-catenin degradation mediates reactive oxygen species-induced epidermal cell death

ONCOGENE, 30(30), 3336–3344.

By: E. Omori n, K. Matsumoto * & J. Ninomiya-Tsuji n

author keywords: apoptosis; beta-catenin; caspase; epidermis; reactive oxygen species
MeSH headings : Animals; Apoptosis / drug effects; Caspases / metabolism; Cell Adhesion / drug effects; Enzyme Activation / drug effects; Epidermal Cells; Epidermis / drug effects; Epidermis / enzymology; Epidermis / metabolism; HEK293 Cells; Humans; Mice; Reactive Oxygen Species / pharmacology; beta Catenin / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells

Cancer Research, 70(21), 8417–8425.

By: E. Omori n, K. Matsumoto  n, S. Zhu  n, R. Smart n  & J. Ninomiya-Tsuji n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271

MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.

By: K. Sakamoto n, B. Huang  n, K. Iwasaki n, K. Hailemariam n, J. Ninomiya-Tsuji n & Y. Tsuji n

MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
Source: Web Of Science
Added: August 6, 2018

2010 journal article

TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

The Journal of Immunology, 185(8), 4729–4737.

By: R. Kajino-Sakamoto  n, E. Omori n, P. Nighot n, A. Blikslager n , K. Matsumoto * & J. Ninomiya-Tsuji n

Contriutors: R. Kajino-Sakamoto  n, E. Omori n, P. Nighot n, A. Blikslager n , K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2333–2339.

By: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line, Transformed; Dermis / cytology; Fibroblasts / cytology; Fibroblasts / enzymology; Gene Deletion; JNK Mitogen-Activated Protein Kinases / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / physiology; Mice; NF-kappa B / metabolism; Phosphoprotein Phosphatases / metabolism; Phosphorylation / physiology; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Ubiquitin / metabolism; Ubiquitination / physiology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

PLOS ONE, 4(2).

By: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & J. Ninomiya-Tsuji n

MeSH headings : Animals; Apoptosis; Cell Proliferation; Colitis / chemically induced; Colitis / etiology; Cyclooxygenase 2; Dextran Sulfate; Interleukin-6; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I / deficiency; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

2009 journal article

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

ONCOGENE, 28(23), 2257–2265.

By: S. Morioka n, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & J. Ninomiya-Tsuji n

author keywords: TAK1; TRAIL; reactive oxygen species; cIAP; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Electrophoretic Mobility Shift Assay; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B / metabolism; RNA, Small Interfering / genetics; Reactive Oxygen Species / metabolism; Recombinant Proteins / pharmacology; TNF-Related Apoptosis-Inducing Ligand / genetics; TNF-Related Apoptosis-Inducing Ligand / pharmacology; Transfection
Source: Web Of Science
Added: August 6, 2018

2008 journal article

203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity

Gastroenterology, 134(4), A-35-A-36.

By: R. Kajino-Sakamoto, M. Inagaki, J. Kim, S. Robine, K. Matsumoto, C. Jobin, J. Ninomiya-Tsuji*

Source: Crossref
Added: August 28, 2020

2008 journal article

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

JOURNAL OF IMMUNOLOGY, 181(2), 1143–1152.

By: R. Kajino-Sakamoto  n, M. Inagaki n, E. Lippert*, S. Akira *, S. Robine *, K. Matsumoto *, C. Jobin *, J. Ninomiya-Tsuji n

MeSH headings : Animals; Apoptosis; Colitis / immunology; Colitis / metabolism; Enterocytes / cytology; Enterocytes / immunology; Enterocytes / metabolism; Ileitis / immunology; Ileitis / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Signal Transduction; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Generation of a conditional mutant allele for Tab1 in mouse

GENESIS, 46(8), 431–439.

By: M. Inagaki*, Y. Komatsu, G. Scott, G. Yamada, M. Ray, J. Ninomiya-Tsuji*, Y. Mishina

author keywords: conditional gene knockout; MAP kinase; BMP; Tab1; TGF-beta
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Animals; Exons; Gene Targeting; Integrases / metabolism; Mice; Mutation
Source: Web Of Science
Added: August 6, 2018

2008 journal article

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.

By: T. Prickett *, J. Ninomiya-Tsuji n, P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

TAK1 is a central mediator of NOD2 signaling in epidermal cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(1), 137–144.

By: J. Kim n, E. Omori n, K. Matsumoto *, G. Nunez * & J. Ninomiya-Tsuji n

MeSH headings : Acetylmuramyl-Alanyl-Isoglutamine / pharmacology; Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; Chemokines, CXC / genetics; Chemokines, CXC / metabolism; Electrophoretic Mobility Shift Assay; Humans; Immunity, Innate / drug effects; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases / genetics; JNK Mitogen-Activated Protein Kinases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Mutant Strains; Models, Biological; NF-kappa B / genetics; NF-kappa B / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Receptor-Interacting Protein Serine-Threonine Kinase 2 / genetics; Receptor-Interacting Protein Serine-Threonine Kinase 2 / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / drug effects; Transfection; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(38), 26161–26168.

