Leslie Sombers

Fast-Scan for In Vivo Measurements of Neurochemical Dynamics

In M. Fakhoury (Ed.), The Brain Reward System (pp. 93–123).

Carbon-Fiber Nanoelectrodes for Real-Time Discrimination of Vesicle Cargo in the Native Cellular Environment

ACS Nano, 14(3), 2917–2926.

Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy

Langmuir, 36(15), 4214–4223.

Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain

ANALYTICAL AND BIOANALYTICAL CHEMISTRY.

Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression

Analytical Chemistry, 91(11), 7319–7327.

Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry

Analytical Chemistry, 90(21), 12994–12999.

Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin

ACS Chemical Neuroscience, 10(4), 2022–2032.

Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH

Analytical Chemistry, 90(3), 1767–1776.

Fast-scan cyclic voltammetry: Chemical sensing in the brain and beyond

Analytical Chemistry, Vol. 90, pp. 490–504.

Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats

ACS Chemical Neuroscience, 10(4), 1935–1940.

NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies

ACS Chemical Neuroscience, 10(3), 1497–1505.

Quantitative Comparison of Enzyme Immobilization Strategies for Glucose Biosensing in Real-Time Using Fast-Scan Cyclic Voltammetry Coupled with Carbon-Fiber Microelectrodes

ChemPhysChem, 19(10), 1197–1204.

Reducing Data Density in Fast-Scan Cyclic Voltammetry Measurements of Dopamine Dynamics

Journal of The Electrochemical Society, 165(12), G3042–G3050.

Background signal as an in situ predictor of dopamine oxidation potential: Improving interpretation of fast-scan cyclic voltammetry data

ACS Chemical Neuroscience, 8(2), 411–419.

Selective and Mechanically Robust Sensors for Electrochemical Measurements of Real-Time Hydrogen Peroxide Dynamics in Vivo

Analytical Chemistry, 90(1), 888–895.

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

ACS Chemical Neuroscience, 8(2), 272–280.

Spectroelectrochemical Characterization of the Dynamic Carbon-Fiber Surface in Response to Electrochemical Conditioning

Langmuir, 33(32), 7838–7846.

The Hydroxyl radical is a critical intermediate in the voltammetric detection of hydrogen peroxide

Journal of the American Chemical Society, 138(8), 2516–2519.

Unmasking the effects of L-DOPA on rapid dopamine signaling with an improved approach for nafion coating carbon-fiber microelectrodes

Analytical Chemistry, 88(16), 8129–8136.

Enzyme-based microbiosensors for selective quantification of rapid molecular fluctuations in brain tissue

Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience, Vol 1: Fundamentals and Applications, 137–160.

Multiple scan rate voltammetry for selective quantification of real-time enkephalin dynamics

Analytical Chemistry, 86(15), 7806–7812.

Peroxygenase and oxidase activities of dehaloperoxidase-hemoglobin from Amphitrite ornata

Journal of the American Chemical Society, 136(22), 7914–7925.

Reducing the sampling rate of biochemical measurements using fast-scan cyclic voltammetry for in vivo applications

IEEE Sensors Journal, 14(9), 2975–2980.

Carbon nanotube yarn electrodes for enhanced detection of neurotransmitter dynamics in live brain tissue

ACS Nano, 7(9), 7864–7873.

Enzyme-modified carbon-fiber microelectrode for the quantification of dynamic fluctuations of nonelectroactive analytes using fast-scan cyclic voltammetry

Analytical Chemistry, 85(18), 8780–8786.

In situ electrode calibration strategy for voltammetric measurements in vivo

Analytical Chemistry, 85(23), 11568–11575.

Quantitation of hydrogen peroxide fluctuations and their modulation of dopamine dynamics in the rat dorsal striatum using fast-scan cyclic voltammetry

ACS Chemical Neuroscience, 4(5), 782–789.

Real-Time Chemical Measurements of Dopamine Release in the Brain

In Methods in Molecular Biology (pp. 275–294).

Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens

Journal of Neurochemistry, 121(2), 252–262.

Trace metal complexation by the triscatecholate siderophore protochelin: structure and stability

Biometals, 25(2), 393–412.

