Works (56)

Updated: August 28th, 2023 09:57

2023 article

A Student Perspective on the 18th Monitoring Molecules in Neuroscience Meeting in Lyon

Forderhase, A. G., Kimble, L. C., & Sombers, L. A. (2023, June 5). ACS CHEMICAL NEUROSCIENCE, Vol. 6.

By: A. Forderhase n, L. Kimble n & L. Sombers n

author keywords: Biosensors; multiplexing; genetically encodedsensors; in vivo; neurochemistry; analyticalmethods
MeSH headings : Humans; Pandemics; COVID-19; Neurosciences
Sources: Web Of Science, ORCID
Added: July 24, 2023

2023 article

Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells

De Alwis, A. C., Denison, J. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, August 8). ACS SENSORS, Vol. 8.

By: A. De Alwis n, J. Denison n, R. Shah n, G. McCarty n & L. Sombers n

author keywords: voltammetry; amperometry; chromaffincell; diffusion; catecholamine; dense corevesicle; carbon fiber microelectrode
Sources: Web Of Science, ORCID
Added: August 21, 2023

2022 article

Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells

McCarty, G. S., Dunaway, L. E., Denison, J. D., & Sombers, L. A. (2022, June 24). ANALYTICAL CHEMISTRY, Vol. 6.

By: G. McCarty n, L. Dunaway n, J. Denison n & L. Sombers n

MeSH headings : Animals; Carbon Fiber; Catecholamines / metabolism; Cattle; Chromaffin Cells / metabolism; Exocytosis / physiology; Microelectrodes; Neurotransmitter Agents / metabolism
Sources: Web Of Science, ORCID
Added: July 18, 2022

2022 article

Virtual Issue: Neurotoxicology

Sombers, L. A., & Patisaul, H. B. (2022, August 3). ACS CHEMICAL NEUROSCIENCE, Vol. 13, pp. 2238–2239.

By: L. Sombers* & H. Patisaul*

Sources: Web Of Science, ORCID
Added: August 15, 2022

2021 chapter

Fast-Scan for In Vivo Measurements of Neurochemical Dynamics

In M. Fakhoury (Ed.), The Brain Reward System (pp. 93–123).

By: C. Meunier n & L. Sombers n

Ed(s): M. Fakhoury

Sources: Crossref, ORCID
Added: February 6, 2021

2020 journal article

Carbon-Fiber Nanoelectrodes for Real-Time Discrimination of Vesicle Cargo in the Native Cellular Environment

ACS Nano, 14(3), 2917–2926.

By: J. Roberts n, E. Mitchell n, L. Dunaway n, G. McCarty n & L. Sombers n

author keywords: intracellular electrochemical cytometry; epinephrine; norepinephrine; dopamine; exocytosis; fast-scan cyclic voltammetry; amperometry
MeSH headings : Animals; Carbon Fiber / chemistry; Electrochemical Techniques; Electrodes; Epinephrine / chemistry; Molecular Structure; Nanotechnology; Neuroendocrine Cells / chemistry; Norepinephrine / chemistry; PC12 Cells; Rats; Single-Cell Analysis; Time Factors; Tumor Cells, Cultured
Sources: Crossref, ORCID
Added: January 18, 2021

2020 journal article

Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy

Langmuir, 36(15), 4214–4223.

By: C. Meunier n, J. Denison n, G. McCarty n & L. Sombers n

MeSH headings : Carbon; Carbon Fiber; Dielectric Spectroscopy; Electric Impedance; Microelectrodes
Sources: Web Of Science, ORCID, Crossref
Added: May 8, 2020

2020 journal article

Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(24), 6611–6624.

By: A. Forderhase n, H. Styers n, C. Lee n & L. Sombers n

author keywords: Fast-scan cyclic voltammetry; Biosensor; In vivo; Carbon-fiber microelectrode; Astrocyte-to-neuron lactate shuttle; Neuroenergetics
MeSH headings : Animals; Biosensing Techniques; Corpus Striatum / chemistry; Corpus Striatum / metabolism; Electric Stimulation; Electrochemical Techniques; Glucose / analysis; Glucose / metabolism; Lactic Acid / analysis; Lactic Acid / metabolism; Male; Mesencephalon / chemistry; Mesencephalon / metabolism; Microelectrodes; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 3, 2020

2019 journal article

Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression

Analytical Chemistry, 91(11), 7319–7327.

