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Works (25)
Updated: April 5th, 2024 00:50
2021 journal article
Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31
JOURNAL OF NEUROVIROLOGY, 27(2), 302–324.
author keywords: Human immunodeficiency virus; Neurocognitive; Neurotrophin; Therapy; Behavior; Neuroprotection
MeSH headings : Animals; Cats; Cognition Disorders / virology; Feline Acquired Immunodeficiency Syndrome / complications; Immunodeficiency Virus, Feline; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Morpholines / pharmacology; Neuroprotective Agents / pharmacology; Receptor, Nerve Growth Factor / agonists
TL;DR:
The data indicate that LM11A-31 is likely to be a potent adjunctive treatment for the control of neurodegeneration in HIV infected individuals.
(via Semantic Scholar)
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2017 journal article
Evaluation of 3D Additively Manufactured Canine Brain Models for Teaching Veterinary Neuroanatomy
JOURNAL OF VETERINARY MEDICAL EDUCATION, 44(4), 612–619.
author keywords: gross anatomy education; neuroanatomy; 3D additive manufacturing; physical models; veterinary students; propensity score matching
MeSH headings : Anatomy, Veterinary / education; Animals; Brain / anatomy & histology; Clinical Competence; Dogs / anatomy & histology; Education, Veterinary; Plastic Embedding; Printing, Three-Dimensional; Program Evaluation; Surveys and Questionnaires
TL;DR:
It is postulate that 3D AM canine brain models are an acceptable alternative to plastinated specimens in teaching veterinary neuroanatomy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Conditioning laboratory cats to handling and transport
LAB ANIMAL, 42(10), 385–389.
MeSH headings : Animal Husbandry / methods; Animal Welfare; Animals; Cats / physiology; Conditioning, Classical; Handling, Psychological; Housing, Animal; Stress, Physiological; Time Factors; Transportation
TL;DR:
A behavioral protocol used in their laboratory to condition cats to condition them to handling and transport benefits the welfare of the cats, the safety of animal technicians and the quality of feline research data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Cell trafficking through the choroid plexus
CELL ADHESION & MIGRATION, 6(5), 390–396.
author keywords: cerebrospinal fluid; pleocytosis; monocytes; macrophages; dendritic cells; T cells; inflammation; adhesion molecules; chemokines
MeSH headings : Animals; Biological Transport; Blood-Brain Barrier / metabolism; Cell Movement; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / metabolism; Central Nervous System Diseases / pathology; Cerebral Ventricles / metabolism; Cerebral Ventricles / pathology; Chemokines / cerebrospinal fluid; Choroid Plexus / blood supply; Choroid Plexus / metabolism; Choroid Plexus / pathology; Dendritic Cells / metabolism; Epithelium / metabolism; Humans; Inflammation / cerebrospinal fluid; Intercellular Adhesion Molecule-1 / metabolism; Macrophages / metabolism; Stromal Cells / metabolism; T-Lymphocytes / metabolism; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR:
The choroid plexus is a multifunctional organ that sits at the interface between the blood and cerebrospinal fluid and is in an excellent position to provide continuous immune surveillance by CD4+ T cells, macrophages and dendritic cells and to regulate immune cell trafficking in response to disease and trauma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
The use of a T-maze to measure cognitive-motor function in cats (Felis catus)
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 8(1), 32–39.
author keywords: feline; cognition; cognitive-motor function; T-maze; feline immunodeficiency virus
TL;DR:
This paradigm provides a relatively rapid and reliable test of cognitive motor performance that can be used in various settings for evaluation of feline cognitive and motor function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus
CELL AND TISSUE RESEARCH, 347(2), 443–455.
author keywords: HIV; FIV; Monocytes; T cells; Cerebrospinal fluid; Brain; Blood-brain barrier; Trafficking
MeSH headings : Animals; Blood-Brain Barrier / immunology; Blood-Brain Barrier / virology; Cats; Cell Movement; Choroid Plexus / cytology; Choroid Plexus / metabolism; Choroid Plexus / virology; Endothelial Cells / metabolism; Epithelium / metabolism; Immunodeficiency Virus, Feline / metabolism; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / metabolism; Macrophages / virology; T-Lymphocytes / cytology; T-Lymphocytes / metabolism
TL;DR:
FIV significantly enhanced translocation of macrophages and T cells indicating that the choroid plexus epithelium is likely to be an active site of immune cell trafficking in response to infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Suppression of Immunodeficiency Virus-Associated Neural Damage by the p75 Neurotrophin Receptor Ligand, LM11A-31, in an In Vitro Feline Model
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 7(2), 388–400.
