Works (138)

Updated: July 9th, 2024 05:02

2024 article

Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

Cheng, X., Henick, B. S., & Cheng, K. (2024, February 23). ACS NANO.

By: X. Cheng n, B. Henick* & K. Cheng*

author keywords: Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy
Source: Web Of Science
Added: April 1, 2024

2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). NATURE NANOTECHNOLOGY, Vol. 1.

By: M. Liu*, S. Hu*, N. Yan*, K. Popowski n & K. Cheng*

TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang*, S. Hu*, K. Popowski n, S. Liu*, D. Zhu*, X. Mei n, J. Li*, Y. Hu* ...

Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Optimizing cell therapy by sorting cells with high extracellular vesicle secretion

NATURE COMMUNICATIONS, 15(1).

By: D. Koo*, X. Cheng n, S. Udani*, S. Baghdasarian*, D. Zhu*, J. Li*, B. Hall, N. Tsubamoto* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: July 8, 2024

2023 journal article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

SCIENCE ADVANCES, 9(25).

By: Z. Wang n, Z. Li n, W. Shi n, D. Zhu n, S. Hu n, P. Dinh n, K. Cheng n

MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
TL;DR: The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2023

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n, K. Huang n, S. Hu n, K. Popowski n, K. Cheng n

TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

NANO RESEARCH, 16(5), 7248–7259.

By: X. Wang*, S. Hu n, D. Zhu n, J. Li n, K. Cheng n & G. Liu

author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR: Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n, S. Liu n, K. Huang n, J. Li n, X. Mei n, Z. Li n, K. Cheng n

author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
TL;DR: Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023

2023 article

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO, Vol. 6.

By: X. Cheng n, S. Hu n & K. Cheng n

author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
TL;DR: The work demonstrates the feasibility and proof-of-concept therapeutic potential of using microneedle patches to directly deliver PROTACs into tumors and can sufficiently degrade ERα in MCF7 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023

2023 article

Pericardial Delivery of SDF-1 α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 15). ADVANCED MATERIALS, Vol. 9.

By: L. Luo*, Y. Li*, Z. Bao*, D. Zhu n, G. Chen*, W. Li*, Y. Xiao*, Z. Wang n ...

author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
TL;DR: SDF‐1α‐encapsulated Puerarin (PUE) hydrogel (SDF‐1α@PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte/macrophages into a repairing phenotype, demonstrating a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2023 journal article

Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models

STAR PROTOCOLS, 4(2).

By: A. Moatti n, Y. Cai n, C. Li n, K. Popowski n, K. Cheng n, F. Ligler*, A. Greenbaum n

author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
TL;DR: A protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal models is presented and a pipeline to count hair cells in antibody-stained and 3D imaged cochleae using open-source software is detailed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 5, 2023

2023 journal article

Wound‐triggered shape change microgels for the development of enhanced biomimetic function platelet‐like particles

Journal of Biomedical Materials Research Part A, 112(4), 613–624.

By: E. Chee n, E. Mihalko*, K. Nellenbach n, J. Sollinger n, K. Huang n, M. Hon n, S. Pandit n, K. Cheng n, A. Brown n

author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
TL;DR: Thrombin-sensitive PLPs are created that exhibit a wound-triggered shape change, induce significant clot retraction following exposure to thrombin and promote hemostasis and healing in vivo after trauma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 6, 2023

2022 article

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE, Vol. 9.

By: M. Fan*, H. Li*, D. Shen*, Z. Wang*, H. Liu*, D. Zhu n, Z. Wang n, L. Li* ...

author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
TL;DR: This decoy exosome strategy serves as a promising therapy to reduce chemo‐induced toxicity and can also promote macrophage polarization into the M2 type for tissue repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.

By: S. Hu n, D. Zhu n, Z. Li n & K. Cheng n

author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
TL;DR: A detachable therapeutic microneedle patch, which is comprised of mesenchymal stromal cell-secreted factors (MSCF)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) in MN tips made of elastin-like polypeptide gel, provides a promising treatment approach for cardiac diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2022 journal article

Engineering stem cell therapeutics for cardiac repair

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 171, 56–68.

By: J. Fang*, J. Li*, X. Zhong*, Y. Zhou*, R. Lee*, K. Cheng n, S. Li*

author keywords: Stem cell engineering; Genetic engineering; Micro; nanotechnology; Cardiovascular bioengineering
MeSH headings : Biocompatible Materials; Heart; Humans; Hydrogels; Stem Cells; Tissue Engineering / methods
TL;DR: This review summarizes the state-of-art stem cell-based therapeutics for cardiac regeneration and discusses the emerged bioengineering approaches toward the enhancement of therapeutic efficacy of stem cell therapies in cardiac repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 22, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING, Vol. 7.

By: Z. Wang n, K. Popowski n, D. Zhu n, B. Abad n, X. Wang n, M. Liu n, H. Lutz n, N. De Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 journal article

Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars

LANGMUIR, 38(29).

By: W. Shi n, X. Cheng n & K. Cheng n

MeSH headings : Adhesiveness; Adhesives; Animals; Finite Element Analysis; Lizards; Locomotion
Source: Web Of Science
Added: August 1, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n, A. Moatti n, G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad n, A. George n, E. Belcher n ...

TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

By: D. Zhu n, S. Liu n, K. Huang n, Z. Wang n, S. Hu n, J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2022 journal article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

JOURNAL OF NANOBIOTECHNOLOGY, 20(1).

By: C. Zhang*, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

Contributors: C. Zhang*, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2022 journal article

Sealing the heart from the inside out

Nature Biomedical Engineering, 7(2), 87–88.

By: K. Huang n & K. Cheng n

UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: February 6, 2023

2022 article

Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). ADVANCED MATERIALS TECHNOLOGIES, Vol. 6.

