Lin He

Works (42)

Updated: July 26th, 2023 21:17

2021 article

Optical properties of segmented Ag-Au wire at single particle level studied with a home-built micro-spectrometer

Neupane, B. B., Chase, T. E., Zhao, L., Wang, G., & He, L. (2021, July 18). ENGINEERING REPORTS.

By: B. Neupane n, T. Chase n, L. Zhao n, G. Wang n & L. He n

author keywords: hetero-metallic nanowires; second harmonic generation; surface plasmon resonance; two-photon excitation luminescence; up-conversion luminescence
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 2, 2021

2019 journal article

Amplification-by-Polymerization in Biosensing for Human Genomic DNA Detection

ACS SENSORS, 4(4), 992–1000.

By: P. He n, X. Lou n, S. Woody n & L. He n

author keywords: amplification-by-polymerization; biosensors; genomic DNA detection; RAFT; ATRP
MeSH headings : Biosensing Techniques / methods; Chromosomes, Human, X / chemistry; Chromosomes, Human, Y / chemistry; DNA / blood; DNA / genetics; DNA Probes / chemistry; DNA Probes / genetics; Female; Genomics / methods; Genotype; Humans; Male; Nucleic Acid Hybridization; Photometry / methods; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polymerization; Proof of Concept Study; Sex
TL;DR: The potential of adopting the described sensing technique without PCR was demonstrated, which could further promote the development of a portable, PCR-free DNA sensing device for point-of-need applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 4, 2019

2016 journal article

Matrix-enhanced nanostructure initiator mass spectrometry (ME-NIMS) for small molecule detection and imaging

Analytical Methods, 8(46), 8234–8240.

By: T. Moening n, V. Brown n & L. He n

TL;DR: Improved performance from ME-NIMS was seen in the detection of lipids and small drug molecules during tissue imaging and at least an order of magnitude improvement in the limit of detection of pentamidine was demonstrated compared to using conventional NIMS only. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Current status and future prospects of mass spectrometry imaging of small molecules

Mass Spectrometry Imaging of Small Molecules, 1203, 1–7.

By: V. Brown & L. He

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Mass spectrometry imaging of small molecules preface

Mass Spectrometry Imaging of Small Molecules, 1203, V-.

By: L. He

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules

Mass Spectrometry Imaging of Small Molecules, 1203, 175–184.

By: V. Brown, Q. Liu & L. He

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues

Mass Spectrometry Imaging of Small Molecules, 1203, 151–157.

By: T. Moening, V. Brown & L. He

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Multiplexed miRNA detection using cationic polythiophene

ANALYTICAL METHODS, 6(7), 2399–2405.

By: W. Zheng n, T. Chase n & L. He n

TL;DR: The use of inherently encoded nanorods allowed simultaneous detection of different miRNA targets with good specificity and a detection limit of fmol amounts of miRNA was achieved, with a linear response spanning across a broad dynamic range. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Quantitative measurements of thermodynamics and kinetics of polythiophene-DNA complex formation in DNA detection

BIOMATERIALS SCIENCE, 2(10), 1471–1479.

By: W. Zheng n & L. He n

TL;DR: A systematic study to quantitatively measure the thermodynamic binding constants and hybridization rates of DNA duplexes in the presence/absence of cationic polythiophene and was able to improve the DNA sensing performance through a combined tuning of reaction temperature and time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Chemical amplification for in-gel DNA detection

ANALYTICAL METHODS, 3(11), 2463–2468.

By: P. He n, E. Tucker n, C. Gorman n  & L. He n

Contributors: P. He n, E. Tucker n, C. Gorman n  & L. He n

TL;DR: This report reports the use of reversible addition–fragmentation chain transfer (RAFT) polymerization as a highly efficient chemical amplification means to direct visualization of DNA in porous polyacrylamide gel for signal amplification for DNA detection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Polymerization-assisted signal amplification for electrochemical detection of biomarkers

Analyst [London], 136(12), 2558–2563.

By: Y. Wu, S. Liu & L. He

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Activators generated electron transfer for atom transfer radical polymerization for immunosensing

BIOSENSORS & BIOELECTRONICS, 26(3), 970–975.