author keywords: Dementia; Encephalitis; Inflammation; Therapy; HIV; FIV
MeSH headings : Animals; Astrocytes / drug effects; Astrocytes / pathology; Astrocytes / virology; Cats; Cells, Cultured; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Immunodeficiency Virus, Feline; Immunohistochemistry; In Vitro Techniques; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Ligands; Microglia / drug effects; Microglia / pathology; Microglia / virology; Morpholines / pharmacology; Neurons / drug effects; Neurons / pathology; Neurons / virology; Neuroprotective Agents / pharmacology; Real-Time Polymerase Chain Reaction; Receptor, Nerve Growth Factor / agonists
TL;DR:
The strong neuroprotection afforded by LM11A-31 in an infectious in vitro model indicates that LM11a-31 may have excellent potential for the treatment of HIV-associated neurodegeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 book
Atlas of feline anatomy for veterinarians
Jackson, WY: Teton NewMedia.
Source: NC State University Libraries
Added: August 6, 2018
2010 review
The neuropathogenesis of feline immunodeficiency virus infection: Barriers to overcome
[Review of ]. VETERINARY JOURNAL, 188(3), 260–269.
author keywords: Feline immunodeficiency virus (Fly); Human immunodeficiency virus (HIV); Neuropathology Blood-brain barrier; CNS
MeSH headings : Animals; Blood-Brain Barrier; Brain / virology; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / virology; HIV Infections; HIV-1; Humans; Immunodeficiency Virus, Feline / pathogenicity
TL;DR:
In this review the results of both in vitro and in vivo FIV studies are assessed in an attempt to elucidate the mechanisms of viral entry into the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Clinical anatomy of the canine brain using magnetic resonance imaging
VETERINARY RADIOLOGY & ULTRASOUND, 49(2), 113–121.
MeSH headings : Animals; Brain / anatomy & histology; Dogs; Magnetic Resonance Imaging; Male
TL;DR:
An magnetic resonsnce (MR) image atlas of clinically relevant brain anatomy and to relate clinical signs to morphology as seen on MR will assist veterinarians to better understand clinically relevant neuroanatomy in MR images.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Endothelial cell suppression of peripheral blood mononuclear cell trafficking in vitro during acute exposure to feline immunodeficiency virus
CELL AND TISSUE RESEARCH, 334(1), 55–65.
author keywords: HIV; astrocytes; microglia; monocyte; T cell; feline
MeSH headings : Animals; Astrocytes / immunology; Astrocytes / virology; B-Lymphocytes / immunology; B-Lymphocytes / virology; Brain / cytology; Brain / immunology; Brain / virology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Cell Movement / immunology; Cells, Cultured; Endothelial Cells / immunology; Endothelial Cells / virology; Immunodeficiency Virus, Feline; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / virology; Microglia / immunology; Microglia / virology
TL;DR:
Initial exposure of PBMCs to FIV is sufficient to induce a general increase in trafficking, whereas initial exposure of endothelial cells to Fiv tends to down-regulate this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery
JOURNAL OF NEUROVIROLOGY, 12(4), 294–306.
author keywords: dementia; HIV; macrophages; T cells; viremia
MeSH headings : Animals; Brain Diseases / cerebrospinal fluid; Brain Diseases / immunology; Brain Diseases / virology; Cats; DNA, Viral / isolation & purification; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Lymphocyte Subsets / immunology; Macrophages / immunology; Macrophages / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid; Viral Load
TL;DR:
Results indicate that free FIV circulating in the CSF promotes infection of the CNS and provides a highly efficient pathway for the transfer of infectious virus to the periphery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation
JOURNAL OF NEUROVIROLOGY, 12(4), 307–321.
