Leah M. Zorrilla

Works (9)

Updated: July 5th, 2023 15:51

2013 article

Expression of Genes Associated with Apoptosis in the Porcine Corpus Luteum During the Oestrous Cycle

Zorrilla, L. M., D'Annibale, M. A., Swing, S. E., & Gadsby, J. E. (2013, March 23). Reproduction in Domestic Animals, Vol. 48, pp. 755–761.

By: L. Zorrilla n, M. D'Annibale n, S. Swing n & J. Gadsby n 

MeSH headings : Animals; Apoptosis / physiology; Corpus Luteum / metabolism; Estrous Cycle / physiology; Female; Gene Expression Regulation / physiology; Pregnancy; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
topics (OpenAlex): Reproductive Physiology in Livestock; Reproductive Biology and Fertility; Heat shock proteins research
TL;DR: It is concluded that apoptosis-associated proteins (i.e. Bcl-x and Caspase 3) may play a critical role in luteolytic sensitivity in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 32(1), 43–51.

By: L. Davis, A. Murr, D. Best, M. Fraites, L. Zorrilla, M. Narotsky, T. Stoker, J. Goldman, R. Cooper

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells

Reproductive Toxicology (Elmsford, N.Y.), 31(2), 184–193.

By: N. Tinfo, M. Hotchkiss, A. Buckalew, L. Zorrilla, R. Cooper & S. Laws

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

The effects of simazine, a chlorotriazine herbicide, on pubertal development in the female Wistar rat

Reproductive Toxicology (Elmsford, N.Y.), 29(4), 393–400.

By: L. Zorrilla, E. Gibson & T. Stoker

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Transforming growth factor-β (TGFβ) and its signaling components in peri-ovulatory pig follicles

Sriperumbudur, R., Zorrilla, L., & Gadsby, J. E. (2010, March 9). Animal Reproduction Science, Vol. 120, pp. 84–94.

By: R. Sriperumbudur n, L. Zorrilla n & J. Gadsby n 

author keywords: Pig; TGF beta; Peri-ovulatory follicles; Luteinization; Granulosa cells; Progesterone
MeSH headings : Animals; Aromatase / genetics; Aromatase / metabolism; Cells, Cultured; Female; Gene Expression Profiling; Ligands; Luteinization / blood; Luteinization / genetics; Luteinization / metabolism; Ovarian Follicle / metabolism; Ovarian Follicle / physiology; Ovulation / blood; Ovulation / genetics; Ovulation / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Progesterone / blood; Progesterone / metabolism; Receptors, Transforming Growth Factor beta / genetics; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction / genetics; Signal Transduction / physiology; Smad Proteins / genetics; Smad Proteins / metabolism; Swine / genetics; Swine / metabolism; Swine / physiology; Time Factors; Transforming Growth Factor beta / blood; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism
topics (OpenAlex): Reproductive Physiology in Livestock; Reproductive Biology and Fertility
TL;DR: Data from the present study on temporal and spatial patterns of expression of the TGFbeta-system suggest that TGF beta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in lute inizing pig follicles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Triclosan exposure modulates estrogen-dependent responses in the female Wistar rat

Toxicological Sciences, 117(1), 45–53.

By: T. Stoker, E. Gibson & L. Zorrilla

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Endothelin-1, endothelin converting enzyme-1 and endothelin receptors in the porcine corpus luteum

Zorrilla, L. M., Sriperumbudur, R., & Gadsby, J. E. (2009, September 19). Domestic Animal Endocrinology, Vol. 38, pp. 75–85.

By: L. Zorrilla n, R. Sriperumbudur n & J. Gadsby n 

author keywords: Pig; Luteolytic sensitivity; Endothelin; Corpus luteum; Prostaglandin-F-2 alpha; Luteolysis
MeSH headings : Animals; Aspartic Acid Endopeptidases / analysis; Aspartic Acid Endopeptidases / genetics; Corpus Luteum / chemistry; Dinoprost / pharmacology; Endothelial Cells / chemistry; Endothelin-1 / analysis; Endothelin-1 / genetics; Endothelin-1 / physiology; Endothelin-Converting Enzymes; Estrous Cycle; Female; Fluorescent Antibody Technique; Gene Expression; Luteal Cells / chemistry; Luteolysis / drug effects; Luteolysis / physiology; Metalloendopeptidases / analysis; Metalloendopeptidases / genetics; Protein Precursors / analysis; Protein Precursors / genetics; Receptor, Endothelin A / analysis; Receptor, Endothelin A / genetics; Receptor, Endothelin A / physiology; Receptors, Endothelin / analysis; Receptors, Endothelin / genetics; Reverse Transcriptase Polymerase Chain Reaction; Swine
topics (OpenAlex): Nitric Oxide and Endothelin Effects; Reproductive Physiology in Livestock; Veterinary Medicine and Surgery
TL;DR: The observed elevation in ECE1 protein concentrations on day 10 and the presence of EDNRA on LLC suggests a possible role for EDN1 (resulting from the actions of E CE1) acting via EDN RA in the control of LS in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Protein kinase C isoforms in the porcine corpus luteum: Temporal and spatial expression patterns

Zorrilla, L. M., Irvin, M. S., & Gadsby, J. E. (2008, December 5). Domestic Animal Endocrinology, Vol. 36, pp. 173–185.

By: L. Zorrilla n, M. Irvin n & J. Gadsby n 

author keywords: Corpus luteum; Protein kinase C; Pig; Luteolytic sensitivity; Prostaglandin-F-2 alpha
MeSH headings : Animals; Corpus Luteum / cytology; Corpus Luteum / enzymology; Estrous Cycle / metabolism; Female; Gene Expression Regulation / physiology; Isoenzymes / genetics; Isoenzymes / metabolism; Luteal Cells / enzymology; Luteinization / metabolism; Protein Kinase C / genetics; Protein Kinase C / metabolism; RNA, Messenger / analysis; Signal Transduction / physiology; Statistics, Nonparametric; Swine; Time Factors; Tissue Distribution
topics (OpenAlex): Calpain Protease Function and Regulation; Protein Kinase Regulation and GTPase Signaling; melanin and skin pigmentation
TL;DR: Since the increase in PRKCE protein expression occurred coincidentally with the onset of LS, these results support a potential role forPRKCE in control of the acquisition of LS in the pig. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats

Zorrilla, L. M., Gibson, E. K., Jeffay, S. C., Crofton, K. M., Setzer, W. R., Cooper, R. L., & Stoker, T. E. (2008, October 21). Toxicological Sciences.

By: L. Zorrilla n, E. Gibson*, S. Jeffay*, K. Crofton *, W. Setzer*, R. Cooper*, T. Stoker *

MeSH headings : Analysis of Variance; Androstenedione / blood; Animals; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Glucuronosyltransferase / metabolism; Male; Microsomes, Liver / enzymology; Rats; Sexual Maturation / drug effects; Testis / anatomy & histology; Testosterone / blood; Thyroid Gland / anatomy & histology; Thyrotropin / blood; Thyroxine / blood; Triclosan / administration & dosage; Triclosan / pharmacology; Triiodothyronine / blood
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Pharmaceutical and Antibiotic Environmental Impacts; Pharmacological Effects and Assays
TL;DR: It is demonstrated that triclosan exposure does not alter androgen-dependent tissue weights or onset of PPS; however, tricrosan exposure significantly impacts thyroid hormone concentrations in the male juvenile rat. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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