Kurt Selle

Works (14)

Updated: April 25th, 2025 17:22

2023 article

Applications of designer phage encoding recombinant gene payloads

Schmitt, D. S., Siegel, S. D., & Selle, K. (2023, October 11). Trends in Biotechnology.

By: D. Schmitt n, S. Siegel n & K. Selle n

MeSH headings : Humans; Bacteriophages / genetics; Genetic Engineering; Bacteria / genetics; Genome, Viral
topics (OpenAlex): Bacteriophages and microbial interactions; Monoclonal and Polyclonal Antibodies Research; CRISPR and Genetic Engineering
Source: Web Of Science
Added: April 29, 2024

2019 article

Outcomes and characterization of chromosomal self-targeting by native CRISPR-Cas systems in Streptococcus thermophilus

Cañez, C., Selle, K., Goh, Y. J., & Barrangou, R. (2019, May 1). FEMS Microbiology Letters, Vol. 366.

By: C. Cañez n, K. Selle n, Y. Goh n & R. Barrangou n 

author keywords: CRISPR; lactic acid bacteria; Cas9; Streptococcus; genome editing
MeSH headings : Bacteriophages / genetics; CRISPR-Cas Systems; Chromosomes, Bacterial / genetics; Gene Editing; Genome, Bacterial; Homologous Recombination; Plasmids / genetics; Streptococcus thermophilus / genetics; Streptococcus thermophilus / virology
topics (OpenAlex): CRISPR and Genetic Engineering; RNA and protein synthesis mechanisms; Bacterial Genetics and Biotechnology
TL;DR: Results suggest that HR contributes to the plasticity and remodeling of bacterial genomes, leading to evasion of genome targeting by CRISPR-Cas systems. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 3, 2019

2019 article

Short communication: Transcriptional response to a large genomic island deletion in the dairy starter culture Streptococcus thermophilus

Selle, K., Andersen, J. M., & Barrangou, R. (2019, July 3). Journal of Dairy Science, Vol. 102, pp. 7800–7806.

By: K. Selle n, J. Andersen n & R. Barrangou n 

author keywords: fermentation; Streptococcus thermophilus; transcriptome; CRISPR
MeSH headings : Animals; Clustered Regularly Interspaced Short Palindromic Repeats; Fermentation; Gene Deletion; Gene Expression Regulation, Bacterial / physiology; Genomic Islands; Genomics; Lactic Acid / metabolism; Lactobacillus delbrueckii / metabolism; Milk / microbiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism; Transcriptome; Yogurt / microbiology
topics (OpenAlex): Probiotics and Fermented Foods; CRISPR and Genetic Engineering; Bacterial Genetics and Biotechnology
TL;DR: Results suggest that deletion of a 102-kb genomic island in Strep. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 26, 2019

2017 article

Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus

Selle, K., Goh, Y. J., Johnson, B. R., Sarah, O. F., Andersen, J. M., Barrangou, R., & Klaenhammer, T. R. (2017, April 11). Frontiers in Microbiology, Vol. 8.

By: K. Selle n, Y. Goh n, B. Johnson n, O. Sarah n, J. Andersen n, R. Barrangou n , T. Klaenhammer n

topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Bacterial Genetics and Biotechnology
TL;DR: Results elucidate the impact of ltaS deletion on the transcriptome and extracellular proteins of L. acidophilus, suggesting roles of LTA in cell morphology and ion homeostasis as a structural component of the Gram positive cell wall. (via Semantic Scholar)
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Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

SIGNR 3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis

Lightfoot, Y. L., Selle, K., Yang, T., Goh, Y. J., Sahay, B., Zadeh, M., … Mohamadzadeh, M. (2015, February 9). The EMBO Journal.

