Kaiyue Zhang

Works (1)

Updated: April 23rd, 2025 18:28

2023 article

Peptonics: A new family of cell‐protecting surfactants for the recombinant expression of therapeutic proteins in mammalian cell cultures

Zhang, K., Barbieri, E., LeBarre, J., Rameez, S., Mostafa, S., & Menegatti, S. (2023, October 16). Biotechnology Journal, Vol. 10.

By: K. Zhang n, E. Barbieri n, J. LeBarre n, S. Rameez*, S. Mostafa* & S. Menegatti n 

author keywords: antibodies; mammalian cells; Peptonics; peptoids; Pluronics; surfactants
MeSH headings : Cricetinae; Animals; Humans; Cricetulus; Poloxamer; Surface-Active Agents / pharmacology; CHO Cells; Antibodies, Monoclonal / chemistry; Cell Culture Techniques; Recombinant Proteins / genetics; Recombinant Proteins / pharmacology
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Protein purification and stability; Monoclonal and Polyclonal Antibodies Research
TL;DR: Peptonics, a novel family of peptide and peptoid surfactants whose monomer composition and sequence are designed to achieve high cell viability and productivity at a fraction of chain length and cost of Pluronics, can improve significantly purification of mAbs, thus increasing their availability at lower cost to patients. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

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