@article{d'anselme_gamsjaeger_ringer_hartnack_2023, title={Clinical application of a described erector spinae plane block for locoregional anaesthesia technique in a cow undergoing standing laparotomy}, volume={11}, ISSN={["2052-6121"]}, url={https://doi.org/10.1002/vrc2.782}, DOI={10.1002/vrc2.782}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={d'Anselme, Olivia and Gamsjaeger, Lisa and Ringer, Simone Katja and Hartnack, Amanda}, year={2023}, month={Nov} }
 @article{gamsjager_chigerwe_2023, title={Clinical presentation, medical management, and outcomes in 35 hospitalized sheep diagnosed with bluetongue virus disease}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16944}, DOI={10.1111/jvim.16944}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Gamsjager, Lisa and Chigerwe, Munashe}, year={2023}, month={Dec} }
 @article{gamsjäger_nuss_hartnack_eckert_gerspach_2023, title={Diagnosis, treatment and outcome of metallic foreign body ingestion in two new world camelids}, volume={11}, url={http://dx.doi.org/10.1002/vrc2.540}, DOI={10.1002/vrc2.540}, abstractNote={Abstract}, number={1}, journal={Veterinary Record Case Reports}, publisher={Wiley}, author={Gamsjäger, Lisa and Nuss, Karl and Hartnack, Amanda and Eckert, Alexandra and Gerspach, Christian}, year={2023}, month={Mar} }
 @article{palmisano_javsicas_mcnaughten_gamsjager_renaud_gomez_2023, title={Effect of plasma transfusion on serum amyloid A concentration in healthy neonatal foals and foals with failure of transfer of passive immunity}, volume={2}, ISSN={["1939-1676"]}, url={http://dx.doi.org/10.1111/jvim.16647}, DOI={10.1111/jvim.16647}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, publisher={Wiley}, author={Palmisano, Megan and Javsicas, Laura and McNaughten, Justin and Gamsjager, Lisa and Renaud, David L. and Gomez, Diego E.}, year={2023}, month={Feb} }
 @article{li_renaud_goetz_jessop_costa_gamsjager_gomez_2023, title={Effect of time of sample collection after onset of diarrhea on fecal microbiota composition of calves}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16801}, DOI={10.1111/jvim.16801}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Li, Lynna and Renaud, David L. and Goetz, Hanne M. and Jessop, Emma and Costa, Marcio C. and Gamsjager, Lisa and Gomez, Diego E.}, year={2023}, month={Jun} }
 @article{host innate immune responses and microbiome profile of neonatal calves challenged with cryptosporidium parvum and the effect of bovine colostrum supplementation_2023, url={https://doi.org/10.3389/fcimb.2023.1165312}, DOI={10.3389/fcimb.2023.1165312}, abstractNote={IntroductionCalves are highly susceptible to gastrointestinal infection with Cryptosporidium parvum (C. parvum), which can result in watery diarrhea and eventually death or impaired development. With little to no effective therapeutics, understanding the host’s microbiota and pathogen interaction at the mucosal immune system has been critical to identify and test novel control strategies.}, journal={Frontiers in Cellular and Infection Microbiology}, year={2023}, month={May} }
 @article{gamsjager_haines_levy_pajor_campbell_windeyer_2023, title={Total and pathogen-specific serum Immunoglobulin G concentrations in neonatal beef calves, Part 1: Risk factors}, volume={220}, ISSN={["1873-1716"]}, url={https://doi.org/10.1016/j.prevetmed.2023.106026}, DOI={10.1016/j.prevetmed.2023.106026}, abstractNote={Maternal antibodies, delivered to the calf via colostrum, are crucial to prevent calfhood diseases and death. However, knowledge regarding the factors influencing this transfer of total and specific Immunoglobulin G (IgG) against common enteric and respiratory disease pathogens under current production conditions is sparse. The objectives of this study were to determine risk factors influencing total and pathogen-specific immunoglobulin G (IgG) concentrations against Escherichia coli (E. coli), bovine Rotavirus (BRoV), Cryptosporidium parvum (C. parvum), Bovine Viral Diarrhea Virus type 1 and 2 (BVDV), Parainfluenza Virus Type 3 (PI-3), Bovine Respiratory Syncytial Virus (BRSV), and Bovine Herpesvirus type 1 (BHV-1) in the serum of newborn beef calves. A total of 420 serum samples were collected from 1- to 7-day-old beef calves born on 6 farms in Alberta, Canada. Samples were analyzed by radial immunodiffusion for total IgG concentration and by enzyme-linked