Keena Ann Elizabeth Mullen

Works (9)

Updated: April 5th, 2024 07:58

2018 journal article

Comparison of the pharmacokinetics of plant-based treatments in milk and plasma of USDA organic dairy cattle with and without mastitis

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 35(9), 1716–1727.

By: S. Mason n, K. Mullen n, S. Washburn n, K. Anderson n & R. Baynes n

author keywords: Pharmacology; milk; organic; thymol; carvacrol; bovine; cattle
MeSH headings : Animals; Cattle; Cymenes; Dairying; Female; Food, Organic / analysis; Garlic / chemistry; Milk / chemistry; Monoterpenes / blood; Thymol / blood; United States; United States Department of Agriculture
TL;DR: Study of the pharmacokinetics of 3 compounds used on organic both healthy and mastitic organic dairy cattle found levels remained below the limit of detection in milk and plasma and thus no withdrawal time appears to be needed for milk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Effect of 3 phytoceutical products on elimination of bacteria in experimentally induced Streptococcus uberis clinical mastitis

JOURNAL OF DAIRY SCIENCE, 101(11), 10409–10413.

By: K. Mullen, R. Lyman n, S. Washburn*, R. Baynes n & K. Anderson n

author keywords: mastitis; Streptococcus uberis; phytoceutical
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Female; Lactation; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / microbiology; Mastitis, Bovine / drug therapy; Mastitis, Bovine / microbiology; Milk / drug effects; Milk / microbiology; Plant Preparations / pharmacology; Random Allocation; Streptococcal Infections / drug therapy; Streptococcal Infections / microbiology; Streptococcal Infections / veterinary; Streptococcus / drug effects
TL;DR: It is concluded that the phytoceuticals tested, as dosed and used in this trial, did not produce bacterial cures in S. uberis-induced mastitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Short communication: Use of an ultrafiltration device in gland cistern for continuous sampling of healthy and mastitic quarters of lactating cattle for pharmacokinetic modeling.

Journal of Dairy Science, 101(11), 10414–10420.

By: D. Mzyk* , C. Bublitz, H. Sylvester*, K. Mullen n, G. Hobgood, R. Baynes*, D. Foster* 

MeSH headings : Administration, Intravenous / veterinary; Animals; Cattle; Chromatography, High Pressure Liquid / veterinary; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Feasibility Studies; Female; Lactation; Mammary Glands, Animal / metabolism; Mass Spectrometry / veterinary; Mastitis, Bovine / diagnosis; Milk / chemistry; Ultrafiltration / veterinary
TL;DR: Collection of ultrafiltration samples from the mammary gland of cows provides a viable means to continuously assess drug concentrations in the milk while continuing to milk the cow normally, and demonstrates the utility of continuous sampling of milk via ultraFiltration for future pharmacokinetic studies in cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, ORCID
Added: November 5, 2018

2017 journal article

Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle

Food Additives & Contaminants: Part A, 34(5), 1–10.

By: S. Mason n, K. Mullen n, K. Anderson n, S. Washburn n, J. Yeatts n & R. Baynes n

author keywords: Mastitis; organic; generally recognised as safe (GRAS); bovine; residue
MeSH headings : Administration, Topical; Allyl Compounds / administration & dosage; Allyl Compounds / pharmacokinetics; Animals; Cattle; Cymenes; Dairying; Disulfides / administration & dosage; Disulfides / pharmacokinetics; Female; Health; Limit of Detection; Mammary Glands, Animal / metabolism; Monoterpenes / administration & dosage; Monoterpenes / pharmacokinetics; Thymol / administration & dosage; Thymol / pharmacokinetics
TL;DR: The plasma pharmacokinetics of three organic mastitis products currently used by organic producers and organic dairy veterinarians are investigated, finding that levels were measurable in the plasma, liver, kidney and fat up to 72 h after the last dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Development of a HS-SPME-GC-MS/MS Method for the Quantitation of Thymol and Carvacrol in Bovine Matrices and To Determine Residue Depletion in Milk and. Tissues

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64(41), 7856–7865.

