Kevan Taylor Knizner
College of Sciences
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Works (13)
Updated: November 25th, 2024 07:12
2024 article
Obtaining 20 μm Spatial Resolution with a 2940 nm Laser by IR-MALDESI Mass Spectrometry Imaging
Eisenberg, S. M., Joignant, A. N., Knizner, K. T., Manni, J. G., & Muddiman, D. C. (2024, November 8). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 11.
author keywords: IR-MALDESI; mass spectrometry imaging; mid-IRlaser; spatial resolution
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024
2023 article
Automatic z-Axis Correction for IR-MALDESI Mass Spectrometry Imaging of Uneven Surfaces
Xi, Y., Knizner, K. T. T., Garrard, K. P. P., & Muddiman, D. C. C. (2023, June 12). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 6.
author keywords: mass spectrometry imaging; nonflat surfaces; IR-MALDESI; automatic z-axis correction
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023
2023 article
Development of an object-based image analysis tool for mass spectrometry imaging ion classification
Eisenberg, S. M., Knizner, K. T., & Muddiman, D. C. (2023, May 24). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 5.
author keywords: IR-MALDESI; Object-based image analysis; Mass spectrometry imaging; Image segmentation; Image classification; MATLAB
TL;DR:
The utility of an ion classification tool (ICT) developed using object-based image analysis in MATLAB is presented, which was able to accurately classify 45/50 ions as on-tissue or background.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023
2023 journal article
Evaluating the optimal tissue thickness for mass spectrometry imaging using infrared matrix-assisted laser desorption electrospray ionization
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 37(22).
TL;DR:
This work defines an optimal sample thickness for IR-MALDESI-MSI and demonstrates the utility of optimizing tissue thickness for MSI platforms of comparable Z resolution.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023
2023 article
Maximized Spatial Information and Minimized Acquisition Time of Top-Hat IR-MALDESI-MSI of Zebrafish Using Nested Regions of Interest (nROIs)
Joignant, A. N., Ritter, M. M., Knizner, K. T., Garrard, K. P., Kullman, S. W., & Muddiman, D. C. (2023, August 1). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 8.
author keywords: IR-MALDESI; mass spectrometry imaging; spatialresolution; nested region of interest; zebrafish
TL;DR:
The nROI method was characterized on mouse liver and applied to top-hat MSI of zebrafish using a novel optical train, which resulted in a significant improvement in both acquisition time and spatial detail of the zebra fish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 article
Metabolite Annotation Confidence Score (MACS): A Novel MSI Identification Scoring Tool
Eisenberg, S. M., Knizner, K. T., & Muddiman, D. C. (2023, August 22). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 8.
author keywords: IR-MALDESI; annotation scoring; mass measurementaccuracy; spectral accuracy; SSIM; MATLAB
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Prototyping an ionization source for non-engineers
JOURNAL OF MASS SPECTROMETRY, 59(1).
author keywords: computer-aided design; hardware interfacing; instrumentation prototyping; microcontroller; software development
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024
2022 journal article
An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(27).
Contributors: P. Thompson n
author keywords: phospholipid metabolism; maize genetics; highland adaptation; flowering time; selection
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 3, 2022
2022 article
High-Throughput Deconvolution of Intact Protein Mass Spectra for the Screening of Covalent Inhibitors
Pu, F., Knizner, K. T., Robey, M. T., Radosevich, A. J., Ugrin, S. A., Elsen, N. L., … Williams, J. D. (2022, November 15). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY.
MeSH headings : Mass Spectrometry; Proteins / chemistry; Software
TL;DR:
A new workflow in ProSight Native is presented for the deconvolution of protein spectra from entire well plates that can be completed within 3 s and may be feasible to analyze and report covalent screening results for >200,000 samples in a single day.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 5, 2022
2022 article
Next-Generation Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Source for Mass Spectrometry Imaging and High-Throughput Screening
Knizner, K. T., Guymon, J. P., Garrard, K. P., Bouvree, G., Manni, J., Hauschild, J.-P., … Muddiman, D. C. (2022, September 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 9.
author keywords: IR-MALDESI; High-Throughput Screening; Mass Spectrometry Imaging; Orbitrap Mass Spectrometer; Design of Experiments
MeSH headings : High-Throughput Screening Assays; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Lasers
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022
2022 journal article
Normalization techniques for high-throughput screening by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry
JOURNAL OF MASS SPECTROMETRY, 57(6).
author keywords: high-throughput screening; IR-MALDESI; normalization; Orbitrap mass spectrometer
MeSH headings : Drug Discovery; High-Throughput Screening Assays; Lasers; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
Optimal solvent compositions for increasing measured analyte abundances with direct analysis by IR‐MALDESI‐MS are reported and normalization strategies, such as adding a normalization standard that is similar or dissimilar in structure to the model target drug, are evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2022 journal article
On the importance of color in mass spectrometry imaging
JOURNAL OF MASS SPECTROMETRY, 57(12).
author keywords: colormap; CVD; data visualization; MSI
MeSH headings : Humans; Mass Spectrometry
TL;DR:
Best practices for choosing a colormap to accurately display MSI data, improve readability, and accommodate all CVDs are presented.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023
2022 journal article
Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 33(2), 328–334.
author keywords: high-throughput screening; IR-MALDESI; Orbitrap mass spectrometer; C-trap
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022
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