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Works (12)
Updated: April 5th, 2024 10:43
2024 article
The effect of ε-aminocaproic acid on blood product requirement, outcome and thromboelastography parameters in severely thrombocytopenic dogs
Wolf, J., Ruterbories, L. K., Handel, I., & Hansen, B. (2024, January 11). JOURNAL OF VETERINARY INTERNAL MEDICINE.
author keywords: antifibrinolytics; hyperfibrinolysis; platelets; thrombocytopenia
TL;DR:
Although EACA increased clot strength, there was no effect on outcome and treatment with EACA at this dosage cannot be recommended as a routine treatment but may be considered for dogs with severe ongoing hemorrhage.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: January 22, 2024
2023 journal article
Evaluation of thrombin generation in dogs administered clopidogrel
Frontiers in Veterinary Science, 10.
author keywords: coagulation; platelet inhibitory; antithrombotic; therapeutic monitoring; canine
TL;DR:
Thrombin generation performed on platelet poor plasma may not be a useful antiplatelet monitoring tool in dogs, despite concomitant changes in TEG-PM variables consistent with platelet inhibition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: September 11, 2023
2023 article
Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome
Lynch, A. M. M., Ruterbories, L. K. K., Robertson, J. B. B., Lunn, K. F. F., & Mowat, F. M. M. (2023, April 19). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.
author keywords: coagulation; fibrinogen; hypercoagulability; SARDS
MeSH headings : Dogs; Animals; Retinal Degeneration / veterinary; Case-Control Studies; Hemostatics; Pilot Projects; Thrombophilia / complications; Thrombophilia / veterinary; Fibrinogen; Antithrombins; Thrombelastography / veterinary; Dog Diseases
TL;DR:
Hypercoagulability was common in both dogs with SARDS and controls, but dogs with ARDS were significantly more hypercoagULable on TEG, which remains to be determined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 20, 2023
2021 journal article
Evaluation of point-of-care coagulation tests as alternatives to anti-Xa activity for monitoring the anticoagulant effects of rivaroxaban in healthy dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 18–24.
author keywords: anticoagulant; antithrombotic; canine direct oral anticoagulants; thromboembolism
MeSH headings : Administration, Oral; Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Blood Coagulation Tests / veterinary; Dogs; Factor Xa Inhibitors / administration & dosage; Factor Xa Inhibitors / pharmacology; Male; Partial Thromboplastin Time / veterinary; Point-of-Care Testing; Prospective Studies; Prothrombin Time / veterinary; Reference Values; Rivaroxaban / administration & dosage; Rivaroxaban / pharmacology; Thrombelastography / veterinary
TL;DR:
Of all the coagulation tests investigated, the PT correlated best with RIVA, and there is potential for PT being a convenient second-line monitoring option in dogs receiving rivaroxaban, but further work is necessary to validate other PT assays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 16, 2020
2021 article
Influence of long-stay jugular catheters on hemostatic variables in healthy dogs
Kielb Basile, J. L., Lynch, A. M., Ruterbories, L., Castaneda, K., Griffith, E., & Ueda, Y. (2021, July 3). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 7.
author keywords: canine; central venous catheter; hemostasis; thromboelastography; venipuncture
MeSH headings : Animals; Catheters, Indwelling / adverse effects; Catheters, Indwelling / veterinary; Dogs; Hemostatics; Jugular Veins; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Prothrombin Time / veterinary
TL;DR:
The data suggest that accurate hemostatic variables may be obtained using blood collected from indwelling jugular catheters, maintained with heparinized saline for at least 72 hours, in healthy dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2021 journal article
Personalized-induced neural stem cell therapy: Generation, transplant, and safety in a large animal model
BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(1).
author keywords: glioblastoma; neural stem cells; stem cell delivery
TL;DR:
This study generates the first canine‐induced neural stem cells (iNSCs) engineered to carry TNFα‐related apoptosis‐inducing ligand and thymidine kinase (TK), as well as magnetic resonance imaging (MRI) contrast agents for in vivo tracking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020
2021 journal article
SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(1), 126–132.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Drug Administration Schedule; Ketoprofen / administration & dosage; Ketoprofen / adverse effects; Ketoprofen / therapeutic use; Thrombelastography; Turtles / blood
TL;DR:
Ketoprofen at 2 mg/kg IM q24hr for up to 5 days in loggerheads appears safe with respect to blood clotting and blood data, although other potential effects were not evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021
2021 journal article
The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 59–65.
author keywords: anticoagulant; antithrombotic; canine direct oral anticoagulants; thromboembolism
MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Anticoagulants / administration & dosage; Anticoagulants / pharmacokinetics; Blood Coagulation Tests / veterinary; Dogs; Factor Xa Inhibitors / administration & dosage; Factor Xa Inhibitors / pharmacokinetics; Male; Meals; Prospective Studies; Reference Values; Rivaroxaban / administration & dosage; Rivaroxaban / pharmacokinetics
TL;DR:
Based on results, dogs treated with rivaroxaban do not require special modification of feeding practices or gastroprotectant drug administration and clinically relevant differences among treatment groups were not identified in combined analyses of time points.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 16, 2020
2021 article
Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders
Mariani, C. L., Niman, Z. E., Boozer, L. B., Ruterbories, L. K., Early, P. J., Munana, K. R., & Olby, N. J. (2021, June 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.
author keywords: biomarker; brain tumor; meningoencephalitis; meningomyelitis
MeSH headings : Animals; Case-Control Studies; Central Nervous System Diseases / veterinary; Cerebrospinal Fluid; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Vascular Endothelial Growth Factor A
TL;DR:
Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders and may serve as a marker of neoplastic and inflammatory CNS disorders relative to other conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 10, 2021
2020 journal article
The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.
MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
TL;DR:
In an ex vivo model, plasma proteins but not PCV impacted TEG variables, suggesting that TEG changes noted with anemia are imparted by changes in available fibrinogen in a fixed microenvironment rather than artifact of anemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2020
2019 journal article
Baseline plasma thromboelastography in Kemp’s ridley (Lepidochelys kempii), green (Chelonia mydas) and loggerhead (Caretta caretta) sea turtles and its use to diagnose coagulopathies in cold-stunned Kemp’s ridley and green sea turtles
Journal of Zoo and Wildlife Medicine, 50(1), 62.
author keywords: Coagulation; coagulopathy; cold stunned; sea turtle; thromboelastography
MeSH headings : Animals; Cold Temperature / adverse effects; Hemostasis; Plasma / chemistry; Reference Values; Species Specificity; Thrombelastography / veterinary; Turtles / blood
TL;DR:
Findings indicate that cold stunning may cause disorders in hemostasis that can contribute to the severity of the condition and early diagnosis of coagulopathies in the clinical assessment of a cold-stunned sea turtle may influence the treatment approach and clinical outcome of the case.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: April 22, 2019
2018 journal article
Targeted repair of heart injury by stem cells fused with platelet nanovesicles
NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.
TL;DR:
The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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