author keywords: brain; cerebrospinal fluid; dementia; evolution; heteroduplex tracking assay; HIV
MeSH headings : Animals; Brain / virology; Cats; Central Nervous System Diseases / blood; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / virology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / virology; Genes, env; Heteroduplex Analysis; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / metabolism; Leukocytes, Mononuclear / virology; Peripheral Nervous System Diseases / blood; Peripheral Nervous System Diseases / cerebrospinal fluid; Peripheral Nervous System Diseases / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid
TL;DR:
Early changes in virus evolution and compartmentalization between peripheral tissues and the central nervous system (CNS) after intracerebroventricular or intraperitoneal inoculation of animals with cell-free feline immunodeficiency virus (FIV) were tracked.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells
BRAIN RESEARCH, 1058(1-2), 148–160.
author keywords: HIV; FIV; CD4 T cell; CD8 T cell; B cell; monocyte
MeSH headings : Animals; Astrocytes / cytology; Astrocytes / physiology; B-Lymphocytes / cytology; B-Lymphocytes / immunology; Blood-Brain Barrier / cytology; Blood-Brain Barrier / immunology; Blood-Brain Barrier / virology; Brain / blood supply; Brain / immunology; Brain / virology; Cats; Cell Communication / immunology; Cells, Cultured; Cerebral Arteries / cytology; Cerebral Arteries / immunology; Cerebral Arteries / virology; Chemotaxis, Leukocyte / immunology; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / physiology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / physiopathology; Immune Tolerance / immunology; Immunodeficiency Virus, Feline / immunology; Lymphocytes / cytology; Lymphocytes / immunology; Microglia / cytology; Microglia / physiology; Monocytes / cytology; Monocytes / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology
TL;DR:
Interaction between the triad of endothelial cells, astrocytes, and microglia played an important, but varying, role in the trafficking of different PBMC subsets, with astroCytes having a positive effect on trafficking of PBMCs, whilemicroglia had a suppressive effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Cerebrospinal fluid centesis at the cerebellomedullary cistern of kittens
Contemporary Topics in Laboratory Animal Science, 41(5), 30–32.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Choroid plexus macrophages proliferate and release toxic factors in response to feline immunodeficiency virus
JOURNAL OF NEUROVIROLOGY, 8(3), 225–239.
author keywords: human immunodeficiency virus; brain; AIDS; neural culture; neurotoxicity
MeSH headings : Animals; CD18 Antigens / analysis; CD40 Ligand / pharmacology; Cats; Cell Division / drug effects; Cell Division / immunology; Cells, Cultured; Cerebral Cortex / cytology; Choroid Plexus / cytology; Choroid Plexus / immunology; Choroid Plexus / virology; Culture Media, Conditioned / pharmacology; Cytotoxins / immunology; Cytotoxins / metabolism; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / immunology; In Vitro Techniques; Macrophages / chemistry; Macrophages / cytology; Macrophages / virology; Neurons / virology; Specific Pathogen-Free Organisms
TL;DR:
The results suggest that lentiviral infection of the choroid plexus can induce a toxic inflammatory response that is fueled by local macrophage proliferation and may contribute to an inflammatory cascade in the brain that progresses independently of systemic and CSF viral load.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Disaster relief management of companion animals affected by the floods of Hurricane Floyd
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 218(3), 354–359.
MeSH headings : Animal Welfare; Animals; Animals, Domestic; Cats; Communication; Disasters; Dogs; Female; Housing, Animal; Humans; Male; North Carolina; Relief Work / organization & administration; Transportation; Veterinarians; Volunteers
TL;DR:
The purpose of this report was to describe disaster relief management performed by the North Carolina State University College of Veterinary Medicine for approximately 375 dogs, 75 cats, and 17 animals of other species affected by flooding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats
JOURNAL OF INFECTIOUS DISEASES, 181(2), 564–575.
