Kathryn M Murphy

Works (16)

Updated: April 5th, 2024 00:56

2022 article

Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-beta, in dogs with atopic dermatitis

Herrmann, I., Mamo, L. B., Holmes, J., Mohammed, J. P., Murphy, K. M., & Bizikova, P. (2022, December 8). VETERINARY DERMATOLOGY.

By: I. Herrmann n, L. Mamo n, J. Holmes n, J. Mohammed n, K. Murphy n & P. Bizikova n

author keywords: canine atopic dermatitis; ciclosporin; oclacitinib; T regulatory cell
MeSH headings : Dogs; Animals; Cyclosporine / therapeutic use; T-Lymphocytes, Regulatory; Interleukin-10; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Transforming Growth Factor beta1 / therapeutic use; Transforming Growth Factor beta / therapeutic use; Immune Tolerance; Dog Diseases / drug therapy
TL;DR: Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2023

2016 article

Pathology in Practice

Meichner, K., Montgomery, S. A., Borst, L. B., Murphy, K. M., & Grindem, C. B. (2016, November 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 249, pp. 1023–1026.

By: K. Meichner*, S. Montgomery*, L. Borst* , K. Murphy & C. Grindem*

MeSH headings : Animals; Biopsy; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Male; Sertoli Cell Tumor / diagnosis; Sertoli Cell Tumor / pathology; Sertoli Cell Tumor / veterinary; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Testicular Neoplasms / diagnosis; Testicular Neoplasms / pathology; Testicular Neoplasms / veterinary
TL;DR: In collaboration with the American College of Veterinary Pathologists, this work presents a probabilistic procedure to identify the immune checkpoints in the connective tissue of the immune system and results indicate which immune checkpoints are responsible for disease progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections

Journal of the American Veterinary Medical Association, 247(8), 938–944.

By: M. Jacob*, J. Hoppin* , N. Steers*, J. Davis*, G. Davidson*, B. Hansen, K. Lunn* , K. Murphy, M. Papich* 

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR: Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

The influence of mometasone furoate ear solution on intradermal test immediate reactions in dogs with atopic dermatitis

VETERINARY DERMATOLOGY, 26(1), 31-+.

By: K. Murphy n & T. Olivry n 

Contributors: K. Marcia Murphy & T. Olivry n 

MeSH headings : Administration, Topical; Alanine Transaminase / blood; Alkaline Phosphatase / blood; Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / adverse effects; Anti-Inflammatory Agents / therapeutic use; Dermatitis, Atopic / diagnosis; Dermatitis, Atopic / veterinary; Dog Diseases / diagnosis; Dogs; Ear, External; Female; Intradermal Tests / veterinary; Male; Mometasone Furoate; Otitis Externa / drug therapy; Otitis Externa / veterinary; Pregnadienediols / administration & dosage; Pregnadienediols / adverse effects; Pregnadienediols / therapeutic use
TL;DR: Results from this study show that a withdrawal period of ≤7 days is possible before performing IDT in atopic dogs with active otitis externa treated with ≤14 days of MF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Eosinophilic esophagitis in a dog

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 235(1), 61–65.

By: M. Mazzei*, S. Bissett*, K. Murphy, S. Hunter* & J. Neel* 

Contributors: M. Mazzei*, S. Bissett*, K. Murphy*, S. Hunter* & J. Neel* 

MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / pathology; Dogs; Eosinophilia / diagnosis; Eosinophilia / therapy; Eosinophilia / veterinary; Esophagitis / diagnosis; Esophagitis / pathology; Esophagitis / therapy; Esophagitis / veterinary; Female; Gastrointestinal Agents / therapeutic use; Prednisone / therapeutic use
TL;DR: The first description of eosinophilic esophagitis (EE) in a dog with a history of allergic skin disease is reported, highlighting the need to consider EE as a differential diagnosis for esphagitis and esophageal strictures in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 personal communication

A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis

Olivry, T., Paps, J. S., Bizikova, P., Murphy, K. M., Jackson, H. A., & Zebala, J. (2007, November).

By: T. Olivry n , J. Paps n, P. Bizikova  n, K. Murphy n, H. Jackson n & J. Zebala *

Contributors: T. Olivry n , J. Paps n, P. Bizikova  n, K. Murphy n, H. Jackson n & J. Zebala *

MeSH headings : Aminopterin / therapeutic use; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dog Diseases / drug therapy; Dogs; Folic Acid Antagonists / therapeutic use; Humans; Models, Animal; Pilot Projects; Treatment Outcome
TL;DR: The efficacy of AMT in the spontaneous canine model of human AD, where methotrexate appears to be more potent and to have a higher bioavailability and lower toxic effects, is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Subtotal Ear Canal Ablation in 18 Dogs and One Cat With Minimal Distal Ear Canal Pathology

Journal of the American Animal Hospital Association, 42(5), 371–380.

