Works (134)

Updated: November 8th, 2023 05:01

2023 journal article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

SCIENCE ADVANCES, 9(25).

By: Z. Wang n, Z. Li n, W. Shi n, D. Zhu n, S. Hu n, P. Dinh n, K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
Sources: Web Of Science, ORCID
Added: June 24, 2023

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n, K. Huang n, S. Hu n, K. Popowski n, K. Cheng

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

NANO RESEARCH, 16(5), 7248–7259.

By: X. Wang n, S. Hu n, D. Zhu n, J. Li n, K. Cheng n & G. Liu*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
Sources: Web Of Science, ORCID
Added: August 28, 2023

2023 journal article

Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n, S. Liu n, K. Huang n, J. Li n, X. Mei n, Z. Li n, K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
Sources: Web Of Science, ORCID, Crossref
Added: April 4, 2023

2023 article

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO, Vol. 6.

By: X. Cheng n, S. Hu n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
Sources: Web Of Science, ORCID
Added: June 26, 2023

2023 article

Pericardial Delivery of SDF-1 α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 15). ADVANCED MATERIALS, Vol. 9.

By: L. Luo*, Y. Li*, Z. Bao*, D. Zhu n, G. Chen*, W. Li*, Y. Xiao*, Z. Wang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
Sources: Web Of Science, ORCID
Added: October 23, 2023

2023 journal article

Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models

STAR PROTOCOLS, 4(2).

By: A. Moatti n, Y. Cai n, C. Li n, K. Popowski n, K. Cheng n, F. Ligler*, A. Greenbaum n

co-author countries: United States of America 🇺🇸
author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
Source: Web Of Science
Added: September 5, 2023

2023 article

Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.

By: E. Chee n, E. Mihalko*, K. Nellenbach n, J. Sollinger n, K. Huang n, M. Hon n, S. Pandit n, K. Cheng n, A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
Sources: Web Of Science, ORCID
Added: November 6, 2023

2022 article

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE, Vol. 9.

By: M. Fan*, H. Li*, D. Shen*, Z. Wang*, H. Liu*, D. Zhu n, Z. Wang n, L. Li* ...

co-author countries: China 🇨🇳 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
Sources: Web Of Science, ORCID
Added: September 12, 2022

2022 article

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.

By: S. Hu n, D. Zhu n, Z. Li n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair
MeSH headings : Animals; Rats; Elastin; Polylactic Acid-Polyglycolic Acid Copolymer; Hyaluronic Acid; Mesenchymal Stem Cells; Myocytes, Cardiac; Myocardium; Nanoparticles; Peptides
Sources: Web Of Science, ORCID
Added: October 11, 2022

2022 journal article

Engineering stem cell therapeutics for cardiac repair

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 171, 56–68.

By: J. Fang*, J. Li*, X. Zhong*, Y. Zhou*, R. Lee*, K. Cheng n, S. Li*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Stem cell engineering; Genetic engineering; Micro; nanotechnology; Cardiovascular bioengineering
MeSH headings : Biocompatible Materials; Heart; Humans; Hydrogels; Stem Cells; Tissue Engineering / methods
Source: Web Of Science
Added: August 22, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING, Vol. 7.

By: Z. Wang n, K. Popowski n, D. Zhu n, B. Abad n, X. Wang n, M. Liu n, H. Lutz n, N. De Naeyer* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars

LANGMUIR, 38(29).

By: W. Shi n, X. Cheng n & K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Adhesiveness; Adhesives; Animals; Finite Element Analysis; Lizards; Locomotion
Source: Web Of Science
Added: August 1, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n, A. Moatti n, G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad n, A. George n, E. Belcher n ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: October 17, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

By: D. Zhu n, S. Liu n, K. Huang n, Z. Wang n, S. Hu n, J. Li n, Z. Li n, K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
Sources: Web Of Science, ORCID
Added: November 14, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
Sources: Web Of Science, ORCID
Added: January 3, 2022

2022 journal article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

JOURNAL OF NANOBIOTECHNOLOGY, 20(1).

By: C. Zhang n, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: C. Zhang n, W. Zhang*, D. Zhu n, Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu*, K. Cheng n, B. Zhong*

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
Sources: Web Of Science, ORCID
Added: January 24, 2022

2022 journal article

Sealing the heart from the inside out

Nature Biomedical Engineering, 7(2), 87–88.

By: K. Huang n & K. Cheng

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: February 6, 2023

2022 article

Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). ADVANCED MATERIALS TECHNOLOGIES, Vol. 6.

By: Y. Liu*, R. Menon*, A. Putcha n, K. Huang n, L. Bonilla n, R. Vora n, J. Li n, L. Zhang* ...

co-author countries: United States of America 🇺🇸
author keywords: biosensors; microneedles; optoelectronics; waveguides; wearable devices
Sources: Web Of Science, ORCID
Added: July 5, 2022

2021 journal article

3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration

Frontiers in Materials, 8.

By: M. Chingale n, K. Cheng n & K. Huang

co-author countries: United States of America 🇺🇸
author keywords: 3D bioprinting; scaffolds-based 3D bioprinting; 3D cardiac patch; cardiac regeneration; cardiac repair
Sources: Web Of Science, Crossref, ORCID
Added: March 7, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

By: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: J. Yao*, K. Huang n, D. Zhu n, T. Chen*, Y. Jiang*, J. Zhang*, L. Mi*, H. Xuan ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
Sources: Web Of Science, ORCID
Added: August 23, 2021

2021 journal article

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

FRONTIERS IN ONCOLOGY, 11.

By: T. Allen*, M. Cullen*, N. Hawkey*, H. Mochizuki n, L. Nguyen, E. Schechter*, L. Borst n, J. Yoder n ...

co-author countries: United States of America 🇺🇸
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Abad n, K. Cheng n

co-author countries: United States of America 🇺🇸

Contributors: X. Mei n, D. Zhu n, J. Li n, K. Huang n, S. Hu n, Z. Li n, B. Juan Abad n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
Sources: Web Of Science, ORCID
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang*, D. Zhu*, Z. Li*, K. Huang*, S. Hu*, H. Lutz*, M. Xie*, X. Mei* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: S. Zhang*, D. Zhu*, Z. Li*, K. Huang*, S. Hu*, H. Lutz*, M. Xie*, X. Mei* ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
Sources: Web Of Science, ORCID
Added: October 12, 2021

2021 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n, X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang*, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
Sources: Web Of Science, ORCID
Added: March 6, 2021

2021 review

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

By: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: S. Zhang n, D. Zhu n, X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang*, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
Sources: Web Of Science, ORCID
Added: March 6, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng

co-author countries: United States of America 🇺🇸

Contributors: J. Li n, S. Hu n, D. Zhu n, K. Huang n, X. Mei n, B. Abad n, K. Cheng

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
Sources: Web Of Science, ORCID
Added: June 10, 2021

2021 journal article

Bioengineering Technologies for Cardiac Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, 9.

