Works (108)
Updated: April 4th, 2024 07:10
2023 article
Draft Genome Sequences of Escherichia coli and Enterococcus faecalis Coisolated from Polymicrobial Extraintestinal Infections of Chickens and Turkeys
Walker, G. K., Harden, L., Suyemoto, M. M., Thakur, S., Jacob, M., & Borst, L. B. (2023, February 21). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, Vol. 2.
TL;DR:
It is reported that draft genome sequences of 18 APEC and 18 E. faecalis strains coisolated from lesions of diseased poultry with colisepticemia are reported.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023
2023 article
Draft genome sequences of 12 Escherichia coli co-isolated with Enterococcus spp. from dogs with polybacterial bacteriuria at a veterinary hospital
Walker, G. K., Harden, L., Suyemoto, M. M., Thakur, S., Jacob, M., & Borst, L. B. (2023, August 8). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, Vol. 8.
author keywords: E; coli; UPEC; canine urinary tract infection; polymicrobial infections
TL;DR:
The draft genome sequences of 12 UPEC co-isolated with Enterococcus spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 journal article
Pancreatic Torsion Resulting in Acute Pancreatic Necrosis in a Young Dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 59(6), 297–301.
TL;DR:
A case of 7 mo old French bulldog referred to North Carolina State University Small Animal Emergency and Triage Services because of acute abdomen, regurgitation, lethargy, and fever showed pathological changes that were supportive of a left-limb pancreatic torsion that was confirmed postmortem.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023
2022 journal article
Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: severe combined immunodeficiency; pig; xenotransplantation; allotransplantation; hematopoietic; RAG2; IL2RG; transgenic
TL;DR:
The data shows that the pig thymus provides a microenvironment conducive to engraftment, survival and development of human T-cells and provides evidence that the developing T-cell compartment can be populated to a significant extent by human cells in large animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022
2022 journal article
Cranial internal hemipelvectomy (iliectomy) with limb sparing for a dog with ilial chondrosarcoma: A case report
CLINICAL CASE REPORTS, 10(1).
author keywords: general surgery; oncology; orthopedics; veterinary
TL;DR:
Iliectomy with adjuvant radiation therapy was well tolerated in a dog with grade II ilial CSA and the dog survived 1,271 days postoperatively and supposedly succumbed to a disease process unrelated to the CSA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022
2022 article
Detection of Escherichia coli and Enterococcus spp. in dogs with polymicrobial urinary tract infections: A 5-year retrospective study
Walker, G. K., Yustyniuk, V., Shamoun, J., Jacob, M. E., Correa, M., Vaden, S. L., & Borst, L. B. (2022, May 27). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 5.
author keywords: antibiotics; bacteriuria; cystitis; urine culture
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteriuria / drug therapy; Bacteriuria / epidemiology; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Doxycycline; Enterococcus; Escherichia coli; Escherichia coli Infections / drug therapy; Escherichia coli Infections / veterinary; Gentamicins; Humans; Retrospective Studies; Urinary Tract Infections / drug therapy; Urinary Tract Infections / epidemiology; Urinary Tract Infections / veterinary
TL;DR:
Polymicrobial UTI had more frequent adverse clinical outcomes for dogs and was more prevalent than monomicrobial UTI, and isolate antimicrobial resistance was more frequently resistant to doxycycline and gentamicin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022
2022 article
Pathology in Practice
Bauer, K., Murillo, D. F. B., Schreeg, M. E., Borst, L. B., & Watanabe, T. T. N. (2022, September). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 260, pp. 1466–1468.
MeSH headings : Animals; Animal Diseases / diagnosis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR:
Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Genomic Characterization of a Nalidixic Acid-Resistant Salmonella Enteritidis Strain Causing Persistent Infections in Broiler Chickens
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: Salmonella Enteritidis; poultry; genomics; antimicrobial resistance; broilers
TL;DR:
P phenotypic and genomic features of a virulent SE strain from persistently infected broiler flocks are reported and a workflow for SE characterization from isolate collection to genome assembly and sequence analysis is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 27, 2021
2020 journal article
Creation of a Continent Urinary Bladder Reservoir Vascularized by Omentum as a Possible Surgical Option for Canine Trigonal/Urethral Urothelial Carcinoma
JOURNAL OF INVESTIGATIVE SURGERY, 35(3), 481–495.
author keywords: Transitional cell carcinoma; urothelial carcinoma; bladder mass; reservoir; ureter; cystectomy
MeSH headings : Animals; Carcinoma, Transitional Cell; Dogs; Female; Omentum / surgery; Urinary Bladder / diagnostic imaging; Urinary Bladder / surgery; Urinary Bladder Neoplasms / surgery; Urinary Reservoirs, Continent
TL;DR:
The study’s objective was to evaluate a continent urine reservoir created from the urinary bladder body and vascularized solely by omentum to allow for primary UC resection while providing continence and limiting complications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
2020 journal article
Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers
VETERINARY SCIENCES, 7(3).
author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
TL;DR:
A microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis is developed and shown to have diverse potential to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020
2020 journal article
Personalized-induced neural stem cell therapy: Generation, transplant, and safety in a large animal model
BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(1).
author keywords: glioblastoma; neural stem cells; stem cell delivery
TL;DR:
This study generates the first canine‐induced neural stem cells (iNSCs) engineered to carry TNFα‐related apoptosis‐inducing ligand and thymidine kinase (TK), as well as magnetic resonance imaging (MRI) contrast agents for in vivo tracking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020
2020 journal article
Plasma metabolomic profiling of healthy pregnant mares and mares with experimentally induced placentitis
Equine Veterinary Journal, 53(1), 85–93.
author keywords: horse; placentitis; diagnosis; plasma; NMR spectroscopy; metabolomics
MeSH headings : Animals; Female; Horse Diseases; Horses; Metabolomics; Placenta Diseases / veterinary; Plasma; Pregnancy; Streptococcus equi
TL;DR:
Two phases of metabolite changes were noted after experimental infection: An immediate rise in metabolite concentration involved in energy, nitrogen, hydrogen, and oxygen metabolism within 4 hours after inoculation that was followed by a decrease in metabolites involved inenergy and nitrogen metabolism at 4 days, coinciding with ultrasonographic diagnosis of placentitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2020 journal article
Research Note: Repetitive element–based polymerase chain reaction genotyping improves efficiency of Salmonella surveillance in a model broiler production system
Poultry Science, 99(5), 2684–2689.
author keywords: Salmonella; antimicrobial resistance; broiler; microbiology; genetic characterization
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Chickens; DNA Fingerprinting / veterinary; Drug Resistance, Bacterial / genetics; Epidemiological Monitoring / veterinary; Genotyping Techniques / veterinary; Polymerase Chain Reaction / veterinary; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Prevalence; Salmonella / genetics; Salmonella / isolation & purification; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / microbiology; Serotyping / veterinary
TL;DR:
Genetic relatedness and antimicrobial susceptibility profiles of Salmonella isolated from poultry and their environment were determined and demonstrated that serovar Altona and Senftenberg were harbored by poultry, the latter appeared to persist in broiler flocks, and both serotypes shared similar patterns of antimacterial susceptibility in an integrated research operation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 1, 2020
2020 journal article
The role ofEnterococcus faecalisduring co-infection with avian pathogenicEscherichia coliin avian colibacillosis
AVIAN PATHOLOGY, 49(6), 589–599.
author keywords: Colibacillosis; Enterococcus; E; coli; co-infection; antimicrobial resistance; broiler; turkey
MeSH headings : Animals; Chick Embryo; Chickens / microbiology; Coinfection / veterinary; Enterococcus faecalis / physiology; Escherichia coli / physiology; Escherichia coli Infections / microbiology; Escherichia coli Infections / pathology; Escherichia coli Infections / veterinary; Female; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / pathology; Gram-Positive Bacterial Infections / veterinary; Phenotype; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Poultry Diseases / pathology; Virulence
TL;DR:
Enterococcus is frequently co-isolated with avian pathogenic E. coli from poultry with colibacillosis, and Enterococcus faecalis (EF) enhances survival of APEC in iron restricted conditions and increases APEC virulence in broiler embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 28, 2020
2019 journal article
Allantoic Metabolites, Progesterone, and Estradiol-17β Remain Unchanged After Infection in an Experimental Model of Equine Ascending Placentitis
Journal of Equine Veterinary Science., 2. http://europepmc.org/abstract/AGR/IND606255595
Source: ORCID
Added: August 20, 2019
2019 journal article
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma
MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.
MeSH headings : Animals; Blood Vessels / pathology; Breast / metabolism; Breast / pathology; Class I Phosphatidylinositol 3-Kinases / genetics; Class Ia Phosphatidylinositol 3-Kinase / genetics; Cyclin-Dependent Kinase Inhibitor p15 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Dogs; Female; Genome / genetics; Genomics; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Humans; Mutation / genetics; Tumor Suppressor Protein p53 / genetics; Viscera / metabolism; Viscera / pathology; Exome Sequencing
TL;DR:
Canine hemangiosarcoma closely models the genomic landscape of human angiosarComa of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019
2019 article
Genomic analysis reveals shared genes and pathways in human and canine angiosarcoma
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019, March).