By: Y. Liu*, R. Menon*, A. Putcha n, K. Huang n, L. Bonilla n, R. Vora n, J. Li n, L. Zhang* ...

author keywords: biosensors; microneedles; optoelectronics; waveguides; wearable devices
TL;DR: A wireless, wearable deep‐tissue sensing patch is put forward by incorporating biocompatible microneedle waveguides at the sensing interface, to bypass the light extinction in epidermic and dermic tissue and enable the tracking of oximetry at muscular tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 5, 2022

2021 journal article

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Frontiers in Materials, 8.

By: M. Chingale n, K. Cheng n & K. Huang

author keywords: 3D bioprinting; scaffolds-based 3D bioprinting; 3D cardiac patch; cardiac regeneration; cardiac repair
TL;DR: The recent progress and challenges in 3D bioprinting strategies for cardiac tissue engineering, including cardiac patches, in vitro cardiac models, valves, and blood vessels are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: March 7, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

By: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan* ...

Contributors: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan* ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR: In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021

2021 journal article

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

FRONTIERS IN ONCOLOGY, 11.

By: T. Allen*, M. Cullen*, N. Hawkey*, H. Mochizuki n, L. Nguyen, E. Schechter*, L. Borst n, J. Yoder n ...

author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR: Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Abad n, K. Cheng n

Contributors: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Juan Abad n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n, Z. Li n, K. Huang n, S. Hu n, H. Lutz n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2021 review

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

By: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

Contributors: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng n

Contributors: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng n

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
TL;DR: An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 journal article

Bioengineering Technologies for Cardiac Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, 9.

By: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

Contributors: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

author keywords: bioengineering; cardiac repair; cell reprogramming; exosome; cardiac patch; targeting
TL;DR: Recent advancements in bioengineering and biotechnologies for cardiac regenerative medicine are discussed, including protein decoration, antibody modification, and platelet membranes have been used for targeting and precision medicine. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 28, 2021

2021 review

Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?

[Review of ]. CELLS, 10(3).

By: D. Zhu n & K. Cheng n

Contributors: D. Zhu n & K. Cheng n

author keywords: stem cell; myocardial infarction; cardiovascular diseases; acellular therapy; exosomes; paracrine effects; biomedical engineering; biomaterials
MeSH headings : Cell- and Tissue-Based Therapy / methods; Heart Failure / pathology; Heart Failure / therapy; Humans; Myocardium / pathology; Myocytes, Cardiac / metabolism; Tissue Engineering / methods
TL;DR: Current therapeutic approaches for cardiac repair are summarized and discussed and a perspective on novel strategies that holding potential opportunities for future research and clinical translation are provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 15, 2021

2021 review

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 173, 504–519.

By: M. Liu n, B. Abad n & K. Cheng n

author keywords: Cardiac fibrosis; Cardiac fibroblast; Myofibroblasts; Myocardial remodeling; Reprogramming; Drug delivery systems
MeSH headings : Animals; Drug Delivery Systems; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Fibrosis / metabolism; Fibrosis / pathology; Humans; Myocardium / metabolism; Myocardium / pathology; Myofibroblasts / metabolism; Myofibroblasts / pathology; Pharmaceutical Preparations / chemistry
TL;DR: This review will outline the progress of cardiac fibrosis and its contributions to the heart failure, and shed light on the role of myoFbs in the regulation of adverse remodeling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 28, 2021

2021 article

Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation

Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY, Vol. 9.

By: A. Carter n, K. Popowski n, K. Cheng n, A. Greenbaum n, F. Ligler n & A. Moatti n

author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
TL;DR: The potential of the converse piezoelectric effect to enhance bone regeneration is highlighted by discussing the activation of beneficial cellular pathways, the properties of piezOElectric biomaterials, and the potential for the more effective administration of the Converse pieZoelectrics effect using wireless control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 25, 2021

2021 review

Exosome therapeutics for COVID-19 and respiratory viruses

[Review of ]. VIEW, 2(3).

By: K. Popowski n, P. Dinh n, A. George n, H. Lutz n & K. Cheng n

author keywords: COVID-19; exosomes; respiratory viruses; SARS-CoV-2
TL;DR: The relationship between exosomes and respiratory viruses is reviewed, potential exosome therapeutics for viral infections are described, and progress toward clinical translation for lung‐derived exosomal therapeutics is summarized. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 19, 2021

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang n, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang n

Contributors: X. Wang n, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang n

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 article

Generation and Manipulation of Exosomes

CARDIAC REGENERATION, Vol. 2158, pp. 295–305.

By: S. Hu n, L. Qiao n & K. Cheng n

author keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection
MeSH headings : Animals; Blood Platelets / chemistry; Cell Culture Techniques / methods; Cell Fractionation / methods; Cell Membrane / chemistry; Cell Membrane / metabolism; Exosomes / ultrastructure; Humans; Mice; Molecular Targeted Therapy; Myocardium / cytology; Peptides / analysis; Peptides / metabolism; Rats; Technology, Pharmaceutical / methods; Ultracentrifugation; Ultrasonic Waves
TL;DR: Generation of exosomes from biopsy, isolation ofExosomes by centrifugal ultrafiltration method, and approaches for manipulation of cardiac homing exosome by chemical engineering for the treatment of myocardial infarction are described. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 30, 2021

2021 article

Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis

MELANOMA, Vol. 2265, pp. 417–425.

By: T. Allen* & K. Cheng n

author keywords: Circulating tumor cells; Metastasis; Intravital microscopy; Cancer Exodus Hypothesis; Extravasation; Angiopellosis; Zebrafish; Tumor infusion; Light sheet microscopy; Tumor cell isolation
MeSH headings : Animals; Animals, Genetically Modified; Cell Line, Tumor; Endothelial Cells / metabolism; Endothelial Cells / pathology; Intravital Microscopy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism; Neoplastic Cells, Circulating / pathology; Zebrafish
TL;DR: The use of intravital microscopy techniques to image and isolate both extravasating melanoma CTCs and the extravasation-participating endothelial cells can be used as a means to study cancer metastasis and as a screening tool for anticancer therapeutics. (via Semantic Scholar)
Source: Web Of Science
Added: August 30, 2021

2021 journal article

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

ADVANCED FUNCTIONAL MATERIALS, 31(15).

