Works (172)

Updated: April 3rd, 2024 20:13

2024 article

Clinical outcome of idiopathic juvenile ventricular arrhythmias in 25 dogs

Reuter, A., DeFrancesco, T. C., Robertson, J. B., & Meurs, K. M. (2024, February). JOURNAL OF VETERINARY CARDIOLOGY, Vol. 51, pp. 188–194.

By: A. Reuter*, T. DeFrancesco n, J. Robertson* & K. Meurs n

author keywords: German Shepherd; Ventricular premature beats; Sudden cardiac death
TL;DR: In most cases, idiopathic juvenile ventricular arrhythmias had a favorable long-term prognosis with reduced ectopy over time in this case series. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 28, 2024

2023 journal article

Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic results of the RAPACAT trial

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(11), 1628–1637.

By: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

Contributors: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

author keywords: HCM; sirolimus; occult; cat; mTOR
TL;DR: It is demonstrated that DR rapamycin was well tolerated and may prevent or delay progressive LV hypertrophy in cats with subclinical HCM and no demographic, echocardiographic, or clinicopathologic values were significantly different between study groups at baseline, confirming successful randomization. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 6, 2024

2023 journal article

Evaluation of Renin-Angiotensin-Aldosterone System Components and Enzymes in Systemically Hypertensive Cats Receiving Amlodipine

ANIMALS, 13(22).

By: D. Adin*, C. Atkins n, O. Domenig, C. Glahn, T. Defrancesco n & K. Meurs n

author keywords: feline; blood pressure; kidney
TL;DR: The findings suggest that the use of concurrent RAAS-suppressant therapy, specifically aldosterone antagonism, in amlodipine-treated SHT cats with chronic kidney disease might be indicated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 journal article

Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease

Scientific Reports, 13(1).

By: A. Walker*, R. Li*, N. Nguyen*, C. Jauregui*, K. Meurs n, A. Gagnon*, J. Stern*

MeSH headings : Animals; Dogs; Arrhythmogenic Right Ventricular Dysplasia; Autoantibodies; Dog Diseases / metabolism; Heart Atria; Prospective Studies; Desmoglein 2 / immunology
TL;DR: This prospective study is the first to evaluate dogs of various breeds and cardiac disease state for anti-desmoglein-2 antibodies and found correlation with some measures of disease severity requires further study with larger populations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 26, 2023

2023 article

Investigation of the cardiac effects of exercise testing on apparently healthy Boxer dogs

Agarwal, D., Cote, E., O'Sullivan, L., Meurs, K. M., & Steiner, J. (2023, August 14). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

author keywords: arrhythmia; arrhythmogenic; cardiomyopathy; electrocardiogram; Holter; premature ventricular complex; right; tachyarrhythmia; tachycardia; telemetry; troponin; ventricular
TL;DR: Exercise testing may improve the binary classification of Boxer dogs with or without ACM by increasing the number of PVCs and [hs‐cTnI] in affected dogs to a greater degree than in unaffected dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response

Reimann, M. J., Faisst, D. N., Knold, M., Meurs, K. M., Stern, J. A., Cremer, S. E., … Olsen, L. H. (2023, September 24). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: M. Reimann*, D. Faisst*, M. Knold*, K. Meurs n, J. Stern*, S. Cremer*, J. Moller*, I. Ljungvall*, J. Haggstrom*, L. Olsen*

author keywords: dogs; genetic variation; heart disease; light transmission aggregometry; pharmacogenetics; platelet inhibition
TL;DR: Dogs with the PDE5A:E90K polymorphism did not appear to have altered platelet function or response to pimobendan treatment, and did not influence in vitro basal platelet aggregation response or the inhibitory effect of pimOBendan on platelets aggregation in CKCS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 23, 2023

2023 article

Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease

McManamey, A. K., DeFrancesco, T. C., Meurs, K. M., & Papich, M. G. (2023, September 30). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: A. McManamey*, T. DeFrancesco n, K. Meurs n & M. Papich n

author keywords: canine; heart failure; valvular heart disease; Vetmedin
TL;DR: The pharmacokinetic parameters were highly variable among this group of dogs with MMVD, and the variability was not associated with the dog's age, body weight or condition score, stage of heart disease, dose, serum creatinine, or alkaline phosphatase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 1, 2023

2023 journal article

The effect of taurine supplementation on the renin-angiotensin-aldosterone system of dogs with congestive heart failure

SCIENTIFIC REPORTS, 13(1).

By: S. Brethel*, S. Locker*, R. Girens*, P. Rivera*, K. Meurs n & D. Adin*

TL;DR: Overall, taurine only lowered AA2 in this group of dogs, however, response heterogeneity was noted, with some dogs showing RAAS suppression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2022 article

A novel mutation of the CLCN1 gene in a cat with myotonia congenita: Diagnosis and treatment

Woelfel, C., Meurs, K., Friedenberg, S., DeBruyne, N., & Olby, N. J. (2022, July 11). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 7.

By: C. Woelfel n, K. Meurs n, S. Friedenberg*, N. DeBruyne n & N. Olby n

author keywords: chloride channel; electromyography; nondystrophic myotonia; phenytoin
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / genetics; Cats; Chloride Channels / genetics; Electromyography / veterinary; Exons; Male; Mutation; Myotonia Congenita / diagnosis; Myotonia Congenita / drug therapy; Myotonia Congenita / genetics; Myotonia Congenita / veterinary
TL;DR: Phenytoin treatment was initiated at 3 mg/kg po q24 h and resulted in long‐term improvement and is reported for the first time its successful treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 18, 2022

2022 review

A review of the underlying genetics and emerging therapies for canine cardiomyopathies

[Review of ]. JOURNAL OF VETERINARY CARDIOLOGY, 40, 2–14.

By: L. Shen*, A. Estrada*, K. Meurs n, M. Sleeper*, C. Vulpe*, C. Martyniuk*, C. Pacak*

author keywords: Dilated cardiomyopathy; Arrhythmogenic right ventricular cardiomyo-pathy; Gene therapy; Gene editing; Clustered regularly in-terspaced short palin-dromic repeats
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathies / genetics; Cardiomyopathies / therapy; Cardiomyopathies / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / therapy; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / therapy; Dogs; Heart Failure / veterinary; Mutation
TL;DR: The known genetics of cardiomyopathies in dogs are discussed, existing gene therapy strategies and the status of their development in canines are reviewed, and ongoing challenges in the clinical translation of these technologies for treating heart disease are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 journal article

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*

JOURNAL OF VETERINARY CARDIOLOGY, 40, 99–109.

By: A. Walker*, T. DeFrancesco n, J. Bonagura n, B. Keene n, K. Meurs n, S. Tou n, K. Kurtz*, B. Aona* ...

author keywords: Canine; Survival; Grain-free; Echocardiography; Nutritional
MeSH headings : Animals; Dogs; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / veterinary; Diet / veterinary; Dog Diseases / diagnosis; Echocardiography / veterinary; Edible Grain; Heart Failure / complications; Heart Failure / therapy; Heart Failure / veterinary; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2022 article

Hands-on learning: from at-risk wolves to teeming Galapagos

Meurs, K. (2022, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 260, pp. 1140–1140.

By: K. Meurs n

MeSH headings : Animals; Behavior, Animal; Learning; Wolves
Sources: Web Of Science, NC State University Libraries
Added: July 18, 2022

2021 journal article

A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs

BMC Veterinary Research, 17(1).

By: K. Meurs n, K. Montgomery n, S. Friedenberg*, B. Williams n & B. Gilger n

author keywords: Corneal ulcer; Chronic; Superficial; Recurrent erosion; NOG; Boxer
MeSH headings : Animals; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Chronic Disease; Corneal Diseases / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Epithelium, Corneal / pathology; Gene Expression Regulation; Genetic Predisposition to Disease; Whole Genome Sequencing
TL;DR: Many Boxer dogs with SCCED have a genetic defect in NOG, a constitutive protein in the cornea which is a potent inhibitor of BMP, which likely regulate limbal epithelial progenitor cells (LEPC). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 9, 2021

2021 journal article

A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat

ORPHANET JOURNAL OF RARE DISEASES, 16(1).

author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR: This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1542–1546.

By: B. Hedgespeth n, A. Birkenheuer n, S. Friedenberg*, N. Olby n & K. Meurs n

author keywords: ciliary dysplasia; congenital; genetics; microtubule; pneumonia; whole genome sequencing
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Male; Mutation; Mutation, Missense; Respiratory Tract Infections / genetics; Respiratory Tract Infections / veterinary; Whole Genome Sequencing / veterinary
TL;DR: W Whole genome sequencing discovered a deleterious missense A/C mutation within the NAT10 gene, a gene essential for microtubule acetylation, appropriate ciliary development, and cytokinesis, suggesting a pathophysiological mechanism for this dog and highlighting an associated mutation or possible novel genetic cause of chronic respiratory infections in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 29, 2021

2021 journal article

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

ANIMAL GENETICS, 52(4), 542–544.

By: . K. O'Donnell n, D. Adin n, C. Atkins n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n

author keywords: cardiomyopathy; feline; genetic; HCM; mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Female; Genetic Variation; Male; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism
TL;DR: The lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement

VETERINARY DERMATOLOGY, 32(4), 379-+.

MeSH headings : Animals; Australia; Cattle; Dog Diseases / genetics; Dogs; Epidermolysis Bullosa, Junctional / genetics; Epidermolysis Bullosa, Junctional / veterinary; Laminin / genetics; Mutation, Missense; Nail Diseases / genetics; Nail Diseases / veterinary
TL;DR: A novel variant in LAMA3 caused a generalized and severe phenotype of JEB with an unique clinical presentation of upper airway obstruction in a litter of puppies with severe upper respiratory involvement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 19, 2021

2021 journal article

Myxomatous mitral valve disease in Miniature Schnauzers and Yorkshire Terriers: 134 cases (2007-2016)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 259(12), 1428–1432.

By: D. DeProspero n, . Kerry A. O'Donnell, T. DeFrancesco n, B. Keene n, S. Tou n, D. Adin n, C. Atkins n, K. Meurs n

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / veterinary; Prospective Studies
TL;DR: Features of the disease among Miniature Schnauzers and Yorkshire Terriers were similar, but there were also a few discernable differences between these 2 breeds and from historical findings for dogs with MMVD of other breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease

Reimann, M. J., Fredholm, M., Cremer, S. E., Christiansen, L. B., Meurs, K. M., Moller, J. E., … Olsen, L. H. (2021, October 2). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 10.

By: M. Reimann*, M. Fredholm*, S. Cremer*, L. Christiansen*, K. Meurs n, J. Moller*, J. Haggstrom*, J. Lykkesfeldt*, L. Olsen*

author keywords: dogs; ELISA; genetic variation; heart disease; HPLC; serum serotonin
MeSH headings : Animals; Dog Diseases / genetics; Dogs / genetics; Female; Male; Mitral Valve; Neurotransmitter Agents / blood; Polymorphism, Single Nucleotide; Prospective Studies; Serotonin Plasma Membrane Transport Proteins / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021

2021 article

Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease

Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021, June 27). HUMAN GENETICS, Vol. 6.