TL;DR:
Canine angiosarcoma closely models human angiosARcoma on a genomic level, and is a powerful tool for investigating the pathogenesis of this devastating disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 20, 2019
2019 journal article
Immune dysregulation and Osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.
Veterinary and Comparative Oncology, 8.
author keywords: comparative oncology; immunotherapy; macrophage; osteosarcoma; Staphylococcus aureus
MeSH headings : Adolescent; Adult; Animals; Bone Neoplasms / immunology; Bone Neoplasms / veterinary; Cytokines / metabolism; Dog Diseases / immunology; Dogs; Down-Regulation; Humans; Macrophages / immunology; Osteosarcoma / immunology; Osteosarcoma / veterinary; Staphylococcus aureus / immunology; Transforming Growth Factor beta; Young Adult
TL;DR:
The findings of this study suggest that infection upregulates the inflammatory immune response to counteract osteosarcoma-induced immune suppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: August 20, 2019
2019 journal article
Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.
Radiation Research, 7.
MeSH headings : Animals; Capillary Permeability / radiation effects; Cell Hypoxia / radiation effects; Endothelial Cells / metabolism; Endothelial Cells / pathology; Endothelial Cells / radiation effects; Gene Deletion; Intestines / pathology; Intestines / radiation effects; Mice; Radiation Tolerance; Time Factors; Tumor Suppressor Protein p53 / deficiency; Tumor Suppressor Protein p53 / genetics
TL;DR:
It is demonstrated that while sensitization of endothelial cells to radiation does not exacerbate the acute GI radiation syndrome, it is sufficient to promote the development of late radiation enteropathy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 20, 2019
2019 journal article
Temporal characterization of wooden breast myopathy ("woody breast") severity and correlation with growth rate and lymphocytic phlebitis in three commercial broiler strains and a random-bred broiler strain
AVIAN PATHOLOGY, 48(4), 319–328.
author keywords: Athens Canadian Random Bred; broiler chickens; growth rate; incubation temperature; lymphocytic phlebitis; pectoralis major muscle; wooden breast myopathy
MeSH headings : Animals; Body Weight; Chickens / growth & development; Female; Lymphatic Vessels / pathology; Lymphatic Vessels / physiopathology; Male; Meat / economics; Meat / standards; Muscular Diseases / pathology; Muscular Diseases / physiopathology; Muscular Diseases / veterinary; Pectoralis Muscles / pathology; Pectoralis Muscles / physiopathology; Phlebitis / etiology; Phlebitis / veterinary; Poultry Diseases / pathology; Poultry Diseases / physiopathology; Random Allocation; Sex Factors; Temperature
TL;DR:
The positive correlation between WBM severity and lymphocytic phlebitis indicates vascular injury is likely an important factor in the pathogenesis of Wooden breast myopathy.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
Wooden Breast in Commercial Broilers Associated with Mortality, Dorsal Recumbency, and Pulmonary Disease
AVIAN DISEASES, 63(3), 514–519.
author keywords: broiler chicken; lungs; mortality; muscular dystrophy; myopathy; Pectoralis major muscle; pulmonary disease; wooden breast
MeSH headings : Animals; Chickens; Female; Lung Diseases / epidemiology; Lung Diseases / etiology; Male; Meat / analysis; Muscular Diseases / mortality; Muscular Diseases / pathology; Muscular Diseases / veterinary; Pectoralis Muscles / pathology; Poultry Diseases / mortality; Poultry Diseases / pathology; Prevalence
TL;DR:
Findings indicate that wooden breast is likely greater than just a problem with meat quality and should be considered an animal well-being issue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2018 journal article
A Review of Enterococcus cecorum Infection in Poultry.
Avian Diseases, 9.
author keywords: enterococcal spondylitis; Enterococcus cecorum; kinky back; bacterial osteomyelitis; Enterococcus spp.; free thoracic vertebra
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Chickens; Drug Resistance, Bacterial; Enterococcus / drug effects; Enterococcus / pathogenicity; Enterococcus / physiology; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; Poultry Diseases / microbiology; Virulence / genetics
TL;DR:
It is shown that strains with increased pathogenicity are genetically related and share several putative virulence genes and may serve as a reservoir for further spread of antimicrobial resistance among other Enterococcus spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: August 20, 2019
2018 journal article
Allantoic Metabolites, Progesterone, and Estradiol-17 beta Remain Unchanged After Infection in an Experimental Model of Equine Ascending Placentitis
JOURNAL OF EQUINE VETERINARY SCIENCE, 73, 95–105.
author keywords: Equine; Ascending placentitis; Metabolomics; Allantoic fluid
TL;DR:
The results of this study established a database of equine allantoic fluid metabolites and confirmed the utility of uteroplacental ultrasound for detection of placentitis before the onset of hematologic changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019
2018 journal article
Assessment of a novel nanoparticle hyperthermia therapy in a murine model of osteosarcoma
Vet Surg, 47(8), 1021–1030.
MeSH headings : Animals; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Disease Models, Animal; Dog Diseases / blood; Dog Diseases / therapy; Dogs; Female; Hyperthermia, Induced / veterinary; Mice; Mice, Inbred C3H; Monocytes / physiology; Nanoparticles; Osteosarcoma / therapy; Osteosarcoma / veterinary; Phenotype; Receptors, CXCR4 / genetics
TL;DR:
Enhancing monocyte/macrophage function in dogs with OS may enhance antitumor immunity and Nanoparticle hyperthermia therapy increased in vitro monocyte chemotaxis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 25, 2019
2018 journal article
Coinfection with Eimeria spp. decreases bacteremia and spinal lesions caused by pathogenic Enterococcus cecorum
Animal Feed Science and Technology, 250, 59–68.
author keywords: Enterococcus cecorum; Gut health; Coccidiosis; Kinky-back
TL;DR:
Findings indicate that the decrease in pathogenic EC bacteremia observed with coccidia coinfection may be due to increased intestinal epithelial turnover or increased immune surveillance of the intestine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2019
2018 journal article
Gross Morphometry, Histomorphometry, and Immunohistochemistry Confirm Early and Persistent Jejunal Crypt Hyperplasia in Poults with Enteritis and Depressed Growth
Avian Diseases, 62(2), 163–170.
author keywords: turkey; poult enteritis; immunohistochemistry; histomorphometry; gross morphometry; crypt hyperplasia; growth; gut health
MeSH headings : Animals; Caspase 3 / metabolism; Chickens; Enteritis / metabolism; Enteritis / pathology; Enteritis / physiopathology; Enteritis / veterinary; Female; Histones / metabolism; Hyperplasia / metabolism; Hyperplasia / pathology; Hyperplasia / physiopathology; Hyperplasia / veterinary; Immunohistochemistry; Jejunum / anatomy & histology; Jejunum / growth & development; Jejunum / metabolism; Male; North Carolina; Phosphorylation; Poultry Diseases / metabolism; Poultry Diseases / pathology; Poultry Diseases / physiopathology; Turkeys / anatomy & histology; Turkeys / growth & development
TL;DR:
It is confirmed that enteritis, in the absence of clinical signs, and depressed growth in turkey poults begins by day 7, can be identified microscopically, persists for at least 35 days, is associated with lower processing weights, and has a profound negative effect on turkey growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 20, 2019
2018 personal communication
Lameness in a 3-year-old backyard chicken Response
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Mast Cells Exert Anti-Inflammatory Effects in an IL10-/- Model of Spontaneous Colitis.
Mediators of Inflammation.
MeSH headings : Animals; Anti-Inflammatory Agents; Bone Marrow Cells / cytology; Bone Morphogenetic Protein 2 / genetics; Bone Morphogenetic Protein 2 / metabolism; Bone Morphogenetic Protein 4 / genetics; Bone Morphogenetic Protein 4 / metabolism; Bone Morphogenetic Protein 6 / genetics; Bone Morphogenetic Protein 6 / metabolism; Bone Morphogenetic Protein 7 / genetics; Bone Morphogenetic Protein 7 / metabolism; Colitis / immunology; Colitis / metabolism; Disease Models, Animal; Inflammatory Bowel Diseases / immunology; Inflammatory Bowel Diseases / metabolism; Interleukin-10 / genetics; Interleukin-10 / metabolism; Mast Cells / cytology; Mast Cells / metabolism; Mice, Knockout; Transforming Growth Factor beta2 / genetics; Transforming Growth Factor beta2 / metabolism
TL;DR:
It is demonstrated that mast cells exert anti-inflammatory properties in an established model of chronic, spontaneous IBD and the present findings provide new insight into the divergent roles of mast cells in modulating inflammation during different stages of colitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: August 20, 2019
2018 journal article
Mast Cells Play a Protective Role in Spontaneous Colitis
Journal of Immunology, 200(Supplement 1).
Event: Immunology 2018 at Austin, TX on May 4-8, 2018
Source: NC State University Libraries
Added: April 8, 2021
2018 journal article
Mast cells exert anti-inflammatory effects in an IL10(-/-) model of spontaneous colitis
Mediators of Inflammation.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Sleep hygiene among veterinary medical students.