By: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

Contributors: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
TL;DR: A ROS‐sensitive cross‐linked poly(vinyl alcohol) (PVA) hydrogel is synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair and protects cardiac function and reduces fibrosis in the post‐I/R heart, with enhanced angiomyogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2021

2021 journal article

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

NATURE COMMUNICATIONS, 12(1).

By: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

Contributors: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

MeSH headings : Animals; Cardiac Surgical Procedures; Cardiovascular Agents / administration & dosage; Cell Differentiation / physiology; Drug Delivery Systems / methods; Exosomes / metabolism; Extracellular Matrix / chemistry; Hydrogels / administration & dosage; Hydrogels / chemistry; Induced Pluripotent Stem Cells / transplantation; Male; Materials Testing; Mesenchymal Stem Cells / cytology; Mice; Minimally Invasive Surgical Procedures / methods; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Pericardium; Rats; Swine
TL;DR: In rodent models of myocardial infarction, it is demonstrated that intrapericardial injection is an effective and safe method to deliver hydrogels containing induced pluripotent stem cells-derived cardiac progenitor cells or mesenchymal stem Cells-derived exosomes. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2021 journal article

Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology

Advanced Biology, 6(2), 2101133.

By: Y. Hsu n, K. Huang n & K. Cheng n

author keywords: cardiac hypertrophy; cardiomyogenesis; heart failure; regeneration
MeSH headings : Biology; Heart Failure / therapy; Humans; Prognosis; Regeneration; Stroke Volume; Ventricular Function, Left
TL;DR: In this review, numerous mediators involved in the pathogenesis of HF are summarized and the recent challenges and development in cardiac regenerative therapy that hold opportunities for future research and clinical translation are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 3, 2022

2021 journal article

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy

ACS NANO, 15(1), 1100–1110.

By: P. Zheng*, M. Fan*, H. Liu*, Y. Zhang*, X. Dai*, H. Li*, X. Zhou*, S. Hu n ...

MeSH headings : Drug Delivery Systems; Humans; Hyperthermia, Induced; Hypoxia; Neoplasms / drug therapy; Phototherapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 29, 2021

2021 review

Visualizing cancer extravasation: from mechanistic studies to drug development

[Review of ]. CANCER AND METASTASIS REVIEWS, 40(1), 71–88.

By: X. Cheng n & K. Cheng n

author keywords: Cancer metastasis; Cancer cell extravasation; Cancer models; Cancer therapies
MeSH headings : Drug Development; Humans; Neoplasm Metastasis; Neoplastic Cells, Circulating / pathology; Transendothelial and Transepithelial Migration
TL;DR: This review focuses on recent progress in cancer extravasation visualization techniques, including the development of both in vitro and in vivo cancerExtravasation models, that shed light on the underlying mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 24, 2020

2020 review

Advances of exosome isolation techniques in lung cancer

[Review of ]. MOLECULAR BIOLOGY REPORTS, 47(9), 7229–7251.

By: E. Mahgoub*, E. Razmara*, A. Bitaraf*, F. Norouzi*, M. Montazeri*, R. Behzadi-Andouhjerdi*, M. Falahati*, K. Cheng n ...

author keywords: Lung cancer; Exosome; Multi-vesicular bodies; Extracellular vesicles; MicroRNAs
MeSH headings : Biomarkers, Tumor / blood; Biomarkers, Tumor / isolation & purification; Cell-Free Nucleic Acids / blood; Cell-Free Nucleic Acids / isolation & purification; Circulating Tumor DNA / blood; Circulating Tumor DNA / isolation & purification; Exosomes / metabolism; Exosomes / pathology; Humans; Lung Neoplasms / blood; Lung Neoplasms / diagnosis; Lung Neoplasms / pathology
TL;DR: This review summarizes the recent investigations regarding isolation and also the characterization of exosomes of LC cells, and discusses the noncoding RNAs as biomarkers and their applications in the diagnosis and prognosis of LC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 31, 2020

2020 journal article

Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19

CARDIOVASCULAR RESEARCH, 116(2), 353–367.

By: P. Huang*, L. Wang*, Q. Li*, X. Tian*, J. Xu*, J. Xu*, Y. Xiong*, G. Chen* ...

author keywords: Exosomes; Atorvastatin; MSCs; lncRNA H19; Myocardial infarction
MeSH headings : Angiogenic Proteins / metabolism; Animals; Apoptosis; Atorvastatin / pharmacology; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endothelial Cells / metabolism; Endothelial Cells / pathology; Exosomes / drug effects; Exosomes / metabolism; Exosomes / transplantation; Female; Humans; Inflammation Mediators / metabolism; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / genetics; Myocardial Infarction / metabolism; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; Rats, Sprague-Dawley; Recovery of Function; Up-Regulation; Ventricular Function, Left
TL;DR: Exosomes obtained from ATV-pretreated MSCs have significantly enhanced therapeutic efficacy for treatment of AMI possibly through promoting endothelial cell function and mediates the cardioprotective roles of MSCATV-Exo in promoting angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 10, 2020

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.

By: T. Su n, K. Huang n, K. Mathews n, V. Scharf n, S. Hu n, Z. Li n, B. Frame*, J. Cores n ...

author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
TL;DR: It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 journal article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

By: S. Hu n, Z. Li n, H. Lutz n, K. Huang n, T. Su n, J. Cores n, P. Dinh n, K. Cheng n

MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR: Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 10, 2020

2020 review

Engineering better stem cell therapies for treating heart diseases

[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).

By: J. Li n, S. Hu n & K. Cheng n

author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR: This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2020 review

Exosome therapeutics for lung regenerative medicine

[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).

