Leslie Sombers

Forderhase, A. G., Kimble, L. C., & Sombers, L. A. (2023, June 5). A Student Perspective on the 18th Monitoring Molecules in Neuroscience Meeting in Lyon. ACS CHEMICAL NEUROSCIENCE, Vol. 6. https://doi.org/10.1021/acschemneuro.3c00271

De Alwis, A. C., Denison, J. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, August 8). Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells. ACS SENSORS, Vol. 8. https://doi.org/10.1021/acssensors.3c00884

Todorov, J., McCarty, G. S., & Sombers, L. A. (2023). Exploring Electrochemistry: A Hydrogen Peroxide Sensor Based on a Screen-Printed Carbon Electrode Modified with Prussian Blue. JOURNAL OF CHEMICAL EDUCATION, 100(12), 4853–4859. https://doi.org/10.1021/acs.jchemed.3c00844

Sombers, L. A. (2023, October 18). Monitoring Molecules in Neuroscience. ACS CHEMICAL NEUROSCIENCE, Vol. 14, pp. 3726–3727. https://doi.org/10.1021/acschemneuro.3c00592

Kimble, L. C., Twiddy, J. S., Berger, J. M., Forderhase, A. G., Mccarty, G. S., Meitzen, J., & Sombers, L. A. (2023). Simultaneous, Real-Time Detection of Glutamate and Dopamine in Rat Striatum Using Fast-Scan Cyclic Voltammetry. ACS SENSORS, 8(11), 4091–4100. https://doi.org/10.1021/acssensors.3c01267

Denison, J. D., De Alwis, A. C., Shah, R., Mccarty, G. S., & Sombers, L. A. (2023). Untapped Potential: Real-Time Measurements of Opioid Exocytosis at Single Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(44), 24071–24080. https://doi.org/10.1021/jacs.3c07487

McCarty, G. S., Dunaway, L. E., Denison, J. D., & Sombers, L. A. (2022, June 24). Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells. ANALYTICAL CHEMISTRY, Vol. 6. https://doi.org/10.1021/acs.analchem.2c00060

Sombers, L. A., & Patisaul, H. B. (2022, August 3). Virtual Issue: Neurotoxicology. ACS CHEMICAL NEUROSCIENCE, Vol. 13, pp. 2238–2239. https://doi.org/10.1021/acschemneuro.2c00375

Meunier, C. J., & Sombers, L. A. (2021). Fast-Scan for In Vivo Measurements of Neurochemical Dynamics. In M. Fakhoury (Ed.), The Brain Reward System (pp. 93–123). https://doi.org/10.1007/978-1-0716-1146-3_5

Roberts, J. G., Mitchell, E. C., Dunaway, L. E., McCarty, G. S., & Sombers, L. A. (2020). Carbon-Fiber Nanoelectrodes for Real-Time Discrimination of Vesicle Cargo in the Native Cellular Environment. ACS Nano, 14(3), 2917–2926. https://doi.org/10.1021/acsnano.9b07318

Meunier, C. J., Denison, J. D., McCarty, G. S., & Sombers, L. A. (2020). Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy. Langmuir, 36(15), 4214–4223. https://doi.org/10.1021/acs.langmuir.9b03941

Forderhase, A. G., Styers, H. C., Lee, C. A., & Sombers, L. A. (2020). Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(24), 6611–6624. https://doi.org/10.1007/s00216-020-02797-0

Meunier, C. J., McCarty, G. S., & Sombers, L. A. (2019). Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression. Analytical Chemistry, 91(11), 7319–7327. https://doi.org/10.1021/acs.analchem.9b01083

Smith, S. K., Gosrani, S. P., Lee, C. A., McCarty, G. S., & Sombers, L. A. (2018). Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry. Analytical Chemistry, 90(21), 12994–12999. https://doi.org/10.1021/acs.analchem.8b03694