By: B. Williams n, S. Friedenberg*, B. Keene n, S. Tou n, T. DeFrancesco n & K. Meurs n

MeSH headings : Animals; Breeding; Dog Diseases / genetics; Dogs; Genetic Variation; Genome-Wide Association Study; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Mutation; Whole Genome Sequencing
TL;DR: The findings indicate that development of MMVD in the dog may be related to a combination of genetic and environmental factors that impact specific molecular pathways rather than a single shared genetic variant across or within breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2020 journal article

A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels

Neuromuscular Disorders, 30(5), 353–359.

By: N. Olby n, S. Friedenberg*, K. Meurs n, D. DeProspero n, J. Guevar n, J. Lau n, O. Yost n, L. Guo*, G. Shelton*

author keywords: Canine; Centronuclear myopathy; Myotubularin myopathy
MeSH headings : Animals; Dogs; Male; Myopathies, Structural, Congenital / genetics; Myopathies, Structural, Congenital / pathology; Myopathies, Structural, Congenital / physiopathology; Pedigree; Phenotype; Protein Tyrosine Phosphatases, Non-Receptor / genetics
TL;DR: The purpose of this study was to report the findings of clinical and genetic evaluation of a 3-month old male Boykin spaniel that presented with progressive weakness that causes a severe form of X-linked myotubular myopathy, comparable to the human counterpart. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 29, 2020

2020 journal article

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.

By: D. Adin*, C. Atkins n, O. Domenig, T. DeFrancesco n, B. Keene n, S. Tou n, J. Stern*, K. Meurs n

author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
TL;DR: The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020

2019 journal article

A QIL1 Variant Associated with Ventricular Arrhythmias and Sudden Cardiac Death in the Juvenile Rhodesian Ridgeback Dog

Genes, 10(2), 168.

By: K. Meurs n, S. Friedenberg*, N. Olby n, J. Condit n, J. Weidman*, S. Rosenthal*, G. Shelton*

author keywords: QIL1; Rhodesian ridgeback; arrhythmia; mitochondrial cristae
MeSH headings : Animals; Death, Sudden, Cardiac / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Male; Mitochondria, Muscle / metabolism; Mitochondria, Muscle / ultrastructure; Mitochondrial Proteins / genetics; Mutation; Tachycardia, Ventricular / genetics; Tachycardia, Ventricular / pathology; Tachycardia, Ventricular / veterinary
TL;DR: A natural animal model of mitochondrial cardiomyopathy provides a large animal model with which to study the development and progression of disease as well as genotypic phenotypic relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: March 25, 2019

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n, S. Friedenberg*, J. Kolb*, C. Saripalli*, P. Tonino*, K. Woodruff n, N. Olby n, B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 article

Applications and efficiencies of the first cat 63 K DNA array (vol 8, 7024, 2018)

Gandolfi, B., Alhaddad, H., Abdi, M., Bach, L. H., Creighton, E. K., Davis, B. W., … Lyons, L. A. (2019, March 12). SCIENTIFIC REPORTS, Vol. 9.

By: B. Gandolfi*, H. Alhaddad*, M. Abdi*, L. Bach*, E. Creighton*, B. Davis*, J. Decker*, N. Dodman* ...

TL;DR: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019

2019 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n, C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Genome-wide association analysis in West Highland White Terriers with atopic dermatitis

Veterinary Immunology and Immunopathology, 209, 1–6.

By: C. Agler n, S. Friedenberg*, T. Olivry n, K. Meurs n & N. Olby n

Contributors: C. Agler n, S. Friedenberg*, T. Olivry n, K. Meurs n & N. Olby n

author keywords: Allergy; Atopic; Canine; Dogs; Genetics; GWAS; Skin
MeSH headings : Animals; Cohort Studies; Dermatitis, Atopic / genetics; Dermatitis, Atopic / veterinary; Dog Diseases / genetics; Dogs; Female; Genome-Wide Association Study / veterinary; Genotyping Techniques / veterinary; Male; Polymorphism, Single Nucleotide
TL;DR: Atopic dermatitis in WHWT is associated with a region on CFA3 that contains several candidate genes and a homozygous variant in the F2R gene present in multiple breeds that also suffer from AD warrants further evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 15, 2019

2019 journal article

INVOLVEMENT OF SEROTONIN IN A CANINE MODEL OF MITRAL VALVE PROLAPSE: A COMPLEX GENETIC APPROACH

Journal of the American College of Cardiology, 73(9), 957.

By: B. Williams n, S. Friedenberg n & K. Meurs n

TL;DR: In humans, mitral valve prolapse is a common heritable condition and dogs serve as a spontaneous animal model of familial MVP, with several breeds genetically predisposed. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2019 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n, D. Adin n, . K. O'Donnell n, B. Keene n, C. Atkins n, T. DeFrancesco n, S. Tou n

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model

Gene, 697, 118–122.

By: O. Yost n, S. Friedenberg*, S. Jesty, N. Olby n & K. Meurs n

author keywords: Canine; Phospholamban; Dilated cardiomyopathy; Sudden death; Genetic
MeSH headings : Animals; Calcium-Binding Proteins / genetics; Calcium-Binding Proteins / physiology; Cardiomyopathy, Dilated / genetics; Death, Sudden / etiology; Death, Sudden / veterinary; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation / genetics; Pedigree; Polymorphism, Single Nucleotide / genetics; Sequence Analysis, DNA
TL;DR: A spontaneous canine model of familial DCM and sudden death with the R9H mutation is described, which was highly penetrant and resulted in sudden death in comparison to a reported human family. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 29, 2019

2018 journal article

A de novo mutation in the EXT2 gene associated with osteochondromatosis in a litter of American Staffordshire Terriers

Journal of Veterinary Internal Medicine, 32(3), 986–992.

By: S. Friedenberg*, D. Vansteenkiste*, O. Yost n, A. Treeful*, K. Meurs n, D. Tokarz n, N. Olby n

author keywords: bone; cartilage; genetics; multiple cartilaginous exostoses; mutation; osteochondroma
MeSH headings : Animals; Cartilage / pathology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Variation / genetics; Male; Mosaicism / veterinary; N-Acetylglucosaminyltransferases / genetics; Osteochondromatosis / genetics; Osteochondromatosis / pathology; Osteochondromatosis / veterinary; Polymorphism, Single Nucleotide / genetics; Whole Genome Sequencing / veterinary
TL;DR: The identical mutation arose de novo in a litter of American Staffordshire Terrier puppies and represents the first reported mutation associated with osteochondromatosis in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease

Pharmacogenetics and Genomics, 28(2), 37–40.

By: K. Meurs*, L. Olsen*, M. Reimann*, B. Keene*, C. Atkins*, D. Adin*, B. Aona*, J. Condit* ...

author keywords: angiotensin-converting enzyme; angiotensin-converting enzyme inhibitor; dog; polymorphism; valve
TL;DR: Dogs with the ACE variant had lower levels of ACE activity even in more advanced mitral valve disease than dogs without the variant, and the CKCS appears to have a high prevalence of theACE variant. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 18, 2020

2018 journal article

Applications and efficiencies of the first cat 63K DNA array

Scientific Reports, 8(1).

By: B. Gandolfi*, H. Alhaddad*, M. Abdi*, L. Bach*, E. Creighton*, B. Davis*, J. Decker*, N. Dodman* ...

TL;DR: The efficient array design and cat genotype dataset continues to advance the understanding of cat breeds and will support monogenic health studies across feline breeds and populations. (via Semantic Scholar)
Source: Crossref
Added: February 5, 2020

2018 journal article

Applications and efficiencies of the first cat 63K DNA array

Scientific Reports, 8.

By: B. Gandolfi, H. Alhaddad, M. Abdi, L. Bach, E. Creighton, B. Davis, J. Decker, N. Dodman ...

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Applications and efficiencies of the first cat 63K DNA array (vol 8, 7024, 2018)

Scientific Reports, Vol. 8.

By: B. Gandolfi, H. Alhaddad, M. Abdi, L. Bach, E. Creighton, B. Davis, J. Decker, N. Dodman ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Author Correction: Applications and efficiencies of the first cat 63K DNA array

Scientific Reports, 8(1).

By: B. Gandolfi*, H. Alhaddad*, M. Abdi*, L. Bach*, E. Creighton*, B. Davis*, J. Decker*, N. Dodman* ...

TL;DR: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2018 chapter

Cardiomyopathy in the boxer dog

In B. Scansen & J. Bonagura (Eds.), Current Veterinary Therapy (Small Animal Practice) (XVI). Philadelphia: WB Saunders.

By: K. Meurs

Ed(s): B. Scansen & J. Bonagura

Source: NC State University Libraries
Added: October 18, 2020

2018 journal article

Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene

Journal of Veterinary Internal Medicine, 32(2), 665–669.

By: J. Guevar n, N. Olby n, K. Meurs n, O. Yost n & S. Friedenberg*

author keywords: deafness; Doberman Pinscher; genetics; PTPRQ; vestibular disease
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Female; Frameshift Mutation; Hearing Loss / genetics; Hearing Loss / veterinary; Receptor-Like Protein Tyrosine Phosphatases, Class 3 / genetics; Vestibular Diseases / genetics; Vestibular Diseases / veterinary; Whole Genome Sequencing
TL;DR: The identification of a genetic alteration on the PTPRQ gene that is associated with congenital hearing and vestibular disorder in a young Doberman Pinscher dog is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2018 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n, S. Friedenberg*, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 chapter

Genetic cardiac disease in the dog and cat

In Current Veterinary Therapy (Small Animal Practice) XVI. Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2018 journal article

Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism

VETERINARY PATHOLOGY, 55(1), 177–181.

By: S. Friedenberg n, D. Brown, K. Meurs n & J. Law n

author keywords: Addison's disease; hypoadrenocorticism; endocrine diseases; adrenal gland; immunophenotype; lymphocyte subsets; dogs
MeSH headings : Addison Disease / pathology; Addison Disease / veterinary; Adrenal Glands / pathology; Animals; CD4 Lymphocyte Count / veterinary; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; In Situ Hybridization / veterinary; Lymphocyte Subsets / pathology; Male
TL;DR: It is shown that the lymphocytes are primarily CD4+ rather than CD8+. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Preliminary Assessment of a Novel 14-Day Electrocardiographic Adhesive Patch Monitor in Dogs

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 54(3), 138–143.

By: J. Lichtenberger n, K. Meurs n & E. Cote n

MeSH headings : Adhesives; Animals; Arrhythmias, Cardiac / diagnosis; Arrhythmias, Cardiac / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography, Ambulatory / instrumentation; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary
TL;DR: Extended continuous ECG monitoring with the APM is feasible in boxer dogs and provides interpretable recordings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n, J. Stern n, C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n, Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: An Update

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 47(5), 1103-+.

