Laura Ann Jeffers

Works (6)

Updated: July 5th, 2023 15:56

2014 journal article

Polymers for the stabilization and delivery of proteins topically and per os to the insect hemocoel through conjugation with aliphatic polyethylene glycol

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 115, 58–66.

By: L. Jeffers n, H. Shen n, B. Bissinger n, S. Khalil  n, T. Gunnoe  n & R. Roe n 

author keywords: Insulin; Heliothis virescens; Tobacco budworm; PEGylation; Polyethylene glycol; Protein delivery
MeSH headings : Animals; Cattle; Drug Delivery Systems / methods; Hemolymph / metabolism; Insulin / chemistry; Insulin / metabolism; Larva / growth & development; Larva / metabolism; Moths / growth & development; Moths / metabolism; Polyethylene Glycols / chemistry; Polymers / chemistry; Polymers / metabolism; Protein Stability; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism
TL;DR: Co-feeding of aliphatic polyethylene glycol (PEG), phospholipase A2, anionic and ionic detergents, and amphipathic glycoside with bovine serum albumin as a model protein to fourth stadium tobacco budworms, Heliothis virescens, did not affect the levels of BSA in the hemolymph. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Enhanced activity of an insecticidal protein, trypsin modulating oostatic factor (TMOF), through conjugation with aliphatic polyethylene glycol

PEST MANAGEMENT SCIENCE, 68(1), 49–59.

By: L. Jeffers n, H. Shen n, S. Khalil  n, B. Bissinger n, A. Brandt, T. Gunnoe  n, R. Roe n 

author keywords: trypsin modulating oostatic factor; TMOF; PEGylation; polyethylene glycol; mosquito; tobacco budworm; cotton bollworm; protein delivery
MeSH headings : Aedes / drug effects; Aedes / growth & development; Animals; Insecticides / chemical synthesis; Insecticides / chemistry; Insecticides / pharmacology; Larva / drug effects; Larva / growth & development; Moths / drug effects; Oligopeptides / chemistry; Oligopeptides / pharmacology; Polyethylene Glycols / chemistry
TL;DR: Aliphatic PEG polymers can be used as a new method for increasing the activity of insecticidal proteins, according to research suggests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Full-length sequence, regulation and developmental studies of a second vitellogenin gene from the American dog tick, Dermacentor variabilis

JOURNAL OF INSECT PHYSIOLOGY, 57(3), 400–408.

By: S. Khalil  n, K. Donohue n, D. Thompson n, L. Jeffers n, U. Ananthapadmanaban n, D. Sonenshine *, R. Mitchell *, R. Roe n 

author keywords: Ticks; Acari; Vitellogenesis; Vitellogenin; Vitellin; Ecdysteroids; Carrier protein; CP; Yolk protein
MeSH headings : Amino Acid Sequence; Animals; Dermacentor / chemistry; Dermacentor / genetics; Dermacentor / growth & development; Dermacentor / metabolism; Female; Gene Expression Regulation, Developmental; Male; Molecular Sequence Data; Organ Specificity; Protein Structure, Tertiary; Sequence Alignment; Species Specificity; Vitellogenins / chemistry; Vitellogenins / genetics; Vitellogenins / metabolism
TL;DR: The characteristics that distinguish Vg from other similar tick storage proteins like the carrier protein, CP (another hemelipoglycoprotein) are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 37(4), 363–374.

By: M. Deborah n, S. Khalil  n, L. Jeffers n, D. Sonenshine*, R. Mitchell *, C. Osgood*, R. Roe n 

author keywords: vitellogenin; vitellin; ticks; Acari; American dog tick; Dermacentor variabilis; heme
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Dermacentor / genetics; Dermacentor / metabolism; Female; Gene Expression Regulation, Developmental; Heme / metabolism; Male; Mass Spectrometry; Molecular Sequence Data; RNA, Messenger / metabolism; Rabbits; Vitellogenins / genetics; Vitellogenins / metabolism
TL;DR: The first full-length mRNA for vitellogenin (Vg) from ticks was sequenced and it is suggested that a second Vg mRNA might be present in the American dog tick, which needs further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 review

The movement of proteins across the insect and tick digestive system

[Review of ]. JOURNAL OF INSECT PHYSIOLOGY, 54(2), 319–332.

By: L. Jeffers n & R. Roe n 

author keywords: digestive system; protein movement; protein insecticide
MeSH headings : Animals; Digestive System / metabolism; Insect Proteins / metabolism; Insecta / metabolism; Protein Transport; Ticks / metabolism
TL;DR: Protein movement was observed for both normal dietary and xenobiotic proteins, which suggest that the mechanism for transfer is not substrate specific and could be highly significant to the future of protein and nucleic acid-based insecticide development as well as traditional chemical insecticidal technologies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

In vivo role of 20-hydroxyecdysone in the regulation of the vitellogenin mRNA and egg development in the American dog tick, Dermacentor variabilis (Say)

JOURNAL OF INSECT PHYSIOLOGY, 51(10), 1105–1116.

By: D. Thompson n, S. Khalil  n, L. Jeffers n, U. Ananthapadmanaban n, D. Sonenshine *, R. Mitchell *, C. Osgood*, C. Apperson n, R. Roe n 

author keywords: 20-hydroxyecdysone; juvenile hormone; vitellogenin; vitellin; tick
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Dermacentor / genetics; Dermacentor / growth & development; Dermacentor / metabolism; Dermacentor / physiology; Ecdysterone / physiology; Female; Gene Expression Regulation, Developmental / physiology; Hemolymph / physiology; Molecular Sequence Data; Ovary / physiology; Peptide Mapping; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sesquiterpenes / metabolism; Vitellogenins / biosynthesis; Vitellogenins / genetics
TL;DR: It is indicated that ecdysteroids and not JH can initiate expression of the Vg gene, Vg protein synthesis and release into hemolymph, and Vg uptake into developing oocytes under bioassay conditions mimicking normal feeding on the host. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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