Works (46)

Updated: March 2nd, 2024 06:15

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu nโ€‰, K. Huang nโ€‰, S. Hu nโ€‰, K. Popowski nโ€‰, K. Cheng

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Intrapericardial long non-coding RNAโ€“Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748โ€“1760.

By: D. Zhu nโ€‰, S. Liu n, K. Huang nโ€‰, J. Li n, X. Mei n, Z. Li n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
Sources: Web Of Science, Crossref, ORCID
Added: April 4, 2023

2023 article

Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions

Chen, J., Tang, X., Wang, Z., Perez, A., Yao, B., Huang, K., โ€ฆ King, M. W. W. (2023, June 26). BIOENGINEERING & TRANSLATIONAL MEDICINE, Vol. 6.

By: J. Chenโ€‰ n, X. Tang n, Z. Wang n, A. Perezโ€‰*, B. Yaoโ€‰*, K. Huang nโ€‰, Y. Zhang nโ€‰, M. King nโ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: abdominal adhesion; adhesion prevention; anti-adhesion strategy; anti-inflammatory; fibrinolytic agent; physical barrier; postsurgical adhesion
Sources: Web Of Science, ORCID
Added: July 24, 2023

2023 article

Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., โ€ฆ Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.

By: E. Chee n, E. Mihalko*, K. Nellenbach n, J. Sollinger n, K. Huang nโ€‰, M. Hon n, S. Pandit n, K. Cheng n, A. Brown n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
Sources: Web Of Science, ORCID
Added: November 6, 2023

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960โ€“2974.

By: K. Popowski nโ€‰, A. Moatti nโ€‰, G. Scull n, D. Silkstone n, H. Lutz n, B. Lรณpez de Juan Abadโ€‰ n, A. George nโ€‰, E. Belcherโ€‰ n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, Crossref, ORCID
Added: October 17, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135โ€“E150.

By: D. Zhu nโ€‰, S. Liu n, K. Huang nโ€‰, Z. Wang n, S. Hu nโ€‰, J. Li n, Z. Li n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
Sources: Web Of Science, ORCID
Added: November 14, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lvโ€‰*, D. Zhu nโ€‰, X. Mei n, K. Huang nโ€‰, X. Wangโ€‰ n, Z. Li n, S. Zhang n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: J. Li n, Y. Lvโ€‰*, D. Zhu nโ€‰, X. Mei n, K. Huang nโ€‰, X. Wangโ€‰ n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
Sources: Web Of Science, ORCID
Added: January 3, 2022

2022 journal article

Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 169, 113โ€“121.

By: G. Cheng n, D. Zhu nโ€‰, K. Huang nโ€‰ & T. Caranasosโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Exosomes; Heart Failure; Hydrogels / therapeutic use; Myocardial Infarction / drug therapy; Myocardium; Rats; Swine
Sources: Web Of Science, ORCID
Added: October 31, 2022

2022 journal article

Sealing the heart from the inside out

Nature Biomedical Engineering, 7(2), 87โ€“88.

By: K. Huang nโ€‰ & K. Cheng

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, ORCID, Crossref
Added: February 6, 2023

2022 article

Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., โ€ฆ Bai, W. (2022, June 29). ADVANCED MATERIALS TECHNOLOGIES, Vol. 6.

By: Y. Liuโ€‰*, R. Menon*, A. Putchaโ€‰ n, K. Huang nโ€‰, L. Bonilla n, R. Vora n, J. Liโ€‰ n, L. Zhangโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: biosensors; microneedles; optoelectronics; waveguides; wearable devices
Sources: Web Of Science, ORCID
Added: July 5, 2022

2022 journal article

Skinโ€Interfaced Deepโ€Tissue Sensing Patch via Microneedle Waveguides (Adv. Mater. Technol. 9/2022)

Advanced Materials Technologies, 7(9), 2270058.