Journal of Education and Health Promotion.
author keywords: College students; health professions; medical education; quality of life; sleep; sleepiness; veterinary medicine; wellness
TL;DR:
A significant percentage of veterinary medical students exhibit poor sleep hygiene habits that may be detrimental to both their health and academic endeavors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 20, 2019
2018 journal article
Vaccination of breeder hens with a polyvalent killed vaccine for pathogenic Enterococcus cecorum does not protect offspring from enterococcal spondylitis
AVIAN PATHOLOGY, 48(1), 17–24.
author keywords: Enterococcus cecorum; kinky-back; vaccine; broiler health; lameness; enterococcal spondylitis
MeSH headings : Animals; Chickens / immunology; Chickens / microbiology; Disease Outbreaks / veterinary; Enterococcus / immunology; Enterococcus / pathogenicity; Female; Genotype; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / prevention & control; Poultry Diseases / microbiology; Poultry Diseases / prevention & control; Spondylitis / microbiology; Spondylitis / prevention & control; Vaccination / veterinary; Vaccines, Inactivated / immunology; Virulence
TL;DR:
Data suggest that pathogenic strains of E. cecorum possess virulence mechanisms that confound antibody-mediated opsinophagocytosis, complicating vaccine development for this pathogen of broilers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2019
2018 journal article
What Is your diagnosis? Gallus gallus domesticus
Journal of the American Veterinary Medical Association, 252(2), 173–175.
MeSH headings : Animals; Chickens; Diagnosis, Differential; Female; Hindlimb; Kidney Neoplasms / complications; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / pathology; Kidney Neoplasms / veterinary; Lameness, Animal / diagnosis; Lameness, Animal / diagnostic imaging; Lameness, Animal / etiology; Marek Disease / complications; Marek Disease / diagnosis; Marek Disease / pathology; Muscular Atrophy / complications; Muscular Atrophy / diagnostic imaging; Muscular Atrophy / veterinary; Poultry Diseases / diagnosis; Poultry Diseases / diagnostic imaging; Poultry Diseases / etiology; Poultry Diseases / pathology; Radiography / veterinary; Sciatic Nerve / pathology; Ultrasonography / veterinary
TL;DR:
On clinical examination, the dog was bright, alert and responsive with a body weight of 17.2kg and a body condition score of 5/9 and the mucous membranes were pink and moist, with a capillary refill time of one second.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Dietary Prebiotics and Arachidonic Acid (ARA) Modulate Intestinal Injury and Microbial Taxa Following Acute Dextran Sodium Sulfate Induced Colitis in Formula-Fed Piglets
The FASEB Journal, 31(1_supplement), 324–324.
Source: NC State University Libraries
Added: August 30, 2019
2017 journal article
Prevalence and severity of osteochondrosis of the free thoracic vertebra in three modern broiler strains and the Athens Canadian Random Bred control broiler
Avian Pathology, 47(2), 1–9.
author keywords: Osteochondrosis; enterococcal spondylitis; Enterococcus cecorum; genetics; sex-associated
MeSH headings : Animals; Chickens; Female; Genetic Predisposition to Disease; Male; Osteochondrosis / epidemiology; Osteochondrosis / genetics; Osteochondrosis / pathology; Osteochondrosis / veterinary; Poultry Diseases / epidemiology; Poultry Diseases / genetics; Poultry Diseases / pathology; Prevalence; Risk Factors
TL;DR:
Findings indicate that OCD of the FTV is common in broiler chickens with similar prevalence observed in broilers with modern genetics and the ACRB broilers which represent 1950s broiler genetics.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
A Comprehensive Wellness Program for Veterinary Medical Education: Design and Implementation at North Carolina State University
International Journal of Higher Education, 6(1), 74.
TL;DR:
This case study paper describes the development and implementation of the model at the North Carolina State University College of Veterinary Medicine and focuses on five broad outcome categories: intellectual growth; mental and emotional health; social distance reduction; cultural competence; and physical health.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019
2016 journal article
Alternative Lengthening of Telomeres Does Exist in Various Canine Sarcomas
MOLECULAR CARCINOGENESIS, 56(3), 923–935.
author keywords: telomerase-independent; non-determined TMM; telomere length; dog; comparative; cancer
MeSH headings : Animals; Cell Line, Tumor; DNA Helicases / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma / genetics; Neuroblastoma / pathology; Nuclear Proteins / genetics; Sarcoma / genetics; Sarcoma / pathology; Sarcoma / veterinary; Telomere / genetics; Telomere Homeostasis; Tumor Suppressor Protein p53 / genetics; X-linked Nuclear Protein
TL;DR:
It is demonstrated that canine sarcomas use alternative lengthening of telomeres (ALT), a telomere maintenance mechanism found in some human tumors such as sarcoma, which seems to share many similarities with their human counterparts and appear an attractive model for comparativeTelomere research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2016 journal article
Culture methods impact recovery of antibiotic-resistant Enterococci including Enterococcus cecorum from pre- and postharvest chicken
LETTERS IN APPLIED MICROBIOLOGY, 64(3), 210–216.
author keywords: food safety; lactic acid bacteria; postharvest; resistance; veterinary
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteriological Techniques / methods; Cecum / microbiology; Chickens; Drug Resistance, Bacterial; Enterococcus / drug effects; Enterococcus / genetics; Enterococcus / growth & development; Enterococcus / isolation & purification; Gram-Positive Bacterial Infections / microbiology; Meat / microbiology; Microbial Sensitivity Tests; Poultry Diseases / microbiology
TL;DR:
Findings confirm that current methodologies may not accurately identify the amount and range of antimicrobial resistance of enterococci from chicken sources and significantly affected recovery ofEnterococcal species other than EC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Dietary Iron Deficiency and Oversupplementation Increase Intestinal Permeability, Ion Transport, and Inflammation in Pigs
JOURNAL OF NUTRITION, 146(8), 1499–1505.
author keywords: intestinal physiology; iron; intestinal barrier function; porcine; inflammation
MeSH headings : Animals; Biological Transport; Diet; Dietary Supplements; Duodenum; Inflammation / etiology; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-5 / metabolism; Intestinal Mucosa / physiopathology; Ions / metabolism; Iron / administration & dosage; Iron / metabolism; Iron Deficiencies; Iron, Dietary / administration & dosage; Iron, Dietary / metabolism; Liver; Male; Malondialdehyde / metabolism; Neutrophils / metabolism; Nutritional Status; Overnutrition; Permeability; Swine; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
It is suggested that adequate but not oversupplementation of dietary iron in pigs is required to maintain intestinal barrier health and function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B-cell lymphoma
Veterinary Clinical Pathology, 46(1), 64–71.
Contributors: K. Meichner *, B. Kraszeski n, J. Durrant n, C. Grindem n, B. Breuhaus n , P. Moore*, J. Neel n , K. Linder n
author keywords: Clonality; equine; leukemia; leukocytosis; lymphoid
MeSH headings : Animals; Female; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horses; Immunohistochemistry / veterinary; Lymphocytosis / diagnostic imaging; Lymphocytosis / pathology; Lymphocytosis / veterinary; Lymphoma, B-Cell / diagnostic imaging; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Microscopy, Electron, Transmission / veterinary; T-Lymphocytes / pathology
TL;DR:
An 11-year-old Haflinger mare presented to the North Carolina State University Veterinary Teaching Hospital with a 2-week history of lethargy and a 3-day duration of anorexia, pyrexia, tachycardia, and ventral edema was diagnosed with diffuse large B-cell lymphoma with a marked hematogenous component.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 chapter
Immunohistochemistry
In Tumors in Domestic Animals (pp. 44–87).
Sources: Crossref, NC State University Libraries
Added: August 28, 2019
2016 journal article
Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma
VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.
Contributors: R. Thomas n, Z. Demeter*, K. Kennedy n, n , K. Singh *, V. Valli, K. Le Boedec *, M. Breen n
author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
MeSH headings : Animals; DNA Copy Number Variations / genetics; DNA Fingerprinting / veterinary; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study / veterinary; Lymphoma, Follicular / etiology; Lymphoma, Follicular / genetics; Lymphoma, Follicular / pathology; Lymphoma, Follicular / veterinary; Male; Risk Factors
TL;DR:
Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(32), E4601–E4609.
author keywords: focal skeletal malignant osteolysis; nanoconjugate drug delivery; large mammalian tumor model; osteosarcoma targeted therapy; canine comparative oncology
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Bone Neoplasms / drug therapy; Diphosphonates / administration & dosage; Diphosphonates / pharmacokinetics; Doxorubicin / administration & dosage; Doxorubicin / toxicity; Female; Mice; Mice, Inbred BALB C; Nanoconjugates / administration & dosage; Osteolysis / drug therapy; Pamidronate
TL;DR:
Through the inclusion of dogs with naturally developing osteosarcoma, biocompatibility, biodistribution, and anticancer activities at clinically relevant dosages were demonstrated in a large mammalian modeling system and the therapeutic was well tolerated without hematologic, nonhematologic, and cardiac toxicities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Pathogenesis of Enterococcal Spondylitis Caused by Enterococcus cecorum in Broiler Chickens
Veterinary Pathology, 54(1), 61–73.
author keywords: Enterococcus cecorum; enterococcal spondylitis; osteochondrosis dissecans; osteochondritis dissecans; kinky back; broiler; chickens; neurologic disease; vertebral osteoarthritis
MeSH headings : Animals; Chickens / microbiology; Enterococcus / genetics; Gram-Positive Bacterial Infections / complications; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; Intestines / microbiology; Paralysis / etiology; Paralysis / microbiology; Paralysis / veterinary; Phylogeny; Poultry Diseases / etiology; Poultry Diseases / microbiology; Poultry Diseases / mortality; Spleen / microbiology; Spondylitis / microbiology; Spondylitis / veterinary; Thoracic Vertebrae / microbiology
TL;DR:
It is suggested that intestinal colonization, bacteremia, and OCD of the FTV in early life are crucial to the pathogenesis of ES.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 article
Pathology in Practice
Meichner, K., Montgomery, S. A., Borst, L. B., Murphy, K. M., & Grindem, C. B. (2016, November 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 249, pp. 1023–1026.
