Kaitlyn Bacon

Chemical & Biomolecular Engr

Works (8)

Updated: July 19th, 2023 21:17

2021 journal article

Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics

JOURNAL OF CHROMATOGRAPHY A, 1635.

By: W. Chu n, R. Prodromou n, K. Day n, J. Schneible n, K. Bacon n, J. Bowen n, R. Kilgore n, C. Catella n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Affinity ligands; peptides; peptoids; pseudopeptides; biotherapeutics
MeSH headings : Antibodies / isolation & purification; Biological Products / isolation & purification; Chemistry, Pharmaceutical / methods; Chromatography, Affinity; Family Characteristics; Humans; Ligands; Peptides / isolation & purification; Peptoids / chemistry; Proteins / isolation & purification
Sources: Web Of Science, ORCID
Added: January 25, 2021

2021 journal article

Quantitative Yeast-Yeast Two Hybrid for the Discovery and Binding Affinity Estimation of Protein-Protein Interactions

ACS SYNTHETIC BIOLOGY, 10(3), 505โ€“514.

By: K. Bacon n, A. Blain n, J. Bowen n, M. Burroughs n, N. McArthurโ€‰ n, S. Menegatti nโ€‰, B. Rao n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: yeast two-hybrid; protein-protein interactions; protein engineering; yeast surface display; post-translational modification; cDNA library
MeSH headings : Gene Library; Genes, Reporter; Protein Binding; Protein Domains; Protein Interaction Maps; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Smad3 Protein / chemistry; Smad3 Protein / metabolism; Transcription Factors / chemistry; Transcription Factors / metabolism; Two-Hybrid System Techniques
Sources: Web Of Science, ORCID
Added: March 29, 2021

2021 journal article

Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4).

By: J. Bowen n, J. Schneible n, K. Bacon n, C. Labar n, S. Menegatti nโ€‰ & B. Rao n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: yeast display library; cyclic peptide; Yes Associated Protein (YAP) 65; WW domain; transglutaminase
MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / metabolism; Albumins / metabolism; Binding Sites; Combinatorial Chemistry Techniques; Endoplasmic Reticulum / metabolism; Flow Cytometry; Ligands; Muramidase / metabolism; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / pharmacology; Protein Binding; Protein Engineering / methods; Transcription Factors / chemistry; Transcription Factors / metabolism; Transglutaminases / metabolism; YAP-Signaling Proteins; Yeasts / genetics; Yeasts / growth & development
Sources: Web Of Science, ORCID
Added: March 22, 2021

2020 journal article

Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display

ACS COMBINATORIAL SCIENCE, 22(10), 519โ€“532.

By: K. Bacon n, A. Blain n, M. Burroughs n, N. McArthrur n, B. Rao n & S. Menegatti nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cyclic peptides; interleukin-17 (IL-17); library screening; yeast-display libraries; affinity ligands
MeSH headings : Biophysical Phenomena; Cell Membrane / chemistry; Cyclization; Flow Cytometry; Humans; Interleukin-17 / chemistry; Molecular Docking Simulation; Peptide Library; Peptides, Cyclic / isolation & purification; Protein Binding; Protein Conformation; Protein Engineering; Recombinant Proteins / chemistry; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / ultrastructure; Structure-Activity Relationship; Surface Properties
Sources: Web Of Science, ORCID
Added: November 9, 2020

2020 review

Past, Present, and Future of Affinity-based Cell Separation Technologies

[Review of ]. ACTA BIOMATERIALIA, 112, 29โ€“51.

By: K. Bacon n, A. Lavoie n, B. Rao n, M. Daniele n & S. Menegatti nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Cell purification; Immunoaffinity; MACS; FACS; Microfluidics
MeSH headings : Cell Separation; Chromatography, Affinity; Flow Cytometry; Ligands; Regenerative Medicine
Sources: Web Of Science, ORCID
Added: August 3, 2020

2020 article

Simultaneous Soluble Secretion and Surface Display of Proteins in Saccharomyces cerevisiae Using Inefficient Ribosomal Skipping

GENOTYPE PHENOTYPE COUPLING: METHODS AND PROTOCOLS, Vol. 2070, pp. 321โ€“334.

By: C. Cruz-Teran n, K. Bacon n & B. Rao n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Yeast surface display; Self-cleaving peptides; 2A peptides; Secretion; Ribosomal skipping; Sso7d
MeSH headings : Peptide Library; Peptides / metabolism; Protein Biosynthesis; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Ribosomes / metabolism; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: September 7, 2020

2020 journal article

Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display Peptide Libraries to Identify Ligands

ACS COMBINATORIAL SCIENCE, 22(12), 738โ€“744.

By: K. Bacon n, J. Bowen n, H. Reese n, B. Rao n & S. Menegatti nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: yeast surface display; yeast magnetization; peptide ligands; mRNA-display library; ligand discovery
MeSH headings : Ligands; Mitochondrial Membrane Transport Proteins / chemistry; Models, Molecular; Peptide Library; RNA, Messenger / chemistry; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae Proteins / chemistry; Transcription Factors / chemistry
Sources: Web Of Science, ORCID
Added: January 11, 2021

2019 journal article

Screening Yeast Display Libraries against Magnetized Yeast Cell Targets Enables Efficient Isolation of Membrane Protein Binders

ACS COMBINATORIAL SCIENCE, 21(12), 817โ€“832.

By: K. Bacon n, M. Burroughs n, A. Blain n, S. Menegatti nโ€‰ & B. Rao n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: yeast magnetization; combinatorial library screening; ligand discovery; yeast surface display; membrane protein; Sso7d; nanobody
MeSH headings : Combinatorial Chemistry Techniques; Drug Evaluation, Preclinical; Ferric Compounds / chemistry; Ferric Compounds / pharmacology; Magnetic Phenomena; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Membrane Transport Proteins / antagonists & inhibitors; Mitochondrial Membrane Transport Proteins / isolation & purification; Mitochondrial Membrane Transport Proteins / metabolism; Nanoparticles / chemistry; Protein Binding / drug effects; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / antagonists & inhibitors; Saccharomyces cerevisiae Proteins / isolation & purification; Saccharomyces cerevisiae Proteins / metabolism; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Sources: Web Of Science, ORCID
Added: December 30, 2019

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