Lisard Iglesias Carres

Works (11)

Updated: January 3rd, 2024 05:03

2023 article

Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes

Satheesh Babu, A. K., Petersen, C., Iglesias-Carres, L., Paz, H. A., Wankhade, U. D., Neilson, A. P., & Anandh Babu, P. V. (2023, November 3). BIOFACTORS.

By: A. Satheesh Babu*, C. Petersen*, L. Iglesias-Carres  n, H. Paz *, U. Wankhade *, A. Neilson n , P. Anandh Babu *

author keywords: blueberry; chlorogenic acid; gut microbes; strawberry; trimethylamine; trimethylamine N-oxide
TL;DR: Dietary blueberries increased the abundance of bacterial taxa that are negatively associated with circulating TMA/TMAO suggesting the role of gut microbes and phenolic profiling indicates that this effect could be due to chlorogenic acid and increased phenolic contents in blueberries. (via Semantic Scholar)
Source: Web Of Science
Added: November 27, 2023

2023 journal article

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 120.

By: L. Iglesias-Carres  n, S. Chadwick-Corbin n , M. Sweet n & A. Neilson n 

author keywords: Atherosclerosis; Cardiovascular disease; FMO3; Trimethylamine; Trimethylamine N-oxide
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 article

Gut Microbiota Depletion Using Antibiotics to Investigate Diet-Derived Microbial Metabolites: An Efficient Strategy

Babu, A. K. S., Petersen, C., Paz, H. A., Iglesias-Carres, L., Li, Y., Zhong, Y., … Babu, P. V. A. (2023, December 6). MOLECULAR NUTRITION & FOOD RESEARCH.

By: A. Babu*, C. Petersen*, H. Paz *, L. Iglesias-Carres  n, Y. Li *, Y. Zhong, A. Neilson n , U. Wankhade *, P. Babu *

author keywords: antibiotics; diet-derived microbial metabolites; gut microbes; metabolic health; trimethylamine; trimethylamine N-oxide
TL;DR: This strategy effectively depletes gut microbes and suppresses the production of microbial metabolites in mice without affecting their metabolic health. (via Semantic Scholar)
Source: Web Of Science
Added: December 18, 2023

2023 journal article

In vitro evidences of the globe artichoke antioxidant, cardioprotective and neuroprotective effects

JOURNAL OF FUNCTIONAL FOODS, 107.

By: L. Iglesias-Carres  n, A. Bruno*, I. 'Antuono *, V. Linsalata *, A. Cardinali * & A. Neilson n 

author keywords: Artichoke; Polyphenols; Antiaging; TMAO; Neuroprotective
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 28, 2023

2023 journal article

Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer

LWT-FOOD SCIENCE AND TECHNOLOGY, 179.

By: L. Iglesias-Carres  n, K. Racine n, S. Chadwick n, C. Nunn  n, S. Kalambur*, A. Neilson n , M. Ferruzzi*

author keywords: Amino acid; Maillard reaction; BHT; Rosemary; Carnosic acid; Tocopherol; Moisture; Solubility; Citric acid; Canola oil
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2022 journal article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 626, 205–210.

By: K. Racine*, L. Iglesias-Carres, J. Herring, M. Ferruzzi*, C. Kay* , J. Tessem, A. Neilson* 

author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022

2022 article

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo-in vitro colonic fermentation model

Iglesias-Carres, L., Racine, K. C., & Neilson, A. P. (2022, July 11). FOOD & FUNCTION.

By: L. Iglesias-Carres  n, K. Racine n & A. Neilson n 

MeSH headings : Atherosclerosis / metabolism; Bacteria / metabolism; Beverages; Chlorogenic Acid; Choline / metabolism; Coffee; Fermentation; Humans; Methylamines / metabolism
TL;DR: Regular cocoa and coffee consumption could be a nutritional strategy able to reduce TMAO levels, and fractionating digested bioactive beverages determined that those fractions rich in chlorogenic acid were the most bioactive. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: July 26, 2022

2022 journal article

Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(10), 3207–3218.

By: L. Iglesias-Carres  n, E. Krueger *, J. Herring, J. Tessem * & A. Neilson n 

author keywords: atherosclerosis; food bioactives; gut microbiota metabolites; phenolic compounds; TMA
MeSH headings : Choline / metabolism; Fermentation; Gastrointestinal Microbiome; High-Throughput Screening Assays; Humans; Methylamines
TL;DR: Overall, caffeic acid, catechin, and epicatechin were the most effective noncytotoxic inhibitors of choline use and TMA production, and these compounds are proposed as lead bioactives to test in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 18, 2022

2021 journal article

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 87.

By: L. Griffin n, L. Essenmacher*, K. Racine n, L. Iglesias-Carres  n, J. Tessem *, S. Smith *, A. Neilson n 

author keywords: Natural products; Genetic diversity; Diabetes; Flavonoids; Personalized nutrition; Interindividual variation
MeSH headings : Animals; Anti-Obesity Agents / therapeutic use; Collaborative Cross Mice / genetics; Collaborative Cross Mice / physiology; Diet, High-Fat / adverse effects; Disease Models, Animal; Female; Genetic Variation; Male; Obesity / drug therapy; Obesity / etiology; Obesity / genetics; Quercetin / therapeutic use; Sex Factors
TL;DR: How diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid is explored to justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools in the field of personalized nutrition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 11, 2021

2021 journal article

Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 91.

By: L. Iglesias-Carres  n, M. Hughes *, C. Steele *, M. Ponder*, K. Davy* & A. Neilson n 

author keywords: Atherosclerosis; Cardiovasculardisease; Phytochemicals; TMAO
MeSH headings : Animals; Atherosclerosis / metabolism; Atherosclerosis / therapy; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / therapy; Drug Discovery; Gastrointestinal Microbiome / drug effects; Humans; Lipid Metabolism / drug effects; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Oxidative Stress / drug effects; Phytochemicals / pharmacology
TL;DR: The information provided by this review outlines the current state of the art of the role of phytochemicals as TMAO reducing agents, providing valuable insight to further advance in this field of study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 26, 2021

2021 article

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Iglesias-Carres, L., & Neilson, A. P. (2021, October 14). FOOD & FUNCTION.

By: L. Iglesias-Carres  n & A. Neilson n 

MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Genetic Variation / genetics; Humans; Mice; Mice, Inbred Strains / genetics; Nutritional Physiological Phenomena / drug effects; Nutritional Physiological Phenomena / genetics; Phytochemicals / administration & dosage; Phytochemicals / pharmacology; Translational Research, Biomedical
TL;DR: This review will focus on the current work performed with genetically diverse mouse populations, and the research opportunities and advantages that these models can offer to phytochemical research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 8, 2021

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