By: K. Meurs n

author keywords: Boxer; ARVC; Cardiomyopathy; Arrhythmia
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / genetics; Dogs; Mutation; Pedigree; Prognosis
TL;DR: Arrhythmogenic right ventricular cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and sometimes systolic dysfunction and heart failure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n, S. Tou n, C. Williams n, M. Breen n, K. Meurs n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 conference paper

Coalescence prevention algorithm for level set method

Proceedings of the asme fluids engineering division summer meeting, 2016, vol 1b.

By: M. Talley n, M. Zimmer n & I. Bolotnov n

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 journal article

Evaluation of artificial selection in Standard Poodles using whole-genome sequencing

Mammalian Genome, 27(11-12), 599–609.

By: S. Friedenberg n, K. Meurs n & T. Mackay n

MeSH headings : Animals; Breeding; Dogs; Genome / genetics; High-Throughput Nucleotide Sequencing; Homozygote; Integrin alpha2 / genetics; Phenotype; Polycomb-Group Proteins / genetics; Polymorphism, Single Nucleotide / genetics; Selection, Genetic; Tenascin / genetics
TL;DR: This study validated variants related to hair coat and skull morphology that have previously been identified as being under selective pressure in Poodles, and flagged additional polymorphisms in genes such as ITGA2B, CBX4, and TNXB that may represent strong candidates for other common Poodle disorders. (via Semantic Scholar)
Source: Crossref
Added: February 5, 2020

2016 journal article

Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing

Mammalian Genome, 28(1-2), 56–65.

By: S. Friedenberg n, K. Lunn n & K. Meurs n

MeSH headings : Addison Disease / genetics; Addison Disease / pathology; Animals; Dog Diseases / genetics; Dogs; Genome-Wide Association Study; Genotyping Techniques; Humans; Hypoadrenocorticism, Familial / genetics; Hypoadrenocorticism, Familial / pathology; Polymorphism, Single Nucleotide; Whole Genome Sequencing / methods
TL;DR: A genome-wide association study of 133 carefully phenotyped Standard Poodles found no markers significantly associated with primary hypoadrenocorticism and identified several candidate genes that may be fixed in both Standard POODles and a small population of dogs of related breeds. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 chapter

Genetics of Feline Heart Disease

In August's Consultations in Feline Internal Medicine (Vol. 7, pp. 412–416).

By: K. Meurs*

Sources: Crossref, NC State University Libraries
Added: September 2, 2022

2016 journal article

Genotype imputation in the domestic dog

MAMMALIAN GENOME, 27(9-10), 485–494.

By: S. Friedenberg n & K. Meurs n

MeSH headings : Alleles; Animals; Breeding; Computer Simulation; Dogs / genetics; Genotype; Models, Genetic; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
TL;DR: These findings demonstrate that genotype imputation from SNP array-derived data to whole genome-level genotypes is both feasible and accurate in the dog with appropriate breed overlap between the target and reference panels. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.

By: S. Friedenberg n, L. Chdid n, B. Keene n, B. Sherry n, A. Motsinger-Reif n & K. Meurs n

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
TL;DR: Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Ventricular arrhythmias in Rhodesian Ridgebacks with a family history of sudden death and results of a pedigree analysis for potential inheritance patterns

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 248(10), 1135–1138.

By: K. Meurs n, J. Weidman, S. Rosenthal, K. Lahmers* & S. Friedenberg n

MeSH headings : Animals; Arrhythmias, Cardiac / pathology; Arrhythmias, Cardiac / veterinary; Death, Sudden / veterinary; Dog Diseases; Dogs; Female; Genetic Predisposition to Disease; Male; Pedigree
TL;DR: Holter monitoring of Rhodesian Ridgebacks with a family history of an arrhythmia or sudden death is recommended for early diagnosis of disease and an autosomal recessive pattern of inheritance in the studied dogs was likely, and inbreeding should be strongly discouraged. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Antiarrhythmic Agents

In Veterinary Pharmacology and Therapeutics (10th ed.). Philadelphia: Wiley-Blackwell.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2015 chapter

Basic veterinary genetics

In Ettinger’s Textbook of Veterinary Internal Medicine (8th ed.). Elsevier, St Louis.

By: K. Meurs & J. Stern

Source: NC State University Libraries
Added: October 10, 2020

2015 journal article

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

By: M. Hensley n, J. Andrade n, B. Keene n, K. Meurs n, J. Tang n, Z. Wang*, T. Caranasos*, J. Piedrahita n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR: It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 chapter

Clinical veterinary genetics

In Ettinger’s Textbook of Veterinary Internal Medicine (8th ed.). Elsevier, St Louis.

By: K. Meurs & J. Stern

Source: NC State University Libraries
Added: October 10, 2020

2015 journal article

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs

Immunogenetics, 68(3), 205–217.

By: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
TL;DR: A strong association is demonstrated between two polymorphic positions (10 bp apart) in exon 2 of one allele in D LA-79, DLA-79*001:02, and multiple immune-mediated diseases, resulting in F33L and N37D amino acid changes that are likely to affect critical interactions with the peptide N-terminus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Identification of striatin, a desmosomal protein, in the canine corneal epithelium

RESEARCH IN VETERINARY SCIENCE, 102, 182–183.

By: J. Stern*, S. Lahmers* & K. Meurs n

author keywords: Hemidesmosome; Cornea; Striatin; Desmosome; Adhesion
MeSH headings : Animals; Calmodulin-Binding Proteins / metabolism; Desmosomes / metabolism; Dogs / metabolism; Epithelium, Corneal / metabolism
TL;DR: It is hypothesized that striatin may be found in the cornea localized to regions of either hemidesmosomes and/or desmosomes, and the role of striatin in corneal disease warrants investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Impact of the canine double-deletion beta 1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a beta 1-selective beta-blocker

PHARMACOGENETICS AND GENOMICS, 25(9), 427–431.

By: K. Meurs n, J. Stern*, Y. Reina-Doreste*, B. Maran, L. Chdid*, S. Lahmers*, B. Keene*, K. Mealey

author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
TL;DR: The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Polymorphisms in the canine and feline renin-angiotensin-aldosterone system genes

Meurs, K. M., Chdid, L., Reina-Doreste, Y., & Stern, J. A. (2015, April). ANIMAL GENETICS, Vol. 46, pp. 226–226.

By: K. Meurs n, L. Chdid n, Y. Reina-Doreste n & J. Stern n

MeSH headings : Animals; Cats; Dogs; Polymorphism, Genetic; Renin-Angiotensin System / genetics; Sequence Analysis, DNA
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 chapter

Primary myocardial disease in the dog

In Textbook of Veterinary Internal Medicine (7th ed., pp. 1320–1328). Philadelphia: WB Saunders.

By: J. Stern & K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2015 journal article

Sudden Death Associated with QT Interval Prolongation and KCNQ1 Gene Mutation in a Family of English Springer Spaniels

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 561–568.

By: W. Ware*, Y. Reina-Doreste n, J. Stern n & K. Meurs n

author keywords: Long QT Syndrome
MeSH headings : Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genetic Predisposition to Disease; KCNQ1 Potassium Channel / genetics; KCNQ1 Potassium Channel / metabolism; Long QT Syndrome / complications; Long QT Syndrome / genetics; Male; Mutation; Pedigree
TL;DR: This family represents the first documentation in dogs of spontaneous familial QT prolongation, which was associated with a KCNQ1 gene mutation and sudden death, and their phenotypic manifestations of QT interval prolongation and abnormal ECG restitution suggested increased risk for sudden arrhythmic death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

The genetic basis of hypertrophic cardiomyopathy in cats and humans

Journal of Veterinary Cardiology, 17, S53–S73.

By: M. Kittleson*, K. Meurs n & S. Harris*

author keywords: Feline; Myosin binding protein C; Mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / genetics; Cats; Humans
TL;DR: The history, genetics, and pathogenesis of HCM in the two species in order to give veterinarians a perspective on the genetics of H CM is reviewed to focus on the aspects of human genetics that are germane to veterinarians and on all aspects of feline HCM genetics. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

The influence of clinical and genetic factors on left ventricular wall thickness in Ragdoll cats

Journal of Veterinary Cardiology, 17, S258–S267.

author keywords: Cardiomyopathy; Genetics; Modifier genes; Breed screening
MeSH headings : Animals; Body Weight; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cats / anatomy & histology; Cats / genetics; Female; Gene Expression Regulation; Genotype; Heart Ventricles / anatomy & histology; Male; Mutation; Polymorphism, Genetic; Sex Factors
TL;DR: Evidence is provided that the MYBPC3:R820W mutation is independently associated with LV wall thickness in Ragdoll cats and body weight is not currently accounted for in HCM screening. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 16, 2019

2014 journal article

A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs

Human Genetics, 133(9), 1139–1148.

By: J. Stern n, S. White*, L. Lehmkuhl, Y. Reina-Doreste n, J. Ferguson n, N. Nascone-Yoder n, K. Meurs*

MeSH headings : Animals; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Base Sequence; Case-Control Studies; Clathrin / antagonists & inhibitors; Clathrin / genetics; Codon / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Male; Molecular Sequence Data; Monomeric Clathrin Assembly Proteins / chemistry; Monomeric Clathrin Assembly Proteins / genetics; Monomeric Clathrin Assembly Proteins / metabolism; Mutagenesis, Insertional; Pedigree; Phosphatidylinositols / metabolism; Prospective Studies; Protein Conformation; Sequence Analysis, RNA; Sex Factors; Xenopus laevis / embryology
TL;DR: A three-nucleotide exonic insertion in phosphatidylinositol-binding clathrin assembly protein (PICALM) that is associated with the development of SAS in Newfoundlands is identified and the role of PICALM in OFT development may aid in future molecular and genetic investigations into other congenital heart defects of various species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Identification of PDE5A:E90K: A Polymorphism in the Canine Phosphodiesterase 5A Gene Affecting Basal cGMP Concentrations of Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(1), 78–83.

By: J. Stern n, Y. Reina-Doreste n, L. Chdid n & K. Meurs n

author keywords: Individualized medicine; Pharmacogenomics; Pulmonary hypertension; Sildenafil citrate; Single nucleotide polymorphisms
MeSH headings : Amino Acid Sequence; Animals; Cyclic GMP / metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5 / genetics; Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism; DNA / chemistry; DNA / genetics; Dogs / genetics; Dogs / metabolism; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Polymorphism, Single Nucleotide / genetics; Sequence Alignment; Sequence Analysis, DNA
TL;DR: A polymorphism exists in the canine PDE5A gene that is associated with variable circulating cGMP concentrations in healthy dogs and warrants investigation in diseases such as pulmonary hypertension. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(4), 1214–1220.

