Jieping Zhao

author keywords: computational biology; bHLH proteins; molecular architecture; multivariate statistics; DNA-binding specificity; molecular evolution

MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / chemistry; Basic Helix-Loop-Helix Transcription Factors / classification; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Binding Sites; Codon / genetics; DNA / metabolism; Dimerization; Humans; Hydrophobic and Hydrophilic Interactions; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity

topics (OpenAlex): Genomics and Chromatin Dynamics; Glycosylation and Glycoproteins Research; RNA and protein synthesis mechanisms

TL;DR: Using multivariate statistical analyses, discriminant analyses describe the multidimensional aspects of physiochemical variation and clarify the structural basis of the prevailing evolutionary classification of basic helix-loop-helix proteins. (via Semantic Scholar)

author keywords: basic helix-loop-helix; molecular evolution; multivariate statistics; amino acid attributes; factor analysis

MeSH headings : Amino Acid Sequence / genetics; Analysis of Variance; Cluster Analysis; Codon / genetics; Computational Biology / methods; Discriminant Analysis; Genetic Variation; Models, Genetic; Multivariate Analysis; Phylogeny; Protein Conformation; Static Electricity; Statistics as Topic / methods

topics (OpenAlex): RNA and protein synthesis mechanisms; Machine Learning in Bioinformatics; Genomics and Phylogenetic Studies

TL;DR: Multivariate statistical analyses on almost 500 amino acid attributes are used to produce a small set of highly interpretable numeric patterns of amino acid variability that reflect polarity, secondary structure, molecular volume, codon diversity, and electrostatic charge. (via Semantic Scholar)