By: C. Meunier n, G. McCarty n & L. Sombers n

MeSH headings : Adenosine / analysis; Animals; Brain / diagnostic imaging; Dopamine / analysis; Electrochemical Techniques; Hydrogen Peroxide / analysis; Least-Squares Analysis; Male; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID, Crossref
Added: June 24, 2019

2018 journal article

Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry

Analytical Chemistry, 90(21), 12994–12999.

By: S. Smith n, S. Gosrani n, C. Lee n, G. McCarty n & L. Sombers n

MeSH headings : Animals; Biosensing Techniques / methods; Carbon Fiber / chemistry; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Enzymes, Immobilized / chemistry; Lactic Acid / analysis; Limit of Detection; Male; Microelectrodes; Mixed Function Oxygenases / chemistry; Neostriatum / metabolism; Rats, Sprague-Dawley; Sensitivity and Specificity
Sources: Web Of Science, ORCID, Crossref
Added: November 26, 2018

2018 journal article

Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin

ACS Chemical Neuroscience, 10(4), 2022–2032.

By: S. Calhoun n, C. Meunier n, C. Lee n, G. McCarty n & L. Sombers n

author keywords: carbon fiber; opioid; chromaffin cell; dopamine; cyclic voltammetry; microelectrode; FSCV
MeSH headings : Adrenal Glands / chemistry; Adrenal Glands / metabolism; Animals; Electrochemical Techniques / methods; Enkephalin, Methionine / analysis; Enkephalin, Methionine / metabolism; Male; Microinjections / methods; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra / chemistry; Substantia Nigra / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2019

2018 journal article

Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH

Analytical Chemistry, 90(3), 1767–1776.

By: C. Meunier n, E. Mitchell n, J. Roberts n, J. Toups n, G. McCarty n & L. Sombers n

MeSH headings : Animals; Brain / metabolism; Electrochemical Techniques / methods; Hydrogen Peroxide / metabolism; Hydrogen-Ion Concentration; Least-Squares Analysis; Male; Principal Component Analysis; Rats, Sprague-Dawley
Sources: Crossref, ORCID
Added: February 5, 2020

2018 review

Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond

[Review of ]. ANALYTICAL CHEMISTRY, 90(1), 490–504.

By: J. Roberts n & L. Sombers n

MeSH headings : Animals; Brain / metabolism; Catecholamines / analysis; Electrochemical Techniques / methods; Humans; Hydrogen Peroxide / analysis; Neurotransmitter Agents / analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats

ACS Chemical Neuroscience, 10(4), 1935–1940.

By: A. Gómez-A*, T. Shnitko*, H. Barefoot*, E. Brightbill*, L. Sombers n, S. Nicola*, D. Robinson*

author keywords: mu-opioid receptor; dopamine; accumbens; phasic; electrochemistry; local infusion
MeSH headings : Animals; Dopamine / metabolism; Dopamine Uptake Inhibitors / administration & dosage; Dose-Response Relationship, Drug; Infusions, Intraventricular; Male; Narcotic Antagonists / administration & dosage; Nucleus Accumbens / drug effects; Nucleus Accumbens / metabolism; Peptide Fragments / administration & dosage; Rats; Rats, Long-Evans; Receptors, Opioid, mu / antagonists & inhibitors; Receptors, Opioid, mu / metabolism; Somatostatin / administration & dosage
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2019

2018 journal article

NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies

ACS Chemical Neuroscience, 10(3), 1497–1505.

By: M. Spanos n, X. Xie n, J. Gras-Najjar n, S. White n & L. Sombers n

author keywords: Glutamate; acetylcholine; dopamine; sensory stimuli; ventral tegmental area
MeSH headings : Animals; Cell Body / drug effects; Cell Body / metabolism; Cholinergic Agonists / administration & dosage; Dopamine / metabolism; Male; Microinjections / methods; N-Methylaspartate / administration & dosage; Photic Stimulation / methods; Psychomotor Performance / drug effects; Psychomotor Performance / physiology; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate / agonists; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Ventral Tegmental Area / drug effects; Ventral Tegmental Area / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: April 9, 2019

2018 journal article

Quantitative Comparison of Enzyme Immobilization Strategies for Glucose Biosensing in Real-Time Using Fast-Scan Cyclic Voltammetry Coupled with Carbon-Fiber Microelectrodes

ChemPhysChem, 19(10), 1197–1204.