By: K. Meurs n, J. Stern n, Y. Reina-Doreste n, A. Spier*, S. Koplitz* & R. Baumwart*

author keywords: Boxer; Holter; Striatin; Sudden death; Ventricular premature complex
MeSH headings : Age Factors; Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genotype; Male; Prospective Studies; Ventricular Premature Complexes / physiopathology; Ventricular Premature Complexes / veterinary
TL;DR: Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion, and the prognosis in many affected dogs is good. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n, J. Stern n, D. Sisson*, M. Kittleson*, S. Cunningham*, M. Ames n, C. Atkins n, T. DeFrancesco n ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 chapter

Cardiomyopathy in the boxer dog

In Current Veterinary Therapy (Small Animal Practice) XV. Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2013 journal article

Extent of linkage disequilibrium in large-breed dogs: chromosomal and breed variation

MAMMALIAN GENOME, 24(9-10), 409–415.

By: J. Stern n, S. White* & K. Meurs n

MeSH headings : Animals; Breeding; Chromosomes, Mammalian / genetics; Dogs / genetics; Female; Genetic Markers; Genome-Wide Association Study; Haplotypes; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide
TL;DR: This is the first reported of SNP-based LD for Newfoundland dogs, the first report based on genome-wide SNPs for Rottweilers, and an almost tenfold improvement in marker density over previous genome- wide studies of LD in Golden Retrievers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Identification of DNA variants in the canine beta-1 adrenergic receptor gene

Research in Veterinary Science, 95(1), 238–240.

By: B. Maran*, K. Mealey, S. Lahmers, O. Nelson & K. Meurs*

author keywords: Pharmacogenomic; Beta blocker; Cardiac
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA / chemistry; DNA / genetics; Dogs / genetics; Genetic Variation; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Receptors, Adrenergic, beta-1 / genetics; Sequence Alignment
TL;DR: Two deletions were identified within the region of the gene that encodes the cytoplasmic tail of ADRB1, which is important in differentiating subtypes of adrenergic receptors and may be associated with control of receptor downregulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2012 journal article

A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher

HUMAN GENETICS, 131(8), 1319–1325.

By: K. Meurs n, S. Lahmers*, B. Keene n, S. White*, M. Oyama*, E. Mauceli*, K. Lindblad-Toh*

MeSH headings : Animals; Blotting, Western; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Chromosome Mapping / veterinary; Dog Diseases / genetics; Dogs; Genome-Wide Association Study; Microscopy, Electron; Mutation; Myocardium / ultrastructure; Protein Kinases / genetics; RNA Splicing; Real-Time Polymerase Chain Reaction
TL;DR: The identification of a splice site deletion in the PDK4 gene that is associated with the development of familial dilated cardiomyopathy in the Doberman pinscher dog is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Auscultatory, echocardiographic, biochemical, nutritional, and environmental characteristics of mitral valve disease in Norfolk terriers

Journal of Veterinary Cardiology, 14(1), 261–267.

By: D. Trafny*, L. Freeman, B. Bulmer, J. MacGregor, J. Rush, K. Meurs*, M. Oyama

author keywords: Heart murmur; Serotonin; NT-proBNP; Nutrition
MeSH headings : Animals; Biomarkers; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Female; Male; Mitral Valve / diagnostic imaging; Mitral Valve Insufficiency / veterinary; Risk Factors
TL;DR: DMVD is relatively common in Norfolk terrier and echocardiographic changes consistent with mild DMVD can be seen in dogs without a heart murmur, as well as select environmental variables from a cohort of apparently healthy Norfolk terriers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2012 journal article

Body size and metabolic differences in Maine Coon cats with and without hypertrophic cardiomyopathy

Journal of Feline Medicine and Surgery, 15(2), 74–80.

By: L. Freeman*, J. Rush*, K. Meurs n, B. Bulmer* & S. Cunningham*

MeSH headings : Animals; Body Size; Cardiomyopathy, Hypertrophic / metabolism; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / metabolism; Cats; Energy Metabolism
TL;DR: The hypothesis that early growth and nutrition, larger body size and obesity may be environmental modifiers of genetic predisposition to HCM is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2012 journal article

Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings

Journal of Small Animal Practice, 53(4), 213–216.

By: J. Stern n, K. Meurs n, O. Nelson*, S. Lahmers* & L. Lehmkuhl*

MeSH headings : Animals; Aortic Stenosis, Subvalvular / diagnostic imaging; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / veterinary; Aortic Valve Insufficiency / diagnostic imaging; Aortic Valve Insufficiency / genetics; Aortic Valve Insufficiency / veterinary; Blood Flow Velocity / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Echocardiography / veterinary; Female; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / genetics; Hypertrophy, Left Ventricular / veterinary; Male; Severity of Illness Index
TL;DR: Severity of stenosis correlates well with cumulative presence of echocardiographic characteristics (left ventricular hypertrophy, subvalvular ridge and aortic insufficiency), and appears familial. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 16, 2019

2012 journal article

Hypertrophic cardiomyopathy in the Sphynx cat: A retrospective evaluation of clinical presentation and heritable etiology

JOURNAL OF FELINE MEDICINE AND SURGERY, 14(4), 246–249.

By: S. Silverman*, J. Stern n & K. Meurs n

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / genetics; Cats; Female; Male; Phenotype; Retrospective Studies; Species Specificity
TL;DR: The observation that Sphynx and Ragdoll breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Identification of beta-1 adrenergic receptor polymorphisms in cats

Research in Veterinary Science, 93(1), 210–212.

By: B. Maran, K. Meurs*, S. Lahmers & O. Nelson

author keywords: Pharmacogenomics; Beta-blocker; Feline; Beta-1 adrenergic receptor
MeSH headings : Adrenergic beta-1 Receptor Antagonists / pharmacology; Amino Acid Substitution / genetics; Animals; Cats / genetics; Heart Diseases / drug therapy; Heart Diseases / veterinary; Polymorphism, Genetic / genetics; Receptors, Adrenergic, beta-1 / genetics; Sequence Analysis, DNA / veterinary
TL;DR: Three polymorphisms within the feline ADRB1 gene were identified, including an AA/CC substitution at the 830-831 base pair sites and an alteration changed the amino acid produced from proline to glutamine at position 277 and computer modeling predicts an altered protein structure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2011 journal article

Comparison of Polymerase Chain Reaction with Bacterial 16s Primers to Blood Culture to Identify Bacteremia in Dogs with Suspected Bacterial Endocarditis

Journal of Veterinary Internal Medicine, 25(4), 959–962.

By: K. Meurs*, A. Heaney*, C. Atkins, T. DeFrancesco*, P. Fox*, B. Keene, H. Kellihan*, M. Miller* ...

author keywords: Bartonella; Canine; Infectious; Molecular; Valvular
MeSH headings : Animals; Bacteremia / blood; Bacteremia / microbiology; Bacteremia / veterinary; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Endocarditis, Bacterial / blood; Endocarditis, Bacterial / microbiology; Endocarditis, Bacterial / veterinary; Female; Male; Polymerase Chain Reaction / veterinary; Prospective Studies; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics
TL;DR: The results of this study suggest that although single sample PCR with 16s primers was not more sensitive than blood culture for detection of bacteremia in dogs with suspect endocarditis, performing both techniques simultaneously did increase the likelihood of identification of bacteria in blood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2010 journal article

Ambulatory electrocardiographic evaluation of clinically normal adult Boxers

Journal of the American Veterinary Medical Association, 236(4), 430–433.

By: J. Stern*, K. Meurs*, A. Spier*, S. Koplitz* & R. Baumwart*

MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / diagnosis; Dogs; Electrocardiography, Ambulatory / veterinary; Female; Male; Ventricular Premature Complexes / veterinary
TL;DR: Clinically normal adult Boxers generally had < 91 VPCs/24 h and an arrhythmia grade < 2 and may have represented dogs with arrhythmogenic right ventricular cardiomyopathy or other disease processes that could have resulted in the development of ventricular arrh rhythmias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: November 16, 2019

2010 journal article

Correlation of heart rate to body weight in apparently normal dogs

Journal of Veterinary Cardiology, 12(2), 107–110.

By: A. Lamb*, K. Meurs* & R. Hamlin*

MeSH headings : Animals; Atrial Premature Complexes / diagnostic imaging; Atrial Premature Complexes / physiopathology; Atrial Premature Complexes / veterinary; Body Weight / physiology; Dogs / anatomy & histology; Dogs / physiology; Electrocardiography, Ambulatory / veterinary; Heart Rate / physiology; Ultrasonography; Ventricular Premature Complexes / diagnostic imaging; Ventricular Premature Complexes / physiopathology; Ventricular Premature Complexes / veterinary
TL;DR: The present study does not support a correlation between heart rate and body weight in apparently healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2010 journal article

Differential methylation of CpG sites in two isoforms of myosin binding protein C, an important hypertrophic cardiomyopathy gene

Environmental and Molecular Mutagenesis, 52(2), 161–164.

By: K. Meurs* & M. Kuan*

author keywords: CpG; cardiac; deamination; cardiomyopathy
MeSH headings : Cardiomegaly / genetics; Cardiomegaly / metabolism; Carrier Proteins / genetics; CpG Islands; DNA Methylation; Exons; Humans; Muscle Proteins / genetics; Muscle Proteins / metabolism; Muscle, Skeletal / metabolism; Protein Isoforms
TL;DR: It is determined that although the mean number of CG sites was identical within the coding region of each gene, the mean methylation level of CpGs was significantly higher in MYBPC3 thanMYBPC2 (P < 0.0001). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2010 chapter

Genetic screening of familial hypertrophic cardiomyopathy

In Consultations in Feline Internal Medicine (pp. 406–408). Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2010 journal article

Genetics of Cardiac Disease in the Small Animal Patient

Veterinary Clinics of North America: Small Animal Practice, 40(4), 701–715.

By: K. Meurs*

author keywords: Familial; Mutation; Cardiomyopathy; Congenital heart disease
MeSH headings : Animals; Breeding; Cat Diseases / genetics; Cat Diseases / prevention & control; Cats; Dog Diseases / genetics; Dog Diseases / prevention & control; Dogs; Female; Genetic Diseases, Inborn / prevention & control; Genetic Diseases, Inborn / veterinary; Genetic Predisposition to Disease; Heart Diseases / genetics; Heart Diseases / prevention & control; Heart Diseases / veterinary; Male; Selection, Genetic
TL;DR: Common forms of inheritance for veterinary diseases include autosomal recessive, autosomal dominant, X-linked recessives, and polygenic and their possible involvement in cardiac disease in small animals are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2010 journal article

Genome-wide association identifies a deletion in the 3′ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy

Human Genetics, 128(3), 315–324.

By: K. Meurs*, E. Mauceli*, S. Lahmers*, G. Acland*, S. White* & K. Lindblad-Toh*

MeSH headings : 3' Untranslated Regions; Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Calmodulin-Binding Proteins / genetics; Chromosome Mapping; DNA Mutational Analysis; Disease Models, Animal; Dogs; Genome-Wide Association Study; Humans; Membrane Proteins / genetics; Microscopy, Fluorescence; Myocardium / metabolism; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Deletion
TL;DR: It is suggested that Striatin may serve as a novel candidate gene for human ARVC, based on the fact that dogs that were homozygous for the deletion had a more severe form of disease based on a significantly higher number of ventricular premature complexes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2010 chapter

Primary myocardial disease in the dog

In Textbook of Veterinary Internal Medicine (7th ed., pp. 1320–1328). Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2010 journal article

W1250 Genome-Wide Association Scan Reveals Polymorphisms in the P67phox Subunit (Ncf2) of the NADPH Oxidase Complex in Boxer Dogs With Adherent and Invasive E.Coli-Associated Granulomatous Colitis: A Potential Model of Chronic Granulomatous Disease

Gastroenterology, 138(5), S-683.