immunosorbent assays for pathogen-specific IgG concentrations against E. coli, BRoV, C. parvum, BVDV, PI-3, BRSV, and BHV-1. Multivariable multilevel linear and logistic regression models were built to evaluate dam- and calf-level risk factors associated with total and pathogen-specific IgG concentrations, failed transfer of passive immunity (FTPI; serum IgG < 10 g/L), and inadequate transfer of passive immunity (ITPI; serum IgG < 24 g/L). Farm was included as a random effect in all models to account for clustering at the herd level. Of the 420 calves included in this study, 5% (n = 20) and 18% (n = 75) of calves had FTPI and ITPI, respectively. Receiving colostrum intervention (i.e., being fed colostrum or colostrum product by either bottle or tube) was the most consistent risk factor for low total IgG concentration and significantly increased the odds of FTPI (Odds ratio (OR): 6.1, 95% CI: 2.0 - 18.9) and ITPI (OR: 4.8, 95% CI: 2.1-10.8). Calves born to cows consistently had higher pathogen-specific IgG concentrations (P < 0.0001), compared to calves born from heifers, and calves born to vaccinated dams had significantly higher BRoV, BVDV, and BHV-1-specific IgG concentrations. Interestingly, E.coli-specific IgG concentrations were associated with dam vaccination only in cows but not in heifers, which was likely due to differing vaccination strategies used. This study highlights the need to review and refine protocols with respect to dam vaccination and colostrum intervention on cow-calf operations.}, journal={PREVENTIVE VETERINARY MEDICINE}, author={Gamsjager, Lisa and Haines, Deborah M. and Levy, Michel and Pajor, Edmond A. and Campbell, John R. and Windeyer, M. Claire}, year={2023}, month={Nov} }
 @article{gamsjager_haines_levy_pajor_campbell_windeyer_2023, title={Total and pathogen-specific serum Immunoglobulin G concentrations in neonatal beef calves, Part 2: Associations with health and growth}, volume={220}, ISSN={["1873-1716"]}, url={https://doi.org/10.1016/j.prevetmed.2023.105993}, DOI={10.1016/j.prevetmed.2023.105993}, abstractNote={The association of poor transfer of passive immunity (TPI) with negative health outcomes is extensively researched in dairy calves. However, few field studies have examined the effect of total and particularly pathogen-specific Immunoglobulin G (IgG) concentrations on pre-weaning health and growth of beef calves. Hence, the objective of this study was to determine the association of total and pathogen-specific immunoglobulin G (IgG) concentrations against selected pathogens associated with neonatal calf diarrhea (NCD) and bovine respiratory disease (BRD) and the odds of pre-weaning treatments, mortality, and the growth of newborn beef calves. A total of 420 serum samples from 1- to 7-day old beef calves born on 6 farms in blinded for review, were available for this observational study. Serum samples were analyzed by radial immunodiffusion for total IgG concentration and by enzyme-linked immunosorbent assays for pathogen-specific IgG concentrations against Escherichia coli (E. coli), bovine Rotavirus (BRoV), Cryptosporidium parvum (C. parvum), Bovine Viral Diarrhea Virus (BVDV), Parainfluenza Virus Type 3 (PI-3), Bovine Respiratory Syncytial Virus (BRSV), and Bovine Herpesvirus-1 (BHV-1). Data about the individual dam- and calf-level risk factors, calf treatments, mortality, and birth and weaning weights were collected. Multivariable multilevel logistic and linear regression models were built to evaluate the association of total and pathogen-specific IgG concentrations with the odds of mortality and average daily gain (ADG), respectively, while their association with the odds of pre-weaning treatment was established by univariable logistic regression analysis. The odds of calves with IgG concentrations <10 g/L of getting treated (OR 7.9, 95% CI 2.7-23.7) and dying (OR: 18.5, 95% CI: 3.7-93.4) were higher than for their counterparts (P < 0.0001). Calves with IgG concentrations <24 g/L also had higher odds of dying (OR: 10.1, 95% CI: 2.6-40.2) and had lower ADG (-0.09 kg, SE: 0.03, P < 0.002) than calves with IgG concentrations ≥24 g/L. Higher BVDV-specific IgG concentration was protective against mortality (OR: 0.97, 95% CI: 0.96-0.99, P < 0.001). This study highlights the negative association of inadequate TPI with health and growth of beef calves and thus, the need to refine protocols for dam vaccination and colostrum intervention in cow-calf operations to meet these higher IgG targets.}, journal={PREVENTIVE VETERINARY MEDICINE}, author={Gamsjager, Lisa and Haines, Deborah M. and Levy, Michel and Pajor, Edmond A. and Campbell, John R. and Windeyer, M. Claire}, year={2023}, month={Nov} }