By: Y. Lightfoot *, K. Selle n, T. Yang *, Y. Goh n, B. Sahay *, M. Zadeh *, J. Owen*, N. Colliou* ...

author keywords: colitis; immune regulation; Lactobacillus acidophilus; SIGNR3; surface layer protein A
MeSH headings : Animals; Antigens, CD / genetics; Antigens, CD / immunology; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Inflammatory Bowel Diseases / genetics; Inflammatory Bowel Diseases / immunology; Inflammatory Bowel Diseases / microbiology; Inflammatory Bowel Diseases / pathology; Intestinal Mucosa / immunology; Intestinal Mucosa / pathology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / immunology; Lectins, C-Type / genetics; Lectins, C-Type / immunology; Lipopolysaccharides / genetics; Lipopolysaccharides / immunology; Mice; Mice, Knockout; Protein Binding / genetics; Protein Binding / immunology; Teichoic Acids / genetics; Teichoic Acids / immunology
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Helicobacter pylori-related gastroenterology studies; Probiotics and Fermented Foods
TL;DR: This work presents critical insights into SlpA/SIGNR3‐induced responses that are integral to the potential development of novel biological therapies for autoinflammatory diseases, including IBD. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

CRISPR-based screening of genomic island excision events in bacteria

Selle, K., Klaenhammer, T. R., & Barrangou, R. (2015, June 15). Proceedings of the National Academy of Sciences, Vol. 112, pp. 8076–8081.

By: K. Selle n, T. Klaenhammer n & R. Barrangou n 

author keywords: CRISPR; lactic acid bacteria; transposons; IS-elements; Cas9
MeSH headings : Clustered Regularly Interspaced Short Palindromic Repeats; Gene Deletion; Genome, Bacterial; Homeostasis; Homologous Recombination; Streptococcus thermophilus / genetics; Streptococcus thermophilus / growth & development
topics (OpenAlex): CRISPR and Genetic Engineering; RNA and protein synthesis mechanisms; Bacteriophages and microbial interactions
TL;DR: This study shows that CRISPR-Cas systems can be directed to target and delete genomic islands that are flanked by insertion-sequence elements and devoid of essential genes, and established that self-targeting CRISpr-cas systems may direct significant evolution of bacterial genomes on a population level, influencing genome homeostasis and remodeling. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Harnessing CRISPR–Cas systems for bacterial genome editing

Selle, K., & Barrangou, R. (2015, February 17). Trends in Microbiology, Vol. 23, pp. 225–232.

By: K. Selle n & R. Barrangou n 

author keywords: genome editing; CRISPR-Cas; Cas9
MeSH headings : Bacteria / genetics; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats; DNA Repair; Genetic Engineering / methods; Genome, Bacterial; Homeostasis / genetics; Mutation; Phenotype
topics (OpenAlex): CRISPR and Genetic Engineering; Innovation and Socioeconomic Development; Insect symbiosis and bacterial influences
TL;DR: This review summarizes recent progress in bacterial genome editing and identifies fundamental genetic and phenotypic outcomes of CRISPR targeting in bacteria, in the context of tool development, genome homeostasis, and DNA repair. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

JFS Special Issue: 75 years of advancing food science, and preparing for the next 75 CRISPR-based technologies and the future of food science

Journal of Food Science, 80(11), R2367–2372.

By: K. Selle & R. Barrangou 

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri

Sanozky-Dawes, R., Selle, K., O'Flaherty, S., Klaenhammer, T., & Barrangou, R. (2015, July 9). Microbiology, Vol. 161, pp. 1752–1761.

By: R. Sanozky-Dawes n, K. Selle n, S. O'Flaherty n, T. Klaenhammer n & R. Barrangou n 

MeSH headings : Base Sequence; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Order; Genome, Bacterial; Lactobacillus / genetics; Molecular Sequence Data; Plasmids / genetics
topics (OpenAlex): CRISPR and Genetic Engineering; Bacteriophages and microbial interactions; Cytomegalovirus and herpesvirus research
TL;DR: The distribution and function of a native type II-A CRISPR-Cas system in the commensal species L. gasseri is reported, which open avenues for applications for bacteriophage protection and genome modification in L.gasseri, and contribute to the fundamental understanding of CRISpr-Cas systems in bacteria. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality

Briner, A. E., Donohoue, P. D., Gomaa, A. A., Selle, K., Slorach, E. M., Nye, C. H., … Barrangou, R. (2014, October 1). Molecular Cell, Vol. 56, pp. 333–339.