By: E. Omori n, S. Morioka  n, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Animals; Antioxidants / metabolism; Cytochromes c / metabolism; Gene Expression Regulation; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Models, Biological; NF-kappa B / metabolism; Oxidative Stress; Proto-Oncogene Proteins c-jun / metabolism; Reactive Oxygen Species; Skin / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(48), 33080–33086.

By: M. Inagaki n, E. Omori n, J. Kim n, Y. Komatsu *, G. Scott*, M. Ray*, G. Yamada *, K. Matsumoto *, Y. Mishina *, J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line; Cytokines / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Activation / physiology; Fibroblasts / cytology; Fibroblasts / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Osmotic Pressure / physiology; Protein Structure, Tertiary / physiology; Signal Transduction / physiology
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Osmotic stress blocks NF-kappa B-dependent in inflammatory responses by inhibiting ubiquitination of I kappa B

FEBS LETTERS, 581(29), 5549–5554.

By: W. HuangFu n, K. Matsumoto * & J. Ninomiya-Tsuji n

author keywords: NF-kappa B; cytokine; osmotic stress; inflammation
MeSH headings : Animals; Cells, Cultured; Humans; I-kappa B Kinase / metabolism; I-kappa B Proteins / antagonists & inhibitors; I-kappa B Proteins / metabolism; Inflammation / metabolism; Interleukin-1 / antagonists & inhibitors; Interleukin-1 / metabolism; Mice; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Osmotic Pressure; Signal Transduction; Ubiquitination / physiology
Source: Web Of Science
Added: August 6, 2018

2007 journal article

TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9475–9481.

By: T. Kajino *, E. Omori n, S. Ishii, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Cell Line, Transformed; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphorylation; Proto-Oncogene Proteins / metabolism; Signal Transduction / physiology; Transforming Growth Factor beta / physiology
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation

Journal of Biological Chemistry, 281(39), 28802–28810.

By: W. HuangFu n, E. Omori n, S. Akira *, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Animals; Cell Line; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; NF-kappa B / metabolism; Osmosis; Protein Binding; Protein Kinases / chemistry; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; RNA, Small Interfering / metabolism
Source: Crossref
Added: August 28, 2020

2006 journal article

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways

Journal of Biological Chemistry, 281(39), 28802–28810.

By: W. Huangfu, E. Omori, S. Akira, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(52), 39891–39896.

By: T. Kajino *, H. Ren*, S. Iemura*, T. Natsume *, B. Stefansson*, D. Brautigan *, K. Matsumoto *, J. Ninomiya-Tsuji n

MeSH headings : Cells, Cultured; Down-Regulation / drug effects; Down-Regulation / physiology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-1 / physiology; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / physiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphoprotein Phosphatases / antagonists & inhibitors; Phosphoprotein Phosphatases / biosynthesis; Phosphoprotein Phosphatases / physiology; Phosphorylation / drug effects; Signal Transduction / drug effects; Signal Transduction / physiology; Up-Regulation / drug effects
Source: Web Of Science
Added: August 6, 2018

2006 journal article

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 7863–7872.

By: N. Uemura n, T. Kajino *, H. Sanjo *, S. Sato *, S. Akira *, K. Matsumoto *, J. Ninomiya-Tsuji n

MeSH headings : Animals; Cell Line; Cytoplasm / metabolism; Enzyme Activation; Enzyme Inhibitors / pharmacology; Fibroblasts / metabolism; Gene Deletion; Herpesvirus 4, Human / metabolism; Humans; Immunoblotting; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Transgenic; Models, Biological; Mutation; NF-kappa B / metabolism; Plasmids / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6 / metabolism; Transfection; Viral Matrix Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610–19617.

By: E. Omori n, K. Matsumoto *, H. Sanjo *, S. Sato *, S. Akira *, R. Smart n , J. Ninomiya-Tsuji n

MeSH headings : Animals; Apoptosis; Cytokines / metabolism; Epidermis / metabolism; Gene Deletion; Homeostasis; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Skin / pathology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

INTERNATIONAL IMMUNOLOGY, 18(10), 1405–1411.

By: S. Sato *, H. Sanjo, T. Tsujimura, J. Ninomiya-Tsuji, M. Yamamoto, T. Kawai, O. Takeuchi, S. Akira

author keywords: IBD; regulatory T cells; signal transduction; TCR
MeSH headings : Aging / genetics; Aging / immunology; Aging / pathology; Animals; B-Lymphocytes / immunology; B-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Colitis / genetics; Colitis / immunology; Colitis / pathology; Colitis / prevention & control; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / immunology; MAP Kinase Signaling System / genetics; MAP Kinase Signaling System / immunology; Mice; Mice, Knockout; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Thymus Gland / immunology; Thymus Gland / pathology
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Tab1

AfCS-Nature Molecule Pages.