 @article{ma_li_chen_cobo_windeyer_gamsjäger_diao_tu_guan_2022, title={Assessment of microRNA profiles in small extracellular vesicles isolated from bovine colostrum with different immunoglobulin G concentrations}, volume={3}, url={http://dx.doi.org/10.3168/jdsc.2022-0225}, DOI={10.3168/jdsc.2022-0225}, abstractNote={Graphical Abstract Summary: A total of 389 microRNA (miRNA) were identified in small extracellular vesicles (sEV) isolated from bovine colostrum, with the top 50 miRNA contributing to more than 90% of total abundance and predicted to target 2,655 genes associated with cellular processes, environmental information processing, and organismal systems. The expression profiles of sEV-associated miRNA in bovine colostrum was independent of the concentrations of immunoglobulin G.}, number={5}, journal={JDS Communications}, publisher={American Dairy Science Association}, author={Ma, T. and Li, W. and Chen, Y. and Cobo, E.R. and Windeyer, C. and Gamsjäger, L. and Diao, Q. and Tu, Y. and Guan, L.L.}, year={2022}, month={Sep}, pages={328–333} }
 @article{gomez_li_goetz_macnicol_gamsjaeger_renaud_2022, title={Calf Diarrhea Is Associated With a Shift From Obligated to Facultative Anaerobes and Expansion of Lactate-Producing Bacteria}, volume={9}, url={http://dx.doi.org/10.3389/fvets.2022.846383}, DOI={10.3389/fvets.2022.846383}, abstractNote={Diarrhea is the leading cause of morbidity, mortality and antimicrobial drug use in calves during the first month of age. Alteration in the bacterial communities of the gastrointestinal tract occurs during diarrhea. Diarrheic calves often develop anion gap (AG) acidosis associated with increased concentrations of unmeasured anions including D- and L-lactate. However, studies investigating the association between gut microbiota alterations and the development of acid-base disorders in diarrheic calves are lacking. We investigated the fecal bacterial alterations of calves with diarrhea and its association with changes in blood pH, and AG. Blood and fecal samples from healthy and diarrheic veal calves were taken 7 days after arrival to the farm. The fecal microbiota of healthy and diarrheic calves was assessed by sequencing of 16S ribosomal RNA gene amplicons. Blood gas analysis was completed using an i-Stat analyzer. In healthy calves, higher richness, evenness, and diversity were observed compared to diarrheic calves. Phocaeicola, Bacteroides, Prevotella, Faecalibacterium, Butyricicoccus, Ruminococcaceae and Lachnospiraceae were enriched in healthy compared with diarrheic calves. Enterococcus, Ligilactobacillus, Lactobacilus, Gallibacterium Streptococcus, and Escherichia/Shigella were enriched in diarrheic calves. In diarrheic calves, an increased abundance of lactate-producing bacteria including Lactobacillus, Streptococcus, Veillonella, Ligilactobacillus and Olsenella was detected. Diarrheic calves had a lower pH and bicarbonate concentration and a higher AG concentration than healthy calves. Together, these results indicate that calf diarrhea is associated with a shift from obligated to facultative anaerobes and expansion of lactate-producing bacteria which are related to acidemia, low bicarbonate and increase AG. Our results highlight the importance of the gastrointestinal microbiota on the clinicopathological changes observed in diarrheic calves.}, journal={Frontiers in Veterinary Science}, publisher={Frontiers Media SA}, author={Gomez, Diego E. and Li, Lynna and Goetz, Hanne and MacNicol, Jennifer and Gamsjaeger, Lisa and Renaud, David L.}, year={2022}, month={Mar} }
 @article{jaramillo_renaud_arroyo_kenney_gamsjaeger_gomez_2022, title={Serum haptoglobin concentration and liver enzyme activity as indicators of systemic inflammatory response syndrome and survival of sick calves}, url={https://doi.org/10.1111/jvim.16357}, DOI={10.1111/jvim.16357}, abstractNote={Abstract}, journal={Journal of Veterinary Internal Medicine}, author={Jaramillo, Camilo and Renaud, David L. and Arroyo, Luis G. and Kenney, Daniel G. and Gamsjaeger, Lisa and Gomez, Diego E.}, year={2022}, month={Mar} }