MeSH headings : Animals; Biopsy; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Male; Sertoli Cell Tumor / diagnosis; Sertoli Cell Tumor / pathology; Sertoli Cell Tumor / veterinary; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Testicular Neoplasms / diagnosis; Testicular Neoplasms / pathology; Testicular Neoplasms / veterinary
TL;DR:
In collaboration with the American College of Veterinary Pathologists, this work presents a probabilistic procedure to identify the immune checkpoints in the connective tissue of the immune system and results indicate which immune checkpoints are responsible for disease progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Scavenging nucleic acid debris to combat autoimmunity and infectious disease
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(35), 9728–9733.
author keywords: nucleic acid; scavenger; autoimmunity; influenza; inflammation
MeSH headings : Animals; Antibodies, Antinuclear / metabolism; Autoimmunity / drug effects; DNA Cleavage; Dendrimers / pharmacology; Humans; Immunologic Factors / pharmacology; Lupus Erythematosus, Cutaneous / drug therapy; Lupus Erythematosus, Cutaneous / immunology; Lupus Erythematosus, Cutaneous / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nucleic Acids / chemistry; Nucleic Acids / isolation & purification; Protein Binding; RNA Cleavage; Skin / drug effects; Skin / immunology; Skin / pathology
TL;DR:
It is demonstrated that nucleic Acid scavengers (NASs) can limit pathological inflammation and nucleic acid-associated autoimmunity in lupus-prone mice and that such NASs do not limit an animal’s ability to combat viral infection, but rather their administration improves survival when animals are challenged with lethal doses of influenza.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
Nature Communications, 9.
MeSH headings : Animals; Bone Marrow Transplantation; DNA Damage / genetics; Flow Cytometry; Hematopoietic Stem Cells / metabolism; Immunoblotting; Lymphoma / etiology; Lymphoma / genetics; Mice; Neoplasms, Radiation-Induced / etiology; Neoplasms, Radiation-Induced / genetics; Proto-Oncogene Proteins p21(ras) / genetics; RNA, Small Interfering; Reverse Transcriptase Polymerase Chain Reaction; Thymocytes / metabolism; Tumor Suppressor Protein p53 / genetics; Whole-Body Irradiation / adverse effects
TL;DR:
It is shown that knocking down p53 during total-body irradiation not only reduces acute toxicity, but prevents the formation of radiation-induced lymphoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
Acute Dextran Sodium Sulfate Dose-Dependently Induces Colitis in Formula-Fed Piglets
The FASEB Journal, 29(Supplement 1), 755–758.
Source: NC State University Libraries
Added: December 21, 2020
2015 journal article
Comparative Genomic Analysis Identifies Divergent Genomic Features of Pathogenic Enterococcus cecorum Including a Type IC CRISPR-Cas System, a Capsule Locus, an epa-Like Locus, and Putative Host Tissue Binding Proteins
PLOS ONE, 10(4).
MeSH headings : Animals; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; CRISPR-Cas Systems / genetics; Chickens; Comparative Genomic Hybridization; Enterococcus / classification; Enterococcus / genetics; Enterococcus / isolation & purification; Evolution, Molecular; Genetic Loci; Genome, Bacterial; Genomics; Genotype; Phylogeny; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Virulence / genetics
TL;DR:
Specific genomic regions, coding sequences, and predicted proteins which may be related to the divergent evolution and increased virulence of emerging pathogenic strains of EC are identified and potential mediators of virulence identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Cytologic Characteristics and World Health Organization Classification in 45 Dogs With Lymphoma
Veterinary Clinical Pathology, 44(4).
Source: NC State University Libraries
Added: December 21, 2020
2015 journal article
Early-life dietary spray-dried plasma influences immunological and intestinal injury responses to later-life Salmonella typhimurium challenge
BRITISH JOURNAL OF NUTRITION, 113(5), 783–793.
author keywords: Spray-dried plasma; Early-life nutrition; Salmonella typhimurium; Intestinal inflammation; Mucosal immunity; Intestinal permeability; Weaning
MeSH headings : Animals; Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / administration & dosage; Blood Proteins / therapeutic use; Crosses, Genetic; Cytokines / blood; Cytokines / metabolism; Diet / adverse effects; Diet / veterinary; Energy Intake; Enterocolitis / immunology; Enterocolitis / microbiology; Enterocolitis / prevention & control; Enterocolitis / veterinary; Feces / microbiology; Female; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Mucosal; Immunotherapy / adverse effects; Immunotherapy / veterinary; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / metabolism; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / prevention & control; Salmonella typhimurium / growth & development; Salmonella typhimurium / immunology; Salmonella typhimurium / isolation & purification; Sus scrofa; Swine; Swine Diseases / immunology; Swine Diseases / metabolism; Swine Diseases / microbiology; Swine Diseases / prevention & control; Weaning; Weight Gain
TL;DR:
Results indicate that inclusion of SDP in PW diets can have an influence on subsequent immunological and intestinal injury responses induced by later-life S. typhimurium challenge.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2
INFECTION AND IMMUNITY, 83(7), 2762–2770.
MeSH headings : Animals; Cell Line; Colon / microbiology; Colon / physiology; Culture Media, Conditioned; Enterococcus faecalis / enzymology; Epithelial Cells / microbiology; Epithelial Cells / physiology; Gelatinases / metabolism; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Mice, Inbred C57BL; Mice, Knockout; Permeability; Receptor, PAR-2 / deficiency; Receptor, PAR-2 / metabolism
TL;DR:
It is demonstrated that GelE from E. faecalis can regulate enteric epithelial permeability via PAR2, and this protease-mediated disruption of the intestinal epithelium is a potential mechanism whereby a dysbiotic enteric microbiota can lead to disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Histiocytic Sarcoma with Central Nervous System Involvement in Dogs: 19 Cases (2006-2012)
Journal of Veterinary Internal Medicine, 29(2), 607–613.
author keywords: Brain tumor; Malignant histiocytosis; Round cell tumor; Spinal cord tumor
MeSH headings : Animals; Central Nervous System Neoplasms / pathology; Central Nervous System Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Female; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Male; Retrospective Studies
TL;DR:
Some unique imaging and clinicopathologic characteristics, particularly brain herniation, profound meningeal enhancement, and pleocytosis in combination with 1 or more mass lesions, might help to differentiate this neoplasm from others involving the CNS, although this requires further study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin - Polylactide Nanoconjugates for Enhanced Cancer Therapy
ACS NANO, 9(5), 5072–5081.
author keywords: nanoconjugate drug delivery; cancer targeting by aptamer; tumor-associated endothelium; comparative tumor model; prostate-specific membrane antigen
MeSH headings : Animals; Antigens, Surface / metabolism; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / genetics; Base Sequence; Cell Line, Tumor; Delayed-Action Preparations; Dogs; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Endothelial Cells / pathology; Female; Gene Expression Regulation, Neoplastic / drug effects; Glutamate Carboxypeptidase II / metabolism; Hemangiosarcoma / blood supply; Hemangiosarcoma / drug therapy; Hemangiosarcoma / pathology; Humans; Male; Mice; Models, Molecular; Molecular Conformation; Nanoconjugates / chemistry; Nanoconjugates / therapeutic use; Nanoconjugates / toxicity; Nanomedicine / methods; Neovascularization, Pathologic / drug therapy; Polyesters / chemistry; Tissue Distribution
TL;DR:
In cHSA-implanted mice, two consecutive intravenous infusions of A10 Doxo-PLA NCs exerted rapid and substantial cytoreductive activities within a period of 7 days, resulting in greater than 70% reduction in macroscopic tumor-associated endothelial cell burden as a consequence of enhanced cell death and necrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
What’s your diagnosis? Purulent upper respiratory discharge in a rabbit
DVM 360. https://www.dvm360.com/view/whats-your-diagnosis-purulent-upper-respiratory-discharge-rabbit
Source: NC State University Libraries
Added: December 22, 2020
2014 journal article
A Chicken Embryo Lethality Assay for Pathogenic Enterococcus cecorum
AVIAN DISEASES, 58(2), 244–248.
author keywords: broiler; chicken; Enterococcus cecorum; enterococcal spondylitis; chicken embryo lethality assay
MeSH headings : Animals; Chick Embryo; Chickens; Electrophoresis, Gel, Pulsed-Field / veterinary; Enterococcus / genetics; Enterococcus / isolation & purification; Enterococcus / pathogenicity; Enterococcus / physiology; Gram-Positive Bacterial Infections / diagnosis; Gram-Positive Bacterial Infections / epidemiology; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; Phylogeny; Poultry Diseases / diagnosis; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; United States; Virulence
TL;DR:
This embryo lethality assay provides a useful tool for understanding the genetic basis of E. cecorum virulence and causes outbreaks of arthritis and osteomyelitis in chickens worldwide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Antimicrobial resistance, virulence determinants and genetic profiles of clinical and nonclinical Enterococcus cecorum from poultry
Letters in Applied Microbiology, 60(2), 111–119.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Chickens / microbiology; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterococcus / drug effects; Enterococcus / genetics; Enterococcus / isolation & purification; Enterococcus / pathogenicity; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; Phenotype; Poultry Diseases / microbiology; Virulence / genetics; Virulence Factors / analysis; Virulence Factors / genetics
TL;DR:
Data suggest that distinguishing the two groups of isolates is difficult based upon the characterization criteria used, and the presence of virulence determinants tested, efaAfm was present in almost all of the isolates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2014 journal article
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
CHROMOSOME RESEARCH, 23(2), 171–186.