By: M. Craven, G. Acland, J. Mezey, A. Boyko, W. Wang, K. Meurs*, S. McDonough, K. Simpson

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2009 chapter

Acquired Heart Diseases in Cattle

In Food Animal Practice (pp. 216–219).

By: K. Meurs*

Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 journal article

Analysis of 8 Sarcomeric Candidate Genes for Feline Hypertrophic Cardiomyopathy Mutations in Cats with Hypertrophic Cardiomyopathy

Journal of Veterinary Internal Medicine, 23(4), 840–843.

By: K. Meurs*, M. Norgard*, M. Kuan*, J. Haggstrom* & M. Kittleson*

author keywords: Cardiovascular; Genetics; Molecular biology; Nucleic acid sequencing
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cats; Female; Gene Expression Regulation / physiology; Male; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 chapter

Cardiomyopathy in the boxer dog

In Current Veterinary Therapy (Small Animal Practice) XIV (pp. 797–799). Philadelphia: WB Saunders.

By: K. Meurs & A. Spier

Source: NC State University Libraries
Added: October 10, 2020

2009 chapter

Congenital Heart Disease in Cattle

In Food Animal Practice (pp. 215–216).

By: K. Meurs*

Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 chapter

Examination of the Bovine Patient with Heart Disease

In Food Animal Practice (pp. 214–215).

By: K. Meurs*

Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 journal article

Magnetic Resonance Imaging of Right Ventricular Morphology and Function in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy

Journal of Veterinary Internal Medicine, 23(2), 271–274.

By: R. Baumwart*, K. Meurs* & S. Raman*

author keywords: ARVC; Boxer; Cardiomyopathy; MRI; Right ventricle
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / physiopathology; Dogs; Heart Rate; Heart Ventricles / anatomy & histology; Magnetic Resonance Imaging / veterinary; Ventricular Dysfunction, Right / physiopathology
TL;DR: These findings could be interpreted to suggest that arrhythmias and myocardial dysfunction precede the development of morphological abnormalities in dogs with ARVC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 journal article

Temporal Variability of Ventricular Arrhythmias in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy

Journal of Veterinary Internal Medicine, 23(5), 1020–1024.

By: B. Scansen*, K. Meurs*, A. Spier*, S. Koplitz & R. Baumwart

author keywords: Arrhythmogenic right ventricular cardiomyopathy; Circadian rhythm; Right ventricular dysplasia; Premature ventricular complex
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Heart Rate / physiology; Prospective Studies; Retrospective Studies; Time Factors
TL;DR: The likelihood of PVC occurrence in Boxer dogs with ARVC was relatively constant throughout the day, although slightly greater during the hours of 0800-1200 and 1600-2000, and a biologically important correlation with HR was not apparent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2009 chapter

Update on Doberman pinscher cardiomyopathy

In Current Veterinary Therapy (Small Animal Practice) XIV (pp. 800–803). Philadelphia: WB Saunders.

By: C. Calvert & K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2008 journal article

An index of myocardial performance applied to the right ventricle of Boxers with arrhythmogenic right ventricular cardiomyopathy

American Journal of Veterinary Research, 69(8), 1029–1033.

By: R. Baumwart* & K. Meurs*

MeSH headings : Animals; Arrhythmias, Cardiac / physiopathology; Arrhythmias, Cardiac / veterinary; Cardiomyopathies / physiopathology; Cardiomyopathies / veterinary; Dog Diseases / physiopathology; Dogs; Heart Function Tests / veterinary; Ventricular Dysfunction, Right / physiopathology; Ventricular Dysfunction, Right / veterinary; Ventricular Function, Right / physiology
TL;DR: Right ventricular dysfunction does not develop in Boxers with ARVC, suggesting that a more severe phenotype of the disease may be necessary for detection of dysfunction or that additional studies that use more sensitive techniques to evaluate myocardial function may be warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 11, 2019

2008 journal article

Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency

Journal of Veterinary Cardiology, 10(1), 1–10.

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / etiology; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Base Sequence; Blotting, Western / veterinary; Breeding; Calcium / metabolism; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Male; Microarray Analysis / veterinary; Polymerase Chain Reaction / veterinary; RNA, Messenger / metabolism; Ryanodine Receptor Calcium Release Channel / genetics; Ryanodine Receptor Calcium Release Channel / metabolism; Tacrolimus Binding Proteins / deficiency; Tacrolimus Binding Proteins / genetics
TL;DR: Calstabin2 deficiency is a potential mechanism of Ca(2+) leak-induced ventricular arrhythmias and heart disease in Boxer dogs with ARVC and was associated with a significantly increased open probability of single RyR2 channels indicating intracellular Ca( 2+) leak. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: December 16, 2019

2008 journal article

Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping

Journal of the American Veterinary Medical Association, 233(6), 921–924.

By: K. Mealey* & K. Meurs*

MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Alleles; Animals; Breeding; Cross-Sectional Studies; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / genetics; Dogs / genetics; Drug Resistance, Multiple / genetics; Female; Gene Deletion; Gene Frequency; Genes, MDR / genetics; Genotype; Male; Polymorphism, Genetic; Veterinary Drugs / adverse effects
TL;DR: The ABCB1-1Delta polymorphism is associated with increased susceptibility to many adverse drug reactions and with suppression of the hypothalamic-pituitary-adrenal axis and is present in many herding breeds of dog. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2008 journal article

Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutations

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 642(1-2), 86–89.

By: K. Meurs* & K. Mealey*

author keywords: hypertrophic cardiomyopathy; mutation; methylation; deamination
MeSH headings : Amino Acid Substitution; Base Sequence; Cardiomyopathy, Hypertrophic / genetics; DNA Methylation; Humans; Mutation; Sarcomeres / genetics
TL;DR: The large number of G to A and C to T mutations as well as the relative mutability of CG may suggest that deamination of methylated CpG is an important mechanism for mutation development in at least some of these cardiac genes. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2008 journal article

Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy

American Journal of Veterinary Research, 69(8), 1050–1053.

By: K. Meurs*, K. Hendrix & M. Norgard

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dogs; Exons; Heart / physiopathology; Lamin Type A / genetics; Lamins / genetics; Myosin Heavy Chains / genetics; Troponin C / genetics; Troponin T / genetics
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2008 journal article

Plasma fatty acid concentrations in Boxers and Doberman Pinschers

American Journal of Veterinary Research, 69(2), 195–198.

By: C. Smith*, L. Freeman*, K. Meurs*, J. Rush* & A. Lamb*

MeSH headings : Animals; Arrhythmias, Cardiac / blood; Arrhythmias, Cardiac / veterinary; Dog Diseases / blood; Dogs / blood; Dogs / genetics; Fatty Acids / blood; Female; Male
TL;DR: It is suggested that plasma fatty acid concentrations may differ between Boxers and Doberman Pinschers and that the relationship between fatty Acid concentrations and VPCs may be different between these 2 breeds. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

2008 journal article

Prevalence of the Myosin-Binding Protein C Mutation in Maine Coon Cats

Journal of Veterinary Internal Medicine, 22(4), 893–896.

By: R. Fries*, A. Heaney* & K. Meurs*

author keywords: hypertrophic cardiomyopathy; genetics; MYBC3
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / epidemiology; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Cat Diseases / epidemiology; Cat Diseases / genetics; Cats; Female; Genetic Predisposition to Disease; Male; Prevalence
TL;DR: Because of the high prevalence of this mutation, a breeding recommendation to eliminate all cats with the mutation could have a substantial impact on the gene pool, and additional studies are indicated to explore the relationship between genotype and clinical outcome in affected cats. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2007 journal article

A Prospective Genetic Evaluation of Familial Dilated Cardiomyopathy in the Doberman Pinscher

Journal of Veterinary Internal Medicine, 21(5), 1016–1020.

By: K. Meurs*, P. Fox*, M. Norgard*, A. Spier*, A. Lamb*, S. Koplitz*, R. Baumwart*

Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2007 journal article

A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy

Genomics, 90(2), 261–264.

By: K. Meurs*, M. Norgard*, M. Ederer*, K. Hendrix* & M. Kittleson*

author keywords: hypertrophic cardiomyopathy; feline; myosin binding protein C; cardiac
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cats; DNA, Recombinant; Disease Models, Animal; Exons; Molecular Sequence Data; Point Mutation
TL;DR: The identification of two separate mutations within this gene in unrelated breeds suggests that these mutations occurred independently rather than being passed on from a common founder. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2007 chapter

Boxer Cardiomyopathy

In Five Minute Veterinary Consult (pp. 206–208). Ames: Blackwell Publishing.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2007 journal article

Desmosomal gene evaluation in Boxers with arrhythmogenic right ventricular cardiomyopathy

American Journal of Veterinary Research, 68(12), 1338–1341.

By: K. Meurs*, M. Ederer* & J. Stern*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Base Sequence; Desmoglein 2 / genetics; Desmoplakins / genetics; Desmosomes / genetics; Dog Diseases / genetics; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Male; Multigene Family; Plakophilins / genetics; RNA Splice Sites / genetics; gamma Catenin / genetics
Sources: Crossref, NC State University Libraries, ORCID
Added: December 16, 2019

2007 journal article

Double Chambered Right Ventricle in 9 Cats

Journal of Veterinary Internal Medicine, 21(1), 76–80.

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2007 journal article

Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy

American Journal of Veterinary Research, 68(5), 524–528.

By: R. Baumwart*, J. Orvalho* & K. Meurs*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / blood; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / blood; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Male; Troponin I / blood; Troponin I / genetics
TL;DR: Compared with clinically normal dogs, Boxers with ARVC had a significant increase in serum cTnI concentration, and correlated with severity of disease in terms of degree of myocardial fibrofatty changes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2007 chapter

Lamb A Ambulatory electrocardiography

In Five-Minute Veterinary Consult (pp. 312–314). Ames: Diagnostic Procedures and Laboratory Tests Blackwell Publishing.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2007 journal article

Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency

Journal of the American Veterinary Medical Association, 231(7), 1061–1069.

By: C. Atkins n, B. Keene*, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, N. Edwards, P. Fox ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Antihypertensive Agents / therapeutic use; Death, Sudden, Cardiac / veterinary; Disease Progression; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / prevention & control; Dogs; Double-Blind Method; Enalapril / therapeutic use; Female; Heart Failure / mortality; Heart Failure / prevention & control; Heart Failure / veterinary; Kaplan-Meier Estimate; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / veterinary; Severity of Illness Index; Time Factors; Treatment Outcome
TL;DR: Chronic enalapril treatment of dogs with naturally occurring, moderate to severe MR significantly delayed onset of CHF, compared with placebo, on the basis of number ofCHF-free days, number of dogs free of CHFs at days 500 and study end, and increased time to a combined secondary endpoint of CHf-all-cause death. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2007 journal article

Tissue Doppler Imaging in Maine Coon Cats with a Mutation of Myosin Binding Protein C with or without Hypertrophy

Journal of Veterinary Internal Medicine, 21(2), 232–237.