By: Y. Wu *, S. Liu * & L. He n

author keywords: Activators generated electron transfer; Atom transfer radical polymerization; Chemiluminescent; Electrochemistry; Signal amplification
MeSH headings : Animals; Antibodies, Immobilized; Antibodies, Monoclonal; Biosensing Techniques / methods; Electrochemical Techniques; Electron Transport; Enzymes, Immobilized; Flow Injection Analysis; Horseradish Peroxidase; Humans; Immunoassay / methods; Luminescence; Male; Mice; Polymers / chemistry; Prostate-Specific Antigen / analysis; Reproducibility of Results
TL;DR: A more than 13- and 14-fold enhancement in the chemiluminescent intensity and electrocatalytic current was achieved comparing to the traditional sandwiched immunoassays using HRP-conjugated antibody directly, paving a new way for ultrasensitive detection of cancer biomarkers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Distance-Dependent Fluorescence Quenching or Conjugated Polymers on Au/kg Striped Nanorods

JOURNAL OF PHYSICAL CHEMISTRY C, 114(41), 17829–17835.

By: W. Zheng n & L. He n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 article

Multiplexed detection of protein cancer markers on Au/Ag-barcoded nanorods using fluorescent-conjugated polymers

Zheng, W., & He, L. (2010, July). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 397, pp. 2261–2270.

By: W. Zheng n & L. He n

author keywords: Protein sensing; Multiplexing; Encoded nanoparticle; Solution array; Fluorescent-conjugated polymer; Cancer marker detection
MeSH headings : Animals; Biomarkers, Tumor / analysis; Cattle; Electronic Data Processing; Fluorescent Dyes; Gold; Humans; Immunoassay / methods; Limit of Detection; Nanotubes / chemistry; Neoplasm Proteins / analysis; Polymers; Sensitivity and Specificity; Silver
TL;DR: Integration of fluorescent-conjugated polymers as detection moiety with metallic striped nanorods for multiplexed detection of clinically important cancer marker proteins in an immunoassay format was demonstrated in this report. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Polymeric macroinitiators for signal amplification in AGET ATRP-based DNA detection

SENSORS AND ACTUATORS B-CHEMICAL, 150(2), 594–600.

By: H. Qian n & L. He n

author keywords: Polylysine (PLL); Macroinitiator; Activators generated by electron transfer for atom transfer radical polymerization; (AGET ATRP); DNA detection; Signal amplification
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Detection of Protein Binding Using Activator Generated by Electron Transfer for Atom Transfer Radical Polymerization

ANALYTICAL CHEMISTRY, 81(23), 9824–9827.

By: H. Qian n & L. He n

MeSH headings : Animals; Cattle; Electron Transport; Immobilized Proteins / chemistry; Immobilized Proteins / metabolism; Polymers / chemistry; Protein Binding
TL;DR: A purge-free controlled living polymerization method, activator generated by electron transfer for atom transfer radical polymerization (AGET ATRP), is used to amplify the occurrence of protein binding events and detection of ovalbumin is demonstrated where binding of femtomole protein is differentiable from the background using ellipsometry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Electrochemical Biosensing Using Amplification-by-Polymerization

ANALYTICAL CHEMISTRY, 81(16), 7015–7021.

By: Y. Wu n, S. Liu  n & L. He n

MeSH headings : Acrylates / chemistry; Biosensing Techniques; Electrochemistry; Epoxy Compounds / chemistry; Limit of Detection; Methacrylates / chemistry; Polymers / chemistry
TL;DR: The results show that the coupling of amplification-by-polymerization concept with electrochemical detection offers great promises in providing a sensitive and cost-effective solution for biosensing applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Impacts of Surface Morphology on Ion Desorption and Ionization in Desorption Ionization on Porous Silicon (DIOS) Mass Spectrometry

JOURNAL OF PHYSICAL CHEMISTRY C, 113(8), 3076–3083.

By: Y. Xiao n, S. Retterer  n, D. Thomas n, J. Tao n & L. He n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Label-Free, Real-Time Multiplexed DNA Detection Using Fluorescent Conjugated Polymers

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(10), 3432-+.

By: W. Zheng n & L. He n

MeSH headings : Base Sequence; DNA / analysis; DNA Probes; Fluorescent Dyes / chemistry; Polymers / chemistry; Surface Plasmon Resonance
TL;DR: A label-free, multiplexed DNA assay using fluorescent conjugated polymers as a detection probe to illustrate hybridization on metallic striped nanorods shows attomole detection sensitivity and single-mutation specificity comparable to those of single-element assays but with much improved throughput. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Surface-Initiated Activators Generated by Electron Transfer for Atom Transfer Radical Polymerization in Detection of DNA Point Mutation

ANALYTICAL CHEMISTRY, 81(11), 4536–4542.