By: Y. Liuโ€‰*, R. Menon*, A. Putchaโ€‰ n, K. Huang nโ€‰, L. Bonilla n, R. Vora n, J. Liโ€‰ n, L. Zhangโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Crossref, ORCID
Added: May 23, 2023

2021 journal article

3D Bioprinting Technology โ€“ One Step Closer Towards Cardiac Tissue Regeneration

Frontiers in Materials, 8.

By: M. Chingale n, K. Cheng n & K. Huangโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: 3D bioprinting; scaffolds-based 3D bioprinting; 3D cardiac patch; cardiac regeneration; cardiac repair
Sources: Web Of Science, Crossref, ORCID
Added: March 7, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099โ€“11111.

By: J. Yao*, K. Huang nโ€‰, D. Zhu nโ€‰, T. Chenโ€‰*, Y. Jiangโ€‰*, J. Zhangโ€‰*, L. Mi*, H. Xuan ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: J. Yao*, K. Huang nโ€‰, D. Zhu nโ€‰, T. Chenโ€‰*, Y. Jiangโ€‰*, J. Zhangโ€‰*, L. Mi*, H. Xuan ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
Sources: Web Of Science, ORCID
Added: August 23, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu nโ€‰, J. Li n, K. Huang nโ€‰, S. Hu nโ€‰, Z. Li n, B. Abadโ€‰ n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: X. Mei n, D. Zhu nโ€‰, J. Li n, K. Huang nโ€‰, S. Hu nโ€‰, Z. Li n, B. Juan Abadโ€‰ n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
Sources: Web Of Science, ORCID
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894โ€“8908.

By: S. Zhang*, D. Zhu*โ€‰, Z. Li*, K. Huang*โ€‰, S. Hu*โ€‰, H. Lutz*, M. Xie*, X. Mei* ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: S. Zhang*, D. Zhu*โ€‰, Z. Li*, K. Huang*โ€‰, S. Hu*โ€‰, H. Lutz*, M. Xie*, X. Mei* ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
Sources: Web Of Science, ORCID
Added: October 12, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu nโ€‰, D. Zhu nโ€‰, K. Huang nโ€‰, X. Mei n, B. Abadโ€‰ n, K. Cheng

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: J. Li n, S. Hu nโ€‰, D. Zhu nโ€‰, K. Huang nโ€‰, X. Mei n, B. Abadโ€‰ n, K. Cheng

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
Sources: Web Of Science, ORCID
Added: June 10, 2021

2021 journal article

Bioengineering Technologies for Cardiac Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, 9.

By: M. Chingale n, D. Zhu nโ€‰, K. Cheng n & K. Huangโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: M. Chingale n, D. Zhu nโ€‰, K. Cheng n & K. Huangโ€‰

author keywords: bioengineering; cardiac repair; cell reprogramming; exosome; cardiac patch; targeting
Sources: Web Of Science, Crossref, ORCID
Added: June 28, 2021

2021 journal article

Cardiac Repair: Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury (Adv. Sci. 1/2021)

Advanced Science, 8(1), 2170005.

By: M. Liu, H. Lutz, D. Zhu, K. Huang*โ€‰, Z. Li, P. Dinh, J. Gao, Y. Zhang, K. Cheng

Sources: Crossref, ORCID
Added: May 23, 2023

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174โ€“1188.

By: S. Hu nโ€‰, Z. Li n, D. Shen n, D. Zhu nโ€‰, K. Huang nโ€‰, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: S. Hu nโ€‰, Z. Li n, D. Shen n, D. Zhu nโ€‰, K. Huang nโ€‰, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
Sources: Web Of Science, ORCID
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767โ€“55779.

By: X. Wangโ€‰*, S. Hu nโ€‰, J. Li n, D. Zhu nโ€‰, Z. Wang n, J. Cores n, K. Cheng n, G. Liuโ€‰*, K. Huangโ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: X. Wangโ€‰*, S. Hu nโ€‰, J. Li n, D. Zhu nโ€‰, Z. Wang n, J. Cores n, K. Cheng n, G. Liuโ€‰*, K. Huangโ€‰

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
Sources: Web Of Science, ORCID
Added: February 21, 2022

2021 journal article

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

NATURE COMMUNICATIONS, 12(1).