MeSH headings : Animals; B-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Gene Products, gag / metabolism; Immunodeficiency Virus, Feline / immunology; Immunohistochemistry; In Situ Hybridization; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interleukin-10 / biosynthesis; Interleukin-10 / genetics; Lymph Nodes / immunology; Lymph Nodes / pathology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocyte Subsets / immunology; Thymus Gland / immunology; Thymus Gland / pathology
TL;DR:
In conclusion, overexpression of IFN-gamma and IL-10 is a feature of the thymus and secondary lymphoid tissues of FIV-infected cats and is likely to cause marked alteration in thymic lymphocyte subpopulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The computed tomographic enhancement pattern of the normal canine pituitary gland
VETERINARY RADIOLOGY & ULTRASOUND, 41(6), 507–510.
MeSH headings : Animals; Dogs / anatomy & histology; Male; Pituitary Gland / anatomy & histology; Pituitary Gland / diagnostic imaging; Reference Values; Tomography, X-Ray Computed / veterinary
TL;DR:
Establishing the enhancement pattern in the canine pituitary gland is the precursor to the clinical application of dynamic CT of the pituitsary gland to diagnose pituitaries microadenomas and/or small macroadenomas before they become exceptionally large.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Shedding of feline immunodeficiency virus in semen of domestic cats during acute infection
American Journal of Veterinary Research, 60(2), 211–215.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats
JOURNAL OF NEURO-ONCOLOGY, 37(1), 45–54.
author keywords: cyclosporin A; blood-tissue barrier; P-glycoprotein; multidrug resistance; doxorubicin; cisplatin
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Blood-Brain Barrier / drug effects; Brain / drug effects; Brain / metabolism; Cisplatin / administration & dosage; Cisplatin / pharmacology; Cyclosporine / administration & dosage; Cyclosporine / pharmacology; Doxorubicin / pharmacokinetics; Evans Blue / pharmacokinetics; Fluorescein / pharmacokinetics; Horseradish Peroxidase / pharmacokinetics; Injections, Intravenous; Injections, Subcutaneous; Male; Platinum / pharmacokinetics; Rats; Rats, Inbred F344; Testis / drug effects; Testis / metabolism; Tissue Distribution / drug effects
TL;DR:
Modulation of Pgp function may prove to be useful for improving chemotherapy efficacy for patients with malignancies affecting tissues with blood-tissue barriers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
Clinical presentation of experimentally induced rabies in horses
JOURNAL OF VETERINARY MEDICINE SERIES B-ZENTRALBLATT FUR VETERINARMEDIZIN REIHE B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH, 43(5), 277–285.
MeSH headings : Animals; Female; Horse Diseases; Horses; Male; Rabies / veterinary
TL;DR:
The furious form was manifested in 43% of rabid horses and some of these furious animals initially manifested the dumb form, and the paralytic form was not observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
MAGNETIC-RESONANCE-IMAGING OF THE NORMAL FELINE BRAIN
VETERINARY RADIOLOGY & ULTRASOUND, 36(4), 267–275.
author keywords: CAT; NEUROANATOMY; NEUROLOGY; CENTRAL NERVOUS SYSTEM; HEAD; ANATOMY
TL;DR:
An atlas of magnetic resonance images (MRI) of the feline brain and associated structures is produced to provide reference for MR morphology of the normal f cat brain and related structures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1993 journal article
HISTOCHEMICAL IDENTIFICATION OF THE STRIATED-MUSCLE OF THE CANINE ESOPHAGUS
ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C-ZENTRALBLATT FUR VETERINARMEDIZIN REIHE C, 22(2), 101–104.
MeSH headings : Adenosine Triphosphatases / analysis; Animals; Dogs / anatomy & histology; Esophagus / anatomy & histology; Esophagus / enzymology; Female; Histocytochemistry; Male; Muscles / anatomy & histology; Muscles / enzymology; NAD / analysis; Succinate Dehydrogenase / analysis
TL;DR:
Histochemistry on the cervical, thoracic, and abdominal esophageal muscle of immature, young, and adult normal dogs revealed type IIA striated musculature in contrast to some other species, suggesting that esophagal muscle type is established at birth and does not vary or that any variation has been completed by 4 weeks‐of‐age unlike some canine limb musculatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Horseradish peroxidase study of the location of extrinsic efferent and afferent neurons innervating the colon of dogs
American Journal of Veterinary Research, 51(11), 1875.
Source: NC State University Libraries
Added: August 6, 2018
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