Contributors: K. Poorman n, n , S. Moroff*, S. Roy n, P. Labelle*, A. Motsinger-Reif n, M. Breen n
author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR:
This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(4), 1312–1319.
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Proliferation / drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation / drug effects; HL-60 Cells; Humans; Hydrazones / chemistry; Hydrazones / pharmacology; Lymphoma / drug therapy; Lymphoma / pathology; Mice; Mice, Inbred C57BL; Molecular Structure; Piperazines / chemistry; Piperazines / pharmacology; Structure-Activity Relationship; Tumor Cells, Cultured
TL;DR:
The data suggest the potential of PAC-1/1541B combinations for the treatment of cancer and demonstrate that differentially acting enzyme activators can potently synergize to give a significantly heightened biological effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma
CHROMOSOME RESEARCH, 22(3), 305–319.
Contributors: R. Thomas n, n , D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh *, J. Modiano *, M. Breen n
author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR:
Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Innate PI3K p110 delta Regulates Th1/Th17 Development and Microbiota-Dependent Colitis
JOURNAL OF IMMUNOLOGY, 192(8), 3958–3968.
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Antigen-Presenting Cells / metabolism; Class Ia Phosphatidylinositol 3-Kinase / genetics; Class Ia Phosphatidylinositol 3-Kinase / metabolism; Colitis / genetics; Colitis / immunology; Colitis / metabolism; Colitis / microbiology; Colitis / pathology; Cytokines / biosynthesis; Disease Models, Animal; Gene Expression Regulation; Immunity, Innate / genetics; Interleukin-10 / biosynthesis; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Macrophages / immunology; Macrophages / metabolism; Male; Mice; Mice, Knockout; Microbiota; TOR Serine-Threonine Kinases / metabolism; Th1 Cells / immunology; Th1 Cells / metabolism; Th17 Cells / immunology; Th17 Cells / metabolism
TL;DR:
The PI3K subunit p110δ controls homeostatic APC–T cell interactions by altering the balance between IL-10 and IL-12/23 and may underlie the pathogenesis of human inflammatory bowel disease and lead to new therapeutic strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Investigating the optimal size of anticancer nanomedicine
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(43), 15344–15349.
author keywords: nanomedicine; size effect; silica nanoparticle; mathematical model; drug delivery
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / therapeutic use; Humans; MCF-7 Cells; Mice, Nude; Nanoconjugates; Nanomedicine; Neoplasm Metastasis; Neoplasms / drug therapy; Particle Size; Silicon Dioxide / chemistry; Tissue Distribution; Xenograft Model Antitumor Assays
TL;DR:
Among the three NCs investigated, the 50-nm NC shows the highest tumor tissue retention integrated over time, which is the collective outcome of deep tumor tissue penetration and efficient cancer cell internalization as well as slow tumor clearance, and thus, the highest efficacy against both primary and metastatic tumors in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Mo1722 Mast Cells Play a Protective Role in Spontaneous Colitis
Gastroenterology, 146(5), S-644.
TL;DR:
It is demonstrated that mast cell deficiency exacerbates disease in a chronic, spontaneous IBD model, indicating that mast cells may have protective functions in IBD, and potentially other chronic inflammatory disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2014 journal article
NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23-Driven Spontaneous Colitis
JOURNAL OF IMMUNOLOGY, 192(4), 1918–1927.
MeSH headings : Adoptive Transfer; Animals; Arabidopsis Proteins / biosynthesis; Basic-Leucine Zipper Transcription Factors / genetics; Basic-Leucine Zipper Transcription Factors / metabolism; Cells, Cultured; Colon / immunology; Colon / pathology; Genetic Predisposition to Disease; Inflammatory Bowel Diseases / genetics; Inflammatory Bowel Diseases / microbiology; Interleukin-10 / genetics; Interleukin-12 Subunit p40 / genetics; Interleukin-12 Subunit p40 / metabolism; Interleukin-23 Subunit p19 / genetics; Interleukin-23 Subunit p19 / metabolism; Membrane Proteins / biosynthesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota / immunology; Th1 Cells / immunology; Th17 Cells / immunology; Tumor Necrosis Factor-alpha / genetics
TL;DR:
NFIL3 is a microbiota-dependent, IL-10–independent regulator of mucosal homeostasis via IL-12p40 via NFIL3, and was abrogated in Nfil3/Il12b double-deficient mice, identifying Il12b dysregulation as a central pathogenic event.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Pro-tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(3), 894–904.
author keywords: Bone resorption; Malignant osteolysis; Pleiotropic cytokine; Tumorigenesis
MeSH headings : Animals; Blotting, Western; Bone Neoplasms / physiopathology; Bone Neoplasms / veterinary; Cell Line, Tumor; Dog Diseases; Dogs; Enzyme-Linked Immunosorbent Assay; Osteosarcoma / physiopathology; Osteosarcoma / veterinary; Pyrazoles / pharmacology; Pyrroles / pharmacology; Signal Transduction / drug effects; Transforming Growth Factor beta1 / biosynthesis; Transforming Growth Factor beta1 / metabolism; Transforming Growth Factor beta1 / physiology; Transforming Growth Factor beta2 / biosynthesis; Transforming Growth Factor beta2 / physiology; Vascular Endothelial Growth Factor A / physiology
TL;DR:
Canine OS cells possess TGF β1 signaling machinery, potentially allowing for the establishment of an autocrine and paracrine pro‐tumorigenic signaling loop, and TGFβ1 inhibitors might impede localized OS progression in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
B Characterization of BcaA, a putative classical autotransporter protein in Burkholderia pseudomallei
Infection and Immunity, 81(4), 1121–1128.
MeSH headings : Animals; Bacterial Adhesion; Bacterial Load; Bacterial Outer Membrane Proteins / genetics; Bacterial Outer Membrane Proteins / metabolism; Bacterial Secretion Systems; Burkholderia pseudomallei / genetics; Burkholderia pseudomallei / metabolism; Burkholderia pseudomallei / pathogenicity; Cell Line; DNA Mutational Analysis; Disease Models, Animal; Epithelial Cells / microbiology; Female; Humans; Liver / microbiology; Lung / microbiology; Melioidosis / microbiology; Melioidosis / pathology; Mice; Mice, Inbred BALB C; Protein Transport; Sequence Deletion; Spleen / microbiology; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
Large in-frame deletion mutations of bcaA and bcaB were constructed in strain Bp340, an efflux pump mutant derivative of the melioidosis clinical isolate 1026b, supporting the idea of a role for this AT in dissemination or in survival in the passage from the site of infection to the spleen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2013 journal article
Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)
VETERINARY AND COMPARATIVE ONCOLOGY, 13(2), 89–97.
author keywords: chemotherapy; grade; jaw; mitotic index; oral tumour
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Mandibular Neoplasms / drug therapy; Mandibular Neoplasms / pathology; Mandibular Neoplasms / surgery; Mandibular Neoplasms / veterinary; Mitotic Index; Neoplasm Grading; Osteosarcoma / drug therapy; Osteosarcoma / pathology; Osteosarcoma / surgery; Osteosarcoma / veterinary; Prognosis; Retrospective Studies
TL;DR:
In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST; and in univariate analysis MI > 40 was prognostic on metastasis-free interval and survival time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Bone marrow-derived cells participate in the formation of normal and neoplastic lung stroma.
Anticancer Research, 3(3), 831–836. http://europepmc.org/abstract/med/23482751
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Chronic Compressive Myelopathy and Progressive Neurologic Signs Associated with Melarsomine Dihydrochloride Administration in a Dog
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 49(6), 389–393.
MeSH headings : Animals; Arsenicals / administration & dosage; Arsenicals / adverse effects; Decompression, Surgical / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Epidural Abscess / chemically induced; Epidural Abscess / diagnosis; Epidural Abscess / veterinary; Injections, Intramuscular / veterinary; Lumbar Vertebrae; Male; Spinal Cord Compression / chemically induced; Spinal Cord Compression / diagnosis; Spinal Cord Compression / veterinary; Thoracic Vertebrae; Triazines / administration & dosage; Triazines / adverse effects
TL;DR:
A 7 yr old castrated male Great Dane presented with a history of progressive myelopathy following the intramuscular injection of melarsomine dihydrochloride 8 wk previously, necessitating surgical decompression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Discovery of a bovine enterovirus in alpaca.