Calhoun, S. E., Meunier, C. J., Lee, C. A., McCarty, G. S., & Sombers, L. A. (2018). Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin. ACS Chemical Neuroscience, 10(4), 2022–2032. https://doi.org/10.1021/acschemneuro.8b00351

Meunier, C. J., Mitchell, E. C., Roberts, J. G., Toups, J. V., McCarty, G. S., & Sombers, L. A. (2018). Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH. Analytical Chemistry, 90(3), 1767–1776. https://doi.org/10.1021/ACS.ANALCHEM.7B03717

Roberts, J. G., & Sombers, L. A. (2018). [Review of Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond]. ANALYTICAL CHEMISTRY, 90(1), 490–504. https://doi.org/10.1021/acs.analchem.7b04732

Gómez-A, A., Shnitko, T. A., Barefoot, H. M., Brightbill, E. L., Sombers, L. A., Nicola, S. M., & Robinson, D. L. (2018). Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats. ACS Chemical Neuroscience, 10(4), 1935–1940. https://doi.org/10.1021/acschemneuro.8b00437

Spanos, M., Xie, X., Gras-Najjar, J., White, S. C., & Sombers, L. A. (2018). NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies. ACS Chemical Neuroscience, 10(3), 1497–1505. https://doi.org/10.1021/acschemneuro.8b00492

Smith, S. K., Lugo-Morales, L. Z., Tang, C., Gosrani, S. P., Lee, C. A., Roberts, J. G., … Sombers, L. A. (2018). Quantitative Comparison of Enzyme Immobilization Strategies for Glucose Biosensing in Real-Time Using Fast-Scan Cyclic Voltammetry Coupled with Carbon-Fiber Microelectrodes. ChemPhysChem, 19(10), 1197–1204. https://doi.org/10.1002/CPHC.201701235

Lee, C. A., Qi, L., Amos, A., Blanton, K., McCarty, G. S., & Sombers, L. A. (2018). Reducing Data Density in Fast-Scan Cyclic Voltammetry Measurements of Dopamine Dynamics. Journal of The Electrochemical Society, 165(12), G3042–G3050. https://doi.org/10.1149/2.0081812jes

Meunier, C. J., Roberts, J. G., McCarty, G. S., & Sombers, L. A. (2017). Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data. ACS CHEMICAL NEUROSCIENCE, 8(2), 411–419. https://doi.org/10.1021/acschemneuro.6b00325

Sombers, L. A., Wilson, L. R., Mason, C. F., & Lee, C. A. (2017). Real-Time Striatal Measurements of Oxidative Stress and Dopamine in the Dyskinetic Rat during Chronic L-DOPA Treatment for Parkinson's Disease. ECS Meeting Abstracts, MA2017–02 2303. https://doi.org/10.1149/MA2017-02/55/2303

Wilson, L. R., Panda, S., Schmidt, A. C., & Sombers, L. A. (2017). Selective and Mechanically Robust Sensors for Electrochemical Measurements of Real-Time Hydrogen Peroxide Dynamics in Vivo. Analytical Chemistry, 90(1), 888–895. https://doi.org/10.1021/acs.analchem.7b03770

Smith, S. K., Lee, C. A., Dausch, M. E., Horman, B. M., Patisaul, H. B., McCarty, G. S., & Sombers, L. A. (2017). Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum. ACS Chemical Neuroscience, 8(2), 272–280. https://doi.org/10.1021/acschemneuro.6b00363

Mitchell, E. C., Dunaway, L. E., McCarty, G. S., & Sombers, L. A. (2017). Spectroelectrochemical Characterization of the Dynamic Carbon-Fiber Surface in Response to Electrochemical Conditioning. Langmuir, 33(32), 7838–7846. https://doi.org/10.1021/acs.langmuir.7b01443

Roberts, J. G., Voinov, M. A., Schmidt, A. C., Smirnova, T. I., & Sombers, L. A. (2016). The Hydroxyl Radical is a Critical Intermediate in the Voltammetric Detection of Hydrogen Peroxide. Journal of the American Chemical Society, 138(8), 2516–2519. https://doi.org/10.1021/jacs.5b13376