By: K. Mathews n, E. Hardie n & K. Murphy n

MeSH headings : Animals; Cat Diseases / surgery; Cats; Dog Diseases / surgery; Dogs; Ear Canal / surgery; Ear Diseases / surgery; Ear Diseases / veterinary; Female; Male; Otitis Externa / surgery; Otitis Externa / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: Further investigation is required before the procedure can be recommended as a treatment for otitis externa not caused by masses or anatomical abnormalities of the horizontal ear canal in dogs with pendulous ears. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2005 journal article

Evaluation of a point-of-care immunodot assay for predicting results of allergen-specific intradermal and immunoglobulin E serological tests

VETERINARY DERMATOLOGY, 16(2), 117–120.

By: T. Olivry* , H. Jackson*, K. Murphy*, K. Tater* & M. Roberts n

Contributors: T. Olivry* , H. Jackson*, K. Murphy*, K. Tater* & M. Roberts n

MeSH headings : Allergens / immunology; Animals; Dermatitis, Atopic / diagnosis; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / diagnosis; Dog Diseases / immunology; Dogs; Female; Immunoblotting / standards; Immunoblotting / veterinary; Immunoglobulin E / analysis; Immunoglobulin E / immunology; Intradermal Tests / standards; Intradermal Tests / veterinary; Male; Predictive Value of Tests; Sensitivity and Specificity; Serologic Tests / methods
TL;DR: In this population of dogs with AD, results of the E-Screen point-of-care immunodot assay was found to often agree with those of allergen-specific intradermal or Allercept tests for selected allerGEN groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor-alpha

VETERINARY DERMATOLOGY, 14(1), 37–46.

By: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n, E. Peters n, G. Dean n

Contributors: T. Olivry n , S. Dunston n, C. Rivierre n, H. Jackson n, K. Murphy n, E. Peters n, G. Dean n

author keywords: allergy; atopic dermatitis; atopy; canine; misoprostol; randomized controlled trial; tumour necrosis factor alpha
MeSH headings : Administration, Oral; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dermatologic Agents / administration & dosage; Dermatologic Agents / pharmacology; Dermatologic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Double-Blind Method; Female; Fluorescent Antibody Technique, Indirect / veterinary; Male; Misoprostol / administration & dosage; Misoprostol / pharmacology; Misoprostol / therapeutic use; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Treatment Outcome; Tumor Necrosis Factor-alpha / drug effects; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The modest efficacy of misoprostol for treatment of canine AD is confirmed and its mild anti-allergic effects are suggested to be associated with either inhibition of inflammatory cell emigration or TNFalpha production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Efficacy of cyclosporine for treatment induction of canine pemphigus foliaceus

Veterinary Record, 152(2), 53–54.

By: T. Olivry n , C. Rivierre n & K. Murphy n

MeSH headings : Administration, Oral; Animals; Breeding; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Pemphigus / drug therapy; Pemphigus / veterinary; Pilot Projects; Severity of Illness Index; Treatment Outcome
TL;DR: This short communication describes a pilot study to investigate whether cyclosporine monotherapy would be effective for the induction of treatment in dogs with PF, and the reduction from the baseline of the PEFESI lesional score. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 6, 2018

2002 article

Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial

Olivry, T., Rivierre, C., Jackson, H. A., Murphy, K. M., Davidson, G., & Sousa, C. A. (2002, April). VETERINARY DERMATOLOGY, Vol. 13, pp. 77–87.