By: D. Zhu nโ€‰, Z. Li n, K. Huang nโ€‰, T. Caranasosโ€‰*, J. Rossiโ€‰* & K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: D. Zhu nโ€‰, Z. Li n, K. Huang nโ€‰, T. Caranasosโ€‰*, J. Rossiโ€‰* & K. Cheng n

MeSH headings : Animals; Cardiac Surgical Procedures; Cardiovascular Agents / administration & dosage; Cell Differentiation / physiology; Drug Delivery Systems / methods; Exosomes / metabolism; Extracellular Matrix / chemistry; Hydrogels / administration & dosage; Hydrogels / chemistry; Induced Pluripotent Stem Cells / transplantation; Male; Materials Testing; Mesenchymal Stem Cells / cytology; Mice; Minimally Invasive Surgical Procedures / methods; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Pericardium; Rats; Swine
Sources: Web Of Science, ORCID
Added: March 6, 2021

2021 journal article

Publisher Correction: Exosome-eluting stents for vascular healing after ischaemic injury

Nature Biomedical Engineering, 5(10), 1239.

By: S. Huโ€‰ n, Z. Liโ€‰ n, D. Shenโ€‰ n, D. Zhu nโ€‰, K. Huang nโ€‰, T. Su n, P. Dinhโ€‰ n, J. Cores n, K. Chengโ€‰ n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: S. Huโ€‰ n, Z. Liโ€‰ n, D. Shenโ€‰ n, D. Zhu nโ€‰, K. Huang nโ€‰, T. Su n, P. Dinhโ€‰ n, J. Cores n, K. Chengโ€‰ n

Source: ORCID
Added: April 21, 2021

2021 journal article

Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology

Advanced Biology, 6(2), 2101133.

By: Y. Hsu n, K. Huang nโ€‰ & K. Cheng

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cardiac hypertrophy; cardiomyogenesis; heart failure; regeneration
MeSH headings : Biology; Heart Failure / therapy; Humans; Prognosis; Regeneration; Stroke Volume; Ventricular Function, Left
Sources: ORCID, Web Of Science, Crossref
Added: January 3, 2022

2020 journal article

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

Science Translational Medicine, 12(538).

By: K. Huang nโ€‰, E. Ozpinar nโ€‰, T. Su n, J. Tang, D. Shenโ€‰ n, L. Qiaoโ€‰ n, S. Huโ€‰ n, Z. Liโ€‰ n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Extracellular Matrix; Heart; Myocardial Infarction / therapy; Myocardium; Rats; Swine
Source: ORCID
Added: April 9, 2020

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309โ€“6320.

By: T. Su n, K. Huang nโ€‰, K. Mathews n, V. Scharf n, S. Hu nโ€‰, Z. Li n, B. Frame*, J. Cores n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
Sources: Web Of Science, ORCID
Added: December 11, 2020

2020 journal article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

By: S. Hu nโ€‰, Z. Li n, H. Lutz n, K. Huang nโ€‰, T. Su n, J. Cores n, P. Dinh n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
Sources: Web Of Science, ORCID
Added: August 10, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu nโ€‰, K. Popowski nโ€‰, M. Gracieux n, J. Cores n, K. Huang nโ€‰, M. Hensley n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
Sources: Web Of Science, ORCID
Added: March 23, 2020

2020 journal article

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

By: Z. Li n, S. Hu nโ€‰, K. Huang nโ€‰, T. Su n, J. Cores n & K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
Sources: Web Of Science, ORCID
Added: March 2, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474โ€“3487.