By: K. Popowski n, H. Lutz n, S. Hu n, A. George n, P. Dinh n & K. Cheng n

author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
TL;DR: The uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies are underline. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2020 journal article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

Contributors: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR: A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020

2020 review

Recent Development in Therapeutic Cardiac Patches

[Review of ]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7.

By: X. Mei n & K. Cheng n

author keywords: biomaterials; cardiac patch; myocardial infarction; cell therapy; cardiac tissue regeneration
TL;DR: This review will present the most state-of-the-art cardiac patches and analysis their compositional details, and the recent advances to obtain scaffold biomaterials will be highlighted, including synthetic and natural materials. (via Semantic Scholar)
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

By: Z. Li n, S. Hu n, K. Huang n, T. Su n, J. Cores n & K. Cheng n

MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
TL;DR: IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair and protects the cardiomyocytes from apoptosis by neutralizing IL–1β and decreasing IL- 1β–driven caspase-3 activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 2, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

By: L. Qiao n, S. Hu n, K. Huang n, T. Su n, Z. Li*, A. Vandergriff n, J. Cores n, P. Dinh n ...

author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR: It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2019 journal article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883–1891.

By: D. Shen n, Z. Li n, S. Hu n, K. Huang n, T. Su n, H. Liang n, F. Liu n, K. Cheng n

author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
TL;DR: Taking advantage of the natural infarct-homing ability of platelets, CD34 antibody-linked platelets (P-CD34) are engineered to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart for effective heart repair. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019)

Advanced Functional Materials, 29(4), 1970019.

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 21, 2020

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang*, Z. Li n, T. Su n, D. Shen*, S. Hu n & K. Cheng n

author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
TL;DR: In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2019 review

Cell and biomaterial-based approaches to uterus regeneration

[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.

By: F. Liu n, S. Hu n, S. Wang* & K. Cheng n

author keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells
TL;DR: This review is a recapitulation of the literature focused on cellular therapies for treating Asherman’s syndrome, exploring the use of cell-based therapeutics, in conjunction with biomaterials, to treat AS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019

2019 review

Chemical Engineering of Cell Therapy for Heart Diseases

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.

By: Z. Li n, S. Hu n & K. Cheng n

MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
TL;DR: The third generation of therapeutic strategies are developed, which utilize cell-free approaches for cardiac cell therapies, and it is hoped that the designs will promote the use of chemical engineering approaches to transform, transport, and fabricate cell- free systems as novel cardiac cell therapeutic agents for clinical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019

2019 review

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

[Review of ]. CIRCULATION RESEARCH, 124(1), 161–169.

author keywords: bioengineering; heart failure; myocardium; stem cells; tissue engineering
MeSH headings : Animals; Biological Science Disciplines; Biomedical Engineering; Biomedical Research; Cooperative Behavior; Diffusion of Innovation; Heart / physiopathology; Heart Failure / metabolism; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Humans; Interdisciplinary Communication; Myocardium / metabolism; Myocardium / pathology; Recovery of Function; Regeneration
TL;DR: Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, held at the University of Alabama at Birmingham. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 4, 2019

2019 journal article

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

ADVANCED HEALTHCARE MATERIALS, 8(14).

By: F. Liu n, S. Hu n, H. Yang n, Z. Li n, K. Huang n, T. Su n, S. Wang*, K. Cheng n

author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
TL;DR: The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy, and holds great potential for the treatment of AS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 journal article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273–11282.

By: S. Hu n, Z. Li n, J. Cores n, K. Huang n, T. Su n, P. Dinh n, K. Cheng n

author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
TL;DR: Results indicate that exosomes from 3D cultured HDF spheroids have anti-skin-aging properties and the potential to prevent and treat cutaneous aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019

2019 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2019 journal article

Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection

ACS Applied Bio Materials, 2(2), 613–618.

author keywords: wound infection; porous organic polymers; Band-Aids; white light
TL;DR: Bacterial Band-Aids, combining porphyrin-based porous organic polymers (POPs) with commercial antibiotic-free Band- Aids, are designed, which are ideal wound dressings for wound disinfection under white light irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 21, 2020

2019 journal article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.

By: L. Qiao n, S. Hu n, S. Liu*, H. Zhang*, H. Ma*, K. Huang n, Z. Li n, T. Su n ...

MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
TL;DR: The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 journal article

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

Advanced Healthcare Materials, 8(2), 1801011.

By: K. Huang n, S. Hu n & K. Cheng n

author keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell- and Tissue-Based Therapy / methods; Endocarditis / metabolism; Endocarditis / therapy; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / physiology; Myocarditis / metabolism; Myocarditis / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanomedicine / methods; Paracrine Communication; Tissue Engineering / methods
TL;DR: The next generation of cell‐based MI therapies will identify and isolate cell products and derivatives, integrate them with biocompatible materials and technologies, and use them for the regeneration of damaged myocardial tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: February 11, 2019

2018 review

Body builder: from synthetic cells to engineered tissues

[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.

By: S. Hu n, B. Ogle* & K. Cheng n

MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
TL;DR: This review summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering, and pointed to challenges and future directions for the field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2018

2018 journal article

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.

By: T. Su n, K. Huang n, M. Daniele n, M. Hensley n, A. Young n, J. Tang n, T. Allen n, A. Vandergriff n ...

author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR: It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018

2018 journal article

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

By: J. Tang n, J. Wang n, K. Huang n, Y. Ye n, T. Su n, L. Qiao n, M. Hensley n, T. Caranasos* ...

MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
TL;DR: The microneedle patch integrated with cardiac stromal cells (MN-CSCs) represents an innovative approach delivering therapeutic cells for heart regeneration and polymeric MNs are used to create “channels” between host myocardium and therapeutic CSCs to promote heart repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 31, 2018

2018 journal article

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Stem Cells Translational Medicine, 7(4), 354–359.