By: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

co-author countries: United States of America 🇺🇸

Contributors: M. Chingale n, D. Zhu n, K. Cheng n & K. Huang

author keywords: bioengineering; cardiac repair; cell reprogramming; exosome; cardiac patch; targeting
Sources: Web Of Science, ORCID, Crossref
Added: June 28, 2021

2021 review

Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?

[Review of ]. CELLS, 10(3).

By: D. Zhu n & K. Cheng n

co-author countries: United States of America 🇺🇸

Contributors: D. Zhu n & K. Cheng n

author keywords: stem cell; myocardial infarction; cardiovascular diseases; acellular therapy; exosomes; paracrine effects; biomedical engineering; biomaterials
MeSH headings : Cell- and Tissue-Based Therapy / methods; Heart Failure / pathology; Heart Failure / therapy; Humans; Myocardium / pathology; Myocytes, Cardiac / metabolism; Tissue Engineering / methods
Sources: Web Of Science, ORCID
Added: March 15, 2021

2021 review

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 173, 504–519.

By: M. Liu n, B. Abad n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Cardiac fibrosis; Cardiac fibroblast; Myofibroblasts; Myocardial remodeling; Reprogramming; Drug delivery systems
MeSH headings : Animals; Drug Delivery Systems; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Fibrosis / metabolism; Fibrosis / pathology; Humans; Myocardium / metabolism; Myocardium / pathology; Myofibroblasts / metabolism; Myofibroblasts / pathology; Pharmaceutical Preparations / chemistry
Source: Web Of Science
Added: June 28, 2021

2021 article

Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation

Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY, Vol. 9.

By: A. Carter n, K. Popowski n, K. Cheng n, A. Greenbaum n, F. Ligler n & A. Moatti n

co-author countries: United States of America 🇺🇸
author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
Sources: Web Of Science, ORCID
Added: September 25, 2021

2021 review

Exosome therapeutics for COVID-19 and respiratory viruses

[Review of ]. VIEW, 2(3).

By: K. Popowski n, P. Dinh n, A. George n, H. Lutz n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: COVID-19; exosomes; respiratory viruses; SARS-CoV-2
Sources: Web Of Science, ORCID
Added: July 19, 2021

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

co-author countries: United States of America 🇺🇸

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
Sources: Web Of Science, ORCID
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
Sources: Web Of Science, ORCID
Added: February 21, 2022

2021 article

Generation and Manipulation of Exosomes

CARDIAC REGENERATION, Vol. 2158, pp. 295–305.

By: S. Hu n, L. Qiao n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection
MeSH headings : Animals; Blood Platelets / chemistry; Cell Culture Techniques / methods; Cell Fractionation / methods; Cell Membrane / chemistry; Cell Membrane / metabolism; Exosomes / ultrastructure; Humans; Mice; Molecular Targeted Therapy; Myocardium / cytology; Peptides / analysis; Peptides / metabolism; Rats; Technology, Pharmaceutical / methods; Ultracentrifugation; Ultrasonic Waves
Sources: Web Of Science, ORCID
Added: August 30, 2021

2021 article

Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis

MELANOMA, Vol. 2265, pp. 417–425.

By: T. Allen* & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Circulating tumor cells; Metastasis; Intravital microscopy; Cancer Exodus Hypothesis; Extravasation; Angiopellosis; Zebrafish; Tumor infusion; Light sheet microscopy; Tumor cell isolation
MeSH headings : Animals; Animals, Genetically Modified; Cell Line, Tumor; Endothelial Cells / metabolism; Endothelial Cells / pathology; Intravital Microscopy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism; Neoplastic Cells, Circulating / pathology; Zebrafish
Source: Web Of Science
Added: August 30, 2021

2021 journal article

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

ADVANCED FUNCTIONAL MATERIALS, 31(15).

By: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: Z. Li n, D. Zhu n, Q. Hui*, J. Bi*, B. Yu*, Z. Huang*, S. Hu n, Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
Sources: Web Of Science, ORCID
Added: February 22, 2021

2021 journal article

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

NATURE COMMUNICATIONS, 12(1).

By: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

co-author countries: United States of America 🇺🇸

Contributors: D. Zhu n, Z. Li n, K. Huang n, T. Caranasos*, J. Rossi* & K. Cheng n

MeSH headings : Animals; Cardiac Surgical Procedures; Cardiovascular Agents / administration & dosage; Cell Differentiation / physiology; Drug Delivery Systems / methods; Exosomes / metabolism; Extracellular Matrix / chemistry; Hydrogels / administration & dosage; Hydrogels / chemistry; Induced Pluripotent Stem Cells / transplantation; Male; Materials Testing; Mesenchymal Stem Cells / cytology; Mice; Minimally Invasive Surgical Procedures / methods; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Pericardium; Rats; Swine
Sources: Web Of Science, ORCID
Added: March 6, 2021

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

co-author countries: United States of America 🇺🇸

Contributors: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
Sources: Web Of Science, ORCID
Added: September 7, 2021

2021 journal article

Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology

Advanced Biology, 6(2), 2101133.

By: Y. Hsu n, K. Huang n & K. Cheng

co-author countries: United States of America 🇺🇸
author keywords: cardiac hypertrophy; cardiomyogenesis; heart failure; regeneration
MeSH headings : Biology; Heart Failure / therapy; Humans; Prognosis; Regeneration; Stroke Volume; Ventricular Function, Left
Sources: Web Of Science, ORCID, Crossref
Added: January 3, 2022

2021 journal article

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy

ACS NANO, 15(1), 1100–1110.

By: P. Zheng*, M. Fan*, H. Liu*, Y. Zhang*, X. Dai*, H. Li*, X. Zhou*, S. Hu n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Drug Delivery Systems; Humans; Hyperthermia, Induced; Hypoxia; Neoplasms / drug therapy; Phototherapy
Sources: Web Of Science, ORCID
Added: March 29, 2021

2021 review

Visualizing cancer extravasation: from mechanistic studies to drug development

[Review of ]. CANCER AND METASTASIS REVIEWS, 40(1), 71–88.

By: X. Cheng n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Cancer metastasis; Cancer cell extravasation; Cancer models; Cancer therapies
MeSH headings : Drug Development; Humans; Neoplasm Metastasis; Neoplastic Cells, Circulating / pathology; Transendothelial and Transepithelial Migration
Source: Web Of Science
Added: November 24, 2020

2020 review

Advances of exosome isolation techniques in lung cancer

[Review of ]. MOLECULAR BIOLOGY REPORTS, 47(9), 7229–7251.

By: E. Mahgoub*, E. Razmara*, A. Bitaraf*, F. Norouzi*, M. Montazeri*, R. Behzadi-Andouhjerdi*, M. Falahati*, K. Cheng n ...

co-author countries: Iran (Islamic Republic of) 🇮🇷 Qatar 🇶🇦 United States of America 🇺🇸
author keywords: Lung cancer; Exosome; Multi-vesicular bodies; Extracellular vesicles; MicroRNAs
MeSH headings : Biomarkers, Tumor / blood; Biomarkers, Tumor / isolation & purification; Cell-Free Nucleic Acids / blood; Cell-Free Nucleic Acids / isolation & purification; Circulating Tumor DNA / blood; Circulating Tumor DNA / isolation & purification; Exosomes / metabolism; Exosomes / pathology; Humans; Lung Neoplasms / blood; Lung Neoplasms / diagnosis; Lung Neoplasms / pathology
Source: Web Of Science
Added: August 31, 2020

2020 journal article

Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19

CARDIOVASCULAR RESEARCH, 116(2), 353–367.

