Lisard Iglesias Carres

Works (11)

Updated: April 23rd, 2025 20:35

2023 journal article

Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes

BioFactors, 50(2), 392–404.

By: A. Satheesh Babu*, C. Petersen*, L. Iglesias‐Carres n, H. Paz *, U. Wankhade *, A. Neilson n , P. Anandh Babu *

author keywords: blueberry; chlorogenic acid; gut microbes; strawberry; trimethylamine; trimethylamine N-oxide
MeSH headings : Humans; Mice; Animals; Gastrointestinal Microbiome; Blueberry Plants / metabolism; Mice, Inbred CBA; Choline / metabolism; Anti-Bacterial Agents / pharmacology; Methylamines
topics (OpenAlex): Gut microbiota and health; Diet and metabolism studies; Tea Polyphenols and Effects
TL;DR: Dietary blueberries increased the abundance of bacterial taxa that are negatively associated with circulating TMA/TMAO suggesting the role of gut microbes and phenolic profiling indicates that this effect could be due to chlorogenic acid and increased phenolic contents in blueberries. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 27, 2023

2023 article

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

Iglesias-Carres, L., Chadwick-Corbin, S. A., Sweet, M. G., & Neilson, A. P. (2023, August 5). The Journal of Nutritional Biochemistry, Vol. 120.

By: L. Iglesias-Carres n, S. Chadwick-Corbin n , M. Sweet n & A. Neilson n 

author keywords: Atherosclerosis; Cardiovascular disease; FMO3; Trimethylamine; Trimethylamine N-oxide
MeSH headings : Rats; Animals; Mixed Function Oxygenases; Microsomes, Liver / metabolism; Chlorogenic Acid; NADP; Phenols; Choline / metabolism
topics (OpenAlex): Alcohol Consumption and Health Effects; Gut microbiota and health; Metabolomics and Mass Spectrometry Studies
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 2, 2024

2023 journal article

Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy

Molecular Nutrition & Food Research, 68(3).

By: A. Satheesh Babu*, C. Petersen*, H. Paz *, L. Iglesias‐Carres n, Y. Li *, Y. Zhong *, A. Neilson n , U. Wankhade *, P. Anandh Babu *

author keywords: antibiotics; diet-derived microbial metabolites; gut microbes; metabolic health; trimethylamine; trimethylamine N-oxide
MeSH headings : Male; Mice; Animals; Gastrointestinal Microbiome; Anti-Bacterial Agents / pharmacology; RNA, Ribosomal, 16S / genetics; Drinking Water; Mice, Inbred C57BL; Diet, High-Fat / adverse effects; Methylamines
topics (OpenAlex): Gut microbiota and health; Clostridium difficile and Clostridium perfringens research; Diet and metabolism studies
TL;DR: This strategy effectively depletes gut microbes and suppresses the production of microbial metabolites in mice without affecting their metabolic health. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 18, 2023

2023 journal article

In vitro evidences of the globe artichoke antioxidant, cardioprotective and neuroprotective effects

Journal of Functional Foods, 107, 105674.

By: L. Iglesias-Carres n, A. Bruno *, I. D'Antuono *, V. Linsalata *, A. Cardinali * & A. Neilson n 

author keywords: Artichoke; Polyphenols; Antiaging; TMAO; Neuroprotective
topics (OpenAlex): Cynara cardunculus studies; Pomegranate: compositions and health benefits
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 28, 2023

2023 journal article

Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer

LWT, 179, 114682.

By: L. Iglesias-Carres n, K. Racine n, S. Chadwick n , C. Nunn  n, S. Kalambur*, A. Neilson n , M. Ferruzzi*

author keywords: Amino acid; Maillard reaction; BHT; Rosemary; Carnosic acid; Tocopherol; Moisture; Solubility; Citric acid; Canola oil
topics (OpenAlex): Edible Oils Quality and Analysis; Potato Plant Research; Dye analysis and toxicity
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 12, 2023

2022 journal article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

Biochemical and Biophysical Research Communications, 626, 205–210.

By: K. Racine n, L. Iglesias-Carres n, J. Herring *, M. Ferruzzi*, C. Kay n , J. Tessem *, A. Neilson n 

author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
topics (OpenAlex): Biochemical Analysis and Sensing Techniques; Antioxidant Activity and Oxidative Stress; Food Chemistry and Fat Analysis
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2022 article

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo – in vitro colonic fermentation model

Iglesias-Carres, L., Racine, K. C., & Neilson, A. P. (2022, January 1). Food & Function, Vol. 7.

