Works (2)
Updated: July 5th, 2023 15:57
2006 journal article
Molecular architecture of the DNA-binding region and its relationship to classification of basic helix-loop-helix proteins
MOLECULAR BIOLOGY AND EVOLUTION, 24(1), 192–202.
author keywords: computational biology; bHLH proteins; molecular architecture; multivariate statistics; DNA-binding specificity; molecular evolution
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / chemistry; Basic Helix-Loop-Helix Transcription Factors / classification; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Binding Sites; Codon / genetics; DNA / metabolism; Dimerization; Humans; Hydrophobic and Hydrophilic Interactions; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity
TL;DR:
Using multivariate statistical analyses, discriminant analyses describe the multidimensional aspects of physiochemical variation and clarify the structural basis of the prevailing evolutionary classification of basic helix-loop-helix proteins.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Solving the protein sequence metric problem
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(18), 6395–6400.
author keywords: basic helix-loop-helix; molecular evolution; multivariate statistics; amino acid attributes; factor analysis
MeSH headings : Amino Acid Sequence / genetics; Analysis of Variance; Cluster Analysis; Codon / genetics; Computational Biology / methods; Discriminant Analysis; Genetic Variation; Models, Genetic; Multivariate Analysis; Phylogeny; Protein Conformation; Static Electricity; Statistics as Topic / methods
TL;DR:
Multivariate statistical analyses on almost 500 amino acid attributes are used to produce a small set of highly interpretable numeric patterns of amino acid variability that reflect polarity, secondary structure, molecular volume, codon diversity, and electrostatic charge.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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