@article{lin_yan_huang_altier_li_carrasco_suyemoto_johnston_wang_wang_et al._2007, title={Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA}, volume={35}, DOI={10.1093/nar/gkl1091}, abstractNote={The boronic acid moiety is a versatile functional group useful in carbohydrate recognition, glycoprotein pull-down, inhibition of hydrolytic enzymes and boron neutron capture therapy. The incorporation of the boronic-acid group into DNA could lead to molecules of various biological functions. We have successfully synthesized a boronic acid-labeled thymidine triphosphate (B-TTP) linked through a 14-atom tether and effectively incorporated it into DNA by enzymatic polymerization. The synthesis was achieved using the Huisgen cycloaddition as the key reaction. We have demonstrated that DNA polymerase can effectively recognize the boronic acid-labeled DNA as the template for DNA polymerization, that allows PCR amplification of boronic acid-labeled DNA. DNA polymerase recognitions of the B-TTP as a substrate and the boronic acid-labeled DNA as a template are critical issues for the development of DNA-based lectin mimics via in vitro selection.}, number={4}, journal={Nucleic Acids Research}, author={Lin, N. and Yan, J. and Huang, Z. and Altier, C. and Li, M. Y. and Carrasco, N. and Suyemoto, M. and Johnston, L. and Wang, S. M. and Wang, Q. and et al.}, year={2007}, pages={1222–1229} } @article{yang_yan_springsteen_deeter_wang_2003, title={A novel type of fluorescent boronic acid that shows large fluorescence intensity changes upon binding with a carbohydrate in aqueous solution at physiological pH}, volume={13}, ISSN={["1464-3405"]}, DOI={10.1016/S0960-894X(03)00086-6}, abstractNote={In this paper we report 8-quinolineboronic acid as a novel type of fluorescent probe for carbohydrates. This boronic acid responds to the binding of a carbohydrate with over 40-fold increases in fluorescence intensity and shows optimal fluorescence change at physiological pH in aqueous solution.}, number={6}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Yang, WQ and Yan, J and Springsteen, G and Deeter, S and Wang, BH}, year={2003}, month={Mar}, pages={1019–1022} } @article{yang_yan_fang_wang_2003, title={The first fluorescent sensor for D-glucarate based on the cooperative action of boronic acid and guanidinium groups}, ISSN={["1364-548X"]}, DOI={10.1039/b300098b}, abstractNote={A new fluorescent sensor (1) with a recognition unit consisting of a boronic acid moiety and a guanidinium unit shows selective binding of D-glucarate in aqueous solution.}, number={6}, journal={CHEMICAL COMMUNICATIONS}, author={Yang, WQ and Yan, J and Fang, H and Wang, BH}, year={2003}, pages={792–793} }