Lhoucine Chdid

Works (5)

Updated: July 5th, 2023 15:43

2016 article

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

Friedenberg, S. G., Chdid, L., Keene, B., Sherry, B., Motsinger-Reif, A., & Meurs, K. M. (2016, June 28). American Journal of Veterinary Research, Vol. 77, pp. 693–699.

By: S. Friedenberg n, L. Chdid n, B. Keene n, B. Sherry n, A. Motsinger-Reif n & K. Meurs n 

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
topics (OpenAlex): Congenital heart defects research; Cardiovascular Conditions and Treatments; Cardiomyopathy and Myosin Studies
TL;DR: Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs

Immunogenetics, 68(3), 205–217.

By: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n , T. Olivry n , J. Guillaumin *, T. O’Toole*, R. Goggs * ...

Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n , T. Olivry n , J. Guillaumin *, T. O’Toole*, R. Goggs * ...

author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
topics (OpenAlex): T-cell and B-cell Immunology; Immune Response and Inflammation
TL;DR: A strong association is demonstrated between two polymorphic positions (10 bp apart) in exon 2 of one allele in D LA-79, DLA-79*001:02, and multiple immune-mediated diseases, resulting in F33L and N37D amino acid changes that are likely to affect critical interactions with the peptide N-terminus. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Impact of the canine double-deletion β1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a β1-selective β-blocker

Meurs, K. M., Stern, J. A., Reina-Doreste, Y., Maran, B. A., Chdid, L., Lahmers, S., … Mealey, K. L. (2015, June 12). Pharmacogenetics and Genomics, Vol. 25, pp. 427–431.

By: K. Meurs* , J. Stern* , Y. Reina-Doreste n, B. Maran*, L. Chdid n, S. Lahmers*, B. Keene n, K. Mealey *

author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
topics (OpenAlex): Receptor Mechanisms and Signaling; Pharmacological Effects and Assays; Neuropeptides and Animal Physiology
TL;DR: The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Polymorphisms in the canine and feline renin-angiotensin-aldosterone system genes

Meurs, K. M., Chdid, L., Reina-Doreste, Y., & Stern, J. A. (2015, January 23). Animal Genetics, Vol. 46, p. 226.

By: K. Meurs n , L. Chdid n, Y. Reina-Doreste n & J. Stern n 

MeSH headings : Animals; Cats; Dogs; Polymorphism, Genetic; Renin-Angiotensin System / genetics; Sequence Analysis, DNA
topics (OpenAlex): Renin-Angiotensin System Studies; Hormonal Regulation and Hypertension; Receptor Mechanisms and Signaling
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 article

Identification of PDE5A:E90K: A Polymorphism in the Canine Phosphodiesterase 5A Gene Affecting Basal cGMP Concentrations of Healthy Dogs

Stern, J. A., Reina-Doreste, Y., Chdid, L., & Meurs, K. M. (2013, December 16). Journal of Veterinary Internal Medicine, Vol. 28, p. 78—83.

By: J. Stern n , Y. Reina-Doreste n, L. Chdid n & K. Meurs n 

author keywords: Individualized medicine; Pharmacogenomics; Pulmonary hypertension; Sildenafil citrate; Single nucleotide polymorphisms
MeSH headings : Amino Acid Sequence; Animals; Cyclic GMP / metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5 / genetics; Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism; DNA / chemistry; DNA / genetics; Dogs / genetics; Dogs / metabolism; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Polymorphism, Single Nucleotide / genetics; Sequence Alignment; Sequence Analysis, DNA
topics (OpenAlex): Cardiovascular Conditions and Treatments; Phosphodiesterase function and regulation; Asthma and respiratory diseases
TL;DR: A polymorphism exists in the canine PDE5A gene that is associated with variable circulating cGMP concentrations in healthy dogs and warrants investigation in diseases such as pulmonary hypertension. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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