By: J. Tang n, J. Cores n, K. Huang n, X. Cui*, L. Luo*, J. Zhang n, T. Li*, L. Qian*, K. Cheng n

author keywords: Myocardial injury; Stem cell therapy; Synthetic stem cells; Biomaterials
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart / physiology; Heart Diseases / therapy; Humans; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / cytology
TL;DR: This concise review provides a brief introduction into stem cell therapies for ischemic heart disease, and summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu*, W. Sun*, J. Wang*, H. Ruan*, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536–6544.

By: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona n, C. Shao* ...

Contributors: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona n, C. Shao* ...

author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
TL;DR: This work fabricated a nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells and further coated it with the membranes of red blood cells to increase blood stability and promote liver cell proliferation in vitro and have lower internalization by macrophage cells. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: September 10, 2019

2018 article

Metastatic melanoma and cervical tumor cell clusters can exit blood vessels through angiopellosis augmenting tumor formation ability

Allen, T., Amu, E., Asad, D., & Cheng, K. (2018, July). CANCER RESEARCH, Vol. 78.

By: T. Allen n, E. Amu n, D. Asad n & K. Cheng n

Source: Web Of Science
Added: June 17, 2019

2018 journal article

NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells

ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796.

author keywords: injectable hydrogels; NIPAM microgel; thermo-responsive microgel; cardiac stromal cells; multicellular spheroids; heart repair
MeSH headings : Acrylamides / administration & dosage; Acrylamides / chemistry; Animals; Cellular Microenvironment / drug effects; Chemokine CXCL12 / genetics; Gene Expression Regulation / drug effects; Humans; Hydrogels / administration & dosage; Hydrogels / chemistry; Hydrophobic and Hydrophilic Interactions / drug effects; Insulin-Like Growth Factor I / genetics; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Polymers / administration & dosage; Polymers / chemistry; Rats; Stromal Cells / drug effects; Stromal Cells / pathology; Succinates / chemistry; T-Lymphocytes / drug effects; Vascular Endothelial Growth Factor A / genetics
TL;DR: The result revealed the treatment-promoted MI heart repair through angiogenesis and inhibition of apoptosis with an improved cell retention rate, which will open a door for tailoring poly( N-isopropylacrylamide)-based microgel as a delivery vehicle for CSC therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018

2018 review

Platelets and their biomimetics for regenerative medicine and cancer therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.

By: Z. Li n, S. Hu n & K. Cheng n

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
TL;DR: This review will highlight the recent progress made in the development of disease-targeting platelets- and platelet-mimicking-vehicles as therapeutic platforms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018

2018 journal article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193–12200.

By: Z. Li n, D. Shen*, S. Hu n, T. Su n, K. Huang n, F. Liu n, L. Hou*, K. Cheng n

author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

By: E. Mihalko n, K. Huang n, E. Sproul n, K. Cheng n & A. Brown n

author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
TL;DR: In vivo and in vitro, FSNs localize to fibrin in injured heart tissue and, when loaded with tPA and Y-27632, showed significant improvement in left ventricular ejection fraction 2 and 4 weeks post-I/R as well as significantly decreased infarct size, α-smooth muscle actin expression, and connective tissue growth factor expression 4 weeks after the I/R. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 21, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang n, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

TL;DR: The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

THERANOSTICS, 8(7), 1869–1878.

author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
TL;DR: By targeting exosomes to the infarcted heart, there was a significant improvement in outcomes with reduced fibrosis and scar size, and increased cellular proliferation and angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart

Tissue Engineering Part C: Methods, 23(3), 146–155.

author keywords: cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
MeSH headings : Animals; Biocompatible Materials / chemistry; Blood Platelets / metabolism; Fibrin / metabolism; Heart / physiology; Male; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Paintings; Rats; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR: The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue, and promoted cardiac repair and attenuated cardiac dysfunction after MI. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

Respiratory Research, 18(1).

By: P. Dinh n, J. Cores n, M. Hensley n, A. Vandergriff n, J. Tang n, T. Allen n, T. Caranasos*, K. Adler n, L. Lobo*, K. Cheng n

author keywords: Pulmonary progenitor cells; Lung spheroid; Stem cell
MeSH headings : Adolescent; Aged; Animals; Biopsy; Bronchi / cytology; Bronchi / physiology; Cell Culture Techniques / methods; Female; Human Umbilical Vein Endothelial Cells / physiology; Humans; Infusions, Intravenous; Lung / cytology; Lung / physiology; Male; Mice; Mice, Nude; Middle Aged; Spheroids, Cellular / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR: These cells could be utilized in long-term expansion of lung progenitor cells and as part of the development of cell-based therapies for the treatment of lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Circulation Research, 120(11), 1768–1775.

author keywords: artificial cells; mesenchymal stem cells; myocardial infarction; regeneration; stem cells; tissue engineering
MeSH headings : Animals; Cells, Cultured; Humans; Lactic Acid / administration & dosage; Male; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Mice; Mice, Inbred C57BL; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Polyglycolic Acid / administration & dosage; Polylactic Acid-Polyglycolic Acid Copolymer; Positron-Emission Tomography / methods; Treatment Outcome
TL;DR: The fabricated synMSC therapeutic particle demonstrated its regenerative potential in mice with acute myocardial infarction and may provide novel insight into tissue engineering for treating multiple diseases. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction

ACS NANO, 11(10), 9738–9749.

author keywords: cardiac stem cells; nanogel; myocardial infarction; biomaterials; mouse model; pig model
MeSH headings : Acrylamides / chemistry; Acrylates / chemistry; Animals; Disease Models, Animal; Female; Humans; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanogels; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Surface Properties; Swine; Temperature
TL;DR: In mice and pigs with acute MI, injection of encapsulated hCSCs preserves cardiac function and reduces scar sizes, whereas injection of hC SCs in saline has an adverse effect on heart healing, suggesting thermosensitive nanogels can be used as a stem cell carrier. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver

Cell Transplantation, 26(12), 1868–1877.