PloS One.
MeSH headings : Animals; Camelids, New World / virology; Cattle; Cell Line; Enterovirus Infections / veterinary; Enterovirus, Bovine / classification; Enterovirus, Bovine / genetics; Enterovirus, Bovine / ultrastructure; Genome, Viral; Molecular Sequence Data; Phylogeny; Viral Proteins / genetics
TL;DR:
A cytopathic virus was isolated using Madin-Darby bovine kidney cells from lung tissue of alpaca that died of a severe respiratory infection, and a highly sensitive generic PCR-based pathogen-detection method was used to identify this pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: August 20, 2019
2013 journal article
Distribution of K and L cells in the feline intestinal tract.
Domestic Animal Endocrinology, 7.
author keywords: Diabetes mellitus; Incretin; Obesity; GLP-1; GLP-2; GIP
MeSH headings : Animals; Antibodies; Cats / anatomy & histology; Cecum / cytology; Colon / cytology; Duodenum / cytology; Female; Gastric Inhibitory Polypeptide / analysis; Gastric Inhibitory Polypeptide / immunology; Glucagon-Like Peptide 1 / analysis; Glucagon-Like Peptide 1 / immunology; Glucagon-Like Peptide 2 / analysis; Glucagon-Like Peptide 2 / immunology; Ileum / cytology; Immunohistochemistry; Intestines / chemistry; Intestines / cytology; Jejunum / cytology; Male; Mice; Neuroendocrine Cells / chemistry; Neuroendocrine Cells / classification; Neuroendocrine Cells / cytology; Rabbits; Species Specificity
TL;DR:
The distribution of GIP-secreting K cells in cats is different from the distribution of K cells that is described in other mammals, and the difference in distribution of GLP-2- andGLP-1-expressing cells suggests that more than 1 distinct population of L cells is present in cats.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2013 journal article
Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10(-/-) Mice
INFLAMMATORY BOWEL DISEASES, 19(4), 712–719.
author keywords: psychological stress; neonatal maternal separation; inflammatory bowel disease; colitis; animal models of IBD; barrier function
MeSH headings : Animals; Animals, Newborn; Cell Membrane Permeability; Cells, Cultured; Colitis / etiology; Colitis / pathology; Colon / metabolism; Colon / pathology; Cytokines / metabolism; Female; Interleukin-10 / physiology; Mast Cells / metabolism; Mast Cells / pathology; Maternal Deprivation; Mice; Mice, Inbred C57BL; Mice, Knockout; Stress, Psychological / complications
TL;DR:
It is demonstrated that colitis in IL-10−/− mice can be exacerbated by NMS stress, and the precise mechanisms of enhanced colitis severity in NMS IL10− /− mice are unclear but persistent defects in intestinal barrier function likely play a contributing role.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Evaluation of the effects of tricaine methanesulfonate on retinal structure and function in koi carp (Cyprinus carpio)
Journal of the American Veterinary Medical Association, 242(11), 1578–1582.
MeSH headings : Aminobenzoates / adverse effects; Aminobenzoates / pharmacology; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Carps; Fish Diseases / chemically induced; Retinal Diseases / chemically induced; Retinal Diseases / veterinary
TL;DR:
Short-term exposure of koi carp to clinically relevant concentrations of MS-222 daily for up to 13 days was not associated with changes in retinal structure or function as measured in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Extrauterine Listeriosis in the Gravid Mouse Influences Embryonic Growth and Development
PLoS ONE, 8(8), e72601.
Ed(s): R. Roop II
MeSH headings : Animals; Female; Listeria monocytogenes / physiology; Listeriosis / embryology; Mice; Placenta / embryology; Placenta / physiology; Pregnancy; Time Factors; Trophoblasts / cytology; Uterus / microbiology; Uterus / physiology
TL;DR:
A model consistent with the authors' observations is one in which products (host or bacterial) generated during an acute infection enter embryos transplacentally and influences embryonic survival and slows normal growth in utero.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
GI-9 Mortality In Foster-Age Kittens Is Associated With A Shift From Ileum Mucosa-Associated Enterococcus Hirae to Colonization By E. Faecalis and Enteropathogenice E. Coli
Journal of Veterinary Internal Medicine, 27(3), 698.
Source: NC State University Libraries
Added: December 22, 2020
2013 journal article
Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL
Cancer Research, 73(16), 5029–5039.
Contributors: K. Richards n, A. Motsinger-Reif n, H. Chen n, Y. Fedoriw n, C. Fan n, D. Nielsen n , G. Small n, R. Thomas n
MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
TL;DR:
These studies identify molecular similarities to h DLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2013 journal article
Histopathologic features of equine superficial, nonhealing, corneal ulcers
Veterinary Ophthalmology, 17(s1), 46–52.
author keywords: corneal; equine; indolent; nonhealing; superficial; ulcer
MeSH headings : Animals; Cornea / pathology; Corneal Stroma / pathology; Corneal Ulcer / pathology; Corneal Ulcer / veterinary; Epithelium, Corneal / pathology; Female; Horse Diseases / pathology; Horses; Male; Retrospective Studies
TL;DR:
The most consistent histopathological characteristics of equine chronic, nonhealing, superficial, corneal ulcers include epithelial nonadherence, epithelial dysmaturity and mild to moderate stromal inflammation; however, one set of histopathology characteristics does not definitively define this syndrome in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Lymphoma Immunophenotype of Dogs Determined by Immunohistochemistry, Flow Cytometry, and Polymerase Chain Reaction for Antigen Receptor Rearrangements
Journal of Veterinary Internal Medicine, 27(6), 1509–1516.
author keywords: Cancer; Flow cytometry; Lineage; Lymph nodes; Specificity
MeSH headings : Animals; Area Under Curve; DNA / chemistry; DNA / genetics; Dog Diseases / immunology; Dogs; Female; Flow Cytometry / veterinary; Immunohistochemistry / veterinary; Immunophenotyping / methods; Immunophenotyping / veterinary; Lymph Nodes / immunology; Lymphoma / genetics; Lymphoma / immunology; Male; Polymerase Chain Reaction / veterinary; Receptors, Antigen / genetics; Receptors, Antigen / immunology; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity
TL;DR:
Flow cytometry is superior to PARR in correctly predicting immunophenotypes when evaluating lymph nodes from dogs already diagnosed with B- or T-cell LSA and if fresh samples are not available for FC, PARR is an acceptable assay for determination of immunophenotype given its high specificity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy
Veterinary Clinical Pathology, 42(3), 314–322.
Contributors: S. Culver n, D. Ito *, n , J. Bell*, J. Modiano * & M. Breen n
author keywords: Chromosome; cytogenetics; hematopoietic cells; remission; vincristine
MeSH headings : Animals; Chromosomes, Human, Pair 7 / genetics; Comparative Genomic Hybridization / veterinary; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Fusion Proteins, bcr-abl / genetics; Humans; In Situ Hybridization, Fluorescence / veterinary; Leukemia, Myelomonocytic, Chronic / drug therapy; Leukemia, Myelomonocytic, Chronic / genetics; Leukemia, Myelomonocytic, Chronic / pathology; Leukemia, Myelomonocytic, Chronic / veterinary; Male; Trisomy / genetics
TL;DR:
Cytology and flow cytometric techniques were used to diagnose chronic myelomonocytic leukemia in a dog and the applicability of cytogenetics techniques to evaluate the cytogenetic response of canine leukemia to chemotherapy was demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Mortality in Kittens Is Associated with a Shift in Ileum Mucosa-Associated Enterococci from Enterococcus hirae to Biofilm-Forming Enterococcus faecalis and Adherent Escherichia coli
JOURNAL OF CLINICAL MICROBIOLOGY, 51(11), 3567–3578.
MeSH headings : Animals; Animals, Newborn; Biofilms / growth & development; Biota; Cat Diseases / microbiology; Cat Diseases / mortality; Cats; Enteritis / microbiology; Enteritis / mortality; Enteritis / veterinary; Enterococcus / isolation & purification; Enterococcus / physiology; Escherichia coli / isolation & purification; Escherichia coli / physiology; Ileum / microbiology; Intestinal Mucosa / microbiology
TL;DR:
A significant difference is identified in the species of enterococci cultured from the ileum mucosa of kittens with terminal illness compared to the species cultured from healthy kittens, which is identified as more common and extensive in healthy kittens than in sick kittens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
YaxAB, a Yersinia enterocolitica Pore-Forming Toxin Regulated by RovA
INFECTION AND IMMUNITY, 81(11), 4208–4219.
MeSH headings : Animals; Bacterial Proteins / metabolism; Bacterial Toxins / biosynthesis; Disease Models, Animal; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Mice; Mice, Inbred BALB C; Microarray Analysis; Protein Conformation; Regulon; Sequence Homology, Amino Acid; Spleen / pathology; Transcription Factors / metabolism; Yersinia Infections / microbiology; Yersinia Infections / pathology; Yersinia enterocolitica / genetics
TL;DR:
This work found that yaxAB encode a probable cytotoxin capable of lysing mammalian cells, that both YaxA and YaxB are required for cytotoxic activity, and that the two proteins associate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
867 NFIL3 Deficient Mice Develop Severe Innate Immune Mediated Spontaneous Colitis
Gastroenterology, 142(5), S-149.