By: T. Olivry n , C. Rivierre n, H. Jackson n, K. Murphy n, G. Davidson n & C. Sousa

Contributors: T. Olivry n , C. Rivierre n, H. Jackson n, K. Murphy n, G. Davidson n & C. Sousa

author keywords: allergy; atopic dermatitis; atopy; canine; ciclosporine; corticosteroids; cyclosporin A; cyclosporin; glucocorticoids; randomized controlled trial
MeSH headings : Administration, Oral; Animals; California; Cyclosporine / administration & dosage; Cyclosporine / adverse effects; Cyclosporine / therapeutic use; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dermatologic Agents / administration & dosage; Dermatologic Agents / adverse effects; Dermatologic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Double-Blind Method; Female; Male; North Carolina; Prednisolone / administration & dosage; Prednisolone / therapeutic use; Prospective Studies; Pruritus / drug therapy; Pruritus / veterinary; Severity of Illness Index; Treatment Outcome; Virginia
TL;DR: It is proposed that oral CsA should be considered as a valuable alternative to glucocorticoid therapy in dogs with AD because of the anti-allergic efficacy that appears comparable with that of prednisolone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 review

A review of techniques for the investigation of otitis externa and otitis media

[Review of ]. CLINICAL TECHNIQUES IN SMALL ANIMAL PRACTICE, 16(4), 236–241.

By: K. Murphy n

MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Dog Diseases / diagnosis; Dogs; Otitis Externa / diagnosis; Otitis Externa / veterinary; Otitis Media / diagnosis; Otitis Media / veterinary
TL;DR: The predisposing, primary, and perpetuating factors involved in ear disease will be presented, along with a review of the techniques used in the diagnosis of otitis externa and otitis media. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Characterization of the inflammatory infiltrate during IgE-mediated late phase reactions in the skin of normal and atopic dogs

VETERINARY DERMATOLOGY, 12(1), 49–58.

By: T. Olivry n , S. Dunston n, K. Murphy n & P. Moore *

Contributors: T. Olivry n , S. Dunston n, K. Murphy n & P. Moore *

author keywords: allergy; atopic dermatitis; dog; late-phase reaction; skin
MeSH headings : Allergens; Animals; Case-Control Studies; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dogs; Immunoglobulin E / immunology; Immunohistochemistry / veterinary; Leukocytes; Mites
TL;DR: Because IgE-mediated late-phase reactions resemble spontaneous atopic canine skin lesions, both at macroscopic and microscopic levels, it is proposed the use of similar challenges to study the anti-inflammatory effects of anti-allergic drugs in a pre-clinical setting. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 journal article

Comparison of T-lymphocyte proliferation in canine epitheliotropic lymphosarcoma and benign lymphocytic dermatoses

Veterinary Dermatology, 11(2), 99–105.

By: K. Murphy n & T. Olivry n 

TL;DR: The purpose of this study was to determine, using a proliferating cell nuclear antigen (PCNA)/CD3 double immunolabelling technique of paraffin-embedded sections, if the rate of T-cell proliferation in canine CTCL was greater than that of other diseases with non-neoplastic lymphocyte epitheliotropism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

A description of cutaneous-subcutaneous pythiosis in fifteen dogs

MEDICAL MYCOLOGY, 37(6), 427–433.

By: M. Dykstra n, N. Sharp, T. Olivry* , A. Hillier, K. Murphy*, L. Kaufman, G. Kunkle, C. Pucheu-Haston

Contributors: M. Dykstra n, N. Sharp, T. Olivry* , A. Hillier, K. Murphy*, L. Kaufman, G. Kunkle, C. Pucheu-Haston

author keywords: canine; diagnosis; pythiosis; therapy
MeSH headings : Animals; Dermatomycoses / diagnosis; Dermatomycoses / pathology; Dermatomycoses / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Male; Pythium / isolation & purification
TL;DR: The prognosis for cutaneous pythiosis in the dog is poor and Histopathological evaluation using the Gomori Methenamine-Silver (GMS) stain was the most useful test for providing presumptive evidence of cutaneouspythiosis. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1999 journal article

Bullous systemic lupus erythematosus (type I) in a dog

VETERINARY RECORD, 145(6), 165–169.

By: T. Olivry n , K. Savary n, K. Murphy n, S. Dunston n & M. Chen*

MeSH headings : Animals; Autoantibodies / analysis; Collagen / immunology; Dapsone / therapeutic use; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lupus Erythematosus, Systemic / diagnosis; Lupus Erythematosus, Systemic / drug therapy; Lupus Erythematosus, Systemic / immunology; Lupus Erythematosus, Systemic / veterinary; Male; Prednisone / therapeutic use; Skin / metabolism; Skin / pathology; Skin Diseases, Vesiculobullous / diagnosis; Skin Diseases, Vesiculobullous / drug therapy; Skin Diseases, Vesiculobullous / immunology; Skin Diseases, Vesiculobullous / veterinary
TL;DR: Anti-collagen Vil type l-BSLE needs to be considered as a possible differential diagnosis for canine autoimmune subepidermal blistering diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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