By: W. Fagg*, N. Liu*, M. Yang*, K. Cheng*, E. Chung*, J. Kim*, G. Wu*, J. Fair*

MeSH headings : Animals; Cell Differentiation / physiology; Cell Proliferation / physiology; Cell Survival / physiology; Hepatocytes / cytology; Hepatocytes / physiology; Liver / cytology; Liver Regeneration / physiology; Mice; Mice, Inbred BALB C; Stem Cells / cytology; Stem Cells / physiology
TL;DR: The cell-based mechanisms of increased initial dwell time through magnetic targeting combined with high rate of proliferation in situ yield significant engraftment in the undamaged liver. (via Semantic Scholar)
Source: Crossref
Added: July 28, 2019

2017 journal article

Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis

STEM CELLS Translational Medicine, 6(10), 1905–1916.

By: J. Cores n, M. Hensley n, K. Kinlaw n, S. Rikard n, P. Dinh n, D. Paudel n, J. Tang n, A. Vandergriff n ...

author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
TL;DR: It is found that infusion of allogeneic LSCs reduces the progression of inflammation and fibrotic manifestation and preserves epithelial and endothelial health without eliciting significant immune rejection. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Nature Communications, 8(1).

By: J. Tang*, D. Shen*, T. Caranasos*, Z. Wang*, A. Vandergriff n, T. Allen n, M. Hensley n, P. Dinh n ...

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Biomimetic Materials / pharmacology; Cell Fractionation; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / transplantation; Cell-Derived Microparticles / chemistry; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Culture Media, Conditioned / chemistry; Culture Media, Conditioned / isolation & purification; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor / genetics; Hepatocyte Growth Factor / metabolism; Humans; Injections, Intralesional; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Paracrine Communication; Recovery of Function / drug effects; Stem Cells / cytology; Stem Cells / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR: A synthetic cell-mimicking microparticle that recapitulates stem cell functions in tissue repair and acts as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(10), 2432–2440.

By: Z. Wang*, N. Dong*, Y. Niu*, Z. Zhang*, C. Zhang*, M. Liu, T. Zhou*, Q. Wu*, K. Cheng n

author keywords: Human villous trophoblasts; myocardial infarction; cell therapy; paracrine effects
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Chorionic Villi / transplantation; Collagen; Drug Combinations; Heart / physiopathology; Human Umbilical Vein Endothelial Cells / physiology; Humans; Laminin; Male; Mice, Inbred C57BL; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / physiology; Neovascularization, Physiologic; Proteoglycans; Rats; Regeneration; Transplantation, Heterologous; Trophoblasts / transplantation
TL;DR: It is shown that HVTs can promote tube formation of human umbilical vein endothelial cells (HUVECs) on Matrigel and enhance the resistance of neonatal rat cardiomyocytes (NRCMs) to oxidative stress in vitro and may be used as a source for cell therapy or a tool to study cell‐derived soluble factors for AMI treatment. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Angiopellosis as an Alternative Mechanism of Cell Extravasation

STEM CELLS, 35(1), 170–180.

By: T. Allen n, D. Gracieux n, M. Talib n, D. Tokarz n, M. Hensley n, J. Cores n, A. Vandergriff n, J. Tang n ...

author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
TL;DR: In injected cardiac and mesenchymal stem cells, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair

STEM CELLS TRANSLATIONAL MEDICINE, 5(6), 793–803.

By: D. Shen*, J. Tang n, M. Hensley n, T. Li*, T. Caranasos*, T. Zhang n, J. Zhang*, K. Cheng n

author keywords: Cardiac stem cells; Platelet fibrin gel; Matrix metalloproteinases; Heart repair
MeSH headings : Animals; Blood Platelets / metabolism; Dipeptides / administration & dosage; Disease Models, Animal; Echocardiography; Fibrin / administration & dosage; Humans; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinases / metabolism; Myocardial Infarction / enzymology; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Rats; Regeneration / drug effects; Stem Cell Transplantation
TL;DR: It is suggested that MMPs play a critical role in the therapeutic benefits of platelet fibrin gel spiked with cardiac stem cells for treating MI. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.

By: E. Henry n, J. Cores n, M. Hensley n, S. Anthony n, A. Vandergriff n, J. Andrade n, T. Allen n, T. Caranasos*, L. Lobo*, K. Cheng n

author keywords: Adult lung stem cells; Mesenchymal stem cells; Pulmonary fibrosis; Spheroid cell culture
MeSH headings : Adult; Animals; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / pharmacology; Bleomycin / adverse effects; Bleomycin / pharmacology; Female; Heterografts; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Mice; Mice, SCID; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / therapy; Regeneration; Spheroids, Cellular / metabolism; Spheroids, Cellular / transplantation
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

By: M. Hensley n, J. Andrade n, B. Keene n, K. Meurs n, J. Tang n, Z. Wang*, T. Caranasos*, J. Piedrahita n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR: It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Cellular Postconditioning Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction

CIRCULATION-HEART FAILURE, 8(2), 322–332.

By: H. Kanazawa, E. Tseliou, K. Malliaras, K. Yee, J. Dawkins, G. De Couto, R. Smith, M. Kreke ...

author keywords: acute myocardial infarction; animal models; coronary interventions; ischemic postconditioning
MeSH headings : Animals; Coronary Vessels; Disease Models, Animal; Heart Failure / surgery; Injections, Intra-Arterial; Ischemic Postconditioning / methods; Myocardial Infarction / complications; Myocardial Infarction / therapy; Myocardial Reperfusion; Stem Cell Transplantation / methods; Swine; Swine, Miniature; Transplantation, Homologous; Ventricular Remodeling / physiology
TL;DR: A novel cardioprotective effect, which the authors call cellular postconditioning, differs from previous strategies to reduce IS in that it works even when initiated with significant delay after reflow. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 chapter

Cryopreservation of Neonatal Cardiomyocytes

In Methods in Molecular Biology (Vol. 1299, pp. 153–160).