By: K. MacDonald*, M. Kittleson*, P. Kass* & K. Meurs*

Sources: NC State University Libraries, NC State University Libraries
Added: October 18, 2020

2006 journal article

Angiographic classification of patent ductus arteriosus morphology in the dog

Journal of Veterinary Cardiology, 8(2), 109–114.

By: M. Miller*, S. Gordon*, A. Saunders*, W. Arsenault*, K. Meurs*, L. Lehmkuhl*, J. Bonagura*, P. Fox*

Contributors: M. Miller*, S. Gordon*, A. Saunders*, W. Arsenault*, K. Meurs*, L. Lehmkuhl*, J. Bonagura*, P. Fox*

TL;DR: Information about angiographic morphology and minimum internal transverse diameter of left-to-right shunting patent ductus arteriosus (PDA) in a large series of dogs should assist planning, selection and deployment of transcatheter occluding devices. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2006 journal article

Differential expression of the cardiac ryanodine receptor in normal and arrhythmogenic right ventricular cardiomyopathy canine hearts

Human Genetics, 120(1), 111–118.

By: K. Meurs*, V. Lacombe*, K. Dryburgh*, P. Fox*, P. Reiser* & M. Kittleson*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Blotting, Western; Dogs; Electrocardiography; Female; Gene Expression Profiling; Genetic Linkage; Genotype; Heart / physiopathology; Male; Myocardium / metabolism; Myosins / metabolism; Pedigree; RNA, Messenger / genetics; RNA, Messenger / metabolism; Ryanodine / metabolism; Ryanodine Receptor Calcium Release Channel / genetics; Ryanodine Receptor Calcium Release Channel / metabolism
TL;DR: It is proposed that the increased susceptibility of the right ventricle to ARVC may be associated with the lower baseline protein concentration of RyR2 in the normal right Ventricle compared to the left ventricles and interventricular septum and that all three areas are equally affected in this canine model of ARVC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 18, 2019

2006 journal article

Echocardiographic Assessment of the Left Ventricular Outflow Tract in the Boxer

Journal of Veterinary Internal Medicine, 20(4), 904–911.

By: S. Koplitz*, K. Meurs* & J. Bonagura*

TL;DR: It is suggested that a relatively smaller LVOT in Boxers predisposes them to increased ejection velocity and development of murmurs, and the contribution of SV to the genesis of these often labile murmurs requires additional study. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2006 journal article

Finding cardiovascular disease genes in the dog

Journal of Veterinary Cardiology, 8(2), 115–127.

By: H. Parker*, K. Meurs* & E. Ostrander*

TL;DR: Recent findings in canine genomics are summarized and discussed and their application to the study of canine cardiac health is discussed. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 18, 2019

2005 journal article

A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy

Human Molecular Genetics, 14(23), 3587–3593.

By: K. Meurs*, X. Sanchez, R. David, N. Bowles, J. Towbin, P. Reiser, J. Kittleson, M. Munro ...

MeSH headings : Amino Acid Substitution; Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cats; Disease Models, Animal; Genotype; Muscle Proteins / genetics; Muscle Proteins / metabolism; Point Mutation; RNA, Messenger / metabolism; Sarcomeres / metabolism
TL;DR: This is the first report of a spontaneous mutation causing HCM in a non-human species and feline familial HCM provides a valuable model for investigators to evaluate pathophysiologic processes and therapeutic manipulations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

2005 journal article

Assessment of plasma brain natriuretic peptide concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy

American Journal of Veterinary Research, 66(12), 2086–2089.

By: R. Baumwart* & K. Meurs*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / blood; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Dog Diseases / blood; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Natriuretic Peptide, Brain / blood; Radioimmunoassay / veterinary
TL;DR: Results suggest that BNP concentration may not be an indicator of ARVC in Boxers, compared with concentrations in clinically normal dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 18, 2019

2005 chapter

Canine Myocardial Disease

In Textbook of Veterinary Internal Medicine (6th ed., pp. 1077–1081). Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

2005 journal article

Clinical, echocardiographic, and electrocardiographic abnormalities in Boxers with cardiomyopathy and left ventricular systolic dysfunction: 48 cases (1985-2003)

Journal of the American Veterinary Medical Association, 226(7), 1102–1104.

By: R. Baumwart*, K. Meurs*, C. Atkins, J. Bonagura*, T. DeFrancesco*, B. Keene, S. Koplitz, V. Fuentes ...

Contributors: R. Baumwart*, K. Meurs*, C. Atkins, J. Bonagura*, T. DeFrancesco*, B. Keene, S. Koplitz, V. Fuentes ...

MeSH headings : Animals; Cardiomyopathies / diagnosis; Cardiomyopathies / physiopathology; Cardiomyopathies / veterinary; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Echocardiography / methods; Echocardiography / veterinary; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary; Female; Male; Radiography, Thoracic / methods; Radiography, Thoracic / veterinary; Retrospective Studies; Ventricular Dysfunction, Left / diagnosis; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / veterinary
TL;DR: Boxers with cardiomyopathy and left ventricular dysfunction frequently have arrhythmias of supraventricular or ventricular origin, and the natural history of myocardial disease in Boxers requires further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 24, 2019

2005 chapter

Molecular genetics of dilated cardiomyaopthy in the dog

In Canine Genetics (pp. 365–382). Cold Spring Harbor.

By: P. Stabej, K. Meurs & B. van Oost

Source: NC State University Libraries
Added: October 10, 2020

2005 journal article

Survival times in dogs with severe subvalvular aortic stenosis treated with balloon valvuloplasty or atenolol

Journal of the American Veterinary Medical Association, 227(3), 420–424.

By: K. Meurs*, L. Lehmkuhl & J. Bonagura*

Contributors: K. Meurs*, L. Lehmkuhl & J. Bonagura*

MeSH headings : Adrenergic beta-Antagonists / therapeutic use; Animals; Aortic Stenosis, Subvalvular / drug therapy; Aortic Stenosis, Subvalvular / therapy; Aortic Stenosis, Subvalvular / veterinary; Atenolol / therapeutic use; Blood Pressure / physiology; Catheterization / methods; Catheterization / veterinary; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Female; Male; Prospective Studies; Survival Analysis
TL;DR: It is suggested that balloon valvuloplasty can result in a significant decrease in the peak systolic pressure gradient in dogs with severe SAS, at least for the short term. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2005 journal article

Tei Index of Myocardial Performance Applied to the Right Ventricle in Normal Dogs

Journal of Veterinary Internal Medicine, 19(6), 828–832.

By: R. Baumwart*, K. Meurs* & J. Bonagura*

TL;DR: It is concluded that the RV IMP is relatively independent of body weight and heart rate within the ranges studied and is consistently lower than values derived from the LV in healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2004 journal article

Arrhythmogenic Right Ventricular Cardiomyopathy Causing Sudden Cardiac Death in Boxer Dogs

Circulation, 109(9), 1180–1185.

By: C. Basso*, P. Fox*, K. Meurs*, J. Towbin*, A. Spier*, F. Calabrese*, B. Maron*, G. Thiene*

author keywords: models, animal; cardiomyopathy; pathology; death, sudden
MeSH headings : Animals; Apoptosis; Arrhythmias, Cardiac / diagnosis; Arrhythmogenic Right Ventricular Dysplasia / complications; Arrhythmogenic Right Ventricular Dysplasia / diagnosis; Arrhythmogenic Right Ventricular Dysplasia / etiology; Death, Sudden, Cardiac / etiology; Disease Models, Animal; Dogs; Electrocardiography; Female; Male; Myocarditis / pathology; Myocardium / pathology
TL;DR: A novel, spontaneous, and genetically transmitted animal model of ARVC associated with sudden death in the boxer dog is described, closely resembling the human disease and may aid in understanding the pathogenic mechanisms of AR VC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Assessment of heart rate variability in Boxers with arrhythmogenic right ventricular cardiomyopathy

Journal of the American Veterinary Medical Association, 224(4), 534–537.

By: A. Spier* & K. Meurs*

MeSH headings : Analysis of Variance; Animals; Arrhythmogenic Right Ventricular Dysplasia / diagnosis; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Electrocardiography, Ambulatory / veterinary; Female; Heart Failure / diagnosis; Heart Failure / physiopathology; Heart Failure / veterinary; Heart Rate / physiology; Male; Prospective Studies; Species Specificity; Ventricular Premature Complexes / diagnosis; Ventricular Premature Complexes / physiopathology; Ventricular Premature Complexes / veterinary
TL;DR: Differences in some HRV variables between Boxers without CHF and control dogs suggest that Boxers may have different autonomic control of heart rate, compared with that of clinically normal non-Boxer dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Boxer dog cardiomyopathy: an update

Veterinary Clinics of North America: Small Animal Practice, 34(5), 1235–1244.

By: K. Meurs*

MeSH headings : Animals; Cardiomyopathies / diagnosis; Cardiomyopathies / therapy; Cardiomyopathies / veterinary; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / therapy; Dogs; Pedigree
TL;DR: Boxer dog cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and, sometimes, systolic dysfunction and heart failure and affected dogs have a variable prognosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 18, 2019

2004 journal article

Determination of electrocardiographic parameters in healthy llamas and alpacas

American Journal of Veterinary Research, 65(12), 1719–1723.

By: M. Kraus*, C. Calvert*, A. Spier*, K. Meurs* & D. Anderson*

MeSH headings : Animals; Camelids, New World / physiology; Electrocardiography / veterinary; Female; Heart / physiology; Male; Reference Values
TL;DR: ECGs of acceptable quality can be consistently recorded in nonsedated standing llamas and alpacas and changes in the morphology of the QRS complexes and mean electrical axis are unlikely to be sensitive indicators of ventricular enlargement in llama andAlpacas. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Evaluation of spontaneous variability in the frequency of ventricular arrhythmias in Boxers with arrhythmogenic right ventricular cardiomyopathy

Journal of the American Veterinary Medical Association, 224(4), 538–541.

By: A. Spier* & K. Meurs*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Dog Diseases / physiopathology; Dogs; Electrocardiography, Ambulatory / veterinary; Female; Heart Rate / physiology; Male; Prospective Studies; Reference Values; Species Specificity
TL;DR: Changes of < or = 80% in the frequency of ventricular arrhythmias may be within the limit of spontaneous variability in dogs with ARVC, and this degree of variability should be considered in evaluations of ambulatory ECG recordings, particularly in the assessment of the efficacy of antiarrhythmic drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

The Relationship of Resting S-T Segment Depression to the Severity of Subvalvular Aortic Stenosis and the Presence of Ventricular Premature Complexes in the Dog

Journal of the American Animal Hospital Association, 40(1), 20–23.