By: H. Qian n & L. He n

MeSH headings : Ascorbic Acid; Base Sequence; Biosensing Techniques / economics; Biosensing Techniques / methods; Catalysis; DNA / analysis; DNA / genetics; Nucleic Acid Hybridization / methods; Oxidation-Reduction; Point Mutation; Sensitivity and Specificity; Time Factors
TL;DR: The employment of a purge-free controlled/"living" polymerization reaction, activators generated by electron transfer for atom transfer radical polymerization (AGET ATRP), to achieve signal amplification upon DNA hybridization substantiates the feasibility of using Amplification-by-Polymerization for high throughput or portable screening of genetic mutations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Synthesis of Surface-Anchored DNA-Polymer Bioconjugates Using Reversible Addition-Fragmentation Chain Transfer Polymerization

BIOMACROMOLECULES, 10(7), 1804–1809.

By: P. He n & L. He n

MeSH headings : DNA / chemistry; Kinetics; Oligonucleotides / chemistry; Polymerization; Polymers / chemical synthesis; Polymers / chemistry
TL;DR: Compared to polymer growth atop small molecules, the experimental results suggest that DNA molecules significantly accelerate polymer growth, which is speculated as a result of the presence of highly charged DNA backbones and purine/pyrimidine moieties surrounding the reaction sites. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Metabolite Imaging Using Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS)

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(1), 80–88.

By: Q. Liu n, Y. Xiao n, C. Pagan-Miranda n, Y. Chiu n & L. He n

MeSH headings : Animals; Brain Chemistry; Cerebellum / chemistry; Cerebrum / chemistry; Diagnostic Imaging / methods; Dimyristoylphosphatidylcholine / chemistry; Female; Mice; Myocardium / chemistry; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: ME-SALDI combines the strengths of traditional matrix-assisted laser desorption/ionization (MALDI) and SALDI and enables successful MS imaging of low-mass species with improved detection sensitivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Particle stability in polymer-assisted reverse colorimetric DNA assays

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 393(4), 1305–1313.

By: W. Zheng n & L. He n

author keywords: Metal divalent ions; DNA-functionalized gold nanoparticles; ATRP; Polymer-assisted reverse colorimetric method
MeSH headings : Colorimetry / methods; DNA / analysis; Kinetics; Metal Nanoparticles; Nucleic Acid Hybridization
TL;DR: The results show that Cu ions used as the polymerization catalyst bind strongly to the bases in DNA molecules, resulting in crosslinking of DNA-attached gold nanoparticles and their subsequent precipitation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Phenylboronic acid immunoaffinity reactor coupled with flow injection chemiluminescence for determination of alpha-fetoprotein

ANALYTICA CHIMICA ACTA, 630(2), 186–193.

By: Y. Wu *, Y. Zhuang *, S. Liu * & L. He n

author keywords: 3-Aminophenylboronic acid; alpha-Fetoprotein; Immunoaffinity reactor; Regeneration; Flow injection chemiluminescence
MeSH headings : Adult; Antibodies / chemistry; Antibodies / immunology; Boronic Acids / metabolism; Flow Injection Analysis / instrumentation; Flow Injection Analysis / methods; Glass / chemistry; Glycoproteins / immunology; Glycoproteins / metabolism; Horseradish Peroxidase / chemistry; Humans; Hydrogen Peroxide / analysis; Immunoassay / economics; Immunoassay / instrumentation; Immunoassay / methods; Immunoenzyme Techniques; Luminescent Measurements / instrumentation; Luminescent Measurements / methods; Luminol / analysis; Microspheres; Serum / chemistry; alpha-Fetoproteins / analysis; alpha-Fetoproteins / immunology
TL;DR: The proposed system showed acceptable detection and fabrication reproducibility, and the results obtained were in acceptable agreement with those from parallel single-analyte test of practical clinical sera. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Prostate-specific antigen detection by using a reusable amperometric immunosensor based on reversible binding and leasing of HRP-anti-PSA from phenylboronic acid modified electrode

CLINICA CHIMICA ACTA, 395(1-2), 51–56.

By: S. Liu *, X. Zhang, Y. Wu *, Y. Tu & L. He n

author keywords: electrocatalytic; amperometric immunosensor; phenylboronic acid assembled monolayer; reusable; prostate-specific antigen; immunocomplex
MeSH headings : Antibodies / chemistry; Antibody Specificity; Antigen-Antibody Reactions; Binding Sites; Binding, Competitive; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Boronic Acids / chemistry; Calibration; Electrochemistry; Electrodes; Gold / chemistry; Horseradish Peroxidase / chemistry; Immunoassay / instrumentation; Immunoassay / methods; Molecular Structure; Prostate-Specific Antigen / analysis; Prostate-Specific Antigen / blood; Sensitivity and Specificity; Surface Properties
TL;DR: This amperometric immunosensor construction based on the enzyme-conjugated prostate-specific antibody (HRP-anti-PSA) reversible binding with a self-assembled phenylboronic acid monolayer on gold could be used for rapid analysis of PSA and potentially other antigens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Reversible addition-fragmentation chain transfer polymerization in DNA biosensing

ANALYTICAL CHEMISTRY, 80(10), 3633–3639.

