Laura D. Mathies

Works (8)

Updated: July 5th, 2023 15:55

2014 journal article

Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad

G3-Genes Genomes Genetics, 4(3), 471–483.

By: E. Large & L. Mathies

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.

By: S. Stowe n, A. Tucker*, R. Thompson*, A. Piper*, J. Richards*, S. Rogers*, L. Mathies n, C. Melander*, J. Cavanagh*

author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
TL;DR: The most effective antibiofilm compound had significant effects when used in conjunction with several standard antibiotics against resistant bacteria and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans

Developmental Biology, 339(1), 51–64.

By: E. Large & L. Mathies

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.

By: J. Richards n, S. Reyes n, S. Stowe n, A. Tucker n, T. Ballard  n, L. Mathies n, J. Cavanagh n, C. Melander n

MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
TL;DR: The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Comparative genetics of sex determination: Masculinizing mutations in Caenorhabditis briggsae

GENETICS, 178(3), 1415–1429.

By: D. Kelleher*, C. Carvalho *, A. Doty*, M. Layton*, A. Cheng*, L. Mathies n, D. Pilgrims, E. Haag *

MeSH headings : Alleles; Animals; Caenorhabditis / genetics; Caenorhabditis elegans; Cell Lineage; Female; Germ Cells; Gonads / cytology; Gonads / growth & development; Helminth Proteins / isolation & purification; Helminth Proteins / metabolism; Male; Mutant Proteins / isolation & purification; Mutant Proteins / metabolism; Mutation / genetics; Phenotype; Sex Determination Processes; Species Specificity; Zygote / metabolism
TL;DR: This work has taken an unbiased forward mutagenesis approach to isolating zygotic mutations that masculinize all tissues of C. briggsae hermaphrodites and shows that in both C. elegans large C-terminal truncations of TRA-1 that retain the DNA-binding domain affect sex determination more strongly than somatic gonad development. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Chromatin regulation and sex determination in Caenorhabditis elegans

TRENDS IN GENETICS, 23(7), 314–317.

By: E. Large n & L. Mathies n

MeSH headings : Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins / physiology; Chromatin / metabolism; Male; Models, Biological; Models, Genetic; Protein Binding; Sex Determination Processes; Sex Factors; Signal Transduction; Transcription, Genetic; Zinc Fingers
TL;DR: This research indicates a possible conserved role for these complexes in either GLI-directed gene repression or sex determination, as recent findings implicate two conserved transcription-repressor complexes in the repression of male-specific genes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types

DEVELOPMENTAL BIOLOGY, 305(1), 347–357.

By: D. Welchman*, L. Mathies n & J. Ahringer *

author keywords: Caenorhabditis elegans; cell migration; polarity; vulva; anchor cell; gonad; Cdc42; Par3; Par6; aPKC
MeSH headings : Animals; Caenorhabditis elegans / embryology; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Cell Differentiation / physiology; Cell Movement / physiology; Cell Polarity / physiology; Germ Cells / metabolism; Gonads / embryology; Gonads / metabolism; Microscopy, Fluorescence; Multiprotein Complexes / metabolism; Neurons / metabolism; Protein Kinase C / genetics; Protein Kinase C / metabolism; Protein Serine-Threonine Kinases; RNA Interference; cdc42 GTP-Binding Protein / genetics; cdc42 GTP-Binding Protein / metabolism
TL;DR: Results indicate that CDC-42 and the PAR-3/PAR-6/aPKC complex function together in diverse cell types and propose a novel role for primordial germ cells in mediating coalescence of the Caenorhabditis elegans gonad. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

TRA-1/GLI controls development of somatic gonadal precursors in C-elegans

Development (Cambridge, England), 131(17), 4333–4343.

By: L. Mathies, M. Schvarzstein, K. Morphy, R. Blelloch, A. Spence & J. Kimble

Source: NC State University Libraries
Added: August 6, 2018

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