By: G. Davainis*, K. Meurs* & N. Wright*

MeSH headings : Age Factors; Animals; Aortic Stenosis, Subvalvular / diagnosis; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Echocardiography, Doppler / methods; Echocardiography, Doppler / veterinary; Electrocardiography / methods; Electrocardiography / veterinary; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary; Retrospective Studies; Severity of Illness Index; Ventricular Premature Complexes / diagnosis; Ventricular Premature Complexes / pathology; Ventricular Premature Complexes / veterinary
TL;DR: Electrocardiograms from 35 dogs with subvalvular aortic stenosis with a left ventricular outflow tract pressure gradient were retrospectively evaluated for S-T segment depression and the significance of STD in the dog with SAS remains uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 18, 2019

2004 journal article

Use of signal-averaged electrocardiography in the evaluation of arrhythmogenic right ventricular cardiomyopathy in Boxers

Journal of the American Veterinary Medical Association, 225(7), 1050–1055.

By: A. Spier* & K. Meurs*

MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / diagnosis; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / prevention & control; Death, Sudden, Cardiac / veterinary; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Electrocardiography / methods; Electrocardiography / veterinary; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary; Female; Heart Failure / diagnosis; Heart Failure / physiopathology; Heart Failure / veterinary; Male; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity
TL;DR: Results suggest that SAECG is a useful noninvasive diagnostic test to evaluate dogs affected with ARVC and identify individuals at risk for cardiac-related death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2003 journal article

Aortic ejection velocity in healthy Boxers with soft cardiac murmurs and Boxers without cardiac murmurs: 201 cases (1997–2001)

Journal of the American Veterinary Medical Association, 222(6), 770–774.

By: S. Koplitz*, K. Meurs*, A. Spier, J. Bonagura*, V. Fuentes & N. Wright

Contributors: S. Koplitz*, K. Meurs*, A. Spier, J. Bonagura*, V. Luis Fuentes & N. Wright

TL;DR: Results suggested that ejection murmurs were common among healthy adult Boxers and that Boxers with murmur were likely to have high (> 2.0 m/s) aortic ejection velocities. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 24, 2019

2003 journal article

Cardiac Amyloidosis in a Horse

Journal of Veterinary Internal Medicine, 17(4), 588–592.

By: Y. Nout*, K. Hinchcliff*, J. Bonagura*, K. Meurs* & T. Papenfuss*

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 8, 2020

2003 chapter

Myocardial Disease

In R. V. Morgan, R. Bright, & M. Swartout (Eds.), Handbook of Small Animal Practice (4th ed., pp. 101–111). Philadelphia: WB Saunders.

By: K. Meurs

Ed(s): R. Morgan, R. Bright & M. Swartout

Source: NC State University Libraries
Added: October 10, 2020

2002 journal article

Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers

Journal of the American Veterinary Medical Association, 221(4), 522–527.

By: K. Meurs*, A. Spier, N. Wright, C. Atkins*, T. DeFrancesco*, S. Gordon, R. Hamlin, B. Keene* ...

MeSH headings : Animals; Anti-Arrhythmia Agents / pharmacology; Anti-Arrhythmia Agents / therapeutic use; Arrhythmias, Cardiac / drug therapy; Arrhythmias, Cardiac / veterinary; Atenolol / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Therapy, Combination; Heart Rate; Mexiletine / therapeutic use; Procainamide / therapeutic use; Random Allocation; Sotalol / therapeutic use; Syncope / drug therapy; Syncope / veterinary; Treatment Outcome; Ventricular Premature Complexes / drug therapy; Ventricular Premature Complexes / veterinary
TL;DR: Significant reductions in number of VPC, severity of arrythmia, and maximum and mean HR were observed in dogs treated with mexiletine-atenolol or sotalol; occurrence of syncope was not significantly different between these 2 treatment groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2002 journal article

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation

Journal of the American Veterinary Medical Association, 221(5), 654–658.

By: C. Atkins n, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, J. Edwards, P. Fox, B. Keene* ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / adverse effects; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Blood Urea Nitrogen; Creatinine / blood; Dog Diseases / drug therapy; Dogs; Enalapril / adverse effects; Enalapril / therapeutic use; Female; Follow-Up Studies; Kidney / drug effects; Kidney Function Tests / veterinary; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / drug therapy; Mitral Valve Insufficiency / veterinary; Time Factors
TL;DR: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2002 journal article

Plasma concentrations of tumor necrosis factor-α in cats with congestive heart failure

American Journal of Veterinary Research, 63(5), 640–642.

By: K. Meurs*, P. Fox*, M. Miller*, S. Kapadia* & D. Mann*

MeSH headings : Animals; Cardiomyopathy, Dilated / blood; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / veterinary; Cat Diseases / blood; Cat Diseases / immunology; Cats; Female; Formazans / chemistry; Male; Mice; Tetrazolium Salts / chemistry; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Concentrations of TNF-α were increased in 10 of 26 cats with CHF but were undetectable in the other 16 cats withCHF and all control cats, indicating increased cytotoxic effects of T NF-α on L929 murine fibrosarcoma cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 8, 2020

2001 journal article

Clinical features of dilated cardiomyopathy in Great Danes and results of a pedigree analysis: 17 cases (1990-2000)

Journal of the American Veterinary Medical Association, 218(5), 729–732.

By: K. Meurs*, M. Miller* & N. Wright*

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Female; Male; Pedigree; Retrospective Studies
TL;DR: Pedigree analysis suggested that DCM was inherited as an X-linked recessive trait, but the mode of inheritance could not be definitively identified and dogs with DCM probably should not be used for breeding, and female offspring of affected dogs should be used cautiously. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 8, 2020

2001 journal article

Comparison of in-hospital versus 24-hour ambulatory electrocardiography for detection of ventricular premature complexes in mature Boxers

Journal of the American Veterinary Medical Association, 218(2), 222–224.

By: K. Meurs*, A. Spier, N. Wright & R. Hamlin

MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Electrocardiography, Ambulatory / methods; Electrocardiography, Ambulatory / veterinary; False Negative Reactions; False Positive Reactions; Female; Male; Predictive Value of Tests; Sensitivity and Specificity; Ventricular Dysfunction / diagnosis; Ventricular Dysfunction / physiopathology; Ventricular Dysfunction / veterinary
TL;DR: The use of in-hospital ECG appears to be inadequate for screening purposes and therapeutic evaluations in mature Boxers with ventricular arrhythmic disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2001 journal article

Correlation of QT dispersion with indices used to evaluate the severity of familial ventricular arrhythmias in Boxers

American Journal of Veterinary Research, 62(9), 1481–1485.

By: A. Spier*, K. Meurs*, W. Muir*, L. Lehmkuhl* & R. Hamlin*

MeSH headings : Animals; Arrhythmias, Cardiac / diagnosis; Arrhythmias, Cardiac / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography / methods; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart Rate; Male; Ventricular Dysfunction / diagnosis; Ventricular Dysfunction / veterinary
TL;DR: QT dispersion does not appear to be a useful noninvasive diagnostic tool in the evaluation of familial ventricular arrhythmias of Boxers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2001 journal article

Evaluation of the cardiac actin gene in Doberman Pinschers with dilated cardiomyopathy

American Journal of Veterinary Research, 62(1), 33–36.

By: K. Meurs*, A. Magnon, A. Spier, M. Miller, L. Lehmkuhl & J. Towbin

MeSH headings : Actins / genetics; Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; DNA / blood; Dog Diseases / genetics; Dogs / genetics; Exons; Humans; Myocardium / metabolism; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Polymorphism, Single-Stranded Conformational; Reference Values; Species Specificity
Sources: Crossref, NC State University Libraries
Added: January 8, 2020

2001 chapter

Hypertrophic Cardiomyopathy

In Consultations in Feline Internal Medicine: Vol. IV (pp. 56–78). WB Saunders.

By: K. Meurs & A. Spier

Source: NC State University Libraries
Added: October 10, 2020

2001 journal article

Polymerase chain reaction analysis for viruses in paraffin-embedded myocardium from dogs with dilated cardiomyopathy or myocarditis

American Journal of Veterinary Research, 62(1), 130–135.

By: T. Maxson n, K. Meurs n, L. Lehmkuhl n, A. Magnon n, S. Weisbrode n & C. Atkins n

MeSH headings : Animals; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Cardiomyopathy, Dilated / virology; Dog Diseases / pathology; Dog Diseases / virology; Dogs; Fibrosis; Genome, Viral; Heart / virology; Inflammation; Myocarditis / pathology; Myocarditis / veterinary; Myocarditis / virology; Myocardium / pathology; Parvovirus, Canine / genetics; Parvovirus, Canine / isolation & purification; Polymerase Chain Reaction / methods; Viruses / isolation & purification
TL;DR: Viral agents canine parvovirus, adenovirus types 1 and 2, and herpesvirus are not commonly associated with DCM or active myocarditis in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2001 journal article

Use of ambulatory electrocardiography for detection of ventricular premature complexes in healthy dogs

Journal of the American Veterinary Medical Association, 218(8), 1291–1295.

By: K. Meurs*, A. Spier*, N. Wright* & R. Hamlin*

MeSH headings : Animals; Arrhythmias, Cardiac / diagnosis; Arrhythmias, Cardiac / veterinary; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Electrocardiography, Ambulatory / veterinary; Female; Male; Ventricular Premature Complexes / diagnosis; Ventricular Premature Complexes / veterinary
TL;DR: It is concluded that healthy mature dogs have infrequent VPC, as detected by use of 24-hour AECG, which may be suggestive of cardiac or systemic disease and may indicate the need for thorough clinical evaluation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

2001 journal article

Use of echocardiography for the diagnosis of heartworm disease in cats: 43 cases (1985-1997)

Journal of the American Veterinary Medical Association, 218(1), 66–69.

By: T. DeFrancesco n, C. Atkins*, M. Miller, K. Meurs* & B. Keene*

MeSH headings : Animals; Antibodies, Helminth / analysis; Antigens, Helminth / analysis; Cat Diseases / diagnostic imaging; Cat Diseases / parasitology; Cats; Dirofilaria immitis / immunology; Dirofilaria immitis / isolation & purification; Dirofilariasis / diagnostic imaging; Echocardiography / veterinary; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / pathology; Radiography, Thoracic / veterinary; Retrospective Studies
TL;DR: Although echocardiography was less sensitive than antigen testing, it was a useful adjunctive test in cats that had negative antigen test results in which there was a suspicion of heartworm disease. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2001 journal article

Use of western immunoblot for evaluation of myocardial dystrophin, -sarcoglycan, and -dystroglycan in dogs with idiopathic dilated cardiomyopathy

American Journal of Veterinary Research, 62(1), 67–71.

