Works (5)

Updated: July 25th, 2023 21:16

2021 review

Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder

[Review of ]. JOURNAL OF PERSONALIZED MEDICINE, 11(3).

author keywords: autism spectrum disorder; mitochondria; oxidative stress; prenatal environment; immune dysfunction
TL;DR: It is proposed that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: April 5, 2021

2021 article

Physiological mediators of prenatal environmental influences in autism spectrum disorder

Frye, R. E., Cakir, J., Rose, S., Palmer, R. F., Austin, C., & Curtin, P. (2021, July 14). BIOESSAYS.

author keywords: air pollution; autism spectrum disorder; epigenetics; inflammation; microbiome; mitochondria; oxidative stress; pesticides; prenatal environment
MeSH headings : Air Pollution; Autism Spectrum Disorder / genetics; Epigenesis, Genetic; Female; Humans; Inflammation; Oxidative Stress; Pregnancy
TL;DR: Network analysis of the scientific literature identified several leading prenatal environmental factors associated with ASD, particularly air pollution, pesticides, the microbiome and epigenetics, which were found to be most associated with inflammation, followed by oxidative stress and mitochondrial dysfunction. (via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021

2021 journal article

Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology

MOLECULAR PSYCHIATRY, 26(5), 1561–1577.

By: R. Frye*, J. Cakir n, S. Rose*, L. Delhey*, S. Bennuri*, M. Tippett*, S. Melnyk*, S. James* ...

MeSH headings : Air Pollutants / adverse effects; Air Pollutants / analysis; Air Pollution / adverse effects; Autism Spectrum Disorder; Child; Female; Humans; Leukocytes, Mononuclear; Male; Maternal Exposure; Mitochondria; Pregnancy; Prenatal Exposure Delayed Effects
TL;DR: The results suggest that prenatal exposure to PM2.5 disrupts neurodevelopment and behavior through complex mechanisms, including long-term changes in mitochondrial respiration and that patterns of early development need to be considered when studying the influence of environmental agents on neurodevelopmental outcomes. (via Semantic Scholar)
Source: Web Of Science
Added: October 12, 2020

2020 journal article

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

TRANSLATIONAL PSYCHIATRY, 10(1).

MeSH headings : Autism Spectrum Disorder; Biomarkers; Child; Energy Metabolism; Female; Humans; Leukocytes, Mononuclear; Pregnancy; Zinc
TL;DR: It is suggested that prenatal nutritional metals may be important for neurodevelopment in children with ASD, and that exposure to toxic metals and differences in nutritional metal exposures is associated with dysregulation of cellular bioenergetics, particularly in the NDR subtype of ASD. (via Semantic Scholar)
Source: Web Of Science
Added: August 10, 2020

2020 journal article

The lifetime social cost of autism: 1990-2029

RESEARCH IN AUTISM SPECTRUM DISORDERS, 72.

By: J. Cakir n, R. Frye* & S. Walker*

author keywords: Autism; Autism cost; Autism rates; Autism policy; US autism; ASD
TL;DR: The financial burden of ASD is significant and identifying the modifiable causes of ASD has the potential to provide tangible benefits, however if the rate of increase in prevalence continues, costs could reach nearly $15 trillion by 2029. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 14, 2020

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