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2012 journal article
An Outbreak and Source Investigation of Enterococcal Spondylitis in Broilers Caused by Enterococcus cecorum
AVIAN DISEASES, 56(4), 768–773.
author keywords: broiler; chicken; Enterococcus cecorum; enterococcal spondylitis
MeSH headings : Animals; Bacterial Typing Techniques / veterinary; Cecum / microbiology; Chickens; Cloaca / microbiology; Disease Outbreaks / veterinary; Electrophoresis, Gel, Pulsed-Field / veterinary; Enterococcus / isolation & purification; Enterococcus / physiology; Fatal Outcome; Gram-Positive Bacterial Infections / diagnosis; Gram-Positive Bacterial Infections / epidemiology; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; North Carolina / epidemiology; Phenotype; Poultry Diseases / diagnosis; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Spondylitis / diagnosis; Spondylitis / epidemiology; Spondylitis / microbiology; Spondylitis / veterinary
TL;DR:
Enterococcus cecorum was isolated from spondylitis lesions in broilers from two flocks in North Carolina that were experiencing increased mortality and revealed paresis and paralysis, clinical signs characteristic of enterococcal spONDylitis (ES).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
B-mode and Doppler ultrasonography in pony mares with experimentally induced ascending placentitis
EQUINE VETERINARY JOURNAL, 44, 88–94.
author keywords: horse; placentitis; Doppler; ultrasound; diagnosis; CTUP
MeSH headings : Animals; Animals, Newborn; Female; Horse Diseases / diagnostic imaging; Horse Diseases / microbiology; Horse Diseases / pathology; Horses; Placenta Diseases / microbiology; Placenta Diseases / pathology; Placenta Diseases / veterinary; Pregnancy; Pregnancy Complications, Infectious / microbiology; Pregnancy Complications, Infectious / pathology; Pregnancy Complications, Infectious / veterinary; Stillbirth; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcal Infections / veterinary; Streptococcus equi; Ultrasonography, Doppler / instrumentation; Ultrasonography, Doppler / methods; Ultrasonography, Doppler / veterinary
TL;DR:
Doppler and B-mode ultrasonography for the detection of experimentally-induced ascending placentitis in mares was compared and the CTUP, but not uterine blood flow, was different between groups (P = 0.00001).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance
GASTROENTEROLOGY, 144(4), 789–798.
author keywords: Mouse Model; IBD; Ulcerative Colitis; Anti-Inflammatory Agent
MeSH headings : Animals; Bacterial Translocation / drug effects; Bacterial Translocation / physiology; Blotting, Western; Carbon Monoxide / pharmacology; Colitis / drug therapy; Colitis / microbiology; Colitis / prevention & control; Disease Models, Animal; Escherichia coli / pathogenicity; Gentamicins / pharmacology; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / metabolism; Macrophages / cytology; Macrophages / physiology; Metagenome; Mice; Mice, Inbred C57BL; Random Allocation; Real-Time Polymerase Chain Reaction; Salmonella typhimurium / physiology
TL;DR:
Colonic HO-1 prevents colonic inflammation in mice and its homeostatic function is mediated, in part, by promoting bactericidal activities of macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Defects in small intestinal epithelial barrier function and morphology associated with peri-weaning failure to thrive syndrome (PFTS) in swine
RESEARCH IN VETERINARY SCIENCE, 93(2), 975–982.
author keywords: Pigs; Weaning; Intestine; Barrier function; Failure-to-thrive
MeSH headings : Animals; Dextrans; Failure to Thrive / pathology; Failure to Thrive / veterinary; Female; Fluorescein-5-isothiocyanate / analogs & derivatives; Intestinal Mucosa / pathology; Intestine, Small / pathology; Swine; Swine Diseases / pathology; Weaning
TL;DR:
It is demonstrated that PFTS is associated with profound disturbances in intestinal epithelial barrier function and alterations in mucosal and epithelial morphology in which anorexia is not the sole factor.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus
JOURNAL OF IMMUNOLOGY, 189(8), 4047–4059.
MeSH headings : Alphavirus Infections / enzymology; Alphavirus Infections / immunology; Alphavirus Infections / therapy; Animals; Arginase / antagonists & inhibitors; Arginase / genetics; Cell Line; Chikungunya virus / immunology; Cricetinae; Gene Deletion; Humans; Inflammation / enzymology; Inflammation / immunology; Inflammation / pathology; Macrophages / enzymology; Macrophages / immunology; Macrophages / virology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells / enzymology; Myeloid Cells / immunology; Myeloid Cells / virology; Neutrophils / enzymology; Neutrophils / immunology; Neutrophils / virology; Ross River virus / immunology; Up-Regulation / immunology; Viral Load / immunology
TL;DR:
It is found that RRV- and CHIKV-induced musculoskeletal inflammatory lesions, and macrophages present in these lesions, have a unique gene-expression pattern characterized by high expression of arginase 1 and Ym1/Chi3l3 in the absence of FIZZ1/Relmα that is consistent with an M2-like activation phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Molecular epidemiology of Enterococcus cecorum isolates recovered from enterococcal spondylitis outbreaks in the southeastern United States
AVIAN PATHOLOGY, 41(5), 479–485.
MeSH headings : Animals; Case-Control Studies; Cecum / microbiology; Cecum / pathology; Chickens; Cluster Analysis; Disease Outbreaks / veterinary; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field / veterinary; Enterococcus / genetics; Enterococcus / isolation & purification; Enterococcus / pathogenicity; Genetic Variation; Genotype; Gram-Positive Bacterial Infections / epidemiology; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / veterinary; Male; Mannitol / metabolism; Molecular Epidemiology; Phenotype; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Southeastern United States / epidemiology; Spondylitis / epidemiology; Spondylitis / microbiology; Spondylitis / veterinary
TL;DR:
Findings indicate that the increase in E. cecorum-associated disease in the southeast United States is due to the emergence of new clones with increased pathogenicity and multidrug resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Nucleic acid scavengers inhibit thrombosis without increasing bleeding
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(32), 12938–12943.
author keywords: polyphosphates/DNA/RNA; platelet; hemorrhage
MeSH headings : Animals; Blood Coagulation / drug effects; Calorimetry; Carotid Artery Injuries / drug therapy; Fibrinolytic Agents / pharmacology; Mice; Nucleic Acids / metabolism; Polyphosphates / pharmacology; Pulmonary Embolism / drug therapy; Thrombelastography; Thrombosis / drug therapy
TL;DR:
It is indicated that nucleic acid-binding polymers are able to scavenge effectively prothrombotic nucleic acids and other polyphosphates in vivo and represent a new and potentially safer class of antithromBotic agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Serum and Colostral Antibody Responses of Pregnant Mares to Salmonella Bacterins and Colostral Antibody Transfer to Their Foals
JOURNAL OF EQUINE VETERINARY SCIENCE, 32(9), 575–578.
author keywords: Salmonella; Maternal vaccination; Foal; Antibody
TL;DR:
Salmonella spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates
ACS NANO, 6(5), 3954–3966.
author keywords: silica nanoparticle; nanoconjugates; chemotherapeutics; nanomedicine; drug delivery; cancer therapy; tumor penetration; cell uptake; nanoparticle biodistribution
MeSH headings : Animals; Female; HeLa Cells; Humans; Kinetics; Mice; Mice, Inbred C57BL; Nanoconjugates; Pharmaceutical Preparations / chemistry; Silicon Dioxide / chemistry
TL;DR:
20 nm NCs are superior to their 50 and 200 nm NC analogues by 2-5- and 10-20-fold, respectively, with regard to tumor accumulation and penetration and cellular internalization, which underscores the importance and necessity of further miniaturizing nanomedicine size for optimized drug delivery applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
A Novel Method of Core Aspirate Cytology Compared to Fine-Needle Aspiration for Diagnosing Canine Osteosarcoma
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 47(5), 317–323.
MeSH headings : Animals; Biopsy, Fine-Needle / veterinary; Biopsy, Needle / veterinary; Bone Neoplasms / diagnosis; Bone Neoplasms / pathology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Male; Osteosarcoma / diagnosis; Osteosarcoma / veterinary; Predictive Value of Tests; Sensitivity and Specificity; Specimen Handling / veterinary
TL;DR:
Aspirate cytology with ALP staining was a safe, accurate, and minimally invasive diagnostic test for the evaluation of suspected OSA lesions in dogs and there was no significant difference in diagnostic accuracy between techniques.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
CLINICAL CHALLENGE
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 42(4), 770–773.