By: A. Spier*, K. Meurs*, D. Coovert*, L. Lehmkuhl*, M. O'Grady*, L. Freeman*, A. Burghes*, J. Towbin*

MeSH headings : Animals; Blotting, Western; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Cytoskeletal Proteins / analysis; Dog Diseases / metabolism; Dogs; Dystroglycans; Dystrophin / analysis; Membrane Glycoproteins / analysis; Muscular Dystrophy, Animal / metabolism; Muscular Dystrophy, Duchenne / metabolism; Myocardium / chemistry; Receptors, Laminin / analysis; Reference Values; Sarcoglycans
TL;DR: Abnormalities in dystrophin, alpha-sarcoglycan, and beta-dystroglycan proteins were not associated with the development of dilated cardiomyopathy in the dogs evaluated in this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2000 journal article

A highly polymorphic marker identified in intron 15 of the feline cardiac troponin T gene by SSCP analysis

Animal Genetics, 31, 236–237.

By: A. Magnon, K. Meurs, M. Kittleson & W. Ware

Source: NC State University Libraries
Added: October 10, 2020

2000 journal article

Arterial blood pressure measurement in a population of healthy geriatric dogs

Journal of the American Animal Hospital Association, 36(6), 497–500.

By: K. Meurs*, M. Miller, M. Slater & K. Glaze

MeSH headings : Aging / physiology; Animals; Blood Pressure; Blood Pressure Determination / methods; Blood Pressure Determination / veterinary; Case-Control Studies; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dog Diseases / physiopathology; Dogs / physiology; Female; Hypertension / diagnosis; Hypertension / epidemiology; Hypertension / physiopathology; Hypertension / veterinary; Male; Prevalence
TL;DR: Diastolic and mean blood pressure measurements were significantly lower in the geriatric group as compared to the control group, and systemic hypertension does not appear to be a common clinical problem in the healthy geriatric dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2000 journal article

Molecular Screening by Polymerase Chain Reaction Detects Panleukopenia Virus DNA in Formalin-Fixed Hearts from Cats with Idiopathic Cardiomyopathy and Myocarditis

Cardiovascular Pathology, 9(2), 119–126.

By: K. Meurs*, P. Fox*, A. Magnon*, S. Liu* & J. Towbin*

MeSH headings : Animals; Cardiomyopathies / pathology; Cardiomyopathies / veterinary; Cat Diseases / virology; Cats; DNA, Viral / analysis; Feline Panleukopenia Virus / genetics; Fixatives; Formaldehyde; Heart / virology; Myocarditis / pathology; Myocarditis / veterinary; Polymerase Chain Reaction
TL;DR: Myocarditis and or feline panleukopenia virus genome was detected in felines with idiopathic hypertrophic, dilated, and restrictive cardiomyopathy, suggesting a possible role of viral infection and inflammation in the pathogenesis of cardiopathy in this species. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2000 journal article

Single nucleotide polymorphisms in intron 5 of the feline myosin regulatory light chain gene detected by SSCP analysis

Animal Genetics, 31(4), 281–282.

By: A. Magnon*, K. Meurs*, M. Kittleson & W. Ware

MeSH headings : Animals; Base Sequence; Cats / genetics; DNA / chemistry; Female; Genotype; Introns; Male; Molecular Sequence Data; Myosin Light Chains / genetics; Pedigree; Polymerase Chain Reaction / veterinary; Polymorphism, Single Nucleotide / genetics; Polymorphism, Single-Stranded Conformational
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2000 journal article

The identification of nine polymorphisms identified within the head region of feline Beta Myosin heavy chain gene

Animal Genetics, 31, 231.

By: K. Meurs, M. Kittleson, W. Ware & M. Miller

Source: NC State University Libraries
Added: October 10, 2020

2000 chapter

Update on Doberman pinscher cardiomyopathy

In Current Veterinary Therapy (Small Animal Practice) XIII (pp. 756–760). Philadelphia: WB Saunders.

By: C. Calvert & K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

1999 journal article

A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene

American Journal of Veterinary Research, 60(9), 1040–1046.

By: S. Schatzberg, N. Olby, S. Steingold, B. Keene, C. Atkins, K. Meurs, G. Solomon, S. Goedegebuure, S. Wilton, N. Sharp

Source: NC State University Libraries
Added: October 18, 2020

1999 journal article

Familial Hypertrophic Cardiomyopathy in Maine Coon Cats

Circulation, 99(24), 3172–3180.

By: M. Kittleson*, K. Meurs*, M. Munro*, J. Kittleson*, S. Liu*, P. Pion*, J. Towbin*

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / diagnostic imaging; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / pathology; Cats; Disease Models, Animal; Echocardiography; Female; Hypertrophy; Male; Muscle Fibers, Skeletal / pathology; Myocardium / pathology; Papillary Muscles / pathology; Pedigree; Phenotype
TL;DR: HCM in this family of Maine coon cats closely resembles the human form of FHCM and should prove a valuable tool for studying the gross, cellular, and molecular pathophysiology of the disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: October 18, 2020

1999 journal article

Familial Ventricular Arrhythmias in Boxers

Journal of Veterinary Internal Medicine, 13(5), 437–439.

By: K. Meurs*, A. Spier*, M. Miller*, L. Lehmkuhl* & J. Towbin*

TL;DR: It is concluded that familial ventricular arrhythmias is inherited as an autosomal dominant trait in some Boxers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1998 journal article

Chronic Trypanosoma cruzi infection in dogs: 11 cases (1987–1996)

Journal of the American Veterinary Medical Association, 213(4), 497–500.

By: K. Meurs, M. Anthony, M. Slater & M. Miller

Source: NC State University Libraries
Added: October 18, 2020

1998 journal article

Insights into the Hereditability of Canine Cardiomyopathy

Veterinary Clinics of North America: Small Animal Practice, 28(6), 1449–1457.

By: K. Meurs*

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dogs; Pedigree
TL;DR: There is evidence for a genetic etiology of dilated cardiomyopathy in at least two breeds, the Doberman pinscher and the Boxer dog, and significant effort will depend on careful characterization of the disease and determination of criteria for diagnosing asymptomatic affected individuals. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1998 journal article

Prevalence of heartworm infection in cats with signs of cardiorespiratory abnormalities

Journal of the American Veterinary Medical Association, 212(4), 517–520.

By: C. Atkins, T. DeFrancesco, M. Miller, K. Meurs & B. Keene

Source: NC State University Libraries
Added: October 18, 2020

1997 journal article

Tricuspid valve atresia with main pulmonary artery atresia in an Arabian foal

Equine Veterinary Journal, 29(2), 160–162.

By: K. Meurs*, M. Miller*, C. Hanson* & C. Honnas*

author keywords: horse; congenital heart defect; tricuspid valve atresia; pulmonary artery atresia
MeSH headings : Animals; Echocardiography / methods; Echocardiography / veterinary; Female; Heart Atria / pathology; Horse Diseases / congenital; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Pulmonary Atresia / diagnosis; Pulmonary Atresia / pathology; Pulmonary Atresia / veterinary; Radiography, Thoracic / methods; Radiography, Thoracic / veterinary; Tricuspid Atresia / diagnosis; Tricuspid Atresia / pathology; Tricuspid Atresia / veterinary
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

1996 journal article

Comparison of the indirect oscillometric and direct arterial methods for blood pressure measurements in anesthetized dogs

Journal of the American Animal Hospital Association, 32(6), 471–475.

By: K. Meurs*, M. Miller & M. Slater

MeSH headings : Animals; Blood Pressure / physiology; Blood Pressure Determination; Blood Pressure Monitors / standards; Blood Pressure Monitors / veterinary; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs / physiology; Female; Hypotension / diagnosis; Hypotension / physiopathology; Hypotension / veterinary; Male; Oscillometry / instrumentation; Oscillometry / methods; Oscillometry / veterinary; Predictive Value of Tests; Sensitivity and Specificity; Unconsciousness / physiopathology
TL;DR: The indirect oscillometric method of blood pressure measurement was compared to the direct arterial puncture method in 15 anesthetized dogs, divided into three weight groups, undergoing a variety of surgical procedures, and appeared to be sensitive and specific for detecting hypotension. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2020

1996 chapter

Myocardial Disease

In Handbook of Small Animal Practice (3rd ed., pp. 560–568). Philadelphia: WB Saunders.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

1995 chapter

Canine Chagas' Myocarditis

In Current Veterinary Therapy (Small Animal Practice) XII (pp. 850–853). Philadelphia: WB Saunders.

By: K. Meurs, M. Miller & R. Helman

Source: NC State University Libraries
Added: October 10, 2020

1995 journal article

Cardiovascular consequences of feline hyperthyroidism

Veterinary Technician, 16, 23–26.

By: K. Glaze & K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

1995 journal article

ECG of the Month

Journal of the American Veterinary Medical Association, 206, 957–959.

By: K. Meurs & M. Miller

Source: NC State University Libraries
Added: October 10, 2020

1995 chapter

Zinc Toxicosis

In Current Veterinary Therapy (Small Animal Practice) XII (pp. 238–240). Philadelphia: WB Saunders.

By: K. Meurs & E. Breitschwerdt

Source: NC State University Libraries
Added: October 10, 2020

1995 chapter

Zinc toxicity

In Five Minute Veterinary Consult (p. 1164). Baltimore: Williams & Wilkens.

By: K. Meurs

Source: NC State University Libraries
Added: October 10, 2020

1994 journal article

Aberrant migration of toxocara larva as a cause of myocarditis in the dog

Journal of the American Animal Hospital Association, 30(6), 580–582.

By: K. Meurs, C. Atkins, L. Khoo & B. Keene

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Syncope associated with cardiac lymphoma in a cat

Journal of the American Animal Hospital Association, 30, 583–585.

By: K. Meurs, M. Miller, J. Mackie & P. Mathison

Source: NC State University Libraries
Added: October 10, 2020

1993 journal article

Chylothorax associated with right-sided heart failure in five cats

Journal of the American Veterinary Medical Association, 204(1), 84–89.

By: T. Fossum, M. Miller, K. Rogers, J. Bonagura & K. Meurs

Source: NC State University Libraries
Added: October 18, 2020

1993 journal article

ECG of the Month

Journal of the American Veterinary Medical Association, 203, 649–650.

By: K. Meurs & M. Miller

Source: NC State University Libraries
Added: October 10, 2020

1992 journal article

Challenging cases in internal medicine - Beagle polyarteritis

Veterinary Medicine, 87, 986–990.

By: L. Sinclair & K. Meurs

Source: NC State University Libraries
Added: October 18, 2020

1991 journal article

Postsurgical mortality secondary to zinc toxicity in dogs

Veterinary and Human Toxicology, 33(6), 579.

By: K. Meurs, E. Breitschwerdt & C. Baty

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Postsurgical mortality secondary to zinc toxicity in dogs

Veterinary and Human Toxicology, 33(6), 579–583.

By: K. Meurs, E. Breitschwerdt, C. Baty & M. Young

Source: NC State University Libraries
Added: October 18, 2020

journal article

Evaluation of artificial selection in Standard Poodles using whole-genome sequencing

Friedenberg, S. G., Meurs, K. M., & Mackay, T. F. C. Mammalian Genome, 27(11-12), 599–609.

By: S. Friedenberg, K. Meurs & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

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