By: L. Qiaoโ€‰ n, S. Hu nโ€‰, K. Huang nโ€‰, T. Su n, Z. Li n, A. Vandergriff n, J. Cores n, P. Dinh n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
Sources: Web Of Science, ORCID
Added: March 30, 2020

2019 journal article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883โ€“1891.

By: D. Shen n, Z. Li n, S. Hu nโ€‰, K. Huang nโ€‰, T. Su n, H. Liang n, F. Liuโ€‰ n, K. Cheng n

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang*โ€‰, Z. Li n, T. Su n, D. Shen*, S. Hu nโ€‰ & K. Cheng n

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
Sources: Web Of Science, ORCID
Added: January 27, 2020

2019 journal article

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

ADVANCED HEALTHCARE MATERIALS, 8(14).

By: F. Liuโ€‰*, S. Hu nโ€‰, H. Yangโ€‰ n, Z. Li n, K. Huang nโ€‰, T. Su n, S. Wangโ€‰*, K. Cheng

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome
MeSH headings : Animals; Disease Models, Animal; Electrocoagulation; Endometrium / injuries; Female; Gynatresia / therapy; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hyaluronic Acid / chemistry; Hydrogels / chemistry; Mesenchymal Stem Cells / metabolism; Pregnancy; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 12, 2019

2019 chapter

Inhalation of Lung Spheroid Cell-Secretome and Exosomes Promotes Therapeutic Lung Repair in Rodent Models of Pulmonary Fibrosis

In A29 Emerging Concepts in Lung Fibrosis (Vol. 199, pp. 1225โ€“1225).

By: P. Dinhโ€‰ n, D. Paudel n, H. Brochuโ€‰ n, J. Cores n, K. Huang nโ€‰, M. Hensley n, E. Harrell n, A. Vandergriffโ€‰ n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Event: American Thoracic Society International Conference

Sources: NC State University Libraries, ORCID
Added: May 23, 2023

2019 journal article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273โ€“11282.

By: S. Hu nโ€‰, Z. Li n, J. Cores n, K. Huang nโ€‰, T. Su n, P. Dinh n, K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
Sources: Web Of Science, ORCID
Added: November 11, 2019

2019 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang nโ€‰, H. Maโ€‰*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
Sources: Web Of Science, ORCID
Added: February 4, 2019

2019 journal article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237โ€“2250.

By: L. Qiaoโ€‰*, S. Hu nโ€‰, S. Liu*, H. Zhangโ€‰*, H. Ma*, K. Huang nโ€‰, Z. Li n, T. Su n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
Sources: Web Of Science, ORCID
Added: June 24, 2019

2018 journal article

A New Era of Cardiac Cell Therapy: Opportunities and Challenges

Advanced Healthcare Materials, 8(2), 1801011.

By: K. Huang nโ€‰, S. Hu nโ€‰ & K. Cheng n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell- and Tissue-Based Therapy / methods; Endocarditis / metabolism; Endocarditis / therapy; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / physiology; Myocarditis / metabolism; Myocarditis / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nanomedicine / methods; Paracrine Communication; Tissue Engineering / methods
Sources: Web Of Science, ORCID, Crossref
Added: February 11, 2019

2018 journal article

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088โ€“33096.

By: T. Su n, K. Huang nโ€‰, M. Daniele n, M. Hensley n, A. Young n, J. Tang n, T. Allen n, A. Vandergriffโ€‰ n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
Sources: Web Of Science, ORCID
Added: October 29, 2018

2018 journal article

Cardiac cell-integrated microneedle patch for treating myocardial infarction

SCIENCE ADVANCES, 4(11).

By: J. Tang n, J. Wang n, K. Huang nโ€‰, Y. Ye n, T. Su n, L. Qiaoโ€‰ n, M. Hensley n, T. Caranasosโ€‰* ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cells, Cultured; Microtechnology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Needles; Rats; Rats, Inbred WKY; Regeneration; Stromal Cells / cytology; Stromal Cells / transplantation; Swine; Tissue Engineering / instrumentation
Sources: Web Of Science, ORCID
Added: December 31, 2018

2018 journal article

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Stem Cells Translational Medicine, 7(4), 354โ€“359.

