@article{wang_wu_chen_shovon_ware_shi_jiang_2025, title={Miniaturized Vortex Ultrasound Transducers with Different Topological Charges}, volume={6}, url={https://doi.org/10.34133/adi.0101}, DOI={10.34133/adi.0101}, abstractNote={Vortex ultrasound has attracted increasing research interest in biomedical engineering such as complex particle manipulation, communication speed improvement, ultrasound imaging edge enhancement, targeted drug delivery, noninvasive therapies, fast blood clot lysis, and tissue ablation. This work presents a way to generate vortex ultrasound waves by integrating a spiral phase structure with a miniaturized transducer. The assembly overcomes the drawbacks of existing transducer arrays such as complicated fabrication, costly multichannel amplifiers, and pricey feedback circuits by providing precise control over topological charges and continuous phase modulation. To assess the design, numerical simulations, analytical calculations, and experimental validation were performed. Transducer prototypes with a central frequency of 5 MHz showed transmitting sensitivity of 12.31 kPa/V peak to peak (Vpp) and 6.15 kPa/Vpp for the peak-to-peak pressure and peak negative pressure, respectively. An acoustic intensity of 0.22 W/cm 2 was measured at 13-Vpp input to the device, which agrees with simulation results. In summary, this work offers a promising path for vortex ultrasound generation with minimal complexity, affordable manufacturing, and compatibility with different transducers compared to traditional arrays.}, journal={Advanced Devices & Instrumentation}, author={Wang, Jing and Wu, Huaiyu and Chen, Mengyue and Shovon, S. M. Abu Naser and Ware, Henry and Shi, Chengzhi and Jiang, Xiaoning}, year={2025}, month={Jan} }
 @article{belekov_annayev_wang_kemal_liu_yamaner_jiang_oralkan_2025, title={Stacked PZT-CMUT hybrid 1D array for acoustic angiography: Preliminary results}, DOI={10.1109/ius62464.2025.11201769}, abstractNote={In this work, we demonstrate the feasibility of a stacked PZT–CMUT array for acoustic angiography with separated transmit and receive bands. The system consists of a 1.9-MHz PZT-5A element bonded to a 64-element 1D CMUT array with a 6.4-MHz center frequency. CMUT’s borosilicate glass substrate serves as an acoustic matching layer for the piezoelectric transducer. Acoustic characterization was performed with a calibrated hydrophone at 22-mm depth, and in-vitro imaging was conducted using a tissue-mimicking phantom containing a 0.38-mm polyethylene tube at 22-mm depth. Microbubbles (2×10<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> #/mL) were flowed at 120 µL/min, and received signals were high pass filtered above the third harmonic (>7.4 MHz). The PZT element generated 714 kPa peak-to-peak pressure with a mechanical index of 0.26, sufficient to induce microbubble resonance. A contrast-to-tissue ratio of 42.41 dB was achieved compared to 0.97 dB for water flow, demonstrating the potential of stacked PZT–CMUT arrays for frequency-separated acoustic angiography.}, author={Belekov, Ermek and Annayev, Muhammetgeldi and Wang, Jing and Kemal, Remzi E. and Liu, Sipan and Yamaner, Feysel Y. and Jiang, Xiaoning and Oralkan, Ömer}, year={2025}, month={Sep} }
 @article{wu_kreager_wang_naderi_xu_dayton_zhou_jiang_2025, title={Thrombolysis transducer with wedged matching for IVUS clot detection}, DOI={10.1109/ius62464.2025.11201803}, abstractNote={Deep vein thrombosis (DVT) affects over 300,000 patients annually in the United States and remains difficult to treat due to the compact structure of retracted thrombi and limitations of current therapies, which carry risks of inefficiency, bleeding, and pulmonary embolism. Ultrasound-enhanced thrombolysis has emerged as a promising strategy, particularly with cavitation agents such as nanodroplets that achieve deeper penetration and higher lysis rates than microbubbles. However, existing intravascular devices often lack combined therapeutic and imaging capabilities, and sub-MHz designs require high activation pressures that hinder clinical translation. Thus, we present a miniaturized intravascular ultrasound system that integrates a low-frequency (750 kHz) therapeutic transducer with a high-frequency (40 MHz) inclined imaging transducer. Rotational B-mode imaging was achieved for thrombolysis with an imaging distance of 4 mm. This unique wedge-matched design enables precise local energy delivery, rotational and forward-looking imaging, and real-time monitoring of thrombolysis, which offers a safer, more effective platform for imaging guided intravascular sonothrombolysis of retracted clots.}, author={Wu, Huaiyu and Kreager, Benjamin C. and Wang, Jing and Naderi, Ali and Xu, Zhen and Dayton, Paul A. and Zhou, Qifa and Jiang, Xiaoning}, year={2025}, month={Sep} }