By: J. Ninomiya-Tsuji* & K. Matsumoto

Source: Crossref
Added: August 28, 2020

2006 journal article

Tak1

AfCS-Nature Molecule Pages.

By: J. Ninomiya-Tsuji* & K. Matsumoto

Source: Crossref
Added: August 28, 2020

2005 journal article

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

CIRCULATION RESEARCH, 97(9), 872–879.

By: J. Li  n, E. Miller  n, J. Ninomiya-Tsuji n, R. Russell n & L. Young  n

author keywords: ischemia; AMP-activated protein kinase; p38 MAPK mitogen-activated protein kinase; transforming growth factor-beta-activated protein kinase 1-binding protein 1; glucose transport
MeSH headings : AMP-Activated Protein Kinases; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / pharmacology; Animals; Anisomycin / pharmacology; Cell Hypoxia; Enzyme Activation; Glucose / metabolism; Glucose Transporter Type 4 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase 3 / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multienzyme Complexes / physiology; Myocardial Ischemia / enzymology; Protein Serine-Threonine Kinases / physiology; Protein Transport; Rats; Rats, Sprague-Dawley; Ribonucleotides / pharmacology; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Essential function for the kinase TAK1 in innate and adaptive immune responses

NATURE IMMUNOLOGY, 6(11), 1087–1095.

By: S. Sato *, H. Sanjo *, K. Takeda *, J. Ninomiya-Tsuji n, M. Yamamoto *, T. Kawai *, K. Matsumoto *, O. Takeuchi *, S. Akira *

MeSH headings : Animals; B-Lymphocytes / drug effects; B-Lymphocytes / enzymology; B-Lymphocytes / immunology; CD40 Antigens / pharmacology; Embryo, Mammalian / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Gene Deletion; Immunity, Innate; Interleukin-17 / pharmacology; Lymphopoiesis; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Membrane Glycoproteins / immunology; Mice; Mice, Mutant Strains; NF-kappa B / pharmacology; Receptors, Antigen, B-Cell / agonists; Receptors, Antigen, B-Cell / immunology; Receptors, Cell Surface / immunology; Toll-Like Receptors; Tumor Necrosis Factor-alpha / pharmacology
Source: Web Of Science
Added: August 6, 2018

2005 journal article

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

GENES TO CELLS, 10(5), 447–454.

By: S. Kishida n, H. Sanjo *, S. Akira *, K. Matsumoto * & J. Ninomiya-Tsuji n

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; I-kappa B Kinase; Interleukin-1 / metabolism; Mice; Mutation; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / metabolism; Protein Structure, Tertiary; Signal Transduction / physiology; TNF Receptor-Associated Factor 6 / metabolism; Ubiquitin / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression

ENDOCRINOLOGY, 146(11), 4814–4824.

By: N. Safwat n, J. Ninomiya-Tsuji n, A. Gore n & W. Miller n

MeSH headings : Activins / pharmacology; Animals; Cell Line; Enzyme Activation / physiology; Follicle Stimulating Hormone, beta Subunit / antagonists & inhibitors; Follicle Stimulating Hormone, beta Subunit / biosynthesis; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Humans; Inhibin-beta Subunits / pharmacology; Kinetics; Lactones / pharmacology; Luciferases / genetics; MAP Kinase Kinase Kinases / metabolism; Phosphorylation; Recombinant Fusion Proteins / biosynthesis; Recombinant Proteins / pharmacology; Resorcinols / pharmacology; Sheep; Transfection; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(35), 36616–36620.

By: S. Akiyama *, T. Yonezawa *, T. Kudo *, M. Li*, H. Wang*, M. Ito*, K. Yoshioka*, J. Ninomiya-Tsuji n ...

MeSH headings : Animals; Blotting, Northern; Carcinoma, Embryonal / metabolism; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus / metabolism; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Developmental; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; MAP Kinase Kinase Kinases / metabolism; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases / metabolism; Neurons / metabolism; Phosphoprotein Phosphatases / metabolism; Precipitin Tests; Protein Phosphatase 2C; Signal Transduction; Transfection; Tretinoin / metabolism; Tubulin / metabolism
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Involvement of ASK1 in Ca 2+ ‐induced p38 MAP kinase activation

EMBO Reports, 5(2), 161–166.

