Leah M. Zorrilla

Works (9)

Updated: July 5th, 2023 15:51

2013 journal article

Expression of Genes Associated with Apoptosis in the Porcine Corpus Luteum During the Oestrous Cycle

REPRODUCTION IN DOMESTIC ANIMALS, 48(5), 755–761.

By: L. Zorrilla n, M. D'Annibale n, S. Swing n & J. Gadsby n 

MeSH headings : Animals; Apoptosis / physiology; Corpus Luteum / metabolism; Estrous Cycle / physiology; Female; Gene Expression Regulation / physiology; Pregnancy; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
TL;DR: It is concluded that apoptosis-associated proteins (i.e. Bcl-x and Caspase 3) may play a critical role in luteolytic sensitivity in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 32(1), 43–51.

By: L. Davis, A. Murr, D. Best, M. Fraites, L. Zorrilla, M. Narotsky, T. Stoker, J. Goldman, R. Cooper

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells

Reproductive Toxicology (Elmsford, N.Y.), 31(2), 184–193.

By: N. Tinfo, M. Hotchkiss, A. Buckalew, L. Zorrilla, R. Cooper & S. Laws

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

The effects of simazine, a chlorotriazine herbicide, on pubertal development in the female Wistar rat

Reproductive Toxicology (Elmsford, N.Y.), 29(4), 393–400.

By: L. Zorrilla, E. Gibson & T. Stoker

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Transforming growth factor-beta (TGF beta) and its signaling components in peni-ovulatory pig follicles

ANIMAL REPRODUCTION SCIENCE, 120(1-4), 84–94.

By: R. Sriperumbudur n, L. Zorrilla n & J. Gadsby n 

author keywords: Pig; TGF beta; Peri-ovulatory follicles; Luteinization; Granulosa cells; Progesterone
MeSH headings : Animals; Aromatase / genetics; Aromatase / metabolism; Cells, Cultured; Female; Gene Expression Profiling; Ligands; Luteinization / blood; Luteinization / genetics; Luteinization / metabolism; Ovarian Follicle / metabolism; Ovarian Follicle / physiology; Ovulation / blood; Ovulation / genetics; Ovulation / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Progesterone / blood; Progesterone / metabolism; Receptors, Transforming Growth Factor beta / genetics; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction / genetics; Signal Transduction / physiology; Smad Proteins / genetics; Smad Proteins / metabolism; Swine / genetics; Swine / metabolism; Swine / physiology; Time Factors; Transforming Growth Factor beta / blood; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism
TL;DR: Data from the present study on temporal and spatial patterns of expression of the TGFbeta-system suggest that TGF beta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in lute inizing pig follicles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Triclosan exposure modulates estrogen-dependent responses in the female Wistar rat

Toxicological Sciences, 117(1), 45–53.

By: T. Stoker, E. Gibson & L. Zorrilla

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Endothelin-1, endothelin converting enzyme-1 and endothelin receptors in the porcine corpus luteum

DOMESTIC ANIMAL ENDOCRINOLOGY, 38(2), 75–85.

By: L. Zorrilla n, R. Sriperumbudur n & J. Gadsby n 

author keywords: Pig; Luteolytic sensitivity; Endothelin; Corpus luteum; Prostaglandin-F-2 alpha; Luteolysis
MeSH headings : Animals; Aspartic Acid Endopeptidases / analysis; Aspartic Acid Endopeptidases / genetics; Corpus Luteum / chemistry; Dinoprost / pharmacology; Endothelial Cells / chemistry; Endothelin-1 / analysis; Endothelin-1 / genetics; Endothelin-1 / physiology; Endothelin-Converting Enzymes; Estrous Cycle; Female; Fluorescent Antibody Technique; Gene Expression; Luteal Cells / chemistry; Luteolysis / drug effects; Luteolysis / physiology; Metalloendopeptidases / analysis; Metalloendopeptidases / genetics; Protein Precursors / analysis; Protein Precursors / genetics; Receptor, Endothelin A / analysis; Receptor, Endothelin A / genetics; Receptor, Endothelin A / physiology; Receptors, Endothelin / analysis; Receptors, Endothelin / genetics; Reverse Transcriptase Polymerase Chain Reaction; Swine
TL;DR: The observed elevation in ECE1 protein concentrations on day 10 and the presence of EDNRA on LLC suggests a possible role for EDN1 (resulting from the actions of E CE1) acting via EDN RA in the control of LS in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Protein kinase C isoforms in the porcine corpus luteum: Temporal and spatial expression patterns

DOMESTIC ANIMAL ENDOCRINOLOGY, 36(4), 173–185.

By: L. Zorrilla n, M. Irvin n & J. Gadsby n 

author keywords: Corpus luteum; Protein kinase C; Pig; Luteolytic sensitivity; Prostaglandin-F-2 alpha
MeSH headings : Animals; Corpus Luteum / cytology; Corpus Luteum / enzymology; Estrous Cycle / metabolism; Female; Gene Expression Regulation / physiology; Isoenzymes / genetics; Isoenzymes / metabolism; Luteal Cells / enzymology; Luteinization / metabolism; Protein Kinase C / genetics; Protein Kinase C / metabolism; RNA, Messenger / analysis; Signal Transduction / physiology; Statistics, Nonparametric; Swine; Time Factors; Tissue Distribution
TL;DR: Since the increase in PRKCE protein expression occurred coincidentally with the onset of LS, these results support a potential role forPRKCE in control of the acquisition of LS in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats

TOXICOLOGICAL SCIENCES, 107(1), 56–64.

By: L. Zorrilla n, E. Gibson*, S. Jeffay*, K. Crofton *, W. Setzer*, R. Cooper*, T. Stoker *

MeSH headings : Analysis of Variance; Androstenedione / blood; Animals; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Glucuronosyltransferase / metabolism; Male; Microsomes, Liver / enzymology; Rats; Sexual Maturation / drug effects; Testis / anatomy & histology; Testosterone / blood; Thyroid Gland / anatomy & histology; Thyrotropin / blood; Thyroxine / blood; Triclosan / administration & dosage; Triclosan / pharmacology; Triiodothyronine / blood
TL;DR: It is demonstrated that triclosan exposure does not alter androgen-dependent tissue weights or onset of PPS; however, tricrosan exposure significantly impacts thyroid hormone concentrations in the male juvenile rat. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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