MeSH headings : Animals; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / veterinary; Fatal Outcome; Male; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Turtles
TL;DR:
A 3.5-yr-old, male red-eared slider was presented to the North Carolina State University College of Veterinary Medicine Veterinary Teaching Hospital (NCSU-CVM VTH) in June 2009 for evaluation of a unilateral progressive soft tissue facial swelling, and treatment with surgical exploration and debridement of the mass was pursued.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Cathepsin K Expression and Activity in Canine Osteosarcoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(1), 126–134.
author keywords: Bone resorption; Cysteine protease; Malignant osteolysis; Surrogate marker
MeSH headings : Animals; Blotting, Western / veterinary; Bone Density Conservation Agents / pharmacology; Bone Neoplasms / enzymology; Bone Neoplasms / veterinary; Cathepsin K / biosynthesis; Cathepsin K / genetics; Cell Line, Tumor; Collagen Type I / metabolism; Dog Diseases / enzymology; Dogs; Immunohistochemistry / veterinary; Osteosarcoma / enzymology; Osteosarcoma / veterinary; Prospective Studies; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Transforming Growth Factor beta1 / pharmacology
TL;DR:
Canine OS is associated with pathologic bone resorption, and CatK inhibitors might aid in the management of canine OS-related malignant osteolysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Characterization of Immune Cell Infiltration Into Canine Intracranial Meningiomas
VETERINARY PATHOLOGY, 49(5), 784–795.
author keywords: brain; dog; immunohistochemistry; lymphocyte; meningioma; microglia; Toll-like receptor; tumor
MeSH headings : Animals; Antigens, CD / analysis; Antigens, CD / immunology; Biomarkers, Tumor / metabolism; Cytokines / metabolism; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Forkhead Transcription Factors / metabolism; Immunohistochemistry / veterinary; Lymphocyte Subsets / immunology; Lymphocytes, Tumor-Infiltrating / immunology; Macrophages / immunology; Male; Meningeal Neoplasms / immunology; Meningeal Neoplasms / pathology; Meningeal Neoplasms / veterinary; Meningioma / immunology; Meningioma / pathology; Meningioma / veterinary; Paraffin Embedding / veterinary; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism
TL;DR:
Investigation of the presence of a variety of immune cell subsets within canine intracranial meningiomas suggests that evaluation of this immune cell infiltrate may provide important prognostic information and may be useful in the design of novel therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Evaluation of a commercially available modified-live Streptococcus equi subsp equi vaccine in ponies
AMERICAN JOURNAL OF VETERINARY RESEARCH, 72(8), 1130–1138.
MeSH headings : Animals; Bacterial Proteins / immunology; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Horse Diseases / immunology; Horse Diseases / prevention & control; Horses; Illinois; Lymph Nodes / microbiology; Lymph Nodes / pathology; Male; Streptococcal Infections / immunology; Streptococcal Infections / prevention & control; Streptococcal Infections / veterinary; Streptococcal Vaccines / administration & dosage; Streptococcal Vaccines / immunology; Streptococcus equi / immunology; Vaccination / veterinary; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / immunology
TL;DR:
Although the vaccine was successful in inducing IgG antibodies against S equi in all ponies, findings suggested that the vaccine may have caused substantial morbidity and some deaths in the young ponies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
Leukemia & Lymphoma, 52(7), 1321–1335.
Contributors: R. Thomas n, E. Seiser n, A. Motsinger-Reif*, n , V. Valli*, K. Kelley n, S. Suter n, D. Argyle*
author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR:
It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2011 journal article
Zebrafish (Danio rerio) as a Screen for Attenuation of Lancefield Group C Streptococci and a Model for Streptococcal Pathogenesis
VETERINARY PATHOLOGY, 50(3), 457–467.
author keywords: animal model; Danio rerio; strangles; streptococcus; zebrafish
MeSH headings : Acute-Phase Proteins / metabolism; Animals; Anti-Infective Agents / metabolism; Blood Coagulation Factors / metabolism; Comparative Genomic Hybridization / veterinary; Disease Models, Animal; Female; Fish Diseases / immunology; Fish Diseases / microbiology; Gene Expression Regulation, Bacterial; Injections, Intramuscular; Kidney / pathology; Male; Muscles / pathology; Mutation; Spleen / pathology; Streptococcal Infections / immunology; Streptococcal Infections / microbiology; Streptococcus / genetics; Streptococcus / immunology; Streptococcus / pathogenicity; Streptococcus equi / genetics; Streptococcus equi / immunology; Streptococcus equi / pathogenicity; Virulence; Virulence Factors / genetics; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / microbiology
TL;DR:
Collectively, these collective findings underscore the value of the zebrafish as a model of streptococcal pathogenesis as well as the need for further research on this topic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
A multiphasic typing approach to subtype Streptococcus equi subspecies equi
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 22(6), 928–936.
author keywords: Genotype; horses; phenotype; Streptococcus equi subspecies equi; szp vaccine; virulence wild type
MeSH headings : Animals; Bacterial Typing Techniques / methods; Bacterial Typing Techniques / veterinary; Bacterial Vaccines / microbiology; Cluster Analysis; Genotype; Streptococcus equi / classification; Streptococcus equi / genetics; Streptococcus equi / isolation & purification
TL;DR:
Dletion of a single guanine residue located in the upstream regulatory region of the szp gene appears to be conserved among vaccine isolates, and shows a 98.5% correlation to Biolog identification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006).
Journal of the American Veterinary Medical Association, 10.
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Female; Male; Mastocytoma / pathology; Mastocytoma / veterinary; Mouth Neoplasms / pathology; Mouth Neoplasms / veterinary; Retrospective Studies
TL;DR:
Results suggested that in dogs with MCTs arising from the oral mucosa, oral mucocutaneous junction, or perioral region of the muzzle, the presence of regional lymph node metastasis at the time of diagnosis was a negative prognostic factor, however, prolonged survival times could be achieved with treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 20, 2019
2010 journal article
Common variable immunodeficiency in a horse with chronic peritonitis
Equine Veterinary Education, 22(8), 393–399.
Source: NC State University Libraries
Added: August 6, 2018
2010 conference paper
Phenotypic analysis of Enterococcus cecorum field isolates associated with vertebral osteoarthritis
AAAP Scientific Program. Presented at the AVMA Annual Convention, Atlanta, GA.
Event: AVMA Annual Convention at Atlanta, GA on July 31 - August 3, 2010
Source: NC State University Libraries
Added: December 22, 2020
2009 thesis
Investigations into a rationally designed modified live vaccine for equine strangles
(PhD thesis). University of Illinois at Urbana-Champaign.
Source: NC State University Libraries
Added: December 22, 2020
2008 journal article
10 INOCULATION OF CULTURE-NEGATIVE PORCINE SEMEN WITH NOVEL BIOFILM-FORMING BACTERIA
Reproduction, Fertility and Development, 20(1), 85.
TL;DR:
Although statistically significant differences were noted in pH, the addition of biofilm bacteria did not negatively affect the motility of extended porcine semen during this time period and no treatment-by-time interaction with sperm motility after inoculation was revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2008 journal article
Clinical, clinicopathological and histological changes observed in 14 cats treated with glucocorticoids.
The Veterinary Record, 6.
MeSH headings : Animals; Blood Cell Count / veterinary; Blood Chemical Analysis / veterinary; Cat Diseases / blood; Cat Diseases / chemically induced; Cat Diseases / drug therapy; Cat Diseases / urine; Cats; Dexamethasone / adverse effects; Dexamethasone / therapeutic use; Dose-Response Relationship, Drug; Erythrocyte Count / veterinary; Glucocorticoids / adverse effects; Glucocorticoids / therapeutic use; Immunohistochemistry / veterinary; Leukocyte Count / veterinary; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Prednisolone / adverse effects; Prednisolone / therapeutic use; Random Allocation; Serum Albumin / analysis; Serum Albumin / drug effects; Time Factors; Urinalysis / veterinary
TL;DR:
Fourteen cats given immunosuppressive doses of either prednisolone or dexamethasone for 56 days developed adverse clinical signs including anorexia, icterus, pruritus and medial curling of the pinnae, some of which were suspected to be related to the glucocorticoid therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 20, 2019
2007 journal article
DESCRIPTION OF GROWTH DYNAMICS OF BIOFILM BACTERIA FOUND IN EXTENDED PORCINE SEMEN
Biology of Reproduction, 77(Suppl_1), 84–85.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019
2006 journal article
Diagnosis and management of Wegener's granulomatosis in a dog
JOURNAL OF VETERINARY DENTISTRY, 23(4), 231–236.
MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Gingivitis / diagnosis; Gingivitis / drug therapy; Gingivitis / veterinary; Granulomatosis with Polyangiitis / diagnosis; Granulomatosis with Polyangiitis / drug therapy; Granulomatosis with Polyangiitis / veterinary; Immunohistochemistry / veterinary; Immunosuppressive Agents / therapeutic use; Male; Treatment Outcome
TL;DR:
A four-year-old male/neutered mixed-breed dog was presented for severe, multifocal, proliferative gingivitis and Histopathologic examination of incisional biopsy supported a diagnosis of Wegener's granulomatosis, an autoimmune vasculitis previously unreported in the veterinary literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018
Employment
Updated: August 1st, 2017 09:58
North Carolina State University Raleigh, NC, US
Associate Professor
Population Health and Pathobiology
Education
Updated: August 1st, 2017 09:59
University of Illinois System Urbana, IL, US
PhD
Pathobiology
2001 - 2005
University of Illinois System Urbana, IL, US
DVM
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.