Keilian John Macculloch

Works (6)

Updated: January 4th, 2025 05:03

2024 article

Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange

Mcbride, S. J., Macculloch, K., Tomhon, P., Browning, A., Meisel, S., Abdulmojeed, M., … Theis, T. (2024, December 10). CHEMMEDCHEM, Vol. 12.

By: S. Mcbride n, K. Macculloch n, P. Tomhon* , A. Browning n, S. Meisel n, M. Abdulmojeed n, B. Goodson *, E. Chekmenev *, T. Theis n 

author keywords: Hyperpolarization; NMR; SABRE; Alpha-ketocarboxylate; Parahydrogen
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 11, 2024

2024 journal article

SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR

JOURNAL OF MAGNETIC RESONANCE OPEN, 19.

By: A. Ortmeier n, K. MacCulloch n, D. Barskiy *, N. Kempf *, J. Myers *, R. Koerber, A. Pravdivtsev *, K. Buckenmaier *, T. Theis n 

author keywords: Hyperpolarization; SABRE; Parahydrogen; ZULF-NMR; Pyruvate
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Sources: Web Of Science, NC State University Libraries
Added: May 28, 2024

2023 journal article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo

JOURNAL OF MAGNETIC RESONANCE OPEN, 16-17.

By: K. Macculloch n, A. Browning n, D. Bedoya, S. Mcbride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen * ...

Contributors: K. MacCulloch n, A. Browning n, D. Guarin Bedoya, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen * ...

author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 15, 2023

2023 article

Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.

By: K. MacCulloch n, A. Browning n, P. TomHon n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n 

Contributors: K. MacCulloch n, A. Browning n, P. Tomhon n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n 

MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
TL;DR: The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%). (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 11, 2023

2023 journal article

Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.

By: A. Browning n, K. Macculloch n, P. TomHon n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n 

Contributors: A. Browning n, K. Macculloch n, P. TomHon n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n 

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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2023

2021 article

Hyperpolarization of common antifungal agents with SABRE

MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.

By: K. MacCulloch n, P. Tomhon n , A. Browning n, E. Akeroyd n, S. Lehmkuhl  n, E. Chekmenev *, T. Theis n 

Contributors: K. MacCulloch n, P. Tomhon n , A. Browning n, E. Akeroyd n, S. Lehmkuhl  n, E. Chekmenev *, T. Theis n 

author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
TL;DR: This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 21, 2021

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