@article{roell_havener_reif_jack_mcleod_wiltshire_motsinger-reif_2019, title={Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines}, volume={10}, ISSN={["1664-8021"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85074258240&partnerID=MN8TOARS}, DOI={10.3389/fgene.2019.00829}, abstractNote={Lymphoblastoid cell lines (LCLs) are a highly successful model for evaluating the genetic etiology of cancer drug response, but applications using this model have typically focused on single drugs. Combination therapy is quite common in modern chemotherapy treatment since drugs often work synergistically, and it is an important progression in the use of the LCL model to expand work for drug combinations. In the present work, we demonstrate that synergy occurs and can be quantified in LCLs across a range of clinically important drug combinations. Lymphoblastoid cell lines have been commonly employed in association mapping in cancer pharmacogenomics, but it is so far untested as to whether synergistic effects have a genetic etiology. Here we use cell lines from extended pedigrees to demonstrate that there is a substantial heritable component to synergistic drug response. Additionally, we perform linkage mapping in these pedigrees to identify putative regions linked to this important phenotype. This demonstration supports the premise of expanding the use of the LCL model to perform association mapping for combination therapies.}, journal={FRONTIERS IN GENETICS}, author={Roell, Kyle R. and Havener, Tammy M. and Reif, David M. and Jack, John and McLeod, Howard L. and Wiltshire, Tim and Motsinger-Reif, Alison A.}, year={2019}, month={Oct} }
 @article{mahapatra_franzosa_roell_kuenemann_houck_reif_fourches_kullman_2018, title={Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays}, volume={8}, journal={Scientific Reports}, author={Mahapatra, D. and Franzosa, J. A. and Roell, K. and Kuenemann, M. A. and Houck, K. A. and Reif, D. M. and Fourches, D. and Kullman, S. W.}, year={2018} }
 @misc{roell_reif_motsinger-reif_2017, title={An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines}, volume={8}, journal={Frontiers in Pharmacology}, author={Roell, K. R. and Reif, D. M. and Motsinger-Reif, A. A.}, year={2017} }
 @article{prevatt_desmarais_janssen_2016, title={Lifetime substance use as a predictor of postpartum mental health}, volume={20}, ISSN={1434-1816 1435-1102}, url={http://dx.doi.org/10.1007/S00737-016-0694-5}, DOI={10.1007/s00737-016-0694-5}, abstractNote={Postpartum mood disorders (PPMD) affect approximately 10-20% of women and have adverse consequences for both mom and baby. Lifetime substance use has received limited attention in relation to PPMD. The present study examined associations of lifetime alcohol and drug use with postpartum mental health problems. Women (n = 100) within approximately 3 months postpartum (M = 2.01, SD = 1.32) participated in semi-structured interviews querying lifetime substance use, mental health history, and postpartum symptoms of anxiety, stress, posttraumatic stress disorder (PTSD), depression, and obsessive compulsive disorder. The study was conducted in an urban Canadian city from 2009 to 2010. Analyses revealed that lifetime substance use increased the variability explained in postpartum PTSD (p = .011), above and beyond sociodemographic characteristics and mental health history. The same trend, though not significant, was observed for stress (p = .059) and anxiety (p = .070). Lifetime drug use, specifically, was associated with postpartum stress (p = .021) and anxiety (p = .041), whereas lifetime alcohol use was not (ps ≥ .128). Findings suggest that lifetime drug use is associated with PPMD. Future research should examine whether screening for lifetime drug use during antenatal and postpartum care improves identification of women experiencing PPMD.}, number={1}, journal={Archives of Women's Mental Health}, publisher={Springer Nature}, author={Prevatt, Betty-Shannon and Desmarais, Sarah L. and Janssen, Patricia A.}, year={2016}, month={Dec}, pages={189–199} }