Lide Cha

Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes

Zheng, Y.-C., Li, X., Cha, L., Paris, J. C., Michael, C., Ushimaru, R., … Chang, W.-chen. (2025, February 4). Journal of the American Chemical Society, Vol. 2.

Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

Phan, H. N., Manley, O. M., Skirboll, S. S., Cha, L., Hilovsky, D., Chang, W.-chen, … Makris, T. M. (2023, November 7). Biochemistry, Vol. 62, pp. 3276–3282.

Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes

Ushimaru, R., Cha, L., Shimo, S., Li, X., Paris, J. C., Mori, T., … Abe, I. (2023, October 24). Journal of the American Chemical Society, Vol. 145, pp. 24210–24217.

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes

Cha, L., Paris, J. C., Zanella, B., Spletzer, M., Yao, A., Guo, Y., & Chang, W.-chen. (2023, March 13). Journal of the American Chemical Society, Vol. 3.

Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration

Wang, B., Lu, Y., Cha, L., Chen, T. Y., Palacios, P. M., Li, L., … Chen, C. (2023, August 28). Angewandte Chemie International Edition, Vol. 9.

Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis

Chen, T.-Y., Zheng, Z., Zhang, X., Chen, J., Cha, L., Tang, Y., … Chang, W.-chen. (2022, January 31). ACS Catalysis, Vol. 2.

Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

Kim, W., Chen, T.-Y., Cha, L., Zhou, G., Xing, K., Canty, N. K., … Chang, W.-chen. (2022, September 12). Nature Communications, Vol. 9.

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis

Manley, O. M., Phan, H. N., Stewart, A. K., Mosley, D. A., Xue, S., Cha, L., … Makris, T. M. (2022, September 19). Proceedings of the National Academy of Sciences, Vol. 119.

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

Cha, L., Milikisiyants, S., Davidson, M., Xue, S., Smirnova, T., Smirnov, A., … Chang, W.-chen. (2020, May 13). Biochemistry, Vol. 59, pp. 1961–1965.

An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2

Cha, L., & Chang, W.-chen. (2020, October 23). Trends in Chemistry, Vol. 2, pp. 1040–1042.

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

Li, J., Liao, H.-J., Tang, Y., Huang, J.-L., Cha, L., Lin, T.-S., … Guo, Y. (2020, March 4). Journal of the American Chemical Society, Vol. 142, pp. 6268–6284.

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

Yu, C.-P., Tang, Y., Cha, L., Milikisiyants, S., Smirnova, T. I., Smirnov, A. I., … Chang, W.-chen. (2018, October 30). Journal of the American Chemical Society, Vol. 140, pp. 15190–15193.