Comparison of electrode materials for the detection of rapid hydrogen peroxide fluctuations using background-subtracted fast scan cyclic voltammetry

The Analyst, 136(17), 3550.

Application of Fast-Scan Cyclic Voltammetry to Monitoring Endogenous Hydrogen Peroxide Fluctuations In Vivo

In B. Westerink, R. Clinckers, I. Smolders, S. Sarre, & Y. Michotte (Eds.), Monitoring Molecules in Neuroscience (pp. 89–91). Brussels, Belgium: Vrije Universiteit.

Specific oxygen-containing functional groups on the carbon surface underlie an enhanced sensitivity to dopamine at electrochemically pretreated carbon fiber microelectrodes

Langmuir, 26(11), 9116–9122.

Voltammetric detection of hydrogen peroxide at carbon fiber microelectrodes

Analytical Chemistry, 82(12), 5205–5210.

Synaptic Overflow of Dopamine in the Nucleus Accumbens Arises from Neuronal Activity in the Ventral Tegmental Area

Journal of Neuroscience, 29(6), 1735–1742.

Dopamine Detection with Fast-Scan Cyclic Voltammetry Used with Analog Background Subtraction

Analytical Chemistry, 80(11), 4040–4048.

Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens

European Journal of Neuroscience, 26(7), 2046–2054.

High Osmolarity andL-DOPA Augment Release via the Fusion Pore in PC12 Cells

ChemPhysChem, 8(17), 2471–2477.

Multicore Vesicles: Hyperosmolarity and l-DOPA Induce Homotypic Fusion of Dense Core Vesicles

Cellular and Molecular Neurobiology, 27(5), 681–685.

Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation

Journal of Neuroscience, 27(4), 791–795.

Burst Firing of Midbrain Dopamine Neurons Contributes to Transient Dopamine Fluctuations Time-Locked to Behavioral Responses in the Nucleus Accumbens of Freely-Moving Rats

In G. Di Chiara, E. Carboni, V. Valentini, E. Acquas, V. Bassareo, & C. Cadoni (Eds.), Monitoring molecules in neuroscience: proceeding of the 11.th International conference on in Vivo Methods 2006 : University of Cagliari, Italy (pp. 560–562). Italy: Grafiche Sainas.

Correlation between Vesicle Quantal Size and Fusion Pore Release in Chromaffin Cell Exocytosis

Biophysical Journal, 88(6), 4411–4420.

Loaded dopamine is preferentially stored in the halo portion of PC12 cell dense core vesicles

Journal of Neurochemistry, 93(5), 1122–1131.

The Effects of Vesicular Volume on Secretion through the Fusion Pore in Exocytotic Release from PC12 Cells

Journal of Neuroscience, 24(2), 303–309.

The Modulation of Vesicular Volume and its Effect on Neurotransmitter Secretion through the Fusion Pore in PC12 Cells

In R. Borges & L. Gandia (Eds.), Cell Biology of the Chromaffin Cell (pp. 43–46). Spain: Instituto Teófilo Hernando.

Amperometric Detection of Exocytosis at Cells and Artificial Cells

In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 171–173). Stockholm, Sweden: Karolinska University Press.

Artificial cells: Unique insights into exocytosis using liposomes and lipid nanotubes

Proceedings of the National Academy of Sciences, 100(2), 400–404.

Vesicular Volume, the Fusion Pore and Potential ‘Presynaptic’ Mechanisms Modulating Neurotransmitter Release

In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 189–191). Stockholm, Sweden: Karolinska University Press.

Differentiated PC12 Cells

Annals of the New York Academy of Sciences, 971(1), 86–88.

Electrochemical Monitoring of Exocytosis from Individual PC12 Cells in Culture

In A. Brajter-Toth & J. Q. Chambers (Eds.), Electroanalytical Methods for Biological Materials (pp. 279–327).

Electrochemical or Separations-Based Sensing of Neurotransmitter Dynamics and Storage at Cells and Varicosities in Culture

In W. T. O'Connor, J. P. Lowry, J. J. O'Connor, & R. D. O'Neill (Eds.), Monitoring molecules in neuroscience : proceedings of the 9th International Conference on In Vivo Methods, June 16-19, 2001, University College Dublin, Ireland (pp. 57–58). Dublin: University College Dublin.