By: S. Smith n, L. Lugo-Morales n, C. Tang n, S. Gosrani n, C. Lee n, J. Roberts n, S. Morton n, G. McCarty n, S. Khan n, L. Sombers n

author keywords: biosensing; carbon-fiber microelectrodes; cyclic voltammetry; dopamine; glucose
MeSH headings : Animals; Biosensing Techniques; Carbon / chemistry; Electrochemical Techniques; Enzymes, Immobilized; Glucose / analysis; Glucose Oxidase / metabolism; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Time Factors
Sources: Crossref, ORCID
Added: January 25, 2020

2018 journal article

Reducing Data Density in Fast-Scan Cyclic Voltammetry Measurements of Dopamine Dynamics

Journal of The Electrochemical Society, 165(12), G3042–G3050.

By: C. Lee, L. Qi, A. Amos, K. Blanton, G. McCarty & L. Sombers*

Sources: Crossref, ORCID
Added: January 18, 2021

2017 journal article

Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data

ACS CHEMICAL NEUROSCIENCE, 8(2), 411–419.

By: C. Meunier n, J. Roberts n, G. McCarty n & L. Sombers n

author keywords: Carbon-fiber microelectrode; electrochemical impedance spectroscopy; electrochemistry; calibration; in vivo
MeSH headings : Analysis of Variance; Animals; Antipsychotic Agents / pharmacology; Biophysics; Brain / drug effects; Brain / metabolism; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Electrodes; Enzyme Inhibitors / pharmacology; Male; Neural Pathways / drug effects; Neural Pathways / metabolism; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reserpine / pharmacology; alpha-Methyltyrosine / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 conference paper

Real-Time Striatal Measurements of Oxidative Stress and Dopamine in the Dyskinetic Rat during Chronic L-DOPA Treatment for Parkinson's Disease

ECS Meeting Abstracts, MA2017–02 2303.

By: L. Sombers*, L. Wilson, C. Mason & C. Lee

Sources: NC State University Libraries, ORCID
Added: September 15, 2022

2017 journal article

Selective and Mechanically Robust Sensors for Electrochemical Measurements of Real-Time Hydrogen Peroxide Dynamics in Vivo

Analytical Chemistry, 90(1), 888–895.

By: L. Wilson n, S. Panda n, A. Schmidt n & L. Sombers n

MeSH headings : Animals; Carbon / chemistry; Corpus Striatum / metabolism; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Hydrogen Peroxide / analysis; Male; Microelectrodes; Phenylenediamines / chemistry; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

ACS Chemical Neuroscience, 8(2), 272–280.

By: S. Smith n, C. Lee n, M. Dausch n, B. Horman n, H. Patisaul n, G. McCarty n, L. Sombers n

author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Spectroelectrochemical Characterization of the Dynamic Carbon-Fiber Surface in Response to Electrochemical Conditioning

Langmuir, 33(32), 7838–7846.

By: E. Mitchell n, L. Dunaway n, G. McCarty n & L. Sombers n

Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

The Hydroxyl Radical is a Critical Intermediate in the Voltammetric Detection of Hydrogen Peroxide

Journal of the American Chemical Society, 138(8), 2516–2519.

By: J. Roberts n, M. Voinov n, A. Schmidt n, T. Smirnova n & L. Sombers n

MeSH headings : Electrochemical Techniques / methods; Electron Spin Resonance Spectroscopy / methods; Hydrogen Peroxide / analysis; Hydrogen Peroxide / chemistry; Hydroxyl Radical / analysis; Hydroxyl Radical / chemistry; Pyrroles / chemistry; Spin Labels
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Unmasking the Effects of L-DOPA on Rapid Dopamine Signaling with an Improved Approach for Nafion Coating Carbon-Fiber Microelectrodes

ANALYTICAL CHEMISTRY, 88(16), 8129–8136.

