Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid usingin vivoultrafiltration
Messenger, K. M., Wofford, J. A., & Papich, M. G. (2015, May 10). Journal of Veterinary Pharmacology and Therapeutics, Vol. 39, pp. 32–39.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Carbazoles / blood; Carbazoles / metabolism; Carbazoles / pharmacokinetics; Carrageenan / toxicity; Dinoprostone / metabolism; Dog Diseases / blood; Dog Diseases / chemically induced; Dog Diseases / metabolism; Dogs; Half-Life; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / veterinary; Ultrafiltration / veterinary
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Antibiotics Pharmacokinetics and Efficacy; Inflammatory mediators and NSAID effects
TL;DR:
In vivo ultrafiltration is a reliable method to determine unbound carprofen in ISF, and that disposition of unbound drug into tissue is much higher than predicted from un bound drug concentration in plasma, however, concentrations and pharmacokinetic parameter estimates are not significantly different in inflamed vs. un-inflamed tissues.
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