By: A. Vandergriff n, M. Hensley n & K. Cheng n

author keywords: Cardiomyocytes; Cryopreservation; Cardiac research
MeSH headings : Animals; Animals, Newborn; Cell Culture Techniques; Cells, Cultured; Cryopreservation / methods; Myocytes, Cardiac / cytology; Rats
TL;DR: A method for cryopreserving neonatal rat cardiomyocytes (NRCMs), and subsequently thawing them for use in assays and to reduce the time requirements and the impact on research animals is described. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

Stem Cells International, 2015, 1–8.

By: A. Vandergriff n, J. de Andrade n, J. Tang n, M. Hensley n, J. Piedrahita n, T. Caranasos*, K. Cheng n

TL;DR: Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis, and mice showed no adverse immune reaction, showing promise for overcoming the limitations of stem cells and improving cardiac therapies. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Journal of Visualized Experiments, (98).

By: A. Vandergriff n, M. Hensley n & K. Cheng n

author keywords: Developmental Biology; Issue 98; Cryopreservation; Cardiomyocytes; Cell-based Assay; Cell Culture; Cardiac Research; In Vitro Assay
MeSH headings : Actinin / analysis; Actinin / metabolism; Animals; Animals, Newborn; Cell Culture Techniques; Cell Separation / methods; Cell Survival / physiology; Cryopreservation / methods; Cryoprotective Agents / chemistry; Dimethyl Sulfoxide / chemistry; Freezing; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Sarcomeres / chemistry; Sarcomeres / metabolism
TL;DR: Cryopreservation methods allow one to easily cryopreserve and thaw neonatal rat cardiomyocytes, which gives researchers a greater amount of flexibility in planning experiments as well as reducing the use of animals. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

By: J. Andrade n, J. Tang n, M. Hensley n, A. Vandergriff n, J. Cores n, E. Henry n, T. Allen n, T. Caranasos* ...

MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
TL;DR: This new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents and improved post-MI survival rate. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy

PLOS ONE, 9(12).

By: K. Yee, K. Malliaras, H. Kanazawa, E. Tseliou, K. Cheng n, D. Luthringer, C. Ho*, K. Takayama* ...

MeSH headings : Administration, Cutaneous; Animals; Cardiomyopathies / complications; Cardiomyopathies / immunology; Cardiomyopathies / pathology; Cardiomyopathies / therapy; Catheters; Cicatrix / complications; Cicatrix / pathology; Dilatation; Endocardium / pathology; Female; Injections; Magnetic Resonance Imaging; Male; Myocardial Ischemia / complications; Myocardial Ischemia / immunology; Myocardial Ischemia / pathology; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Spheroids, Cellular / cytology; Spheroids, Cellular / transplantation; Survival Analysis; Sus scrofa; Transplantation, Homologous / adverse effects
TL;DR: Dose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy, consistent with therapeutic regeneration. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction

Journal of the American Heart Association, 3(5), 001260.

By: K. Cheng, A. Ibrahim, M. Hensley, B. Sun, W. Liu, R. Smith, E. Marban

Source: NC State University Libraries
Added: April 24, 2021

2014 journal article

Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling

Stem Cells, 32, 2397–2406.

By: Y. Xie, A. Ibrahim, K. Cheng, K. Malliaras, D. Shen, B. Sun, H. Cho, M. Human

Source: NC State University Libraries
Added: July 28, 2019

2014 journal article

Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block

Journal of the American College of Cardiology, 64(24), 2575–2585.

By: E. Cingolani, V. Ionta*, K. Cheng*, A. Giacomello*, H. Cho & E. Marbán

author keywords: arrhythmias; cardiac tissue engineering; gap junctions; heart conduction system
MeSH headings : Animals; Atrioventricular Block / pathology; Atrioventricular Block / physiopathology; Atrioventricular Block / surgery; Cell Transplantation / methods; Cells, Cultured; Electromagnetic Fields; Heart Conduction System / pathology; Heart Conduction System / physiopathology; Heart Conduction System / surgery; Heart Ventricles / pathology; Immunoconjugates / pharmacology; In Vitro Techniques; Magnets; Models, Cardiovascular; Myocytes, Cardiac / pathology; Rats; Rats, Sprague-Dawley; Sarcoglycans / immunology; Sarcoglycans / pharmacology; Tissue Engineering
TL;DR: An EECT can re-establish electrical conduction in the heart and could, in principle, be used not only to treat cardiac arrhythmias but also to repair other organs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

Stem Cell Reports, 2(5), 606–619.

By: A. Ibrahim*, K. Cheng* & E. Marbán*

MeSH headings : Albumins / pharmacology; Aniline Compounds / pharmacology; Animals; Benzylidene Compounds / pharmacology; Cell Differentiation; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Disease Models, Animal; Exosomes / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Mice, SCID; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardial Infarction / therapy; Myocardial Infarction / veterinary; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Polyesters / pharmacology; Rats; Rats, Sprague-Dawley; Regeneration
TL;DR: Exosomes secreted by human CDCs are identified as key mediators of CDC-induced regeneration, while highlighting the potential utility of exosomes as cell-free therapeutic candidates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair

JACC: Heart Failure, 2(1), 49–61.

By: K. Cheng*, K. Malliaras, R. Smith*, D. Shen*, B. Sun, A. Blusztajn*, Y. Xie, A. Ibrahim ...

author keywords: cardiosphere-derived cells; heart failure; myocardial infarction; patient characteristics; stromal cell-derived factor 1
MeSH headings : Adult; Aged; Animals; Cardiomyopathies / physiopathology; Extracellular Matrix; Female; Graft Survival / physiology; Heart / physiology; Heart Failure / physiopathology; Humans; Intercellular Signaling Peptides and Proteins / metabolism; Male; Mice, SCID; Middle Aged; Myocardial Infarction / physiopathology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Oxidative Stress / physiology; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology; Transplantation, Autologous
TL;DR: CDCs from advanced HF patients exhibit augmented potency in ameliorating ventricular dysfunction post-MI, possibly through SDF-1–mediated mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells

STEM CELLS, 32(9), 2397–2406.