By: L. Qi n, E. Thomas n, S. White n, S. Smith n, C. Lee n, L. Wilson n, L. Sombers n

MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Carbon / chemistry; Carbon Fiber; Dopamine / analysis; Electrochemical Techniques; Electrodes, Implanted; Evoked Potentials / drug effects; Levodopa / pharmacology; Male; Microelectrodes; Parkinson Disease / metabolism; Parkinson Disease / pathology; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Enzyme-based microbiosensors for selective quantification of rapid molecular fluctuations in brain tissue

Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience, Vol 1: Fundamentals and Applications, 137–160.

By: L. Lugo-Morales n & L. Sombers n

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Multiple Scan Rate Voltammetry for Selective Quantification of Real-Time Enkephalin Dynamics

ANALYTICAL CHEMISTRY, 86(15), 7806–7812.

By: A. Schmidt n, L. Dunaway n, J. Roberts n, G. McCarty n & L. Sombers n

MeSH headings : Animals; Electrodes; Enkephalins / physiology; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata

Journal of the American Chemical Society, 136(22), 7914–7925.

By: D. Barrios n, J. D’Antonio n, N. McCombs n, J. Zhao n, S. Franzen n, A. Schmidt n, L. Sombers n, R. Ghiladi n

MeSH headings : Animals; Catalytic Domain; Hemoglobins / chemistry; Hemoglobins / metabolism; Indoles / chemistry; Indoles / metabolism; Mixed Function Oxygenases / metabolism; Models, Molecular; Oxidoreductases / metabolism; Oxygen / chemistry; Oxygen Consumption; Oxygen Radioisotopes; Polychaeta / enzymology; Protein Conformation
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Reducing the Sampling Rate of Biochemical Measurements Using Fast-Scan Cyclic Voltammetry for In Vivo Applications

IEEE SENSORS JOURNAL, 14(9), 2975–2980.

By: A. Amos n, J. Roberts n, L. Qi n, L. Sombers n & G. McCarty n

author keywords: Carbon fiber microelectrodes; dopamine; electrochemistry; wireless protocol
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Carbon Nanotube Yarn Electrodes for Enhanced Detection of Neurotransmitter Dynamics in Live Brain Tissue

ACS NANO, 7(9), 7864–7873.

By: A. Schmidt n, X. Wang n, Y. Zhu n & L. Sombers n

author keywords: FSCV; carbon fiber; microelectrode; dopamine; voltammetry
MeSH headings : Action Potentials / physiology; Animals; Brain / physiology; Conductometry / instrumentation; Equipment Design; Equipment Failure Analysis; Male; Microelectrodes; Molecular Imaging / instrumentation; Nanofibers / chemistry; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure; Neurotransmitter Agents / metabolism; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Synaptic Transmission / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Enzyme-Modified Carbon-Fiber Microelectrode for the Quantification of Dynamic Fluctuations of Nonelectroactive Analytes Using Fast-Scan Cyclic Voltammetry

ANALYTICAL CHEMISTRY, 85(18), 8780–8786.

By: L. Lugo-Morales n, P. Loziuk n, A. Corder n, J. Toups n, J. Roberts n, K. McCaffrey n, L. Sombers n

MeSH headings : Animals; Biosensing Techniques / methods; Carbon / chemistry; Carbon Fiber; Electrochemical Techniques / methods; Enzyme Induction; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

In Situ Electrode Calibration Strategy for Voltammetric Measurements In Vivo

ANALYTICAL CHEMISTRY, 85(23), 11568–11575.

By: J. Roberts n, J. Toups n, E. Eyualem n, G. McCarty n & L. Sombers n

MeSH headings : Animals; Calibration; Electrochemical Techniques / methods; Electrodes, Implanted; Flow Injection Analysis / methods; Male; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

ACS CHEMICAL NEUROSCIENCE, 4(5), 782–789.

By: M. Spanos n, J. Gras-Najjar n, J. Letchworth n, A. Sanford n, J. Toups n & L. Sombers n

author keywords: oxidative stress; reactive oxygen species; H2O2; FSCV; Parkinson's disease; basal dopamine concentrations
MeSH headings : Animals; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Hydrogen Peroxide / metabolism; Male; Neostriatum / drug effects; Neostriatum / metabolism; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species / metabolism; Rotenone / pharmacology; Uncoupling Agents / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 chapter

Real-Time Chemical Measurements of Dopamine Release in the Brain

In Methods in Molecular Biology (pp. 275–294).

