Jun Tsuji

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).

Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation

STEM CELLS, 37(6), 766–778.

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

GENESIS, 56(3).

Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

Scientific Reports, 7(1).

Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGF beta-activated kinase 1

SCIENTIFIC REPORTS, 7.

TAK1 regulates resident macrophages by protecting lysosomal integrity

CELL DEATH & DISEASE, 8.

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

TAK1 regulates Paneth cell integrity partly through blocking necroptosis

CELL DEATH & DISEASE, 7.

TAK1 regulates hepatic lipid homeostasis through SREBP

ONCOGENE, 35(29), 3829–3838.

Tak1, Smad4 and Trim33 redundantly mediate TGF-beta 3 signaling during palate development

DEVELOPMENTAL BIOLOGY, 398(2), 231–241.

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

PLOS ONE, 9(4).

TAK1 Binding Protein 2 Is Essential for Liver Protection from Stressors

PLOS ONE, 9(2).

TAK1 control of cell death

[Review of ]. CELL DEATH AND DIFFERENTIATION, 21(11), 1667–1676.

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

The Journal of Cell Biology, 204(4), 607–623.

Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-kappa B Activation

MOLECULAR AND CELLULAR BIOLOGY, 33(6), 1149–1163.

TGF-beta-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(19), 13467–13480.

Epithelial transforming growth factor  -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

Proceedings of the National Academy of Sciences, 109(9), 3365–3370.

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

PLoS ONE, 7(11), e51073.

Inhibition of autophagy by TAB2 and TAB3

EMBO JOURNAL, 30(24), 4908–4920.

Non-canonical beta-catenin degradation mediates reactive oxygen species-induced epidermal cell death

ONCOGENE, 30(30), 3336–3344.

Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells

Cancer Research, 70(21), 8417–8425.

Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271

MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.

TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

The Journal of Immunology, 185(8), 4729–4737.

Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2333–2339.

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

PLOS ONE, 4(2).

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

ONCOGENE, 28(23), 2257–2265.

203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity

Gastroenterology, 134(4), A-35-A-36.

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

JOURNAL OF IMMUNOLOGY, 181(2), 1143–1152.

Generation of a conditional mutant allele for Tab1 in mouse

GENESIS, 46(8), 431–439.

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.

TAK1 is a central mediator of NOD2 signaling in epidermal cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(1), 137–144.

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(38), 26161–26168.

TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(48), 33080–33086.

Osmotic stress blocks NF-kappa B-dependent in inflammatory responses by inhibiting ubiquitination of I kappa B

FEBS LETTERS, 581(29), 5549–5554.

TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9475–9481.

Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation

Journal of Biological Chemistry, 281(39), 28802–28810.

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways

Journal of Biological Chemistry, 281(39), 28802–28810.

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(52), 39891–39896.

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 7863–7872.

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610–19617.

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

INTERNATIONAL IMMUNOLOGY, 18(10), 1405–1411.

Tab1

AfCS-Nature Molecule Pages.

Tak1

AfCS-Nature Molecule Pages.

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

CIRCULATION RESEARCH, 97(9), 872–879.

Essential function for the kinase TAK1 in innate and adaptive immune responses

NATURE IMMUNOLOGY, 6(11), 1087–1095.

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

GENES TO CELLS, 10(5), 447–454.

Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression

ENDOCRINOLOGY, 146(11), 4814–4824.

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(35), 36616–36620.

Involvement of ASK1 in Ca 2+ ‐induced p38 MAP kinase activation

EMBO Reports, 5(2), 161–166.

A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 307(2), 332–337.

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(20), 18485–18490.

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2C epsilon)

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(14), 12013–12021.

TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway

JOURNAL OF MOLECULAR BIOLOGY, 326(1), 105–115.

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

MECHANISMS OF DEVELOPMENT, 119(2), 239–249.