By: J. Tang n, J. Cores n, K. Huang nโ€‰, X. Cuiโ€‰*, L. Luoโ€‰*, J. Zhang n, T. Liโ€‰*, L. Qianโ€‰*, K. Cheng n

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ Japan ๐Ÿ‡ฏ๐Ÿ‡ต New Zealand ๐Ÿ‡ณ๐Ÿ‡ฟ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Myocardial injury; Stem cell therapy; Synthetic stem cells; Biomaterials
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart / physiology; Heart Diseases / therapy; Humans; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / cytology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536โ€“6544.

By: H. Liang n, K. Huang nโ€‰, T. Su n, Z. Liโ€‰ n, S. Huโ€‰ n, P. Dinhโ€‰ n, E. Wrona n, C. Shaoโ€‰* ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Contributors: H. Liang n, K. Huang nโ€‰, T. Su n, Z. Liโ€‰ n, S. Huโ€‰ n, P. Dinhโ€‰ n, E. Wrona n, C. Shaoโ€‰* ...

author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
MeSH headings : Animals; Apoptosis; Biomimetic Materials / chemistry; Biomimetic Materials / therapeutic use; Carbon Tetrachloride; Cell Line; Cell Proliferation; Disease Models, Animal; Erythrocyte Membrane / chemistry; Humans; Liver Failure, Acute / chemically induced; Liver Failure, Acute / pathology; Liver Failure, Acute / physiopathology; Liver Failure, Acute / therapy; Liver Regeneration; Male; Mesenchymal Stem Cells / chemistry; Mice; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / therapeutic use
Sources: Crossref, ORCID
Added: September 10, 2019

2018 journal article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193โ€“12200.

By: Z. Li n, D. Shen*, S. Hu nโ€‰, T. Su n, K. Huang nโ€‰, F. Liuโ€‰ n, L. Houโ€‰*, K. Cheng

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
Sources: Web Of Science, ORCID
Added: January 14, 2019

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826โ€“7837.

By: E. Mihalkoโ€‰ n, K. Huang nโ€‰, E. Sproul n, K. Cheng n & A. Brown n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
Sources: Crossref, ORCID
Added: February 21, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17โ€“26.

By: J. Tangโ€‰ n, T. Su n, K. Huangโ€‰, P. Dinh n, Z. Wangโ€‰*, A. Vandergriff n, M. Hensley n, J. Cores n ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ Japan ๐Ÿ‡ฏ๐Ÿ‡ต United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

THERANOSTICS, 8(7), 1869โ€“1878.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction
MeSH headings : Administration, Intravenous; Animals; Biological Products / administration & dosage; Biological Products / pharmacokinetics; Biological Therapy / methods; Cell Survival; Disease Models, Animal; Echocardiography; Exosomes; Molecular Targeted Therapy / methods; Myocardial Infarction / therapy; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Peptides / administration & dosage; Peptides / pharmacokinetics; Rats; Treatment Outcome
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Hydrodynamically Controlled Fabrication of Three-dimensional Microvasculature for Engineering Thick Vascularized Cardiac Tissues

Tissue Engineering Part A, 23(S1), 134โ€“134.

By: T. Su, M. Daniele, P. Erb, K. Huangโ€‰, M. Hensley, A. Young, T. Allen, A. Vandergriff ...

Event: 2017 TERMIS at Charlotte, NC on December 3-6, 2017

Source: NC State University Libraries
Added: May 23, 2023

Funding History

Funding history based on the linked ORCID record. Updated: July 6th, 2023 11:42

grant July 1, 2021 - June 30, 2024
A Minimal-Invasively Injectable SynCSC Adhesive (MISA) for Aging Rats with Heart Failure
American Heart Association

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