Khue Nguyen

Works (6)

Updated: January 17th, 2025 05:00

2024 journal article

Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

ACTA BIOMATERIALIA, 191, 386–397.

By: L. Weiss *, M. Schluck *, R. Classens *, P. Jonge, A. Waart, K. Nguyen n, T. Nguyen n, D. Zaharoff n ...

author keywords: Immunotherapy; Natural killer cell engagement; Immunofilaments; Cytokine delivery; Interleukin-12
Source: Web Of Science
Added: January 13, 2025

2023 journal article

Focal Cryo-Immunotherapy with Intratumoral IL-12 Prevents Recurrence of Large Murine Tumors

CANCERS, 15(8).

By: M. Vrabel  n, J. Schulman  n, F. Gillam n, S. Mantooth n, K. Nguyen n & D. Zaharoff n

author keywords: focal ablation; cryoablation; IL-12; intratumoral; immunotherapy; abscopal response; checkpoint therapy
TL;DR: Cryo-immunotherapy with localized CS/IL-12 reduces recurrences and enhances the elimination of large primary tumors, and induces significant but limited systemic antitumor immunity. (via Semantic Scholar)
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Source: Web Of Science
Added: May 15, 2023

2022 article

IDENTIFICATION OF VASOACTIVE INTESTINAL PEPTIDE (VIP)-SPECIFIC SINGLE-CHAIN ANTIBODY FRAGMENTS (SCFVS) VIA YEAST SURFACE DISPLAY

Zaharoff, D., & Nguyen, K. (2022, November). JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol. 10, pp. A1424–A1425.

By: D. Zaharoff n & K. Nguyen n

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Source: Web Of Science
Added: April 24, 2023

2022 journal article

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

FRONTIERS IN IMMUNOLOGY, 13.

By: K. Nguyen n, S. Mantooth n, M. Vrabel  n & D. Zaharoff n

author keywords: Intranasal vaccination; COVID-19; mucosal immunity; SARS-CoV-2; Receptor binding domain (RBD); chitosan; CpG
MeSH headings : Animals; Antibody Formation; COVID-19 / prevention & control; COVID-19 Vaccines; Humans; Immunoglobulin G; Mice; SARS-CoV-2; Vaccines, Subunit
TL;DR: Data indicate that the designed vaccine platform is versatile, adaptable and capable of overcoming key constraints of current COVID-19 vaccines. (via Semantic Scholar)
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Source: Web Of Science
Added: May 31, 2022

2022 journal article

Raman spectroscopy reveals phenotype switches in breast cancer metastasis

THERANOSTICS, 12(12), 5351–5363.

By: S. Paidi *, J. Troncoso*, M. Harper*, Z. Liu *, K. Nguyen n, S. Ravindranathan *, L. Rebello*, D. Lee * ...

author keywords: Raman spectroscopy; Cancer metastasis; Random forests; Phenotype switch; TWIST
MeSH headings : Animals; Cell Line, Tumor; Melanoma; Mice; Neoplasm Metastasis; Neoplasms, Second Primary; Phenotype; Skin Neoplasms; Spectrum Analysis, Raman
TL;DR: The findings indicate that Raman spectroscopy may offer a novel strategy to evaluate metastatic risk during primary tumor biopsies in clinical patients and provide evidence that machine learning models built on spectral data can allow the accurate identification of metastatic phenotype of independent test tumors. (via Semantic Scholar)
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Source: Web Of Science
Added: August 1, 2022

2021 journal article

Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders

BLADDER CANCER, 7(4), 427–437.

By: K. Nguyen n, E. Wagner n, M. Vrabel  n, S. Mantooth n, D. Meritet n & D. Zaharoff n

author keywords: Bladder cancer; Interleukin-12; immunotherapy; chitosan; intravesical
TL;DR: The lack of cystitis and acute inflammation justifies continued investigation of intravesical CS/IL-12 immunotherapy in larger animals and patients with bladder cancer. (via Semantic Scholar)
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Source: Web Of Science
Added: January 10, 2022

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