@article{simon_russell_mondino_yang_case_anderson_whitley_griffith_gruen_olby_2024, title={A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination}, volume={14}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-024-63031-w}, abstractNote={Abstract Age-related decline in mobility and cognition are associated with cellular senescence and NAD + depletion in dogs and people. A combination of a novel NAD + precursor and senolytic, LY-D6/2, was examined in this randomized controlled trial. Seventy dogs with mild to moderate cognitive impairment were enrolled and allocated into placebo, low or full dose groups. Primary outcomes were change in cognitive impairment measured with the owner-reported Canine Cognitive Dysfunction Rating (CCDR) scale and change in activity measured with physical activity monitors. Fifty-nine dogs completed evaluations at the 3-month primary endpoint, and 51 reached the 6-month secondary endpoint. There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p = 0.02) with the largest decrease in the full dose group. No difference was detected between groups using in house cognitive testing. There were no significant differences between groups in changes in measured activity. The proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full dose group than other groups, however this difference was not significant. Adverse events occurred equally across groups. All groups showed improvement in cognition, frailty, and activity suggesting placebo effect and benefits of trial participation. We conclude that LY-D6/2 improves owner-assessed cognitive function over a 3-month period and may have broader, but more subtle effects on frailty, activity and happiness as reported by owners.}, number={1}, journal={SCIENTIFIC REPORTS}, author={Simon, Katherine E. and Russell, Katharine and Mondino, Alejandra and Yang, Chin-Chieh and Case, Beth C. and Anderson, Zachary and Whitley, Christine and Griffith, Emily and Gruen, Margaret E. and Olby, Natasha J.}, year={2024}, month={May} }
 @article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={A novel task of canine olfaction for use in adult and senior pet dogs}, volume={13}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC9908929}, DOI={10.1038/s41598-023-29361-x}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha and Gruen, Margaret}, year={2023}, month={Feb} }
 @article{mondino_ludwig_menchaca_russell_simon_griffith_kis_lascelles_gruen_olby_2023, title={Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs}, volume={13}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-023-40048-1}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Mondino, A. and Ludwig, C. and Menchaca, C. and Russell, K. and Simon, K. E. and Griffith, E. and Kis, A. and Lascelles, B. D. X. and Gruen, M. E. and Olby, N. J.}, year={2023}, month={Aug} }
 @article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs}, volume={9}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2022.1052193}, abstractNote={IntroductionThe aim of this study was to evaluate the engagement of aging dogs with a cognitively challenging and potentially frustrating task (the impossible task). Based on previous observations, we predicted that dogs showing signs of cognitive impairment in other cognitive tests and owner-completed questionnaires would show reduced engagement with the task.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha J. and Gruen, Margaret E.}, year={2023}, month={Jan} }
 @article{mondino_wagner_russell_lobaton_griffith_gruen_lascelles_olby_2022, title={Static posturography as a novel measure of the effects of aging on postural control in dogs}, volume={17}, ISSN={["1932-6203"]}, url={http://dx.doi.org/10.1371/journal.pone.0268390}, DOI={10.1371/journal.pone.0268390}, abstractNote={Aging is associated with impairment in postural control in humans. While dogs are a powerful model for the study of aging, the associations between age and postural control in this species have not yet been elucidated. The aims of this work were to establish a reliable protocol to measure center of pressure excursions in standing dogs and to determine age-related changes in postural sway. Data were obtained from 40 healthy adult dogs (Group A) and 28 senior dogs (Group B) during seven trials (within one session of data collection) of quiet standing on a pressure sensitive walkway system. Velocity, acceleration, root mean square, 95% ellipse area, range and frequency revolve were recorded as measures of postural sway. In Group A, reliability was assessed with intraclass correlation, and the effect of morphometric variables was evaluated using linear regression. By means of stepwise linear regression we determined that root mean square overall and acceleration in the craniocaudal direction were the best variables able to discriminate between Group A and Group B. The relationship between these two center-of-pressure (COP) measures and the dogs’ fractional lifespan was examined in both groups and the role of pain and proprioceptive deficits was evaluated in Group B. All measures except for frequency revolve showed good to excellent reliability. Weight, height and length were correlated with most of the measures. Fractional lifespan impacted postural control in Group B but not Group A. Joint pain and its interaction with proprioceptive deficits influence postural sway especially in the acceleration in the craniocaudal direction, while fractional lifespan was most important in the overall COP displacement. In conclusion, our study found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural sway is affected by morphometric parameters and increases with age and joint pain.}, number={7}, journal={PLOS ONE}, publisher={Public Library of Science (PLoS)}, author={Mondino, Alejandra and Wagner, Grant and Russell, Katharine and Lobaton, Edgar and Griffith, Emily and Gruen, Margaret and Lascelles, B. Duncan X. and Olby, Natasha Jane}, editor={Evans, RichardEditor}, year={2022}, month={Jul} }
 @article{nolan_berman_watson-skaggs_quinn_marcus_russell_yoshikawa_olby_gieger_2022, title={Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity}, volume={260}, ISSN={["1943-569X"]}, DOI={10.2460/javma.22.03.0141}, abstractNote={Abstract}, number={12}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Nolan, Michael W. and Berman, Alyssa R. and Watson-Skaggs, Maegan L. and Quinn, Claire N. and Marcus, Karen L. and Russell, Katharine and Yoshikawa, Hiroto and Olby, Natasha J. and Gieger, Tracy L.}, year={2022}, month={Sep}, pages={1496–1506} }