By: A. Briner n, P. Donohoue *, A. Gomaa n, K. Selle n, E. Slorach*, C. Nye*, R. Haurwitz*, C. Beisel n, A. May *, R. Barrangou n 

MeSH headings : Bacterial Proteins / chemistry; CRISPR-Associated Protein 9; CRISPR-Associated Proteins / chemistry; CRISPR-Cas Systems; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / chemistry; DNA Cleavage; Endonucleases / chemistry; Genetic Engineering / methods; HEK293 Cells; Humans; Nucleic Acid Conformation; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / ultrastructure
topics (OpenAlex): CRISPR and Genetic Engineering; RNA and protein synthesis mechanisms; RNA regulation and disease
TL;DR: Six conserved modules within native crRNA:tracrRNA duplexes and single guide RNAs that direct Cas9 endonuclease activity are identified and characterized and it is shown the bulge and nexus are necessary for DNA cleavage and the nexus and hairpins are instrumental in defining orthogonality between systems. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems

Gomaa, A. A., Klumpe, H. E., Luo, M. L., Selle, K., Barrangou, R., & Beisel, C. L. (2014, January 28). MBio, Vol. 5, pp. e00928–13-e00928–13.

By: A. Gomaa n, H. Klumpe  n, M. Luo n, K. Selle n, R. Barrangou n  & C. Beisel n

MeSH headings : CRISPR-Cas Systems; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Escherichia coli / genetics; Genome, Bacterial; Hydrolysis; Microbial Viability
topics (OpenAlex): CRISPR and Genetic Engineering; Bacteriophages and microbial interactions; Vibrio bacteria research studies
TL;DR: It is demonstrated that genome targeting with CRISPR-Cas systems can be employed for the sequence-specific and titratable removal of individual bacterial strains and species and may open new avenues for the development of “smart” antibiotics that circumvent multidrug resistance and differentiate between pathogenic and beneficial microorganisms. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 article

Sortase-deficient lactobacilli: effect on immunomodulation and gut retention

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & Sarah, O. F. (2014, December 13). Microbiology.

By: E. Call n, Y. Goh n, K. Selle n, T. Klaenhammer n & O. Sarah n

MeSH headings : Aminoacyltransferases / genetics; Aminoacyltransferases / immunology; Aminoacyltransferases / metabolism; Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Caco-2 Cells; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Cysteine Endopeptidases / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Gastrointestinal Tract / immunology; Gastrointestinal Tract / microbiology; Humans; Immunomodulation; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / physiology; Mice; Swine; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Biochemical and Structural Characterization; Probiotics and Fermented Foods; Biochemical Analysis and Sensing Techniques
TL;DR: It is shown for the first time that sortase-dependent proteins contribute to gut retention of probiotic microbes in the gastrointestinal tract. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Genomic and phenotypic evidence for probiotic influences ofLactobacillus gasserion human health

Selle, K., & Klaenhammer, T. R. (2013, March 15). FEMS Microbiology Reviews.

By: K. Selle n & T. Klaenhammer n

author keywords: gastrointestinal tract; acidophilus complex; bacteriocin; lactic acid bacteria; autochthonous; microbiota
MeSH headings : Animals; Bacteriocins / metabolism; Female; Gastrointestinal Tract / microbiology; Gastrointestinal Tract / physiology; Genome, Bacterial; Health; Helicobacter Infections / diet therapy; Helicobacter pylori; Homeostasis; Humans; Hypersensitivity / prevention & control; Immune System / physiology; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / physiology; Probiotics / therapeutic use; Vagina / microbiology; Vagina / physiology; Virus Diseases / diet therapy
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies
TL;DR: The genomic and empirical evidence supporting use of L. gasseri in probiotic applications is substantiated by clinical trial data displaying maintenance of vaginal homeostasis, mitigation of Helicobacter pylori infection, and amelioration of diarrhea. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM

Johnson, B., Selle, K., Sarah, O. F., Goh, Y. J., & Klaenhammer, T. (2013, September 4). Microbiology.

By: B. Johnson n, K. Selle n, O. Sarah n, Y. Goh n & T. Klaenhammer n

MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Probiotics and Fermented Foods; Bacterial Genetics and Biotechnology; Antimicrobial Peptides and Activities
TL;DR: P phenotypic characterization of the deletion mutant demonstrated that the SLAP LBA1029 contributes to a pro-inflammatory TNF-α response from murine DCs, and appears to impart important surface display features and immunological properties to microbes that are coated by S-layers. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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