By: P. He n, W. Zheng n, E. Tucker  n, C. Gorman n  & L. He n

MeSH headings : Base Sequence; Biopolymers / chemistry; Biosensing Techniques; Chromatography, High Pressure Liquid; DNA / chemistry; DNA Probes; Nuclear Magnetic Resonance, Biomolecular; Spectroscopy, Fourier Transform Infrared
TL;DR: Significant improvement in assay sensitivity was realized in comparison to the previously reported polymerization-based sensing method by enhancing polymer growth rate and reducing background noises caused by nonspecific adsorption. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

A binary matrix for background suppression in MALDI-MS of small molecules

Guo, Z., & He, L. (2007, March). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 387, pp. 1939–1944.

By: Z. Guo n & L. He n

author keywords: MALDI-MS; binary matrix; matrix background suppression; small molecule detection
TL;DR: An approach in which a mixture of two conventional MALDI matrices with different proton affinity was used to suppress the formation of matrix clusters and fragments yields cleaner MS spectra of fewer background peaks in both positive and negative-mode detection of small molecules. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Core-shell Au nanoparticle formation with DNA-polymer hybrid coatings using aqueous ATRP

BIOMACROMOLECULES, 8(5), 1385–1390.

By: X. Lou n, C. Wang n & L. He n

MeSH headings : Coated Materials, Biocompatible / chemical synthesis; DNA / chemistry; Electrophoresis; Gold / chemistry; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Polymers / chemistry; Water / chemistry
TL;DR: A direct surface-grafting approach to forming DNA-containing polymer shells outside of Au nanoparticles using aqueous atom transfer radical polymerization (ATRP) was reported, providing the basis for DNA sensing in homogeneous solutions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Cu(0) as the reaction additive in purge-free ATRP-assisted DNA detection

Biosensors & Bioelectronics, 23(4), 588–592.

By: G. Okelo & L. He

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Electrochemistry of cytochrome P450 enzyme on nanoparticle-containing membrane-coated electrode and its applications for drug sensing

ANALYTICAL BIOCHEMISTRY, 375(2), 209–216.

By: S. Liu *, L. Peng *, X. Yang *, Y. Wu * & L. He n

author keywords: cytochrome p450 2136; colloidal gold nanoparticles; Bupropion; bioelectrocatalysis; drug metabolism
MeSH headings : Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / metabolism; Biosensing Techniques / instrumentation; Carbon / chemistry; Catalysis; Chitosan / chemistry; Coated Materials, Biocompatible / chemistry; Cytochrome P-450 CYP2B6; Electric Conductivity; Electrochemistry; Electrodes; Gold / chemistry; Humans; Metal Nanoparticles / chemistry; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / metabolism; Oxygen / chemistry
TL;DR: An improved system to study the two-electron delivery reaction pathway of cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B 6) in vitro confirmed that C-hydroxylation and heteroatom release were the main pathways for CYP2B6-mediated drug oxidation, similar to what occurred in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Mass spectrometry imaging of small molecules using desorption/ionization on silicon

ANALYTICAL CHEMISTRY, 79(10), 3535–3541.

By: Q. Liu n, Z. Guo n & L. He n

MeSH headings : Animals; Cell Line; Cytological Techniques; Diagnostic Imaging / methods; Humans; Lasers; Liver / cytology; Liver / ultrastructure; Mass Spectrometry / methods; Mice; Phosphatidylcholines; Propidium; Silicon
TL;DR: The use of a matrix-free mass spectrometric imaging method, i.e., desorption/ionization on silicon (DIOS), for biological surface analysis, and a good correlation of the spatial distribution of cells confirmed the validity of this DIOS imaging approach. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Quantitative study of solvent and surface effects on analyte ionization in desorption ionization on silicon (DIOS) mass spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 19(1), 8–13.

By: Q. Liu n & L. He n

TL;DR: Improved MS detection of small molecules via proper surface treatment and solvent selection is demonstrated and a direct correlation between ionization of triethylamine and the relative acidities of the surface and the solvent is evident. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Recognition of glycoprotein peroxidase via con A-carrying self-assembly layer on gold

BIOMACROMOLECULES, 8(7), 2142–2148.