By: P. Huang*, L. Wang*, Q. Li*, X. Tian*, J. Xu*, J. Xu*, Y. Xiong*, G. Chen* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Exosomes; Atorvastatin; MSCs; lncRNA H19; Myocardial infarction
MeSH headings : Angiogenic Proteins / metabolism; Animals; Apoptosis; Atorvastatin / pharmacology; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endothelial Cells / metabolism; Endothelial Cells / pathology; Exosomes / drug effects; Exosomes / metabolism; Exosomes / transplantation; Female; Humans; Inflammation Mediators / metabolism; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / genetics; Myocardial Infarction / metabolism; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; Rats, Sprague-Dawley; Recovery of Function; Up-Regulation; Ventricular Function, Left
Source: Web Of Science
Added: March 10, 2020

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.

By: T. Su n, K. Huang n, K. Mathews n, V. Scharf n, S. Hu n, Z. Li n, B. Frame*, J. Cores n ...

co-author countries: United States of America 🇺🇸
author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
Sources: Web Of Science, ORCID
Added: December 11, 2020

2020 journal article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

By: S. Hu n, Z. Li n, H. Lutz n, K. Huang n, T. Su n, J. Cores n, P. Dinh n, K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
Sources: Web Of Science, ORCID
Added: August 10, 2020

2020 review

Engineering better stem cell therapies for treating heart diseases

[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).

By: J. Li*, S. Hu* & K. Cheng*

author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
Sources: Web Of Science, ORCID
Added: May 26, 2020

2020 review

Exosome therapeutics for lung regenerative medicine

[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).

By: K. Popowski n, H. Lutz n, S. Hu n, A. George n, P. Dinh n & K. Cheng*

co-author countries: United States of America 🇺🇸
author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
Sources: Web Of Science, ORCID
Added: July 20, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
Sources: Web Of Science, ORCID
Added: March 23, 2020

2020 journal article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: H. Liang*, Z. Li n, Z. Ren*, Q. Jia*, L. Guo*, S. Li*, H. Zhang*, S. Hu n ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
Sources: Web Of Science, ORCID
Added: June 29, 2020

2020 review

Recent Development in Therapeutic Cardiac Patches

[Review of ]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7.

By: X. Mei n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: biomaterials; cardiac patch; myocardial infarction; cell therapy; cardiac tissue regeneration
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

By: Z. Li n, S. Hu n, K. Huang n, T. Su n, J. Cores n & K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
Sources: Web Of Science, ORCID
Added: March 2, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

By: L. Qiao n, S. Hu n, K. Huang n, T. Su n, Z. Li n, A. Vandergriff n, J. Cores n, P. Dinh n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
Sources: Web Of Science, ORCID
Added: March 30, 2020

2019 journal article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883–1891.

By: D. Shen n, Z. Li n, S. Hu n, K. Huang n, T. Su n, H. Liang n, F. Liu n, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 journal article

Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019)

Advanced Functional Materials, 29(4), 1970019.

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 21, 2020

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang*, Z. Li n, T. Su n, D. Shen*, S. Hu n & K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
Sources: Web Of Science, ORCID
Added: January 27, 2020

2019 review

Cell and biomaterial-based approaches to uterus regeneration

[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.

By: F. Liu n, S. Hu n, S. Wang* & K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells
Sources: Web Of Science, ORCID
Added: September 16, 2019

2019 review

Chemical Engineering of Cell Therapy for Heart Diseases

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.

By: Z. Li n, S. Hu n & K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics / methods; Cardiomyopathy, Dilated / therapy; Cell- and Tissue-Based Therapy / methods; Chemical Engineering / methods; Exosomes; Humans; Hydrogels / chemistry; Myocardial Infarction / therapy; Stem Cells / chemistry; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: July 15, 2019

2019 review

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

[Review of ]. CIRCULATION RESEARCH, 124(1), 161–169.

By: J. Berry*, W. Zhu*, Y. Tang*, P. Krishnamurthy*, Y. Ge*, J. Cooke*, Y. Chen*, D. Garry* ...

co-author countries: China 🇨🇳 France 🇫🇷 Japan 🇯🇵 Singapore 🇸🇬 United States of America 🇺🇸
author keywords: bioengineering; heart failure; myocardium; stem cells; tissue engineering
MeSH headings : Animals; Biological Science Disciplines; Biomedical Engineering; Biomedical Research; Cooperative Behavior; Diffusion of Innovation; Heart / physiopathology; Heart Failure / metabolism; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Humans; Interdisciplinary Communication; Myocardium / metabolism; Myocardium / pathology; Recovery of Function; Regeneration
Source: Web Of Science
Added: February 4, 2019

2019 journal article

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

ADVANCED HEALTHCARE MATERIALS, 8(14).

By: F. Liu*, S. Hu n, H. Yang n, Z. Li n, K. Huang n, T. Su n, S. Wang*, K. Cheng

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 12, 2019

2019 journal article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273–11282.

By: S. Hu n, Z. Li n, J. Cores n, K. Huang n, T. Su n, P. Dinh n, K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
Sources: Web Of Science, ORCID
Added: November 11, 2019

2019 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
Sources: Web Of Science, ORCID
Added: February 4, 2019

2019 journal article

Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection

ACS Applied Bio Materials, 2(2), 613–618.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: wound infection; porous organic polymers; Band-Aids; white light
Source: Crossref
Added: February 21, 2020

2019 journal article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.

By: L. Qiao*, S. Hu n, S. Liu*, H. Zhang*, H. Ma*, K. Huang n, Z. Li n, T. Su n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
Sources: Web Of Science, ORCID
Added: June 24, 2019

2018 journal article

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

Advanced Healthcare Materials, 8(2), 1801011.

By: K. Huang n, S. Hu n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell- and Tissue-Based Therapy / methods; Endocarditis / metabolism; Endocarditis / therapy; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / physiology; Myocarditis / metabolism; Myocarditis / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanomedicine / methods; Paracrine Communication; Tissue Engineering / methods
Sources: Web Of Science, ORCID, Crossref
Added: February 11, 2019

2018 review

Body builder: from synthetic cells to engineered tissues

[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.

By: S. Hu n, B. Ogle* & K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Artificial Cells / metabolism; Humans; Models, Biological; Regenerative Medicine; Tissue Engineering / methods
Sources: Web Of Science, ORCID
Added: November 12, 2018

2018 journal article

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.

By: T. Su n, K. Huang n, M. Daniele n, M. Hensley n, A. Young n, J. Tang n, T. Allen n, A. Vandergriff n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
Sources: Web Of Science, ORCID
Added: October 29, 2018

2018 journal article

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

By: J. Tang n, J. Wang n, K. Huang n, Y. Ye n, T. Su n, L. Qiao n, M. Hensley n, T. Caranasos* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
Sources: Web Of Science, ORCID
Added: December 31, 2018

2018 journal article

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Stem Cells Translational Medicine, 7(4), 354–359.