Qi, L., Thomas, E., White, S. H., Smith, S. K., Lee, C. A., Wilson, L. R., & Sombers, L. A. (2016). Unmasking the Effects of L-DOPA on Rapid Dopamine Signaling with an Improved Approach for Nafion Coating Carbon-Fiber Microelectrodes. ANALYTICAL CHEMISTRY, 88(16), 8129–8136. https://doi.org/10.1021/acs.analchem.6b01871

Lugo-Morales, L. Z., & Sombers, L. (2015). Enzyme-based microbiosensors for selective quantification of rapid molecular fluctuations in brain tissue. Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience, Vol 1: Fundamentals and Applications, 137–160. https://doi.org/10.1142/9789814619776_0006

Schmidt, A. C., Dunaway, L. E., Roberts, J. G., McCarty, G. S., & Sombers, L. A. (2014). Multiple Scan Rate Voltammetry for Selective Quantification of Real-Time Enkephalin Dynamics. ANALYTICAL CHEMISTRY, 86(15), 7806–7812. https://doi.org/10.1021/ac501725u

Barrios, D. A., D’Antonio, J., McCombs, N. L., Zhao, J., Franzen, S., Schmidt, A. C., … Ghiladi, R. A. (2014). Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata. Journal of the American Chemical Society, 136(22), 7914–7925. https://doi.org/10.1021/ja500293c

Amos, A. N., Roberts, J. G., Qi, L., Sombers, L. A., & McCarty, G. S. (2014). Reducing the Sampling Rate of Biochemical Measurements Using Fast-Scan Cyclic Voltammetry for In Vivo Applications. IEEE SENSORS JOURNAL, 14(9), 2975–2980. https://doi.org/10.1109/jsen.2014.2321479

Schmidt, A. C., Wang, X., Zhu, Y., & Sombers, L. A. (2013). Carbon Nanotube Yarn Electrodes for Enhanced Detection of Neurotransmitter Dynamics in Live Brain Tissue. ACS NANO, 7(9), 7864–7873. https://doi.org/10.1021/nn402857u

Lugo-Morales, L. Z., Loziuk, P. L., Corder, A. K., Toups, J. V., Roberts, J. G., McCaffrey, K. A., & Sombers, L. A. (2013). Enzyme-Modified Carbon-Fiber Microelectrode for the Quantification of Dynamic Fluctuations of Nonelectroactive Analytes Using Fast-Scan Cyclic Voltammetry. ANALYTICAL CHEMISTRY, 85(18), 8780–8786. https://doi.org/10.1021/ac4017852

Roberts, J. G., Toups, J. V., Eyualem, E., McCarty, G. S., & Sombers, L. A. (2013). In Situ Electrode Calibration Strategy for Voltammetric Measurements In Vivo. ANALYTICAL CHEMISTRY, 85(23), 11568–11575. https://doi.org/10.1021/ac402884n

Spanos, M., Gras-Najjar, J., Letchworth, J. M., Sanford, A. L., Toups, J. V., & Sombers, L. A. (2013). Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry. ACS CHEMICAL NEUROSCIENCE, 4(5), 782–789. https://doi.org/10.1021/cn4000499

Roberts, J. G., Lugo-Morales, L. Z., Loziuk, P. L., & Sombers, L. A. (2012). Real-Time Chemical Measurements of Dopamine Release in the Brain. In Methods in Molecular Biology (pp. 275–294). https://doi.org/10.1007/978-1-62703-251-3_16

Owesson-White, C. A., Roitman, M. F., Sombers, L. A., Belle, A. M., Keithley, R. B., Peele, J. L., … Wightman, R. M. (2012). Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens. JOURNAL OF NEUROCHEMISTRY, 121(2), 252–262. https://doi.org/10.1111/j.1471-4159.2012.07677.x