By: S. Liu  n, K. Wang  n, D. Du  n, Y. Sun  n & L. He n

MeSH headings : Concanavalin A / chemistry; Electrodes; Gold / chemistry; Peroxidases / chemistry
TL;DR: The approach described in this study provides a simple yet selective means to immobilize glycoproteins on a solid support and is desirable in biosensor fabrication, glycoprotein separation, recognition, and purification as well as in drug-releasing systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Surface passivation using oligo(ethylene glycol) in ATRP-assisted DNA detection

SENSORS AND ACTUATORS B-CHEMICAL, 129(1), 225–230.

By: X. Lou n & L. He n

author keywords: surface passivation; oligo(ethylene glycol); self-assembled monolayer; DNA sensing
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

DNA-accelerated atom transfer radical polymerization on a gold surface

LANGMUIR, 22(6), 2640–2646.

By: X. Lou n & L. He n

MeSH headings : Base Sequence; DNA, Single-Stranded / chemistry; Gold / chemistry; Nuclear Magnetic Resonance, Biomolecular
TL;DR: The results show that the presence of DNA molecules, although at a less-than-1% surface coverage, significantly accelerated the growth rates of both poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(oligoethylene glycol methacries) (POEGMA) at the beginning of the ATRP reactions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 review

Radical polymerization in biosensing

[Review of ]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 386(3), 525–531.

By: X. Lou n, P. He n, G. Okelo n & L. He n

author keywords: free radical polymerization; controlled; living radical polymerization; biosensors; biosensing
MeSH headings : Artifacts; Biosensing Techniques / methods; Free Radicals; Polymers; Surface Properties
TL;DR: Advancements in surface modification aimed at improving sensor biocompatibility and reducing nonspecific background noises are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Detection of DNA point mutation by atom transfer radical polymerization

ANALYTICAL CHEMISTRY, 77(15), 4698–4705.

By: X. Lou n, M. Lewis n, C. Gorman n  & L. He n

Contributors: X. Lou n, M. Lewis n, C. Gorman n  & . al.

MeSH headings : DNA / analysis; DNA / genetics; DNA / ultrastructure; Free Radicals / chemistry; Microscopy, Atomic Force; Molecular Structure; Point Mutation / genetics; Polyhydroxyethyl Methacrylate / chemistry; Spectrum Analysis
TL;DR: A new DNA detection method in which polymer growth in atom transfer radical polymerization (ATRP) is used as a means to amplify detection signals and laid the groundwork for the future development of detector-free testing kits in single-nucleotide polymorphism screenings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 review

Nanomaterials in mass spectrometry ionization and prospects for biological application

[Review of ]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 384(3), 584–592.

By: Z. Guo n, A. Ganawi n, Q. Liu n & L. He n

author keywords: nanomaterials; mass spectrometry; bioanalysis
MeSH headings : Biology; Mass Spectrometry / methods; Nanostructures / analysis; Nanostructures / chemistry; Nanostructures / ultrastructure; Sensitivity and Specificity
TL;DR: A brief review summarizes recent developments in the field with the focus on the use of nanomaterials as alternative media to facilitate analyte ionization in laser-desorption ionization–mass spectrometry (LDI–MS) and secondary ion mass spectrometer (SIMS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Ordered silicon nanocavity arrays in surface-assisted desorption/ionization mass spectrometry

ANALYTICAL CHEMISTRY, 77(4), 1088–1095.

By: N. Finkel n, B. Prevo n, O. Velev n  & L. He n

Contributors: N. Finkel n, B. Prevo n, O. Velev n  & L. He n

MeSH headings : Arabidopsis / chemistry; Arabidopsis / metabolism; Nanotubes; Plant Roots / chemistry; Silicon; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A simple method to generate ordered nanocavity arrays on a Si wafer and use it in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS), which demonstrated that the in-plane width and out-of-plane depth of the cavities were adjustable by varying etching times, and the intercavity spacing was controllable by varying the number of particle layers deposited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Barcoding the microworld

Analytical Chemistry, 76(19), 353A–359.

By: N. Finkel, X. Lou, C. Wang & L. He

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

The distance-dependence of colloidal Au-amplified surface plasmon resonance

JOURNAL OF PHYSICAL CHEMISTRY B, 108(30), 10973–10980.

By: L. He*, E. Smith *, M. Natan* & C. Keating *

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 review

Nanoparticles for bioanalysis

[Review of ]. Current Opinion in Chemical Biology, 7(5), 609–615.

By: S. Penn, L. He & M. Natan

Source: NC State University Libraries
Added: August 6, 2018

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