 @article{gamsjäger_elsohaby_pearson_levy_pajor_windeyer_2021, title={Evaluation of 3 refractometers to determine transfer of passive immunity in neonatal beef calves}, url={https://doi.org/10.1111/jvim.16016}, DOI={10.1111/jvim.16016}, abstractNote={Abstract}, journal={Journal of Veterinary Internal Medicine}, author={Gamsjäger, Lisa and Elsohaby, Ibrahim and Pearson, Jennifer M. and Levy, Michel and Pajor, Edmond A. and Windeyer, M. Claire}, year={2021}, month={Jan} }
 @article{gamsjäger_haines_pajor_lévy_windeyer_2021, title={Impact of volume, immunoglobulin G concentration, and feeding method of colostrum product on neonatal nursing behavior and transfer of passive immunity in beef calves}, volume={15}, url={http://dx.doi.org/10.1016/j.animal.2021.100345}, DOI={10.1016/j.animal.2021.100345}, abstractNote={One-third of beef calves fail to achieve adequate transfer of passive immunity (TPI) through timely ingestion of colostrum, which substantially increases their risk of preweaning morbidity and mortality. Two randomized clinical trials were designed to assess the impact of volume, immunoglobulin G (IgG) concentration, and feeding method of colostrum product on neonatal nursing behavior and TPI. In Trial 1, 47 calves were randomly assigned to receive one of three colostrum interventions by oro-esophageal tube feeder (OET): 1 L with 100 g/L IgG, 1.4 L with 70 g/L IgG, or 2 L with 100 g/L IgG. In Trial 2, 29 calves were randomly assigned to be fed 1 L of colostrum product with 100 g/L IgG by either nipple bottle (NB) or OET. Colostrum intervention (i.e. feeding of colostrum product) occurred within 60 minutes of birth. Cow-calf pairs were monitored by video surveillance in individual stalls for 24 h. Dam colostrum was collected at 10 minutes and calf serum was collected at 24-36 h after birth to assess IgG concentration. Differences among colostrum intervention groups on latency to stand and nurse were analyzed using Kaplan-Meier survival curves and Cox proportional hazard models. The impact of colostrum intervention group on TPI was assessed using multivariable linear regression modeling. In Trial 1, calves fed 1.4 L with 70 g/L IgG by OET nursed from their dams statistically significantly earlier compared to calves fed 1 L with 100 g/L IgG (P = 0.003) and calves fed 2 L with 100 g/L IgG (P = 0.008). Six of the 15 calves in the NB group in Trial 2 refused to consume part of the colostrum feeding offered by bottle and required follow-up tube feeding of the remaining volume. These calves were analyzed as a separate group (NB + OET). Calves fed 1 L by NB stood and nursed statistically significantly earlier than calves fed by OET (P = 0.005) or a combination of NB + OET (P = 0.003). Calf serum IgG concentrations were not statistically significantly different among colostrum intervention groups (P > 0.1). Overall, the colostrum interventions assessed in this study led to only one calf with failed TPI. While statistically significant differences in serum IgG concentrations were not detected in this study, subsequent nursing behavior did vary and was improved by feeding a moderate volume (1.4 L with 70 g/L IgG) of colostrum when using an OET, and by using the NB when feeding a smaller volume (1 L with 100 g/L IgG).}, number={9}, journal={Animal}, publisher={Elsevier BV}, author={Gamsjäger, L. and Haines, D.M. and Pajor, E.A. and Lévy, M. and Windeyer, M.C.}, year={2021}, month={Sep}, pages={100345} }
 @article{gamsjäger_chigerwe_2021, title={Risk factors for, frequency, and type of complications after temporary tube cystostomy in goats, sheep, and pigs}, url={https://doi.org/10.1111/vsu.13553}, DOI={10.1111/vsu.13553}, abstractNote={Abstract}, journal={Veterinary Surgery}, author={Gamsjäger, Lisa and Chigerwe, Munashe}, year={2021}, month={Feb} }
 @article{gamsjäger_elsohaby_pearson_levy_pajor_haines_windeyer_2020, title={Assessment of Brix refractometry to estimate immunoglobulin G concentration in beef cow colostrum}, url={https://doi.org/10.1111/jvim.15805}, DOI={10.1111/jvim.15805}, abstractNote={Abstract}, journal={Journal of Veterinary Internal Medicine}, author={Gamsjäger, Lisa and Elsohaby, Ibrahim and Pearson, Jennifer M. and Levy, Michel and Pajor, Edmond A. and Haines, Deborah M. and Windeyer, M. Claire}, year={2020}, month={Jul} }