Harrington, J. M., Bargar, J. R., Jarzecki, A. A., Roberts, J. G., Sombers, L. A., & Duckworth, O. W. (2012). Trace metal complexation by the triscatecholate siderophore protochelin: structure and stability. BIOMETALS, 25(2), 393–412. https://doi.org/10.1007/s10534-011-9513-7

Roberts, J. G., Hamilton, K. L., & Sombers, L. A. (2011). Comparison of electrode materials for the detection of rapid hydrogen peroxide fluctuations using background-subtracted fast scan cyclic voltammetry. The Analyst, 136(17), 3550. https://doi.org/10.1039/c1an15337d

Sanford, A. L., Letchworth, J., & Sombers, L. A. (2010). Application of Fast-Scan Cyclic Voltammetry to Monitoring Endogenous Hydrogen Peroxide Fluctuations In Vivo. In B. Westerink, R. Clinckers, I. Smolders, S. Sarre, & Y. Michotte (Eds.), Monitoring Molecules in Neuroscience (pp. 89–91). Brussels, Belgium: Vrije Universiteit.

Roberts, J. G., Moody, B. P., McCarty, G. S., & Sombers, L. A. (2010). Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes. LANGMUIR, 26(11), 9116–9122. https://doi.org/10.1021/la9048924

Sanford, A. L., Morton, S. W., Whitehouse, K. L., Oara, H. M., Lugo-Morales, L. Z., Roberts, J. G., & Sombers, L. A. (2010). Voltammetric Detection of Hydrogen Peroxide at Carbon Fiber Microelectrodes. ANALYTICAL CHEMISTRY, 82(12), 5205–5210. https://doi.org/10.1021/ac100536s

Sombers, L. A., Beyene, M., Carelli, R. M., & Mark Wightman, R. (2009). Synaptic Overflow of Dopamine in the Nucleus Accumbens Arises from Neuronal Activity in the Ventral Tegmental Area. Journal of Neuroscience, 29(6), 1735–1742. https://doi.org/10.1523/jneurosci.5562-08.2009

Hermans, A., Keithley, R. B., Kita, J. M., Sombers, L. A., & Wightman, R. M. (2008). Dopamine Detection with Fast-Scan Cyclic Voltammetry Used with Analog Background Subtraction. Analytical Chemistry, 80(11), 4040–4048. https://doi.org/10.1021/ac800108j

Wightman, R. M., Heien, M. L. A. V., Wassum, K. M., Sombers, L. A., Aragona, B. J., Khan, A. S., … Carelli, R. M. (2007). Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. European Journal of Neuroscience, 26(7), 2046–2054. https://doi.org/10.1111/j.1460-9568.2007.05772.x

Sombers, L. A., Wittenberg, N. J., Maxson, M. M., Adams, K. L., & Ewing, A. G. (2007). High Osmolarity andL-DOPA Augment Release via the Fusion Pore in PC12 Cells. ChemPhysChem, 8(17), 2471–2477. https://doi.org/10.1002/cphc.200700291

Sombers, L. A., Maxson, M. M., & Ewing, A. G. (2007). Multicore Vesicles: Hyperosmolarity and l-DOPA Induce Homotypic Fusion of Dense Core Vesicles. Cellular and Molecular Neurobiology, 27(5), 681–685. https://doi.org/10.1007/S10571-007-9156-Y

Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L. A. V., Ariansen, J. L., Aragona, B. J., … Wightman, R. M. (2007). Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation. Journal of Neuroscience, 27(4), 791–795. https://doi.org/10.1523/jneurosci.4152-06.2007

Sombers, L. A., Beyene, M., Ariansen, J. L., Owesson White, C. A., Cheer, J. F., & Wightman, R. M. (2006). Burst Firing of Midbrain Dopamine Neurons Contributes to Transient Dopamine Fluctuations Time-Locked to Behavioral Responses in the Nucleus Accumbens of Freely-Moving Rats. In G. Di Chiara, E. Carboni, V. Valentini, E. Acquas, V. Bassareo, & C. Cadoni (Eds.), Monitoring molecules in neuroscience: proceeding of the 11.th International conference on in Vivo Methods 2006 : University of Cagliari, Italy (pp. 560–562). Italy: Grafiche Sainas.

