Ke Cheng

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Mei, X., Li, J., Wang, Z., Zhu, D., Huang, K., Hu, S., … Cheng, K. (2023, February 9). NATURE MATERIALS, Vol. 2.

3D Bioprinting Technology - One Step Closer Towards Cardiac Tissue Regeneration

[Review of ]. FRONTIERS IN MATERIALS, 8.

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE, Vol. 9.

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). ACS NANO, Vol. 9.

Engineering stem cell therapeutics for cardiac repair

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 171, 56–68.

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING, Vol. 7.

Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars

LANGMUIR, 38(29).

Inhalable dry powder mRNA vaccines based on extracellular vesicles

MATTER, 5(9), 2960–2974.

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

JOURNAL OF NANOBIOTECHNOLOGY, 20(1).

Sealing the heart from the inside out

Huang, K., & Cheng, K. (2022, December 29). NATURE BIOMEDICAL ENGINEERING.

Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). ADVANCED MATERIALS TECHNOLOGIES.

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

FRONTIERS IN ONCOLOGY, 11.

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

Bioengineering Technologies for Cardiac Regenerative Medicine

[Review of ]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 9.

Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?

[Review of ]. CELLS, 10(3).

Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 173, 504–519.

Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation

Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY, Vol. 9.

Exosome therapeutics for COVID-19 and respiratory viruses

[Review of ]. VIEW, 2(3).

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

Generation and Manipulation of Exosomes

CARDIAC REGENERATION, Vol. 2158, pp. 295–305.

Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis

MELANOMA, Vol. 2265, pp. 417–425.

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

ADVANCED FUNCTIONAL MATERIALS, 31(15).

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

NATURE COMMUNICATIONS, 12(1).

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology

Hsu, Y., Huang, K., & Cheng, K. (2021, December 22). ADVANCED BIOLOGY.

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy

ACS NANO, 15(1), 1100–1110.

Visualizing cancer extravasation: from mechanistic studies to drug development

[Review of ]. CANCER AND METASTASIS REVIEWS, 40(1), 71–88.

Advances of exosome isolation techniques in lung cancer

[Review of ]. MOLECULAR BIOLOGY REPORTS, 47(9), 7229–7251.

Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19

CARDIOVASCULAR RESEARCH, 116(2), 353–367.

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

Engineering better stem cell therapies for treating heart diseases

[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).

Exosome therapeutics for lung regenerative medicine

[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

Recent Development in Therapeutic Cardiac Patches

[Review of ]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7.

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

[Review of ]. ADVANCED HEALTHCARE MATERIALS, 8(2).

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883–1891.

Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019)

Advanced Functional Materials, 29(4), 1970019.

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

Cell and biomaterial-based approaches to uterus regeneration

[Review of ]. REGENERATIVE BIOMATERIALS, 6(3), 141–148.

Chemical Engineering of Cell Therapy for Heart Diseases

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696.

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

[Review of ]. CIRCULATION RESEARCH, 124(1), 161–169.

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

ADVANCED HEALTHCARE MATERIALS, 8(14).

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273–11282.

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection

ACS Applied Bio Materials, 2(2), 613–618.

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.

Body builder: from synthetic cells to engineered tissues

[Review of ]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42.

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

[Review of ]. STEM CELLS TRANSLATIONAL MEDICINE, 7(4), 354–359.

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536–6544.

Metastatic melanoma and cervical tumor cell clusters can exit blood vessels through angiopellosis augmenting tumor formation ability

Allen, T., Amu, E., Asad, D., & Cheng, K. (2018, July). CANCER RESEARCH, Vol. 78.

NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells

ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796.

Platelets and their biomimetics for regenerative medicine and cancer therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365.

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193–12200.

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

THERANOSTICS, 8(7), 1869–1878.

A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart

Tissue Engineering Part C: Methods, 23(3), 146–155.

Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies

Respiratory Research, 18(1).

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Circulation Research, 120(11), 1768–1775.

Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction

ACS NANO, 11(10), 9738–9749.

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver

Cell Transplantation, 26(12), 1868–1877.

Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis

STEM CELLS Translational Medicine, 6(10), 1905–1916.

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Nature Communications, 8(1).

Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(10), 2432–2440.

Angiopellosis as an Alternative Mechanism of Cell Extravasation

STEM CELLS, 35(1), 170–180.

Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair

STEM CELLS TRANSLATIONAL MEDICINE, 5(6), 793–803.

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

Cellular Postconditioning Allogeneic Cardiosphere-Derived Cells Reduce Infarct Size and Attenuate Microvascular Obstruction When Administered After Reperfusion in Pigs With Acute Myocardial Infarction

CIRCULATION-HEART FAILURE, 8(2), 322–332.

Cryopreservation of Neonatal Cardiomyocytes

In Methods in Molecular Biology (Vol. 1299, pp. 153–160).

Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy

Stem Cells International, 2015, 1–8.

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Journal of Visualized Experiments, (98).

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy

PLOS ONE, 9(12).

CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction

Journal of the American Heart Association, 3(5), 001260.

Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling

Stem Cells, 32, 2397–2406.

Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block

Journal of the American College of Cardiology, 64(24), 2575–2585.

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

Stem Cell Reports, 2(5), 606–619.

Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair

JACC: Heart Failure, 2(1), 49–61.

Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells

STEM CELLS, 32(9), 2397–2406.

Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction

Journal of the American College of Cardiology, 63(2), 110–122.

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Nature Communications, 5(1).

Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction

BIOMATERIALS, 35(30), 8528–8539.

Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).

Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy

European Heart Journal, 36(12), 751–762.

Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart

EMBO Molecular Medicine, 5(2), 191–209.

INTRACORONARY CARDIOSPHERE-DERIVED CELLS AFTER MYOCARDIAL INFARCTION: MAGNETIC RESONANCE IMAGING ANALYSIS OF REGENERATION AND DETERMINANTS OF EFFICACY IN THE FINAL 1-YEAR RESULTS OF THE CADUCEUS TRIAL

Journal of the American College of Cardiology, 61(10), E104.

Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction

Circulation, 128(25), 2764–2775.

Brief Report: Mechanism of Extravasation of Infused Stem Cells

STEM CELLS, 30(12), 2835–2842.

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells

Journal of the American College of Cardiology, 59(10), 942–953.

Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction

Journal of Cellular and Molecular Medicine, 16(9), 2112–2116.

Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel

Biomaterials, 33(21), 5317–5324.

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

The Lancet, 379(9819), 895–904.