By: J. Roberts n, L. Lugo-Morales n, P. Loziuk n & L. Sombers n

MeSH headings : Anesthesia; Animals; Brain / metabolism; Brain / surgery; Carbon / chemistry; Carbon Fiber; Dopamine / metabolism; Electric Stimulation; Electrochemistry / instrumentation; Electrochemistry / methods; Microelectrodes; Rats; Software; Time Factors
Sources: Crossref, ORCID
Added: February 5, 2021

2012 journal article

Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens

JOURNAL OF NEUROCHEMISTRY, 121(2), 252–262.

By: C. Owesson-White*, M. Roitman*, L. Sombers n, A. Belle*, R. Keithley*, J. Peele*, R. Carelli*, R. Wightman*

author keywords: basal level; carbon-fiber; Dopamine; FSCV; transients
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Dopamine / metabolism; Dopamine / physiology; Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors; Electrophysiological Phenomena; Extracellular Space / metabolism; Lidocaine / administration & dosage; Lidocaine / pharmacology; Male; Microdialysis; Nucleus Accumbens / metabolism; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrabenazine / pharmacology; Ventral Tegmental Area; Vesicular Monoamine Transport Proteins / antagonists & inhibitors; Vesicular Monoamine Transport Proteins / metabolism; Vesicular Neurotransmitter Transport Proteins / antagonists & inhibitors; Vesicular Neurotransmitter Transport Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Trace metal complexation by the triscatecholate siderophore protochelin: structure and stability

BIOMETALS, 25(2), 393–412.

By: J. Harrington n, J. Bargar*, A. Jarzecki*, J. Roberts n, L. Sombers n & O. Duckworth n

author keywords: Siderophores; Catechol; Iron; Manganese; Cobalt; Complexation
MeSH headings : Coordination Complexes / chemistry; Hydrogen-Ion Concentration; Oxidation-Reduction; Siderophores / chemistry; Solubility; Trace Elements / chemistry; Trace Elements / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Comparison of electrode materials for the detection of rapid hydrogen peroxide fluctuations using background-subtracted fast scan cyclic voltammetry

The Analyst, 136(17), 3550.

By: J. Roberts n, K. Hamilton n & L. Sombers n

MeSH headings : Biosensing Techniques / methods; Carbon / chemistry; Carbon Fiber; Electrochemical Techniques / methods; Electrodes; Fluorocarbon Polymers / chemistry; Hydrogen Peroxide / analysis; Microelectrodes; Platinum / chemistry; Sensitivity and Specificity; Time Factors
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 conference paper

Application of Fast-Scan Cyclic Voltammetry to Monitoring Endogenous Hydrogen Peroxide Fluctuations In Vivo

In B. Westerink, R. Clinckers, I. Smolders, S. Sarre, & Y. Michotte (Eds.), Monitoring Molecules in Neuroscience (pp. 89–91). Brussels, Belgium: Vrije Universiteit.

By: A. Sanford, J. Letchworth & L. Sombers

Ed(s): B. Westerink, R. Clinckers, I. Smolders, S. Sarre & Y. Michotte

Event: 13th International Conference on In Vivo Methods at Brussels, Belgium on September 12-16, 2010

Source: NC State University Libraries
Added: February 12, 2021

2010 journal article

Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes

LANGMUIR, 26(11), 9116–9122.

By: J. Roberts n, B. Moody n, G. McCarty n & L. Sombers n

MeSH headings : Carbon / chemistry; Dopamine / chemistry; Electrochemistry / instrumentation; Microelectrodes; Microscopy, Atomic Force; Oxygen / chemistry; Spectrum Analysis, Raman
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Voltammetric Detection of Hydrogen Peroxide at Carbon Fiber Microelectrodes

ANALYTICAL CHEMISTRY, 82(12), 5205–5210.