By: J. Tang n, J. Cores n, K. Huang n, X. Cui*, L. Luo*, J. Zhang n, T. Li*, L. Qian*, K. Cheng n

co-author countries: China 🇨🇳 Japan 🇯🇵 New Zealand 🇳🇿 United States of America 🇺🇸
author keywords: Myocardial injury; Stem cell therapy; Synthetic stem cells; Biomaterials
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart / physiology; Heart Diseases / therapy; Humans; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / cytology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan n, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536–6544.

By: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona n, C. Shao* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸

Contributors: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona n, C. Shao* ...

author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
Sources: Crossref, ORCID
Added: September 10, 2019

2018 article

Metastatic melanoma and cervical tumor cell clusters can exit blood vessels through angiopellosis augmenting tumor formation ability

Allen, T., Amu, E., Asad, D., & Cheng, K. (2018, July). CANCER RESEARCH, Vol. 78.

By: T. Allen n, E. Amu n, D. Asad n & K. Cheng n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: June 17, 2019

2018 journal article

NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells

ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796.

co-author countries: Australia 🇦🇺 China 🇨🇳 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: injectable hydrogels; NIPAM microgel; thermo-responsive microgel; cardiac stromal cells; multicellular spheroids; heart repair
MeSH headings : Acrylamides / administration & dosage; Acrylamides / chemistry; Animals; Cellular Microenvironment / drug effects; Chemokine CXCL12 / genetics; Gene Expression Regulation / drug effects; Humans; Hydrogels / administration & dosage; Hydrogels / chemistry; Hydrophobic and Hydrophilic Interactions / drug effects; Insulin-Like Growth Factor I / genetics; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Polymers / administration & dosage; Polymers / chemistry; Rats; Stromal Cells / drug effects; Stromal Cells / pathology; Succinates / chemistry; T-Lymphocytes / drug effects; Vascular Endothelial Growth Factor A / genetics
Source: Web Of Science
Added: December 3, 2018

2018 review

Platelets and their biomimetics for regenerative medicine and cancer therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.

By: Z. Li n, S. Hu n & K. Cheng n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Blood Platelets / chemistry; Blood Platelets / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Drug Carriers / chemistry; Humans; Nanoparticles / chemistry; Regenerative Medicine / methods
Sources: Web Of Science, ORCID
Added: December 10, 2018

2018 journal article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193–12200.

By: Z. Li n, D. Shen*, S. Hu n, T. Su n, K. Huang n, F. Liu n, L. Hou*, K. Cheng

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: January 14, 2019

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

By: E. Mihalko n, K. Huang n, E. Sproul n, K. Cheng n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
Sources: Crossref, ORCID
Added: February 21, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

THERANOSTICS, 8(7), 1869–1878.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart

Tissue Engineering Part C: Methods, 23(3), 146–155.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
MeSH headings : Animals; Biocompatible Materials / chemistry; Blood Platelets / metabolism; Fibrin / metabolism; Heart / physiology; Male; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Paintings; Rats; Rats, Sprague-Dawley; Regeneration / physiology
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

Respiratory Research, 18(1).

By: P. Dinh n, J. Cores n, M. Hensley n, A. Vandergriff n, J. Tang n, T. Allen n, T. Caranasos*, K. Adler n, L. Lobo*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Pulmonary progenitor cells; Lung spheroid; Stem cell
MeSH headings : Adolescent; Aged; Animals; Biopsy; Bronchi / cytology; Bronchi / physiology; Cell Culture Techniques / methods; Female; Human Umbilical Vein Endothelial Cells / physiology; Humans; Infusions, Intravenous; Lung / cytology; Lung / physiology; Male; Mice; Mice, Nude; Middle Aged; Spheroids, Cellular / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Circulation Research, 120(11), 1768–1775.

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
author keywords: artificial cells; mesenchymal stem cells; myocardial infarction; regeneration; stem cells; tissue engineering
MeSH headings : Animals; Cells, Cultured; Humans; Lactic Acid / administration & dosage; Male; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Mice; Mice, Inbred C57BL; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Polyglycolic Acid / administration & dosage; Polylactic Acid-Polyglycolic Acid Copolymer; Positron-Emission Tomography / methods; Treatment Outcome
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction

ACS NANO, 11(10), 9738–9749.

co-author countries: Australia 🇦🇺 China 🇨🇳 United States of America 🇺🇸
author keywords: cardiac stem cells; nanogel; myocardial infarction; biomaterials; mouse model; pig model
MeSH headings : Acrylamides / chemistry; Acrylates / chemistry; Animals; Disease Models, Animal; Female; Humans; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanogels; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Surface Properties; Swine; Temperature
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver

Cell Transplantation, 26(12), 1868–1877.

By: W. Fagg*, N. Liu*, M. Yang*, K. Cheng*, E. Chung*, J. Kim*, G. Wu*, J. Fair*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Differentiation / physiology; Cell Proliferation / physiology; Cell Survival / physiology; Hepatocytes / cytology; Hepatocytes / physiology; Liver / cytology; Liver Regeneration / physiology; Mice; Mice, Inbred BALB C; Stem Cells / cytology; Stem Cells / physiology
Source: Crossref
Added: July 28, 2019

2017 journal article

Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis

STEM CELLS Translational Medicine, 6(10), 1905–1916.

By: J. Cores n, M. Hensley n, K. Kinlaw n, S. Rikard n, P. Dinh n, D. Paudel n, J. Tang n, A. Vandergriff n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Nature Communications, 8(1).

By: J. Tang n, D. Shen*, T. Caranasos*, Z. Wang*, A. Vandergriff n, T. Allen n, M. Hensley n, P. Dinh n ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Biomimetic Materials / pharmacology; Cell Fractionation; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / transplantation; Cell-Derived Microparticles / chemistry; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Culture Media, Conditioned / chemistry; Culture Media, Conditioned / isolation & purification; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor / genetics; Hepatocyte Growth Factor / metabolism; Humans; Injections, Intralesional; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Paracrine Communication; Recovery of Function / drug effects; Stem Cells / cytology; Stem Cells / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(10), 2432–2440.

By: Z. Wang*, N. Dong*, Y. Niu*, Z. Zhang*, C. Zhang*, M. Liu, T. Zhou*, Q. Wu*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Human villous trophoblasts; myocardial infarction; cell therapy; paracrine effects
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Chorionic Villi / transplantation; Collagen; Drug Combinations; Heart / physiopathology; Human Umbilical Vein Endothelial Cells / physiology; Humans; Laminin; Male; Mice, Inbred C57BL; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / physiology; Neovascularization, Physiologic; Proteoglycans; Rats; Regeneration; Transplantation, Heterologous; Trophoblasts / transplantation
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Angiopellosis as an Alternative Mechanism of Cell Extravasation

STEM CELLS, 35(1), 170–180.

