Karen Anna Von Dollen

Works (5)

Updated: July 5th, 2023 15:32

2020 article

Metabolomic Profile of Allantoic and Amniotic Fluid in Late-term Gestational Mares Characterized by 1H-nuclear Magnetic Resonance Spectroscopy

Beachler, T. M., Bailey, C. S., Gracz, H. S., Morgan, D. R., Dollen, K. A. V., Ellis, K. E., … Lyle, S. K. (2020, August 24). Journal of Equine Veterinary Science, Vol. 94.

By: T. Beachler n, C. Bailey n, H. Gracz n, D. Morgan n, K. Dollen n, K. Ellis n, J. Gadsby n , S. Lyle n

author keywords: Equine; Metabolomics; Allantoic; Amniotic; Nuclear magnetic resonance spectroscopy
MeSH headings : Allantois; Amniotic Fluid; Animals; Body Fluids; Female; Horses; Magnetic Resonance Spectroscopy; Pregnancy; Protons
topics (OpenAlex): Reproductive Physiology in Livestock; Ruminant Nutrition and Digestive Physiology; Fatty Acid Research and Health
TL;DR: The goal of this study was to characterize the global metabolomic profile of equine allantoic and amniotic fluid through nuclear magnetic resonance spectroscopy offetal fluids from 12 pregnancies through ultrasound-guided transabdominal puncture. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

Plasma metabolomic profiling of healthy pregnant mares and mares with experimentally induced placentitis

Equine Veterinary Journal, 53(1), 85–93.

By: T. Beachler n, H. Gracz n, D. Morgan n, S. Bembenek Bailey  n, L. Borst n , K. Ellis n, K. Von Dollen n, S. Lyle n ...

author keywords: horse; placentitis; diagnosis; plasma; NMR spectroscopy; metabolomics
MeSH headings : Animals; Female; Horse Diseases; Horses; Metabolomics; Placenta Diseases / veterinary; Plasma; Pregnancy; Streptococcus equi
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Reproductive Physiology in Livestock; Ruminant Nutrition and Digestive Physiology
TL;DR: Two phases of metabolite changes were noted after experimental infection: An immediate rise in metabolite concentration involved in energy, nitrogen, hydrogen, and oxygen metabolism within 4 hours after inoculation that was followed by a decrease in metabolites involved inenergy and nitrogen metabolism at 4 days, coinciding with ultrasonographic diagnosis of placentitis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2019 article

Antimicrobial Activity of Ceftiofur and Penicillin With Gentamicin Against Escherichia coli and Streptococcus equi Subspecies zooepidemicus in an Ex Vivo Model of Equine Postpartum Uterine Disease

Dollen, K. A. V., Jones, M., Beachler, T., Harris, T. L., Papich, M. G., Lyle, S. K., & Bailey, C. S. (2019, June 20). Journal of Equine Veterinary Science, Vol. 79, pp. 121–126.

By: K. Dollen n, M. Jones n, T. Beachler n, T. Harris n, M. Papich n , S. Lyle n, C. Bailey n

author keywords: E. coli; S. zooepidemicus; Postpartum mare; Antibiotic use
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cephalosporins; Drug Resistance, Bacterial; Escherichia coli; Female; Gentamicins; Horse Diseases / drug therapy; Horses; Humans; Penicillins; Postpartum Period; Streptococcus equi; Uterine Diseases / drug therapy; Uterine Diseases / veterinary
topics (OpenAlex): Reproductive Physiology in Livestock; Veterinary Equine Medical Research; Animal health and immunology
TL;DR: The intrauterine infusion of procaine penicillin G with gentamicin in cases of postpartum uterine disease caused by E. coli or S. zooepidemicus is supported by the results of this work. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2018 article

Allantoic Metabolites, Progesterone, and Estradiol-17β Remain Unchanged After Infection in an Experimental Model of Equine Ascending Placentitis

Beachler, T., Gracz, H., Long, N. M., Borst, L., Morgan, D., Nebel, A., … Bailey, C. S. (2018, November 29). Journal of Equine Veterinary Science, Vol. 73, pp. 95–105.

By: T. Beachler n, H. Gracz n, N. Long *, L. Borst n , D. Morgan n, A. Nebel n, N. Andrews n, J. Koipillai n ...

author keywords: Equine; Ascending placentitis; Metabolomics; Allantoic fluid
topics (OpenAlex): Reproductive Physiology in Livestock; Ruminant Nutrition and Digestive Physiology; Genetic and phenotypic traits in livestock
TL;DR: The results of this study established a database of equine allantoic fluid metabolites and confirmed the utility of uteroplacental ultrasound for detection of placentitis before the onset of hematologic changes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019

2018 article

Pharmacokinetics of Intrarectal Altrenogest in Horses

Ellis, K. E., Dollen, K. A. V., Beachler, T. M., Bailey, C. S., Davis, J. L., & Lyle, S. K. (2018, October 10). Journal of Equine Veterinary Science.

By: K. Ellis n, K. Dollen n, T. Beachler n, C. Bailey n, J. Davis* & S. Lyle

author keywords: Horse; Altrenogest; Pharmacokinetics; Intrarectal administration
MeSH headings : Administration, Rectal; Animals; Cross-Over Studies; Female; Horses / metabolism; Pregnancy; Pregnancy Maintenance / drug effects; Trenbolone Acetate / analogs & derivatives; Trenbolone Acetate / pharmacokinetics
topics (OpenAlex): Reproductive Physiology in Livestock; Veterinary Equine Medical Research; Preterm Birth and Chorioamnionitis
TL;DR: Altrenogest is rapidly absorbed following PR administration in the horse and reaches therapeutic concentrations, making this a viable method of treatment in NPO mares, and the decreased bioavailability and shorter detection time suggest 0.088 mg/kg PR q 4–8 hours would be necessary to maintain therapeutic concentrations over a 24‐hour period. (via Semantic Scholar)
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Source: Web Of Science
Added: January 7, 2019

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