Amatore, C., Arbault, S., Bonifas, I., Bouret, Y., Erard, M., Ewing, A. G., & Sombers, L. A. (2005). Correlation between Vesicle Quantal Size and Fusion Pore Release in Chromaffin Cell Exocytosis. Biophysical Journal, 88(6), 4411–4420. https://doi.org/10.1529/biophysj.104.053736

Sombers, L. A., Maxson, M. M., & Ewing, A. G. (2005). Loaded dopamine is preferentially stored in the halo portion of PC12 cell dense core vesicles. Journal of Neurochemistry, 93(5), 1122–1131. https://doi.org/10.1111/j.1471-4159.2005.03087.x

Sombers, L. A. (2004). The Effects of Vesicular Volume on Secretion through the Fusion Pore in Exocytotic Release from PC12 Cells. Journal of Neuroscience, 24(2), 303–309. https://doi.org/10.1523/jneurosci.1119-03.2004

Sombers, L. A., Hanchar, H. J., Colliver, T. L., Wittenberg, N., Cans, A., Arbault, S., … Ewing, A. G. (2004). The Modulation of Vesicular Volume and its Effect on Neurotransmitter Secretion through the Fusion Pore in PC12 Cells. In R. Borges & L. Gandia (Eds.), Cell Biology of the Chromaffin Cell (pp. 43–46). Spain: Instituto Teófilo Hernando.

Ewing, A. G., Cans, A. S., Sombers, L., Wittenberg, N., Eves, D., Karlsson, R., … Orwar, O. (2003). Amperometric Detection of Exocytosis at Cells and Artificial Cells. In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 171–173). Stockholm, Sweden: Karolinska University Press.

Cans, A.-S., Wittenberg, N., Karlsson, R., Sombers, L., Karlsson, M., Orwar, O., & Ewing, A. (2003). Artificial cells: Unique insights into exocytosis using liposomes and lipid nanotubes. Proceedings of the National Academy of Sciences, 100(2), 400–404. https://doi.org/10.1073/pnas.232702599

Sombers, L., Maxson, M., & Ewing, A. G. (2003). Vesicular Volume, the Fusion Pore and Potential ‘Presynaptic’ Mechanisms Modulating Neurotransmitter Release. In J. Kehr, K. Fuxe, U. Ungerstedt, & T. Svensson (Eds.), Monitoring molecules in neuroscience : proceedings of the 10th International Conference on In Vivo Methods : Karolinska Institutet, Stockholm, Sweden June 24-27, 2003 (pp. 189–191). Stockholm, Sweden: Karolinska University Press.

Sombers, L. A., Colliver, T. L., & Ewing, A. G. (2002). Differentiated PC12 Cells. Annals of the New York Academy of Sciences, 971(1), 86–88. https://doi.org/10.1111/j.1749-6632.2002.tb04439.x

Sombers, L., & Ewing, A. (2002). Electrochemical Monitoring of Exocytosis from Individual PC12 Cells in Culture. In A. Brajter-Toth & J. Q. Chambers (Eds.), Electroanalytical Methods for Biological Materials (pp. 279–327). https://doi.org/10.1201/9780203908907.pt3

Ewing, A. G., Sombers, L. A., Woods, L. A., Colliver, T. L., Achalabun, M., Moran, K., … Cans, A. S. (2001). Electrochemical or Separations-Based Sensing of Neurotransmitter Dynamics and Storage at Cells and Varicosities in Culture. In W. T. O'Connor, J. P. Lowry, J. J. O'Connor, & R. D. O'Neill (Eds.), Monitoring molecules in neuroscience : proceedings of the 9th International Conference on In Vivo Methods, June 16-19, 2001, University College Dublin, Ireland (pp. 57–58). Dublin: University College Dublin.