By: T. Allen n, D. Gracieux n, M. Talib n, D. Tokarz n, M. Hensley n, J. Cores n, A. Vandergriff n, J. Tang n ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair

STEM CELLS TRANSLATIONAL MEDICINE, 5(6), 793–803.

By: D. Shen*, J. Tang n, M. Hensley n, T. Li*, T. Caranasos*, T. Zhang n, J. Zhang*, K. Cheng n

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
author keywords: Cardiac stem cells; Platelet fibrin gel; Matrix metalloproteinases; Heart repair
MeSH headings : Animals; Blood Platelets / metabolism; Dipeptides / administration & dosage; Disease Models, Animal; Echocardiography; Fibrin / administration & dosage; Humans; Matrix Metalloproteinase Inhibitors / administration & dosage; Matrix Metalloproteinases / metabolism; Myocardial Infarction / enzymology; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Rats; Regeneration / drug effects; Stem Cell Transplantation
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.

By: E. Henry n, J. Cores n, M. Hensley n, S. Anthony n, A. Vandergriff n, J. Andrade n, T. Allen n, T. Caranasos*, L. Lobo*, K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Adult lung stem cells; Mesenchymal stem cells; Pulmonary fibrosis; Spheroid cell culture
MeSH headings : Adult; Animals; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / pharmacology; Bleomycin / adverse effects; Bleomycin / pharmacology; Female; Heterografts; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Mice; Mice, SCID; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / therapy; Regeneration; Spheroids, Cellular / metabolism; Spheroids, Cellular / transplantation
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

By: M. Hensley n, J. Andrade n, B. Keene n, K. Meurs n, J. Tang n, Z. Wang*, T. Caranasos*, J. Piedrahita n ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Cellular Postconditioning Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction

CIRCULATION-HEART FAILURE, 8(2), 322–332.

By: H. Kanazawa*, E. Tseliou, K. Malliaras, K. Yee, J. Dawkins, G. De Couto, R. Smith, M. Kreke* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
author keywords: acute myocardial infarction; animal models; coronary interventions; ischemic postconditioning
MeSH headings : Animals; Coronary Vessels; Disease Models, Animal; Heart Failure / surgery; Injections, Intra-Arterial; Ischemic Postconditioning / methods; Myocardial Infarction / complications; Myocardial Infarction / therapy; Myocardial Reperfusion; Stem Cell Transplantation / methods; Swine; Swine, Miniature; Transplantation, Homologous; Ventricular Remodeling / physiology
Source: Web Of Science
Added: August 6, 2018

2015 chapter

Cryopreservation of Neonatal Cardiomyocytes

In Methods in Molecular Biology (Vol. 1299, pp. 153–160).

By: A. Vandergriff n, M. Hensley n & K. Cheng n

co-author countries: United States of America 🇺🇸
author keywords: Cardiomyocytes; Cryopreservation; Cardiac research
MeSH headings : Animals; Animals, Newborn; Cell Culture Techniques; Cells, Cultured; Cryopreservation / methods; Myocytes, Cardiac / cytology; Rats
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

Stem Cells International, 2015, 1–8.

By: A. Vandergriff n, J. de Andrade n, J. Tang n, M. Hensley n, J. Piedrahita n, T. Caranasos*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Journal of Visualized Experiments, (98).

By: A. Vandergriff n, M. Hensley n & K. Cheng n

co-author countries: Taiwan, Province of China 🇹🇼 United States of America 🇺🇸
author keywords: Developmental Biology; Issue 98; Cryopreservation; Cardiomyocytes; Cell-based Assay; Cell Culture; Cardiac Research; In Vitro Assay
MeSH headings : Actinin / analysis; Actinin / metabolism; Animals; Animals, Newborn; Cell Culture Techniques; Cell Separation / methods; Cell Survival / physiology; Cryopreservation / methods; Cryoprotective Agents / chemistry; Dimethyl Sulfoxide / chemistry; Freezing; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Sarcomeres / chemistry; Sarcomeres / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

By: J. Andrade n, J. Tang n, M. Hensley n, A. Vandergriff n, J. Cores n, E. Henry n, T. Allen n, T. Caranasos* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy

PLOS ONE, 9(12).

By: K. Yee, K. Malliaras, H. Kanazawa, E. Tseliou, K. Cheng n, D. Luthringer, C. Ho*, K. Takayama* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Administration, Cutaneous; Animals; Cardiomyopathies / complications; Cardiomyopathies / immunology; Cardiomyopathies / pathology; Cardiomyopathies / therapy; Catheters; Cicatrix / complications; Cicatrix / pathology; Dilatation; Endocardium / pathology; Female; Injections; Magnetic Resonance Imaging; Male; Myocardial Ischemia / complications; Myocardial Ischemia / immunology; Myocardial Ischemia / pathology; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Spheroids, Cellular / cytology; Spheroids, Cellular / transplantation; Survival Analysis; Sus scrofa; Transplantation, Homologous / adverse effects
Source: Web Of Science
Added: August 6, 2018

2014 journal article

CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction

Journal of the American Heart Association, 3(5), 001260.

By: K. Cheng, A. Ibrahim, M. Hensley, B. Sun, W. Liu, R. Smith, E. Marban

Source: NC State University Libraries
Added: April 24, 2021

2014 journal article

Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling

Stem Cells, 32, 2397–2406.

By: Y. Xie, A. Ibrahim, K. Cheng, K. Malliaras, D. Shen, B. Sun, H. Cho, M. Human

Source: NC State University Libraries
Added: July 28, 2019

2014 journal article

Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block

Journal of the American College of Cardiology, 64(24), 2575–2585.

By: E. Cingolani, V. Ionta*, K. Cheng*, A. Giacomello*, H. Cho & E. Marbán

co-author countries: Italy 🇮🇹
author keywords: arrhythmias; cardiac tissue engineering; gap junctions; heart conduction system
MeSH headings : Animals; Atrioventricular Block / pathology; Atrioventricular Block / physiopathology; Atrioventricular Block / surgery; Cell Transplantation / methods; Cells, Cultured; Electromagnetic Fields; Heart Conduction System / pathology; Heart Conduction System / physiopathology; Heart Conduction System / surgery; Heart Ventricles / pathology; Immunoconjugates / pharmacology; In Vitro Techniques; Magnets; Models, Cardiovascular; Myocytes, Cardiac / pathology; Rats; Rats, Sprague-Dawley; Sarcoglycans / immunology; Sarcoglycans / pharmacology; Tissue Engineering
Source: Crossref
Added: July 21, 2019

2014 journal article

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

Stem Cell Reports, 2(5), 606–619.

By: A. Ibrahim*, K. Cheng* & E. Marbán*

co-author countries: United States of America 🇺🇸
MeSH headings : Albumins / pharmacology; Aniline Compounds / pharmacology; Animals; Benzylidene Compounds / pharmacology; Cell Differentiation; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Disease Models, Animal; Exosomes / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Mice, SCID; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardial Infarction / therapy; Myocardial Infarction / veterinary; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Polyesters / pharmacology; Rats; Rats, Sprague-Dawley; Regeneration
Source: Crossref
Added: July 21, 2019

2014 journal article

Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair

JACC: Heart Failure, 2(1), 49–61.