By: Y. Xie*, A. Ibrahim, K. Cheng*, Z. Wu*, W. Liang, K. Malliaras, B. Sun, W. Liu ...

author keywords: Cardiosphere-derived cells; Cardiomyocyte; Proliferation; Paracrine factors; Cell-cell communication; beta 1 integrin
MeSH headings : Animals; Cell Communication / physiology; Cell Differentiation / physiology; Cells, Cultured; Humans; Integrin beta1 / metabolism; Male; Mice; Mice, SCID; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats
TL;DR: The hypothesis that cell‐cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects, is tested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2014 journal article

Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction

Journal of the American College of Cardiology, 63(2), 110–122.

By: K. Malliaras, R. Makkar, R. Smith, K. Cheng*, E. Wu*, R. Bonow*, L. Marbán, A. Mendizabal* ...

author keywords: cardiosphere-derived cells; myocardial infarction; myocardial regeneration
MeSH headings : Aged; Biopsy; Coronary Vessels; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Ventricles / pathology; Heart Ventricles / physiopathology; Humans; Injections, Intra-Arterial; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction / complications; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Recovery of Function; Stem Cell Transplantation / methods; Time Factors; Transplantation, Autologous; Treatment Outcome; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / surgery; Ventricular Function, Left / physiology
TL;DR: Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarctedMyocardium at 1 year post-treatment, which are consistent with therapeutic regeneration and merit further investigation in future trials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Nature Communications, 5(1).

By: K. Cheng*, D. Shen*, M. Hensley n, R. Middleton*, B. Sun*, W. Liu*, G. De Couto*, E. Marbán*

MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
TL;DR: The authors use magnetic iron nanoparticles conjugated with antibodies that bind therapeutic cells and cardiomyocytes to treat myocardial ischemia/reperfusion injury in rats and show that targeting to the heart is enhanced upon local application of a magnetic field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction

BIOMATERIALS, 35(30), 8528–8539.

By: A. Vandergriff n, T. Hensley n, E. Henry n, D. Shen*, S. Anthony n, J. Zhang*, K. Cheng n

author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
TL;DR: FHP labeling is safe to cardiac stem cells and facilitates magnetically-targeted stem cell delivery into the heart which leads to augmented cell engraftment and therapeutic benefit, and magnetic targeting increased cardiac retention of transplanted FHP-rCDCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).

By: K. Cheng n, A. Ibrahim, M. Hensley n, D. Shen*, B. Sun, R. Middleton, W. Liu, R. Smith*, E. Marban

author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
TL;DR: It is shown, surprisingly, that c‐kit expression has no relationship to CDCs' therapeutic efficacy in humans, and depletion of c‐Kit+ cells does not undermine the structural and functional benefits of CDCs in a mouse model of myocardial infarction. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy

European Heart Journal, 36(12), 751–762.

By: M. Aminzadeh*, E. Tseliou*, B. Sun*, K. Cheng*, K. Malliaras*, R. Makkar*, E. Marban*

author keywords: Cardiomyopathy; Heart failure; Cell transplantation
MeSH headings : Animals; Apoptosis / physiology; CREB-Binding Protein / metabolism; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / therapy; Cell Differentiation; Cell Lineage; Disease Models, Animal; Doxorubicin / pharmacology; Fibrosis; Graft Survival; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Injections, Intralesional; Male; Mice, Transgenic; Myocarditis / physiopathology; Myocardium / pathology; Myocytes, Cardiac / transplantation; Oxidative Stress / physiology; Protein Kinase C / metabolism; Signal Transduction; Stem Cell Transplantation / methods; Ventricular Remodeling / physiology
TL;DR: The ability to impact favourably on disease progression in non-ischaemic heart failure heralds new potential therapeutic applications of CDCs, which reverse fundamental abnormalities in cell signalling, prevent adverse remodelling, and improve survival in a mouse model of DCM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2013 journal article

Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart

EMBO Molecular Medicine, 5(2), 191–209.

By: K. Malliaras, Y. Zhang, J. Seinfeld, G. Galang, E. Tseliou, K. Cheng*, B. Sun, M. Aminzadeh, E. Marbán

author keywords: cardiac regeneration; cardiomyogenesis; cell therapy; fate mapping; myocardial infarction
MeSH headings : Animals; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Female; Humans; Male; Mice; Mice, 129 Strain; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Stem Cells / cytology
TL;DR: CDCs induce myocardial regeneration by differentially upregulating two mechanisms of endogenous cell proliferation, which cannot be explained by cardiomyocyte polyploidization, bi/multinucleation, cell fusion or DNA repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2013 journal article

INTRACORONARY CARDIOSPHERE-DERIVED CELLS AFTER MYOCARDIAL INFARCTION: MAGNETIC RESONANCE IMAGING ANALYSIS OF REGENERATION AND DETERMINANTS OF EFFICACY IN THE FINAL 1-YEAR RESULTS OF THE CADUCEUS TRIAL

Journal of the American College of Cardiology, 61(10), E104.

By: K. Malliaras, K. Cheng*, R. Smith, E. Wu, R. Bonow, A. Mendizabal, G. Gerstenblith, P. Johnston ...

TL;DR: Cardiosphere-derived cells exert regenerative effects in post-MI patients with LV dysfunction in the CADUCEUS trial and correlates of efficacy are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: January 21, 2021

2013 journal article

Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction

Circulation, 128(25), 2764–2775.

By: K. Malliaras*, R. Smith*, H. Kanazawa*, K. Yee*,