By: A. Sanford n, S. Morton n, K. Whitehouse n, H. Oara n, L. Lugo-Morales n, J. Roberts n, L. Sombers n

MeSH headings : Animals; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Brain Chemistry; Carbon / chemistry; Carbon Fiber; Electrochemistry / instrumentation; Electrochemistry / methods; Hydrogen Peroxide / analysis; Hydrogen Peroxide / metabolism; Limit of Detection; Male; Microelectrodes; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Synaptic Overflow of Dopamine in the Nucleus Accumbens Arises from Neuronal Activity in the Ventral Tegmental Area

Journal of Neuroscience, 29(6), 1735–1742.

By: L. Sombers*, M. Beyene, R. Carelli & R. Mark Wightman

author keywords: in vivo voltammetry; neurotransmission; carbon-fiber microelectrode; cocaine; intracranial self-stimulation; burst firing
MeSH headings : Animals; Dopamine / physiology; Male; Neurons / physiology; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Synapses / physiology; Synaptic Transmission / physiology; Ventral Tegmental Area / physiology
Sources: Crossref, ORCID
Added: February 6, 2021

2008 journal article

Dopamine Detection with Fast-Scan Cyclic Voltammetry Used with Analog Background Subtraction

Analytical Chemistry, 80(11), 4040–4048.

By: A. Hermans*, R. Keithley*, J. Kita*, L. Sombers* & R. Wightman*

MeSH headings : Analog-Digital Conversion; Anesthesia; Animals; Brain / metabolism; Brain / physiology; Carbon / chemistry; Carbon Fiber; Dopamine / analysis; Electrochemistry; Male; Microelectrodes; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Time Factors; Transducers; Walking
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens

European Journal of Neuroscience, 26(7), 2046–2054.

By: R. Wightman*, M. Heien*, K. Wassum*, L. Sombers*, B. Aragona*, A. Khan*, J. Ariansen*, J. Cheer*, P. Phillips*, R. Carelli*

author keywords: carbon-fiber microelectrode; in vivo voltammetry; neurotransmission; temporal coding
MeSH headings : Action Potentials / physiology; Animals; Cocaine / pharmacology; Dopamine / metabolism; Dopamine Plasma Membrane Transport Proteins / metabolism; Dopamine Uptake Inhibitors / pharmacology; Electric Stimulation / methods; Electrochemistry / instrumentation; Electrochemistry / methods; Glutamate Decarboxylase / metabolism; Male; Nerve Net / metabolism; Neurons / drug effects; Neurons / physiology; Neurons / radiation effects; Nucleus Accumbens / anatomy & histology; Nucleus Accumbens / metabolism; Rats; Rats, Sprague-Dawley; Wakefulness
Sources: Crossref, ORCID
Added: February 6, 2021

2007 journal article

High Osmolarity andL-DOPA Augment Release via the Fusion Pore in PC12 Cells

ChemPhysChem, 8(17), 2471–2477.

By: L. Sombers*, N. Wittenberg*, M. Maxson*, K. Adams* & A. Ewing*

author keywords: amperometry; catecholamines; fusion pores; hyperosmotic solutions; membranes
MeSH headings : Animals; Biophysical Phenomena; Biophysics; Cell Membrane Structures / drug effects; Cell Membrane Structures / metabolism; Dopamine / metabolism; Exocytosis / drug effects; Levodopa / pharmacology; Models, Biological; Osmolar Concentration; PC12 Cells; Porosity / drug effects; Rats
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Multicore Vesicles: Hyperosmolarity and l-DOPA Induce Homotypic Fusion of Dense Core Vesicles

Cellular and Molecular Neurobiology, 27(5), 681–685.

By: L. Sombers*, M. Maxson* & A. Ewing*

author keywords: exocytosis; secretory granules; electron microscopy; PC12; cationized ferritin; quantal size; amperometry; catecholamines
MeSH headings : Animals; Dopamine Agents / pharmacology; Exocytosis / drug effects; Exocytosis / physiology; Levodopa / pharmacology; Membrane Fusion / drug effects; Microscopy, Electron, Transmission; Neurons / drug effects; Neurons / ultrastructure; Osmolar Concentration; PC12 Cells; Rats; Saline Solution, Hypertonic / pharmacology; Secretory Vesicles / drug effects; Secretory Vesicles / ultrastructure
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation

Journal of Neuroscience, 27(4), 791–795.