By: L. Iglesias-Carres n, K. Racine n & A. Neilson n 

MeSH headings : Atherosclerosis / metabolism; Bacteria / metabolism; Beverages; Chlorogenic Acid; Choline / metabolism; Coffee; Fermentation; Humans; Methylamines / metabolism
topics (OpenAlex): Food composition and properties; Food Chemistry and Fat Analysis; Microbial Metabolites in Food Biotechnology; Probiotics and Fermented Foods
TL;DR: Regular cocoa and coffee consumption could be a nutritional strategy able to reduce TMAO levels, and fractionating digested bioactive beverages determined that those fractions rich in chlorogenic acid were the most bioactive. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 26, 2022

2022 article

Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model

Iglesias-Carres, L., Krueger, E. S., Herring, J. A., Tessem, J. S., & Neilson, A. P. (2022, March 2). Journal of Agricultural and Food Chemistry, Vol. 3, pp. 3207–3218.

By: L. Iglesias-Carres n, E. Krueger *, J. Herring *, J. Tessem * & A. Neilson n 

author keywords: atherosclerosis; food bioactives; gut microbiota metabolites; phenolic compounds; TMA
MeSH headings : Choline / metabolism; Fermentation; Gastrointestinal Microbiome; High-Throughput Screening Assays; Humans; Methylamines
topics (OpenAlex): Tea Polyphenols and Effects; Neurological Disease Mechanisms and Treatments; Gut microbiota and health
TL;DR: Overall, caffeic acid, catechin, and epicatechin were the most effective noncytotoxic inhibitors of choline use and TMA production, and these compounds are proposed as lead bioactives to test in vivo. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 18, 2022

2021 journal article

Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

The Journal of Nutritional Biochemistry, 91, 108600.

By: L. Iglesias-Carres n, M. Hughes *, C. Steele *, M. Ponder *, K. Davy * & A. Neilson n 

author keywords: Atherosclerosis; Cardiovasculardisease; Phytochemicals; TMAO
MeSH headings : Animals; Atherosclerosis / metabolism; Atherosclerosis / therapy; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / therapy; Drug Discovery; Gastrointestinal Microbiome / drug effects; Humans; Lipid Metabolism / drug effects; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Oxidative Stress / drug effects; Phytochemicals / pharmacology
topics (OpenAlex): Gut microbiota and health; Dietary Effects on Health; Tryptophan and brain disorders
TL;DR: The information provided by this review outlines the current state of the art of the role of phytochemicals as TMAO reducing agents, providing valuable insight to further advance in this field of study. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 26, 2021

2021 journal article

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Food & Function, 12(22), 11077–11105.

By: L. Iglesias-Carres n & A. Neilson n 

MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Genetic Variation / genetics; Humans; Mice; Mice, Inbred Strains / genetics; Nutritional Physiological Phenomena / drug effects; Nutritional Physiological Phenomena / genetics; Phytochemicals / administration & dosage; Phytochemicals / pharmacology; Translational Research, Biomedical
topics (OpenAlex): Plant biochemistry and biosynthesis; Biochemical Analysis and Sensing Techniques; Nutrition, Genetics, and Disease
TL;DR: This review will focus on the current work performed with genetically diverse mouse populations, and the research opportunities and advantages that these models can offer to phytochemical research. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: November 8, 2021

2020 journal article

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

The Journal of Nutritional Biochemistry, 87, 108521.

By: L. Griffin n, L. Essenmacher *, K. Racine n, L. Iglesias-Carres n, J. Tessem *, S. Smith *, A. Neilson n 

author keywords: Natural products; Genetic diversity; Diabetes; Flavonoids; Personalized nutrition; Interindividual variation
MeSH headings : Animals; Anti-Obesity Agents / therapeutic use; Collaborative Cross Mice / genetics; Collaborative Cross Mice / physiology; Diet, High-Fat / adverse effects; Disease Models, Animal; Female; Genetic Variation; Male; Obesity / drug therapy; Obesity / etiology; Obesity / genetics; Quercetin / therapeutic use; Sex Factors
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Adipose Tissue and Metabolism; Genetic and phenotypic traits in livestock
TL;DR: How diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid is explored to justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools in the field of personalized nutrition. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 11, 2021

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