@misc{moore_murthy_graham-gurysh_hingtgen_bachelder_ainslie_2020, title={Polymeric Biomaterial Scaffolds for Tumoricidal Stem Cell Glioblastoma Therapy}, volume={6}, ISSN={["2373-9878"]}, DOI={10.1021/acsbiomaterials.0c00477}, abstractNote={Glioblastoma (GBM) is the most common primary brain tumor and has a poor prognosis; as such, there is an urgent need to develop innovative new therapies. Tumoricidal stem cells are an emerging therapy that has the potential to combat limitations of traditional local and systemic chemotherapeutic strategies for GBM by providing a source for high, sustained concentrations of tumoricidal agents locally to the tumor. One major roadblock for tumoricidal stem cell therapy is that the persistence of tumoricidal stem cells injected as a cell suspension into the GBM surgical resection cavity is limited. Polymeric biomaterial scaffolds have been utilized to enhance the delivery of tumoricidal stem cells in the surgical resection cavity and extend their persistence in the brain, ultimately increasing their therapeutic efficacy against GBM. In this review, we examine three main scaffold categories explored for tumoricidal stem cell therapy: microcapsules, hydrogels, and electrospun scaffolds. Furthermore, considering the significant impact of surgery on the brain and recurrent GBM, we survey a brief history of orthotopic models of GBM surgical resection.}, number={7}, journal={ACS BIOMATERIALS SCIENCE & ENGINEERING}, author={Moore, Kathryn M. and Murthy, Ananya B. and Graham-Gurysh, Elizabeth G. and Hingtgen, Shawn D. and Bachelder, Eric M. and Ainslie, Kristy M.}, year={2020}, month={Jul}, pages={3762–3777} }
 @article{graham-gurysh_moore_satterlee_sheets_lin_bachelder_miller_hingtgen_ainslie_2018, title={Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection}, volume={15}, ISSN={["1543-8384"]}, DOI={10.1021/acs.molpharmaceut.7b01114}, abstractNote={The primary cause of mortality for glioblastoma (GBM) is local tumor recurrence following standard-of-care therapies, including surgical resection. With most tumors recurring near the site of surgical resection, local delivery of chemotherapy at the time of surgery is a promising strategy. Herein drug-loaded polymer scaffolds with two distinct degradation profiles were fabricated to investigate the effect of local drug delivery rate on GBM recurrence following surgical resection. The novel biopolymer, acetalated dextran (Ace-DEX), was compared with commercially available polyester, poly(l-lactide) (PLA). Steady-state doxorubicin (DXR) release from Ace-DEX scaffolds was found to be faster when compared with scaffolds composed of PLA, in vitro. This increased drug release rate translated to improved therapeutic outcomes in a novel surgical model of orthotopic glioblastoma resection and recurrence. Mice treated with DXR-loaded Ace-DEX scaffolds (Ace-DEX/10DXR) resulted in 57% long-term survival out to study completion at 120 days compared with 20% survival following treatment with DXR-loaded PLA scaffolds (PLA/10DXR). Additionally, all mice treated with PLA/10DXR scaffolds exhibited disease progression by day 38, as defined by a 5-fold growth in tumor bioluminescent signal. In contrast, 57% of mice treated with Ace-DEX/10DXR scaffolds displayed a reduction in tumor burden, with 43% exhibiting complete remission. These results underscore the importance of polymer choice and drug release rate when evaluating local drug delivery strategies to improve prognosis for GBM patients undergoing tumor resection.}, number={3}, journal={MOLECULAR PHARMACEUTICS}, author={Graham-Gurysh, Elizabeth and Moore, Kathryn M. and Satterlee, Andrew B. and Sheets, Kevin T. and Lin, Feng-Chang and Bachelder, Eric M. and Miller, C. Ryan and Hingtgen, Shawn D. and Ainslie, Kristy M.}, year={2018}, month={Mar}, pages={1309–1318} }