By: J. Cheer, K. Wassum, L. Sombers*, M. Heien, J. Ariansen, B. Aragona, P. Phillips, R. Wightman

author keywords: rimonabant; dopamine; cocaine; nicotine; ethanol; cyclic voltammetry
MeSH headings : Animals; Cannabinoid Receptor Modulators / agonists; Cannabinoid Receptor Modulators / antagonists & inhibitors; Cannabinoid Receptor Modulators / metabolism; Dopamine / metabolism; Illicit Drugs / pharmacology; Nucleus Accumbens / drug effects; Nucleus Accumbens / metabolism; Piperidines / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 / agonists; Receptor, Cannabinoid, CB1 / antagonists & inhibitors; Receptor, Cannabinoid, CB1 / metabolism; Rimonabant; Time Factors
Sources: Crossref, ORCID
Added: February 6, 2021

2006 conference paper

Burst Firing of Midbrain Dopamine Neurons Contributes to Transient Dopamine Fluctuations Time-Locked to Behavioral Responses in the Nucleus Accumbens of Freely-Moving Rats

In G. Di Chiara, E. Carboni, V. Valentini, E. Acquas, V. Bassareo, & C. Cadoni (Eds.), Monitoring molecules in neuroscience: proceeding of the 11.th International conference on in Vivo Methods 2006 : University of Cagliari, Italy (pp. 560–562). Italy: Grafiche Sainas.

By: L. Sombers, M. Beyene, J. Ariansen, C. Owesson White, J. Cheer & R. Wightman

Ed(s): G. Di Chiara, E. Carboni, V. Valentini, E. Acquas, V. Bassareo & C. Cadoni

Event: 11th International Conference on In Vivo Methods at Cagliari, Sardinia, Italy on May 19-22, 2006

Source: NC State University Libraries
Added: February 12, 2021

2005 journal article

Correlation between Vesicle Quantal Size and Fusion Pore Release in Chromaffin Cell Exocytosis

Biophysical Journal, 88(6), 4411–4420.

By: C. Amatore*, S. Arbault*, I. Bonifas*, Y. Bouret*, M. Erard*, A. Ewing*, L. Sombers*

MeSH headings : Animals; Biophysical Phenomena; Biophysics; Catecholamines / metabolism; Cattle; Chromaffin Cells / metabolism; Chromaffin Cells / physiology; Electrophysiology; Exocytosis / physiology; In Vitro Techniques; Kinetics; Membrane Fusion / physiology; Models, Biological; Secretory Vesicles / physiology
Sources: Crossref, ORCID
Added: February 5, 2021

2005 journal article

Loaded dopamine is preferentially stored in the halo portion of PC12 cell dense core vesicles

Journal of Neurochemistry, 93(5), 1122–1131.

By: L. Sombers*, M. Maxson* & A. Ewing*

author keywords: amperometry; dense core vesicles; exocytosis; PC12 cells; vesicular volume
MeSH headings : Animals; Catecholamines / metabolism; Dopamine / pharmacokinetics; Dopamine Agents / pharmacology; Electrochemistry; Extracellular Fluid / metabolism; Levodopa / pharmacology; Models, Theoretical; Osmolar Concentration; Osmosis; PC12 Cells / metabolism; Rats; Secretory Vesicles / metabolism; Tissue Distribution
Sources: Crossref, ORCID
Added: February 6, 2021

2004 journal article

The Effects of Vesicular Volume on Secretion through the Fusion Pore in Exocytotic Release from PC12 Cells

Journal of Neuroscience, 24(2), 303–309.

By: L. Sombers*

author keywords: fusion pore; exocytosis; amperometry; transmission electron microscopy; PC12 cells; vesicle volume; foot
MeSH headings : Action Potentials; Animals; Cell Membrane / ultrastructure; Cell Size; Exocytosis; Membrane Fusion; Neurons / chemistry; Neurons / physiology; Neurons / ultrastructure; Neurotransmitter Agents / analysis; Neurotransmitter Agents / metabolism; PC12 Cells; Rats; Secretory Vesicles / chemistry; Secretory Vesicles / metabolism; Secretory Vesicles / ultrastructure; Synapses / metabolism
Sources: Crossref, ORCID
Added: February 5, 2021

2004 chapter

The Modulation of Vesicular Volume and its Effect on Neurotransmitter Secretion through the Fusion Pore in PC12 Cells

In R. Borges & L. Gandia (Eds.), Cell Biology of the Chromaffin Cell (pp. 43–46). Spain: Instituto Teófilo Hernando.