By: K. Cheng*, K. Malliaras, R. Smith, D. Shen*, B. Sun, A. Blusztajn*, Y. Xie, A. Ibrahim ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
author keywords: cardiosphere-derived cells; heart failure; myocardial infarction; patient characteristics; stromal cell-derived factor 1
MeSH headings : Adult; Aged; Animals; Cardiomyopathies / physiopathology; Extracellular Matrix; Female; Graft Survival / physiology; Heart / physiology; Heart Failure / physiopathology; Humans; Intercellular Signaling Peptides and Proteins / metabolism; Male; Mice, SCID; Middle Aged; Myocardial Infarction / physiopathology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Oxidative Stress / physiology; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology; Transplantation, Autologous
Source: Crossref
Added: July 21, 2019

2014 journal article

Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells

STEM CELLS, 32(9), 2397–2406.

By: Y. Xie*, A. Ibrahim, K. Cheng*, Z. Wu*, W. Liang, K. Malliaras, B. Sun, W. Liu ...

co-author countries: China 🇨🇳
author keywords: Cardiosphere-derived cells; Cardiomyocyte; Proliferation; Paracrine factors; Cell-cell communication; beta 1 integrin
MeSH headings : Animals; Cell Communication / physiology; Cell Differentiation / physiology; Cells, Cultured; Humans; Integrin beta1 / metabolism; Male; Mice; Mice, SCID; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats
Source: Crossref
Added: August 28, 2020

2014 journal article

Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction

Journal of the American College of Cardiology, 63(2), 110–122.

By: K. Malliaras, R. Makkar, R. Smith, K. Cheng*, E. Wu*, R. Bonow*, L. Marbán, A. Mendizabal* ...

co-author countries: United States of America 🇺🇸
author keywords: cardiosphere-derived cells; myocardial infarction; myocardial regeneration
MeSH headings : Aged; Biopsy; Coronary Vessels; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Ventricles / pathology; Heart Ventricles / physiopathology; Humans; Injections, Intra-Arterial; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction / complications; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Recovery of Function; Stem Cell Transplantation / methods; Time Factors; Transplantation, Autologous; Treatment Outcome; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / surgery; Ventricular Function, Left / physiology
Source: Crossref
Added: July 21, 2019

2014 journal article

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Nature Communications, 5(1).

By: K. Cheng n, D. Shen*, M. Hensley n, R. Middleton, B. Sun, W. Liu, G. De Couto, E. Marbán

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction

BIOMATERIALS, 35(30), 8528–8539.

By: A. Vandergriff*, T. Hensley n, E. Henry*, D. Shen*, S. Anthony n, J. Zhang*, K. Cheng n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).

By: K. Cheng n, A. Ibrahim, M. Hensley n, D. Shen*, B. Sun, R. Middleton, W. Liu, R. Smith*, E. Marban

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy

European Heart Journal, 36(12), 751–762.

By: M. Aminzadeh*, E. Tseliou*, B. Sun*, K. Cheng*, K. Malliaras*, R. Makkar*, E. Marban*

co-author countries: United States of America 🇺🇸
author keywords: Cardiomyopathy; Heart failure; Cell transplantation
MeSH headings : Animals; Apoptosis / physiology; CREB-Binding Protein / metabolism; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / therapy; Cell Differentiation; Cell Lineage; Disease Models, Animal; Doxorubicin / pharmacology; Fibrosis; Graft Survival; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Injections, Intralesional; Male; Mice, Transgenic; Myocarditis / physiopathology; Myocardium / pathology; Myocytes, Cardiac / transplantation; Oxidative Stress / physiology; Protein Kinase C / metabolism; Signal Transduction; Stem Cell Transplantation / methods; Ventricular Remodeling / physiology
Source: Crossref
Added: July 21, 2019

2013 journal article

Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart

EMBO Molecular Medicine, 5(2), 191–209.

By: K. Malliaras, Y. Zhang, J. Seinfeld, G. Galang, E. Tseliou, K. Cheng*, B. Sun, M. Aminzadeh, E. Marbán

author keywords: cardiac regeneration; cardiomyogenesis; cell therapy; fate mapping; myocardial infarction
MeSH headings : Animals; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Female; Humans; Male; Mice; Mice, 129 Strain; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Stem Cells / cytology
Source: Crossref
Added: July 21, 2019

2013 journal article

INTRACORONARY CARDIOSPHERE-DERIVED CELLS AFTER MYOCARDIAL INFARCTION: MAGNETIC RESONANCE IMAGING ANALYSIS OF REGENERATION AND DETERMINANTS OF EFFICACY IN THE FINAL 1-YEAR RESULTS OF THE CADUCEUS TRIAL

Journal of the American College of Cardiology, 61(10), E104.

By: K. Malliaras*, K. Cheng*, R. Smith*, E. Wu*, R. Bonow*, A. Mendizabal*, G. Gerstenblith*, P. Johnston* ...

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: January 21, 2021

2013 journal article

Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction

Circulation, 128(25), 2764–2775.

By: K. Malliaras, R. Smith*, H. Kanazawa*, K. Yee*, J. Seinfeld*, E. Tseliou*, J. Dawkins*, M. Kreke* ...

co-author countries: United States of America 🇺🇸
author keywords: adult stem cells; allogeneic transplantation; cell transplantation; magnetic resonance imaging; myocardial infarction; regeneration
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Cicatrix / pathology; Disease Models, Animal; Gadolinium; Heart / physiopathology; Immune System / physiopathology; Magnetic Resonance Imaging / methods; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Regeneration / physiology; Swine; Swine, Miniature; Time Factors; Treatment Outcome
Source: Crossref
Added: July 21, 2019

2012 journal article

Brief Report: Mechanism of Extravasation of Infused Stem Cells

STEM CELLS, 30(12), 2835–2842.

By: K. Cheng*, D. Shen*, Y. Xie*, E. Cingolani, K. Malliaras & E. Marbán

co-author countries: China 🇨🇳
author keywords: Cell migration; Extravasation; Vasculature; Cell adhesion molecules; Metalloproteinases
MeSH headings : Animals; Cell Movement / physiology; Endothelium, Vascular / cytology; Endothelium, Vascular / metabolism; Female; Humans; Integrins / metabolism; MCF-7 Cells; Matrix Metalloproteinases / metabolism; Myocardium / cytology; Myocardium / metabolism; Peripheral Blood Stem Cell Transplantation / methods; Rats; Rats, Inbred WKY; Spheroids, Cellular; Stem Cells / cytology; Stem Cells / metabolism; Transplantation, Autologous
Source: Crossref
Added: July 21, 2019

2012 journal article

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells

Journal of the American College of Cardiology, 59(10), 942–953.