By: K. Takeda*, A. Matsuzawa *, H. Nishitoh *, K. Tobiume*, S. Kishida*, J. Ninomiya‐Tsuji *, K. Matsumoto *, H. Ichijo *

MeSH headings : Animals; Calcium / metabolism; Calcium / pharmacology; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Transferase / analysis; MAP Kinase Kinase Kinase 5 / metabolism; MAP Kinase Kinase Kinase 5 / physiology; MAP Kinase Signaling System / physiology; Marine Toxins / pharmacology; Mice; Mice, Inbred C57BL; Oxocins / pharmacology; Phosphorylation; Potassium Channels, Calcium-Activated / metabolism; RNA, Small Interfering / pharmacology; Synaptosomes / drug effects; Synaptosomes / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
Source: Crossref
Added: January 5, 2021

2003 journal article

A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 307(2), 332–337.

By: K. Ono, T. Ohtomo, J. Ninomiya-Tsuji n & M. Tsuchiya

author keywords: transforming growth factor-beta; TGF-beta activated kinase 1; dominant negative inhibitor; fibrotic marker proteins
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carrier Proteins / metabolism; Cell Line; Collagen Type I / metabolism; Collagen Type IV / metabolism; Extracellular Matrix / metabolism; Fibronectins / metabolism; Fibrosis / metabolism; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Plasminogen Activator Inhibitor 1 / metabolism; Protein Binding; Signal Transduction / physiology; Transforming Growth Factor beta / metabolism; Two-Hybrid System Techniques
Source: Web Of Science
Added: August 6, 2018

2003 journal article

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(20), 18485–18490.

By: J. Ninomiya-Tsuji n, T. Kajino *, K. Ono, T. Ohtomo, M. Matsumoto, M. Shiina, M. Mihara, M. Tsuchiya, K. Matsumoto *

MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Female; Genes, Reporter; Genetic Vectors; Humans; Immunoblotting; Inflammation; Inhibitory Concentration 50; Interleukin-1 / metabolism; Isoenzymes / metabolism; Lactones / chemistry; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases / metabolism; Models, Chemical; Precipitin Tests; Prostaglandin-Endoperoxide Synthases / metabolism; Protein Binding; Signal Transduction; Time Factors; Transfection; Zearalenone / analogs & derivatives; Zearalenone / chemistry; Zearalenone / pharmacology; p38 Mitogen-Activated Protein Kinases
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2C epsilon)

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(14), 12013–12021.

By: M. Li*, K. Katsura*, H. Nomiyama *, K. Komaki*, J. Ninomiya-Tsuji n, K. Matsumoto *, T. Kobayashi *, S. Tamura *

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes, Reporter; In Vitro Techniques; Interleukin-1 / pharmacology; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphoprotein Phosphatases / genetics; Phosphoprotein Phosphatases / metabolism; Phosphorylation; Point Mutation; Protein Phosphatase 2C; Protein-Tyrosine Kinases / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Transcription Factor AP-1 / genetics; p38 Mitogen-Activated Protein Kinases
Source: Web Of Science
Added: August 6, 2018

2003 journal article

TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway

JOURNAL OF MOLECULAR BIOLOGY, 326(1), 105–115.

By: G. Takaesu *, R. Surabhi*, K. Park*, J. Ninomiya-Tsuji n, K. Matsumoto * & R. Gaynor*

author keywords: NF-kappa B; I kappa B kinase; TAK1; signal transduction; RNA interference
MeSH headings : Enzyme Activation / drug effects; Gene Expression; HeLa Cells; Humans; I-kappa B Kinase; Interleukin-1 / pharmacology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proteins / genetics; Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Signal Transduction / drug effects; TNF Receptor-Associated Factor 2; Transfection; Tumor Necrosis Factor-alpha / pharmacology
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

MECHANISMS OF DEVELOPMENT, 119(2), 239–249.

By: Y. Komatsu *, H. Shibuya *, N. Takeda*, J. Ninomiya-Tsuji n, T. Yasui *, K. Miyado *, T. Sekimoto*, N. Ueno *, K. Matsumoto *, G. Yamada *

author keywords: bone morphogenetic protein; mitogen-activated protein kinase; mouse; signal transduction; TGF-beta activated kinase-1 binding protein-1; TGF-beta activated kinase-1; transforming growth factor-beta
MeSH headings : Adaptor Proteins, Signal Transducing; Alleles; Amino Acid Sequence; Animals; Blotting, Western; Cell Differentiation; Cell Division; Cloning, Molecular; Genotype; HIV Envelope Protein gp120 / genetics; HIV Envelope Protein gp120 / physiology; Heart / embryology; Homozygote; Humans; Immunoblotting; In Situ Hybridization; Luciferases / metabolism; Lung / embryology; MAP Kinase Kinase Kinases / metabolism; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotides, Antisense / pharmacology; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / physiology; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Transforming Growth Factor beta / metabolism
Source: Web Of Science
Added: August 6, 2018