By: L. Sombers, H. Hanchar, T. Colliver, N. Wittenberg, A. Cans, S. Arbault, C. Amatore, A. Ewing

Ed(s): R. Borges & L. Gandia

Source: NC State University Libraries
Added: February 12, 2021

2003 conference paper

Amperometric Detection of Exocytosis at Cells and Artificial Cells

In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 171–173). Stockholm, Sweden: Karolinska University Press.

By: A. Ewing, A. Cans, L. Sombers, N. Wittenberg, D. Eves, R. Karlsson, M. Karlsson, A. Karlsson, O. Orwar

Ed(s): J. Kehr, K. Fuxe, U. Ungerstedt & T. Svensson

Event: 10th International Conference on In Vivo Methods at Stockholm, Sweden on June 24-27, 2003

Source: NC State University Libraries
Added: February 12, 2021

2003 journal article

Artificial cells: Unique insights into exocytosis using liposomes and lipid nanotubes

Proceedings of the National Academy of Sciences, 100(2), 400–404.

MeSH headings : Animals; Biological Transport; Exocytosis / physiology; Lipid Metabolism; Liposomes / metabolism; Membrane Fusion; Microscopy, Fluorescence; PC12 Cells; Rats
Sources: Crossref, ORCID
Added: February 5, 2021

2003 conference paper

Vesicular Volume, the Fusion Pore and Potential ‘Presynaptic’ Mechanisms Modulating Neurotransmitter Release

In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 189–191). Stockholm, Sweden: Karolinska University Press.

By: L. Sombers, M. Maxson & A. Ewing

Ed(s): J. Kehr, K. Fuxe, U. Ungerstedt & T. Svensson

Event: 10th International Conference on In Vivo Methods at Stockholm, Sweden on June 24-27, 2003

Source: NC State University Libraries
Added: February 12, 2021

2002 journal article

Differentiated PC12 Cells

Annals of the New York Academy of Sciences, 971(1), 86–88.

By: L. Sombers*, T. Colliver & A. Ewing

author keywords: PC 12; differentiation; varicosity; exocytosis; VMAT; catecholamine
MeSH headings : Animals; Catecholamines / metabolism; Cell Communication; Cell Differentiation; Electrophysiology / methods; Exocytosis; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / physiology; Membrane Transport Proteins; Neurons / cytology; Neurons / physiology; Neuropeptides; PC12 Cells; Rats; Time Factors; Vesicular Biogenic Amine Transport Proteins
Sources: Crossref, ORCID
Added: February 5, 2021

2002 chapter

Electrochemical Monitoring of Exocytosis from Individual PC12 Cells in Culture

In A. Brajter-Toth & J. Q. Chambers (Eds.), Electroanalytical Methods for Biological Materials (pp. 279–327).

By: L. Sombers* & A. Ewing

Ed(s): A. Brajter-Toth & J. Chambers

Sources: Crossref, ORCID
Added: February 6, 2021

2001 chapter

Electrochemical or Separations-Based Sensing of Neurotransmitter Dynamics and Storage at Cells and Varicosities in Culture

In W. T. O'Connor, J. P. Lowry, J. J. O'Connor, & R. D. O'Neill (Eds.), Monitoring molecules in neuroscience : proceedings of the 9th International Conference on In Vivo Methods, June 16-19, 2001, University College Dublin, Ireland (pp. 57–58). Dublin: University College Dublin.

By: A. Ewing, L. Sombers, L. Woods, T. Colliver, M. Achalabun, K. Moran, J. Lapos, T. Paxon, A. Cans

Ed(s): W. O'Connor, J. Lowry, J. O'Connor & R. O'Neill

Event: 9th International Conference on In Vivo Methods at Dublin, Ireland on June 16-19, 2001

Source: NC State University Libraries
Added: February 12, 2021