2016 journal article

Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration


By: K. Messenger n, J. Wofford n & M. Papich n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Carbazoles / blood; Carbazoles / metabolism; Carbazoles / pharmacokinetics; Carrageenan / toxicity; Dinoprostone / metabolism; Dog Diseases / blood; Dog Diseases / chemically induced; Dog Diseases / metabolism; Dogs; Half-Life; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / veterinary; Ultrafiltration / veterinary
TL;DR: In vivo ultrafiltration is a reliable method to determine unbound carprofen in ISF, and that disposition of unbound drug into tissue is much higher than predicted from un bound drug concentration in plasma, however, concentrations and pharmacokinetic parameter estimates are not significantly different in inflamed vs. un-inflamed tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Canine epidermolysis bullosa acquisita: A retrospective study of 20 cases

Veterinary Dermatology, 26(6), 441-.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs


By: T. Olivry n, J. Wofford n, J. Paps n & S. Dunston n

Contributors: T. Olivry n, J. Wofford n, J. Paps n & S. Dunston n

MeSH headings : Allergens / administration & dosage; Allergens / immunology; Animals; Antigens, Dermatophagoides / immunology; CD4-Positive T-Lymphocytes / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dermatophagoides farinae / immunology; Dog Diseases / immunology; Dogs; Epidermis / immunology; Female; Immunoglobulin E / blood; Interleukin-2 Receptor alpha Subunit / biosynthesis; Intradermal Tests; Ki-1 Antigen / biosynthesis; Lymphocyte Activation; Male; Pilot Projects
TL;DR: Observations implicate a role of the SC as a barrier limiting sensitization to exogenous allergens in this experimental atopic dog model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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