By: T. Li*, K. Cheng*, K. Malliaras, R. Smith*, Y. Zhang, B. Sun, N. Matsushita, A. Blusztajn* ...

co-author countries: Greece 🇬🇷 Japan 🇯🇵 United States of America 🇺🇸
author keywords: cardiac stem cells; mesenchymal stem cells; myocardial regeneration; paracrine effects
MeSH headings : Albumins / pharmacology; Animals; Apoptosis; Bone Marrow Cells / cytology; Cell Differentiation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; In Situ Nick-End Labeling; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mice; Mice, SCID; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Paracrine Communication / physiology; Polyesters / pharmacology; Rats; Rats, Inbred WKY; Stem Cell Transplantation; Wound Healing
Source: Crossref
Added: July 21, 2019

2012 journal article

Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction

Journal of Cellular and Molecular Medicine, 16(9), 2112–2116.

By: D. Shen*, K. Cheng* & E. Marbán

co-author countries: China 🇨🇳
author keywords: cell transplantation; stem cells; cardiospheres; myocardial infarction; dose effects
MeSH headings : Acute Disease; Animals; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Spheroids, Cellular; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / metabolism; Ventricular Remodeling
Source: Crossref
Added: July 28, 2019

2012 journal article

Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel

Biomaterials, 33(21), 5317–5324.

By: K. Cheng*, A. Blusztajn*, D. Shen*, T. Li*, B. Sun*, G. Galang*, T. Zarembinski*, G. Prestwich* ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
author keywords: Acute myocardial infarction; Biodegradable polymers; Hyaluronan; Cardiac stem cells
MeSH headings : Animals; Apoptosis / drug effects; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Survival / drug effects; Gelatin / pharmacology; Humans; Hyaluronic Acid / pharmacology; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Male; Mice; Microscopy, Fluorescence; Myocardium / cytology; Neovascularization, Physiologic / drug effects; Polymerization / drug effects; Spheroids, Cellular / cytology; Spheroids, Cellular / drug effects; Spheroids, Cellular / transplantation; Tissue Preservation
Source: Crossref
Added: July 28, 2019

2012 journal article

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

The Lancet, 379(9819), 895–904.

By: R. Makkar, R. Smith, K. Cheng*, K. Malliaras, L. Thomson, D. Berman, L. Czer, L. Marbán ...

co-author countries: United States of America 🇺🇸
MeSH headings : Cicatrix / etiology; Cicatrix / pathology; Coronary Vessels; Female; Heart / physiopathology; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocardium / pathology; Regeneration; Stem Cell Transplantation; Stroke Volume; Transplantation, Autologous; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / therapy
Source: Crossref
Added: July 28, 2019

2012 journal article

Intramyocardial Injection of Platelet Gel Promotes Endogenous Repair and Augments Cardiac Function in Rats With Myocardial Infarction

Journal of the American College of Cardiology, 59(3), 256–264.

By: K. Cheng*, K. Malliaras, D. Shen*, E. Tseliou, V. Ionta, J. Smith, G. Galang, B. Sun, C. Houde, E. Marbán

co-author countries: China 🇨🇳
author keywords: biomaterials; endogenous recruitment; myocardial infarction
MeSH headings : Animals; Blood Platelets; Female; Gels; Heart Function Tests / methods; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Random Allocation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration / physiology
Source: Crossref
Added: July 28, 2019

2012 journal article

Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells

Circulation, 125(1), 100–112.

By: K. Malliaras*, T. Li*, D. Luthringer*, J. Terrovitis*, K. Cheng*, T. Chakravarty*, G. Galang*, Y. Zhang* ...

co-author countries: United States of America 🇺🇸
author keywords: allogeneic transplantation; paracrine communication; regeneration; stem cells
MeSH headings : Animals; Cell Survival / physiology; Cells, Cultured; Female; Graft Survival / genetics; Graft Survival / physiology; Humans; Male; Myocardial Infarction / pathology; Myocardial Infarction / surgery; Myocytes, Cardiac / pathology; Myocytes, Cardiac / physiology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred BN; Rats, Inbred WKY; Spheroids, Cellular / pathology; Spheroids, Cellular / physiology; Spheroids, Cellular / transplantation; Transplantation, Homologous; Treatment Outcome
Source: Crossref
Added: July 28, 2019

2012 journal article

Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue

PLoS ONE, 7(9), e45074.

By: Y. Lai*, K. Cheng* & W. Kisaalita*

co-author countries: Georgia 🇬🇪

Ed(s): G. Cymbalyuk

MeSH headings : Animals; Calcium / metabolism; Calcium Channels / metabolism; Caveolae / physiology; Caveolin 1 / genetics; Caveolin 1 / metabolism; Cell Culture Techniques; Coated Materials, Biocompatible / chemistry; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gene Expression; Ion Channel Gating / physiology; Lactic Acid / chemistry; Mice; Molecular Imaging; Polyesters; Polymers / chemistry; Polystyrenes / chemistry; Superior Cervical Ganglion / cytology; Superior Cervical Ganglion / metabolism; Tissue Scaffolds
Source: Crossref
Added: July 21, 2019

2012 journal article

Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction

Biomaterials, 33(10), 2872–2879.

By: K. Cheng*, D. Shen*, J. Smith*, G. Galang*, B. Sun*, J. Zhang*, E. Marbán*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Cardiac stem cells; Platelet gel; Myocardial infarction; Cardiac regeneration
MeSH headings : Animals; Blood Platelets / cytology; Blood Platelets / ultrastructure; Cell Shape; Cells, Cultured; Endothelial Cells / cytology; Gels / pharmacology; Heart Function Tests; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration; Stem Cell Transplantation
Source: Crossref
Added: July 28, 2019

2011 journal article

Neural Cell 3D Microtissue Formation Is Marked by Cytokines' Up-Regulation

PLoS ONE, 6(10), e26821.

By: Y. Lai*, A. Asthana*, K. Cheng* & W. Kisaalita*

co-author countries: Georgia 🇬🇪

Ed(s): M. Wanunu

MeSH headings : Biomarkers; Cytokines / biosynthesis; Humans; Neural Stem Cells / cytology; Primary Cell Culture / methods; Tissue Engineering / methods; Up-Regulation
Source: Crossref
Added: July 28, 2019

2011 journal article

The CADUCEUS (CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction) Trial

Circulation, 124, 2365–2374.

By: R. Makkar, R. Smith, K. Cheng, K. Malliaras, L. Thomson, D. Berman, L. Czer, L. Marbán ...

Source: NC State University Libraries
Added: April 24, 2021

2011 journal article

The amelioration of cardiac dysfunction after myocardial infarction by the injection of keratin biomaterials derived from human hair

Biomaterials, 32(35), 9290–9299.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Heart; Keratin; Scaffold; Angiogenesis; Cardiac tissue engineering
MeSH headings : Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / pharmacology; Blotting, Western; Disease Models, Animal; Female; Hair / chemistry; Heart / drug effects; Heart / physiopathology; Heart Function Tests / drug effects; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Inflammation / complications; Inflammation / pathology; Injections; Keratins / administration & dosage; Keratins / pharmacology; Mechanical Phenomena / drug effects; Myocardial Infarction / complications; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Pathologic / complications; Neovascularization, Pathologic / pathology; Paracrine Communication / drug effects; Rats; Rats, Sprague-Dawley; Tissue Scaffolds / chemistry; Ventricular Remodeling / drug effects
Source: Crossref
Added: July 28, 2019

2010 journal article

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

STEM CELLS, 28(11), 2088–2098.

