Works (11)

Updated: February 3rd, 2024 05:01

2023 journal article

Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

BIOCHEMISTRY, 62(22), 3276–3282.

By: H. Phan n, O. Manley n, S. Skirboll n, L. Cha n, D. Hilovsky n, W. Chang n, P. Thompson n, X. Liu n, T. Makris n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: December 12, 2023

2023 journal article

Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(44), 24210–24217.

By: R. Ushimaru*, L. Cha n, S. Shimo*, X. Li n, J. Paris*, T. Mori*, K. Miyamoto*, L. Coffer n ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: December 11, 2023

2023 article

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes

Cha, L., Paris, J. C., Zanella, B., Spletzer, M., Yao, A., Guo, Y., & Chang, W.-chen. (2023, March 13). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 3.

By: L. Cha n, J. Paris*, B. Zanella n, M. Spletzer*, A. Yao n, Y. Guo*, W. Chang n

co-author countries: United States of America 🇺🇸
MeSH headings : Iron / chemistry; Aziridines; Hydroxylation; Catalysis
Sources: Web Of Science, ORCID
Added: April 4, 2023

2023 article

Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration

Wang, B., Lu, Y., Cha, L., Chen, T.-Y., Palacios, P. M., Li, L., … Chen, C. (2023, September 6). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol. 9.

By: B. Wang*, Y. Lu*, L. Cha n, T. Chen n, P. Palacios*, L. Li*, Y. Guo*, W. Chang n, C. Chen*

co-author countries: United States of America 🇺🇸
author keywords: Biocatalysis; Hydrogen Atom Transfer; Mukaiyama Hydration; Nonheme Fe/2OG-Dependent Oxygenase
Sources: Web Of Science, ORCID
Added: September 11, 2023

2022 journal article

Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis

ACS CATALYSIS, 12(4), 2270–2279.

By: T. Chen n, Z. Zheng*, X. Zhang*, J. Chen*, L. Cha n, Y. Tang*, Y. Guo*, J. Zhou* ...

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: isocyanide; oxygenase; natural product; reaction mechanism; desaturation; C-N bond formation
Sources: Web Of Science, ORCID
Added: March 28, 2022

2022 journal article

Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

NATURE COMMUNICATIONS, 13(1).

By: W. Kim*, T. Chen n, L. Cha n, G. Zhou*, K. Xing*, N. Canty n, Y. Zhang*, W. Chang n

co-author countries: United States of America 🇺🇸
MeSH headings : Iron / metabolism; Ketoglutaric Acids / metabolism; Tyrosine
Sources: Web Of Science, ORCID
Added: September 26, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).

By: O. Manley n, H. Phan n, A. Stewart n, D. Mosley n, S. Xue*, L. Cha n, H. Bai n, V. Lightfoot* ...

co-author countries: United States of America 🇺🇸

Contributors: T. Williams n

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
Sources: Web Of Science, ORCID
Added: September 21, 2022

2020 journal article

Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring

BIOCHEMISTRY, 59(21), 1961–1965.

co-author countries: United States of America 🇺🇸

Contributors: L. Cha n, S. Milikisiyants n, M. Davidson n, S. Xue*, T. Smirnova n, A. Smirnov n, Y. Guo*, W. Chang n

MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Leucine / chemistry; Leucine / metabolism; Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Molecular Conformation; Nostoc / enzymology; Substrate Specificity
Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 article

An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2

Cha, L., & Chang, W.-chen. (2020, December). TRENDS IN CHEMISTRY, Vol. 2, pp. 1040–1042.

By: L. Cha n & W. Chang n

co-author countries: United States of America 🇺🇸

Contributors: L. Cha n & W. Chang n

Sources: Web Of Science, ORCID
Added: January 4, 2021

2020 journal article

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(13), 6268–6284.

By: J. Li*, H. Liao*, Y. Tang*, J. Huang n, L. Cha n, T. Lin*, J. Lee*, I. Kurnikov* ...

co-author countries: Taiwan, Province of China 🇹🇼 United States of America 🇺🇸

Contributors: J. Li*, H. Liao*, Y. Tang*, J. Huang n, L. Cha n, T. Lin*, J. Lee*, I. Kurnikov* ...

MeSH headings : Aspergillus nidulans / chemistry; Aspergillus nidulans / enzymology; Aspergillus nidulans / metabolism; Crystallography, X-Ray; Epoxy Compounds / chemistry; Epoxy Compounds / metabolism; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Iron / chemistry; Iron / metabolism; Ketoglutaric Acids / metabolism; Models, Molecular; Oxygen / chemistry; Oxygen / metabolism; Oxygenases / chemistry; Oxygenases / metabolism
Sources: Web Of Science, ORCID
Added: May 26, 2020

2018 journal article

Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 140(45), 15190–15193.

co-author countries: United States of America 🇺🇸

Contributors: C. Yu n, Y. Tang*, L. Cha n, S. Milikisiyants n, T. Smirnova n, A. Smirnov n, Y. Guo*, W. Chang n

MeSH headings : Alkenes / chemistry; Alkenes / metabolism; Biocatalysis; Decarboxylation; Molecular Structure; Nonheme Iron Proteins / metabolism
Sources: Web Of Science, ORCID
Added: December 10, 2018

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