By: S. Armorini*, J. Yeatts*, K. Mullen*, S. Mason*, E. Mehmeti*, K. Anderson*, S. Washburn*, R. Baynes*

author keywords: organic; thymol; carvacrol; milk; bovine tissues; residues
TL;DR: A rapid and sensitive HS-SPME-GC-MS/MS method was developed for the detection of thymol and carvacrol in bovine milk, plasma, liver, kidney, and fat and stability studies showed that both compounds are stable over a 2 month period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Effect of 2 herbal intramammary products on milk quantity and quality compared with conventional and no dry cow therapy

JOURNAL OF DAIRY SCIENCE, 97(6), 3509–3522.

By: K. Mullen n, K. Anderson n & S. Washburn n

author keywords: dry cow therapy; organic mastitis treatment; alternative to antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Bismuth / therapeutic use; Cattle; Diet / veterinary; Dihydrostreptomycin Sulfate / therapeutic use; Drugs, Chinese Herbal / administration & dosage; Female; Food Contamination / prevention & control; Food Microbiology; Food, Organic / microbiology; Lactation; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / microbiology; Mastitis, Bovine / drug therapy; Mastitis, Bovine / microbiology; Milk / microbiology; Penicillins / therapeutic use
TL;DR: The efficacy of the herbal products was similar to that of conventional therapy, and the herbal Products had no apparent adverse effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 article

Invited review: Genetic considerations for various pasture-based dairy systems

Washburn, S. P., & Mullen, K. A. E. (2014, October). JOURNAL OF DAIRY SCIENCE, Vol. 97, pp. 5923–5938.

By: S. Washburn n & K. Mullen n

author keywords: pasture; systems; genetics; management
MeSH headings : Animals; Breeding; Cattle / genetics; Dairying / economics; Dairying / trends; Female; Grassland; Lactation; Milk / metabolism; Reproduction
TL;DR: It is document from studies and observations covered herein that optimal breeds, breed strains, and selection strategies can differ based on varying management constraints and objectives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Short communication: An in vitro assessment of the antibacterial activity of plant-derived oils

JOURNAL OF DAIRY SCIENCE, 97(9), 5587–5591.

By: K. Mullen n, A. Lee n, R. Lyman n, S. Mason*, S. Washburn n & K. Anderson n

author keywords: mastitis; plant-derived oils; alternative to antibiotics; organic
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Female; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / microbiology; Mastitis, Bovine / drug therapy; Mastitis, Bovine / microbiology; Milk / microbiology; Oils, Volatile / pharmacology; Plant Oils / pharmacology; Staphylococcus / drug effects; Staphylococcus aureus / drug effects; Streptococcus / drug effects; Thymus Plant / chemistry
TL;DR: Only thyme essential oil had consistent antibacterial activity against the 3 mastitis-causing organisms tested in vitro, and further evaluation of physiological effects of thyme oil in various preparations on mammary tissue is recommended to determine potential suitability for mastitis therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Comparisons of milk quality on North Carolina organic and conventional dairies

Journal of Dairy Science, 96(10), 6753–6762.

By: K. Mullen, L. Sparks n, R. Lyman n, S. Washburn* & K. Anderson n

author keywords: organic; milk quality; mastitis; somatic cell score
MeSH headings : Animals; Cattle; Corynebacterium / isolation & purification; Dairying / standards; Female; Food Contamination / statistics & numerical data; Food Quality; Food, Organic / microbiology; Mastitis, Bovine / epidemiology; Mastitis, Bovine / microbiology; Mastitis, Bovine / transmission; Milk / microbiology; North Carolina; Prevalence; Seasons; Staphylococcus / isolation & purification; Staphylococcus aureus / isolation & purification; Streptococcus / isolation & purification
TL;DR: Despite differences in herd management, milk quality was remarkably similar between the organic and conventional dairies compared for this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

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