By: T. Li, K. Cheng*, S. Lee, S. Matsushita, D. Davis, K. Malliaras, Y. Zhang, N. Matsushita, R. Smith, E. Marbán

author keywords: Cardiac stem cells; Stem cell niche; Extracellular-matrix molecules; Adhesion molecule
MeSH headings : Animals; Blotting, Western; Cells, Cultured; Echocardiography; Extracellular Matrix / metabolism; Flow Cytometry; Histone Deacetylase 2 / metabolism; Humans; Insulin-Like Growth Factor I / metabolism; Integrin alpha2 / metabolism; Laminin / metabolism; Mice; Mice, SCID; Myocardial Infarction / metabolism; Myocardial Infarction / therapy; Myocardium / cytology; Myocardium / metabolism; Oxidative Stress / physiology; Polymerase Chain Reaction; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism; Telomerase / metabolism
Source: Crossref
Added: July 28, 2019

2010 journal article

Dedifferentiation and Proliferation of Mammalian Cardiomyocytes

PLoS ONE, 5(9), e12559.

By: Y. Zhang*, T. Li*, S. Lee*, K. Wawrowsky*, K. Cheng*, G. Galang*, K. Malliaras*, M. Abraham*, C. Wang*, E. Marbán*

co-author countries: United States of America 🇺🇸

Ed(s): A. Kowaltowski

MeSH headings : Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; GATA4 Transcription Factor / genetics; GATA4 Transcription Factor / metabolism; Homeobox Protein Nkx-2.5; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Male; Mice; Mice, Transgenic; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Rats, Inbred WKY; Transcription Factors / genetics; Transcription Factors / metabolism
Source: Crossref
Added: July 28, 2019

2010 journal article

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair

Cardiovascular Research, 89(1), 157–165.

By: T. Li*, K. Cheng*, K. Malliaras*, N. Matsushita*, B. Sun*, L. Marbán*, Y. Zhang*, E. Marbán*

co-author countries: United States of America 🇺🇸
author keywords: Physiological oxygen; Ex vivo expansion; Cardiac stem cells
MeSH headings : Adult; Adult Stem Cells / cytology; Adult Stem Cells / physiology; Adult Stem Cells / transplantation; Aneuploidy; Animals; Cell Differentiation; Cell Proliferation; Cellular Senescence; DNA Damage; Humans; In Vitro Techniques; Male; Mice; Mice, SCID; Muscle Development / physiology; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / cytology; Oxidative Stress; Oxygen / physiology; Reactive Oxygen Species / metabolism; Regeneration / physiology; Transplantation, Heterologous
Source: Crossref
Added: July 28, 2019

2010 journal article

Exploring cellular adhesion and differentiation in a micro-/nano-hybrid polymer scaffold

Biotechnology Progress, 26(3), 838–846.

By: K. Cheng* & W. Kisaalita*

co-author countries: United States of America 🇺🇸
author keywords: tissue engineering; scaffold; stem cell; micro-/nano-fabrication; adhesion
MeSH headings : Cell Adhesion; Cell Differentiation; Cells, Cultured; Fibroblasts / cytology; Humans; Materials Testing; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Nanostructures / chemistry; Nanostructures / ultrastructure; Neurons / cytology; Porosity; Shear Strength; Stem Cells / cytology; Tissue Engineering / methods; Tissue Scaffolds / chemistry
Source: Crossref
Added: July 28, 2019

2010 journal article

Heart to Heart

Circulation, 121(18), 1981–1984.

By: E. Marbán & K. Cheng*

author keywords: Editorials; heart; regenerative medicine; stem cells
MeSH headings : Bone Marrow Cells / cytology; Hematopoietic Stem Cell Transplantation; Humans; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Regeneration
Source: Crossref
Added: July 28, 2019

2010 journal article

Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction

Circulation Research, 106(10), 1570–1581.

By: K. Cheng*, T. Li*, K. Malliaras*, D. Davis*, Y. Zhang* & E. Marbán*

co-author countries: United States of America 🇺🇸
author keywords: cardiac progenitor cells; cell transplantation; myocardial infarction; targeted cell delivery
MeSH headings : Animals; Cell Differentiation; Cell Survival; Echocardiography; Female; Genes, sry; In Situ Nick-End Labeling; Inflammation / physiopathology; Iron; Male; Mesenchymal Stem Cell Transplantation / methods; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Polymerase Chain Reaction; Rats; Rats, Inbred WKY
Source: Crossref
Added: July 28, 2019

2009 journal article

Validation of the Cardiosphere Method to Culture Cardiac Progenitor Cells from Myocardial Tissue

PLoS ONE, 4(9), e7195.

By: D. Davis*, Y. Zhang*, R. Smith*, K. Cheng*, J. Terrovitis*, K. Malliaras*, T. Li*, A. White*, R. Makkar*, E. Marbán*

co-author countries: United States of America 🇺🇸

Ed(s): A. Leri

MeSH headings : Adult; Animals; Cell Culture Techniques / methods; Cell Lineage; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; Middle Aged; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats; Rats, Inbred WKY; Stem Cells / cytology
Source: Crossref
Added: July 28, 2019

2008 journal article

ENStem-A human neural progenitors cultured in 3D polystyrene scaffolds for high physiological relevance

Cellutions, 3, 4–6.

By: K. Cheng, Y. Lai & W. Kisaalita

Source: NC State University Libraries
Added: April 24, 2021

2008 journal article

Taking Cell Culture in Drug Discovery to the Third Dimension - A Patent Review

Recent Patents on Biomedical Engineeringe, 1(2), 103–115.

By: Y. Lai, L. Wang, K. Cheng* & W. Kisaalita*

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: July 28, 2019

2008 journal article

Three-dimensional polymer scaffolds for high throughput cell-based assay systems

Biomaterials, 29(18), 2802–2812.

By: K. Cheng*, Y. Lai* & W. Kisaalita*

co-author countries: United States of America 🇺🇸
author keywords: biomimetic material; ECM; cell culture; scaffold; stem cell
MeSH headings : Biocompatible Materials / chemistry; Biological Assay / methods; Blotting, Western; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Cell Line; Humans; Microscopy, Electron, Scanning; Neurons / cytology; Neurons / metabolism; Neurons / ultrastructure; Oligonucleotide Array Sequence Analysis; Polymers / chemistry; Porosity; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / ultrastructure; Tissue Scaffolds
Source: Crossref
Added: July 28, 2019

2003 journal article

Application potentials of on-line near infrared spectroscopy technology in manufacturing of traditional chinese medicine

China Journal of Chinese Materia Medica, 28, 1117–1119.

By: G. Hu, X. Lu, K. Cheng & D. Liu

Source: NC State University Libraries
Added: April 24, 2021