 @article{gamsjäger_ley_knych_mcarthur_heller_2020, title={Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves}, volume={81}, url={http://dx.doi.org/10.2460/ajvr.81.8.673}, DOI={10.2460/ajvr.81.8.673}, abstractNote={Abstract}, number={8}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Gamsjäger, Lisa and Ley, Brian L. Vander and Knych, Heather K. and McArthur, Gary R. and Heller, Meera C.}, year={2020}, month={Aug}, pages={673–680} }
 @article{windeyer_gamsjäger_2019, title={Vaccinating Calves in the Face of Maternal Antibodies}, volume={35}, url={http://dx.doi.org/10.1016/j.cvfa.2019.07.004}, DOI={10.1016/j.cvfa.2019.07.004}, abstractNote={A growing body of evidence has shown that calves can mount an immune response when vaccinated in the face of maternal antibodies (IFOMA), albeit inconsistently and often in ways that differ from seronegative calves or older cattle. Several previous reviews have endeavored to explain bovine neonatal immunology and have documented the issue of vaccinating young calves. However, as preweaning vaccination becomes more common in both beef and dairy production systems, so too has research on the impacts of such vaccination programs. This article aims to briefly review the challenges and opportunities for vaccinating calves IFOMA.}, number={3}, journal={Veterinary Clinics of North America: Food Animal Practice}, publisher={Elsevier BV}, author={Windeyer, M. Claire and Gamsjäger, Lisa}, year={2019}, month={Nov}, pages={557–573} }
 @article{gamsjaeger_chigerwe_2018, title={Indications for and outcomes of limb amputation in goats and sheep}, volume={252}, url={http://dx.doi.org/10.2460/javma.252.7.860}, DOI={10.2460/javma.252.7.860}, abstractNote={Abstract}, number={7}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Gamsjaeger, Lisa and Chigerwe, Munashe}, year={2018}, month={Apr}, pages={860–863} }
 @article{chigerwe_angelos_gamsjäeger_heller_2017, title={Transpalpebral exenteration in cattle: a retrospective study of 115 cases}, volume={20}, url={http://dx.doi.org/10.1111/vop.12446}, DOI={10.1111/vop.12446}, abstractNote={Abstract}, number={5}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Chigerwe, Munashe and Angelos, John A. and Gamsjäeger, Lisa and Heller, Meera C.}, year={2017}, month={Sep}, pages={435–440} }
 @article{valencak_gamsjäger_ohrnberger_culbert_ruf_2015, title={Healthy n-6/n-3 fatty acid composition from five European game meat species remains after cooking}, volume={8}, url={http://dx.doi.org/10.1186/s13104-015-1254-1}, DOI={10.1186/s13104-015-1254-1}, abstractNote={Intensive farming of livestock along with recent food scandals and consumer deception have increased awareness about risks for human nutrition. In parallel, the demand for meat obtained under more natural conditions from animals that can freely forage has largely increased. Interestingly, the consumption of game meat has not become more common despite its excellent quality and content of polyunsaturated fatty acids (PUFAs).We addressed the question if game meat fatty acid composition is modified through kitchen preparation. By analysing muscle fatty acid (FA) composition (polar and total lipids) of five European game species in a raw and a processed state, we aimed to quantify the proportion of PUFA that are oxidised and hydrogenated during processing. All game meat species originated from local hunters and free-living individuals. To mimic a realistic situation a professional chef prepared the meat samples with gentle use of heat in a standardised way.Expectedly, the overall content of polyunsaturated fatty acids declined during the cooking process but the decrease size was <5% and the nutritiously most important n-3/n-6 ratio was not affected by processing (F1,54 = 0.46; p = 0.5). Generally, our samples contained species-specific high PUFA and n-3 FA contents but we point out that differentiating between species is necessary.Game meat thus provides a healthy meat source, as cooking does not substantially alter its favourable fatty acid composition. Further research is needed to elucidate species-specific differences and the role of habitat quality and locomotion for tissue composition.}, number={1}, journal={BMC Research Notes}, publisher={Springer Science and Business Media LLC}, author={Valencak, Teresa G and Gamsjäger, Lisa and Ohrnberger, Sarah and Culbert, Nicole J and Ruf, Thomas}, year={2015}, month={Dec} }