Khue Nguyen

Works (8)

Updated: June 5th, 2025 07:22

2025 article

An injectable hydrogel enhances intratumoral retention and antitumor efficacy of cytokine immunotherapy in murine triple negative breast tumor models

Mantooth, S. M., Green, J. M., Green, W. D., Nguyen, K. G., Mantooth, K. A., Meritet, D. M., … Zaharoff, D. A. (2025, April 25). Journal of Controlled Release.

By: S. Mantooth*, J. Green, W. Green, K. Nguyen*, K. Mantooth, D. Meritet n, J. Milner, D. Zaharoff*

author keywords: Hydrogel; Intratumoral; Immunotherapy; Breast cancer; Cytokine; Chitosan
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Cells and Metastasis; Immune cells in cancer
Source: Web Of Science
Added: May 27, 2025

2024 article

Development of Humanized Antibodies Against Vasoactive Intestinal Polypeptide for Increased T Cell Anti-Leukemia Activity

Adeyeye, J., Giver, C. R., Cohen, J., Wang, Y., Charles, T. P., Nguyen, K. G., … Waller, E. K. (2024, November 5). Blood.

By: J. Adeyeye*, C. Giver *, J. Cohen *, Y. Wang *, T. Charles*, K. Nguyen n, J. Li *, J. Wrammert *, D. Zaharoff n, E. Waller *

topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Peptidase Inhibition and Analysis; Glycosylation and Glycoproteins Research
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Source: Web Of Science
Added: March 17, 2025

2024 article

Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

Weiss, L., Schluck, M., Classens, R., Jonge, P. K. J. D., Waart, A., Nguyen, K. G., … Hammink, R. (2024, November 9). Acta Biomaterialia.

By: L. Weiss *, M. Schluck *, R. Classens *, P. Jonge *, A. Waart*, K. Nguyen n, T. Nguyen n, D. Zaharoff n ...

author keywords: Immunotherapy; Natural killer cell engagement; Immunofilaments; Cytokine delivery; Interleukin-12
MeSH headings : Killer Cells, Natural / immunology; Interleukin-12 / metabolism; Interferon-gamma / metabolism; Humans; Animals; Nanoparticles / chemistry; Receptors, IgG / metabolism; Mice; Lymphocyte Activation / drug effects
topics (OpenAlex): Immune Cell Function and Interaction; Immunotherapy and Immune Responses; T-cell and B-cell Immunology
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Source: Web Of Science
Added: January 13, 2025

2023 article

Focal Cryo-Immunotherapy with Intratumoral IL-12 Prevents Recurrence of Large Murine Tumors

Vrabel, M. R., Schulman, J. A., Gillam, F. B., Mantooth, S. M., Nguyen, K. G., & Zaharoff, D. A. (2023, April 8). Cancers.

By: M. Vrabel  n, J. Schulman  n, F. Gillam n, S. Mantooth n, K. Nguyen n & D. Zaharoff n

author keywords: focal ablation; cryoablation; IL-12; intratumoral; immunotherapy; abscopal response; checkpoint therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Cancer Immunotherapy and Biomarkers; Cancer Cells and Metastasis
TL;DR: Cryo-immunotherapy with localized CS/IL-12 reduces recurrences and enhances the elimination of large primary tumors, and induces significant but limited systemic antitumor immunity. (via Semantic Scholar)
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Source: Web Of Science
Added: May 15, 2023

2022 article

1371 Identification of vasoactive intestinal peptide (VIP)-specific single-chain antibody fragments (scFvs) via yeast surface display

Zaharoff, D., & Nguyen, K. (2022, November 1). Regular and Young Investigator Award Abstracts.

By: D. Zaharoff n & K. Nguyen n

topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Advanced Biosensing Techniques and Applications; Glycosylation and Glycoproteins Research
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 24, 2023

2022 article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

Nguyen, K. G., Mantooth, S. M., Vrabel, M. R., & Zaharoff, D. A. (2022, May 3). Frontiers in Immunology.

By: K. Nguyen n, S. Mantooth n, M. Vrabel  n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; Immunotherapy and Immune Responses; Respiratory viral infections research
TL;DR: Data indicate that the designed vaccine platform is versatile, adaptable and capable of overcoming key constraints of current COVID-19 vaccines. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 31, 2022

2022 article

Raman spectroscopy reveals phenotype switches in breast cancer metastasis

Paidi, S. K., Troncoso, J. R., Harper, M. G., Liu, Z., Nguyen, K. G., Ravindranathan, S., … Barman, I. (2022, January 1). Theranostics.

By: S. Paidi *, J. Troncoso*, M. Harper*, Z. Liu *, K. Nguyen n, S. Ravindranathan *, L. Rebello*, D. Lee * ...

author keywords: Raman spectroscopy; Cancer metastasis; Random forests; Phenotype switch; TWIST
MeSH headings : Animals; Cell Line, Tumor; Melanoma; Mice; Neoplasm Metastasis; Neoplasms, Second Primary; Phenotype; Skin Neoplasms; Spectrum Analysis, Raman
topics (OpenAlex): Spectroscopy Techniques in Biomedical and Chemical Research; Molecular Biology Techniques and Applications; Identification and Quantification in Food
TL;DR: The findings indicate that Raman spectroscopy may offer a novel strategy to evaluate metastatic risk during primary tumor biopsies in clinical patients and provide evidence that machine learning models built on spectral data can allow the accurate identification of metastatic phenotype of independent test tumors. (via Semantic Scholar)
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Source: Web Of Science
Added: August 1, 2022

2021 article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

Nguyen, K. G., Wagner, E. S., Vrabel, M. R., Mantooth, S. M., Meritet, D. M., & Zaharoff, D. A. (2021, October 25). Bladder Cancer.

By: K. Nguyen n, E. Wagner n, M. Vrabel  n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
topics (OpenAlex): Urinary Tract Infections Management; Immune Cell Function and Interaction; Bladder and Urothelial Cancer Treatments
TL;DR: The lack of cystitis and acute inflammation justifies continued investigation of intravesical CS/IL-12 immunotherapy in larger animals and patients with bladder cancer. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 10, 2022

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